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Protein

Fascin-3

Gene

Fscn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an actin bundling protein.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament bundle assembly Source: GO_Central
  • cell migration Source: GO_Central
  • establishment or maintenance of cell polarity Source: GO_Central
  • spermatid development Source: MGI

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin-3
Alternative name(s):
Testis fascin
Gene namesi
Name:Fscn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1890386 Fscn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193841 – 498Fascin-3Add BLAST498

Proteomic databases

PaxDbiQ9QXW4
PRIDEiQ9QXW4

PTM databases

PhosphoSitePlusiQ9QXW4

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiENSMUSG00000029707 Expressed in 16 organ(s), highest expression level in seminiferous tubule of testis
GenevisibleiQ9QXW4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031719

Structurei

3D structure databases

ProteinModelPortaliQ9QXW4
SMRiQ9QXW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000029285
HOVERGENiHBG051663
InParanoidiQ9QXW4
KOiK17456
OMAiCNMDQPD
OrthoDBiEOG091G0C6S
TreeFamiTF323992

Family and domain databases

CDDicd00257 Fascin, 3 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030143 FSCN3
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF1 PTHR10551:SF1, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 2 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequencei

Sequence statusi: Complete.

Q9QXW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVDWIHRH PKAEDLRVGL ISWAGTYLTF EAYKSSVTAS AKSLGRRQTW
60 70 80 90 100
ELLVSNEHES QAVIRLKSLQ GLYLLCEADG TVCYGRPRTS HHGCFLLRFH
110 120 130 140 150
RNGKWTLQCI ISGRYLESDG EDVFCNSRVL SAYHMWTPRP ALHVHVILYS
160 170 180 190 200
PIYHSYARAD HTVGRIWVDA AIPCLEECGF LLHFQDGCYH LETSTHHFLS
210 220 230 240 250
RVDRLVPQRS SQTAFHMQVR PRGLVALCDG EGGTLYPQGS HLLLGMGSAP
260 270 280 290 300
MKGEEWFVLQ HFPTWVSLKS KSRRFLSVIY DAEVCAASER LTQMSLFQYE
310 320 330 340 350
CDSETPTLQL RSANGYYLAQ RRHRAIIADG HPMESDTFFR VHWNCGKITL
360 370 380 390 400
QSPNGRFLGI ASDGLLMANV TIPGPNEELG IRFANRPFLV LRGRYGYVGS
410 420 430 440 450
SSDHDLLKCN MDQPDCIQLL PCRQGIYHFQ AQGGSFWSIT SFGTFRPWGK
460 470 480 490
FALNFCIELQ GSSLLTVLAP NGFYLRADRS GTLLADSEEI TKECIWEF
Length:498
Mass (Da):56,443
Last modified:July 27, 2011 - v2
Checksum:iC377EE05825BA529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238Q → A in AAF19797 (PubMed:11925108).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176024 mRNA Translation: AAF19797.1
CH466533 Genomic DNA Translation: EDL13800.1
BC050759 mRNA Translation: AAH50759.1
CCDSiCCDS39446.1
RefSeqiNP_062515.2, NM_019569.2
UniGeneiMm.31708

Genome annotation databases

EnsembliENSMUST00000031719; ENSMUSP00000031719; ENSMUSG00000029707
GeneIDi56223
KEGGimmu:56223
UCSCiuc009bcr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176024 mRNA Translation: AAF19797.1
CH466533 Genomic DNA Translation: EDL13800.1
BC050759 mRNA Translation: AAH50759.1
CCDSiCCDS39446.1
RefSeqiNP_062515.2, NM_019569.2
UniGeneiMm.31708

3D structure databases

ProteinModelPortaliQ9QXW4
SMRiQ9QXW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031719

PTM databases

PhosphoSitePlusiQ9QXW4

Proteomic databases

PaxDbiQ9QXW4
PRIDEiQ9QXW4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031719; ENSMUSP00000031719; ENSMUSG00000029707
GeneIDi56223
KEGGimmu:56223
UCSCiuc009bcr.1 mouse

Organism-specific databases

CTDi29999
MGIiMGI:1890386 Fscn3

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000029285
HOVERGENiHBG051663
InParanoidiQ9QXW4
KOiK17456
OMAiCNMDQPD
OrthoDBiEOG091G0C6S
TreeFamiTF323992

Miscellaneous databases

PROiPR:Q9QXW4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029707 Expressed in 16 organ(s), highest expression level in seminiferous tubule of testis
GenevisibleiQ9QXW4 MM

Family and domain databases

CDDicd00257 Fascin, 3 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030143 FSCN3
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF1 PTHR10551:SF1, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 2 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFSCN3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXW4
Secondary accession number(s): Q80YU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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