UniProtKB - Q9QXW2 (FBXW5_MOUSE)
F-box/WD repeat-containing protein 5
Fbxw5
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- protein kinase binding Source: MGI
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein ubiquitination Source: UniProtKB
- regulation of centrosome duplication Source: UniProtKB
- regulation of mitotic nuclear division Source: UniProtKB
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/WD repeat-containing protein 5Alternative name(s): F-box and WD-40 domain-containing protein 5 |
Gene namesi | Name:Fbxw5 Synonyms:Fbw5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354731, Fbxw5 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- SCF ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050993 | 1 – 573 | F-box/WD repeat-containing protein 5Add BLAST | 573 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 151 | Phosphoserine; by PLK4By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9QXW2 |
PaxDbi | Q9QXW2 |
PRIDEi | Q9QXW2 |
ProteomicsDBi | 267720 [Q9QXW2-1] 267721 [Q9QXW2-2] |
PTM databases
iPTMneti | Q9QXW2 |
PhosphoSitePlusi | Q9QXW2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000015095, Expressed in spermatocyte and 282 other tissues |
ExpressionAtlasi | Q9QXW2, baseline and differential |
Genevisiblei | Q9QXW2, MM |
Interactioni
Subunit structurei
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5.
Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1.
Interacts with CDC20, TSC1, TSC2 and SASS6 (By similarity).
Interacts with EPS8.
Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
By similarity3 PublicationsBinary interactionsi
Q9QXW2
With | #Exp. | IntAct |
---|---|---|
Skp1 [Q9WTX5] | 2 | EBI-16031930,EBI-1202363 |
GO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 205976, 4 interactors |
DIPi | DIP-60700N |
IntActi | Q9QXW2, 1 interactor |
STRINGi | 10090.ENSMUSP00000015239 |
Miscellaneous databases
RNActi | Q9QXW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 49 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 90 – 129 | WD 1Add BLAST | 40 | |
Repeati | 470 – 509 | WD 2Add BLAST | 40 | |
Repeati | 511 – 551 | WD 3Add BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 308 – 316 | D-box | 9 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | ENOG502QTGQ, Eukaryota |
GeneTreei | ENSGT00730000111276 |
HOGENOMi | CLU_021121_0_0_1 |
InParanoidi | Q9QXW2 |
OMAi | PHQIGFK |
OrthoDBi | 771384at2759 |
TreeFami | TF324320 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR042508, FBXW5 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR20995, PTHR20995, 1 hit |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEGGLPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWKEQF
60 70 80 90 100
YRYYQVARDV PRHPAATSWY EEFRRLYDMV PCVEVQTLKE HTDQVLHLSF
110 120 130 140 150
SHSGYQFASC SKDCTVKIWN NDLTISLLHS ADMRPYNWSY TQFSQFNQDD
160 170 180 190 200
SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS
210 220 230 240 250
LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTIR
260 270 280 290 300
TVMVADCSRF DSPDLLLDAS DQAGLPCRVF DLGGDTEEEA TDPGLHTSGS
310 320 330 340 350
DHVKKGLRRV FDSVLDGHGQ LSDCALETKV AELLAQGHTK PPECNDADTR
360 370 380 390 400
NKYLIFTTGC LTYSPHQIGI KQILPHQMTT AGPVLGEGRG SDAFFDALDH
410 420 430 440 450
VIDVHGHIIG MGLSPDNRYL YVNSRAWPPG SVVADPMQPP PIAEEIDLLV
460 470 480 490 500
FDLKTMREVK RALRAHRAYT PNDECFFIFL DVSRDFVASG AEDRHGYIWD
510 520 530 540 550
RHYNICLAKL RHEDVVNSVA FSPQEQELLL TASDDATIKA WRSPRIVRVL
560 570
QAPRPRPRPR PRPFFSWFAS HRR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQH6 | A0A0A0MQH6_MOUSE | F-box/WD repeat-containing protein ... | Fbxw5 | 246 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042293 | 1 | M → MLSAVEFSGGQLVGLARTAM SGTPDYQSLPGVGDEEAWVQ SRHWWVSGPSGQNVTM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_042294 | 530 – 573 | LTASD…ASHRR → PDSQRRCHYQSLAFTTHCSC SAGSTPSPPPSPPPLLLLVC QP in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176520 mRNA Translation: AAF09130.1 AK019715 mRNA Translation: BAB31841.1 AK154911 mRNA Translation: BAE32921.1 AL732557 Genomic DNA Translation: CAM25629.1 AL732557 Genomic DNA Translation: CAM25630.1 Sequence problems. CH466542 Genomic DNA Translation: EDL08255.1 BC010776 mRNA Translation: AAH10776.1 |
CCDSi | CCDS15778.1 [Q9QXW2-1] |
RefSeqi | NP_038936.1, NM_013908.4 [Q9QXW2-1] |
Genome annotation databases
Ensembli | ENSMUST00000015239; ENSMUSP00000015239; ENSMUSG00000015095 [Q9QXW2-1] |
GeneIDi | 30839 |
KEGGi | mmu:30839 |
UCSCi | uc008isj.1, mouse [Q9QXW2-1] uc008isk.1, mouse [Q9QXW2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176520 mRNA Translation: AAF09130.1 AK019715 mRNA Translation: BAB31841.1 AK154911 mRNA Translation: BAE32921.1 AL732557 Genomic DNA Translation: CAM25629.1 AL732557 Genomic DNA Translation: CAM25630.1 Sequence problems. CH466542 Genomic DNA Translation: EDL08255.1 BC010776 mRNA Translation: AAH10776.1 |
CCDSi | CCDS15778.1 [Q9QXW2-1] |
RefSeqi | NP_038936.1, NM_013908.4 [Q9QXW2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 205976, 4 interactors |
DIPi | DIP-60700N |
IntActi | Q9QXW2, 1 interactor |
STRINGi | 10090.ENSMUSP00000015239 |
PTM databases
iPTMneti | Q9QXW2 |
PhosphoSitePlusi | Q9QXW2 |
Proteomic databases
EPDi | Q9QXW2 |
PaxDbi | Q9QXW2 |
PRIDEi | Q9QXW2 |
ProteomicsDBi | 267720 [Q9QXW2-1] 267721 [Q9QXW2-2] |
Protocols and materials databases
Antibodypediai | 32276, 152 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015239; ENSMUSP00000015239; ENSMUSG00000015095 [Q9QXW2-1] |
GeneIDi | 30839 |
KEGGi | mmu:30839 |
UCSCi | uc008isj.1, mouse [Q9QXW2-1] uc008isk.1, mouse [Q9QXW2-2] |
Organism-specific databases
CTDi | 54461 |
MGIi | MGI:1354731, Fbxw5 |
Phylogenomic databases
eggNOGi | ENOG502QTGQ, Eukaryota |
GeneTreei | ENSGT00730000111276 |
HOGENOMi | CLU_021121_0_0_1 |
InParanoidi | Q9QXW2 |
OMAi | PHQIGFK |
OrthoDBi | 771384at2759 |
TreeFami | TF324320 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 30839, 2 hits in 52 CRISPR screens |
ChiTaRSi | Fbxw5, mouse |
PROi | PR:Q9QXW2 |
RNActi | Q9QXW2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015095, Expressed in spermatocyte and 282 other tissues |
ExpressionAtlasi | Q9QXW2, baseline and differential |
Genevisiblei | Q9QXW2, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR042508, FBXW5 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR20995, PTHR20995, 1 hit |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBXW5_MOUSE | |
Accessioni | Q9QXW2Primary (citable) accession number: Q9QXW2 Secondary accession number(s): A2AJ36 Q3U368 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families