UniProtKB - Q9QXW2 (FBXW5_MOUSE)

BLAST

>sp|Q9QXW2|FBXW5_MOUSE F-box/WD repeat-containing protein 5 OS=Mus musculus OX=10090 GN=Fbxw5 PE=1 SV=1
MDEGGLPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWKEQFYRYYQVARDV
PRHPAATSWYEEFRRLYDMVPCVEVQTLKEHTDQVLHLSFSHSGYQFASCSKDCTVKIWN
NDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFAL
LSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFK
IQNLNASTIRTVMVADCSRFDSPDLLLDASDQAGLPCRVFDLGGDTEEEATDPGLHTSGS
DHVKKGLRRVFDSVLDGHGQLSDCALETKVAELLAQGHTKPPECNDADTRNKYLIFTTGC
LTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDVHGHIIGMGLSPDNRYL
YVNSRAWPPGSVVADPMQPPPIAEEIDLLVFDLKTMREVKRALRAHRAYTPNDECFFIFL
DVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVVNSVAFSPQEQELLLTASDDATIKA
WRSPRIVRVLQAPRPRPRPRPRPFFSWFASHRR

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History
Entry version 134 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

F-box/WD repeat-containing protein 5

Gene

Fbxw5

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression.By similarity1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

protein kinase binding Source: MGI
ubiquitin-protein transferase activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 23314863
regulation of centrosome duplication Source: UniProtKB
regulation of mitotic nuclear division
Source: UniProtKB
Inferred from direct assayⁱ
- 23314863
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 23314863

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8951664 Neddylation R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: F-box/WD repeat-containing protein 5 Alternative name(s): F-box and WD-40 domain-containing protein 5
Gene namesⁱ	Name:Fbxw5 Synonyms:Fbw5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1354731 Fbxw5

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050993	1 – 573	F-box/WD repeat-containing protein 5Add BLAST		573

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	151	Phosphoserine; by PLK4By similarity		1

Post-translational modificationⁱ

Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.By similarity

Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9QXW2
PRIDEⁱ	Q9QXW2

PTM databases

iPTMnetⁱ	Q9QXW2
PhosphoSitePlusⁱ	Q9QXW2

Expressionⁱ

Tissue specificityⁱ

Widely expressed in adult and embryonal tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000015095 Expressed in 266 organ(s), highest expression level in testis
CleanExⁱ	MM_FBXW5
ExpressionAtlasⁱ	Q9QXW2 baseline and differential
Genevisibleⁱ	Q9QXW2 MM

Interactionⁱ

Subunit structureⁱ

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1 and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5 and RBX1. Interacts with CDC20, TSC1, TSC2 and SASS6 (By similarity). Interacts with EPS8. Interacts with TNFAIP8L1; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Skp1	Q9WTX5	2	EBI-16031930,EBI-1202363

With

Entry

#Exp.

IntAct

Notes

Skp1

Q9WTX5

EBI-16031930,EBI-1202363

GO - Molecular functionⁱ

protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	205976, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-60700N
IntActⁱ	Q9QXW2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000015239

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QXW2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	3 – 49	F-boxPROSITE-ProRule annotationAdd BLAST	47
Repeatⁱ	90 – 129	WD 1Add BLAST	40
Repeatⁱ	470 – 509	WD 2Add BLAST	40
Repeatⁱ	511 – 551	WD 3Add BLAST	41

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	308 – 316	D-box		9

Domainⁱ

The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WD repeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes.By similarity

The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesⁱ

Belongs to the FBXW5 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEAX Eukaryota ENOG410XTK0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111276
HOGENOMⁱ	HOG000231549
HOVERGENⁱ	HBG051595
InParanoidⁱ	Q9QXW2
KEGG Orthology (KO) More...KOⁱ	K10263
OMAⁱ	VFGCWLT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04E0
TreeFamⁱ	TF324320

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12937 F-box-like, 1 hit PF00400 WD40, 2 hits
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit SM00320 WD40, 3 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit PS50082 WD_REPEATS_2, 2 hits PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9QXW2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEGGLPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWKEQF 
        60         70         80         90        100
YRYYQVARDV PRHPAATSWY EEFRRLYDMV PCVEVQTLKE HTDQVLHLSF 
       110        120        130        140        150
SHSGYQFASC SKDCTVKIWN NDLTISLLHS ADMRPYNWSY TQFSQFNQDD 
       160        170        180        190        200
SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS 
       210        220        230        240        250
LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTIR 
       260        270        280        290        300
TVMVADCSRF DSPDLLLDAS DQAGLPCRVF DLGGDTEEEA TDPGLHTSGS 
       310        320        330        340        350
DHVKKGLRRV FDSVLDGHGQ LSDCALETKV AELLAQGHTK PPECNDADTR 
       360        370        380        390        400
NKYLIFTTGC LTYSPHQIGI KQILPHQMTT AGPVLGEGRG SDAFFDALDH 
       410        420        430        440        450
VIDVHGHIIG MGLSPDNRYL YVNSRAWPPG SVVADPMQPP PIAEEIDLLV 
       460        470        480        490        500
FDLKTMREVK RALRAHRAYT PNDECFFIFL DVSRDFVASG AEDRHGYIWD 
       510        520        530        540        550
RHYNICLAKL RHEDVVNSVA FSPQEQELLL TASDDATIKA WRSPRIVRVL 
       560        570 
QAPRPRPRPR PRPFFSWFAS HRR

Length:573

Mass (Da):64,646

Last modified:May 1, 2000 - v1

Checksum:ⁱB71B3B207D3091B1

Isoform 2 (identifier: Q9QXW2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLSAVEFSGGQLVGLARTAMSGTPDYQSLPGVGDEEAWVQSRHWWVSGPSGQNVTM
530-573: LTASDDATIK...FFSWFASHRR → PDSQRRCHYQ...PPLLLLVCQP

« Hide

        10         20         30         40         50
MLSAVEFSGG QLVGLARTAM SGTPDYQSLP GVGDEEAWVQ SRHWWVSGPS 
        60         70         80         90        100
GQNVTMDEGG LPLLPDSLVY QIFLSLGPAD VLAAGLVCRQ WQAVSRDEFL 
       110        120        130        140        150
WKEQFYRYYQ VARDVPRHPA ATSWYEEFRR LYDMVPCVEV QTLKEHTDQV 
       160        170        180        190        200
LHLSFSHSGY QFASCSKDCT VKIWNNDLTI SLLHSADMRP YNWSYTQFSQ 
       210        220        230        240        250
FNQDDSLLLA SGVFLGPHNS SSGEIAVISL DSFALLSRVR NKPYDVFGCW 
       260        270        280        290        300
LTETSLISGN LHRIGDITSC SVLWLNNAFQ DVESENVNVV KRLFKIQNLN 
       310        320        330        340        350
ASTIRTVMVA DCSRFDSPDL LLDASDQAGL PCRVFDLGGD TEEEATDPGL 
       360        370        380        390        400
HTSGSDHVKK GLRRVFDSVL DGHGQLSDCA LETKVAELLA QGHTKPPECN 
       410        420        430        440        450
DADTRNKYLI FTTGCLTYSP HQIGIKQILP HQMTTAGPVL GEGRGSDAFF 
       460        470        480        490        500
DALDHVIDVH GHIIGMGLSP DNRYLYVNSR AWPPGSVVAD PMQPPPIAEE 
       510        520        530        540        550
IDLLVFDLKT MREVKRALRA HRAYTPNDEC FFIFLDVSRD FVASGAEDRH 
       560        570        580        590        600
GYIWDRHYNI CLAKLRHEDV VNSVAFSPQE QELLPDSQRR CHYQSLAFTT 
       610        620 
HCSCSAGSTP SPPPSPPPLL LLVCQP

Note: No experimental confirmation available.

Show »

Length:626

Mass (Da):69,687

Checksum:ⁱA1B30E41EB835282

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MQH6	A0A0A0MQH6_MOUSE		F-box/WD repeat-containing protein ... F-box/WD repeat-containing protein 5	Fbxw5	246	Annotation score:

Sequence cautionⁱ

The sequence CAM25630 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042293	1	M → MLSAVEFSGGQLVGLARTAM SGTPDYQSLPGVGDEEAWVQ SRHWWVSGPSGQNVTM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_042294	530 – 573	LTASD…ASHRR → PDSQRRCHYQSLAFTTHCSC SAGSTPSPPPSPPPLLLLVC QP in isoform 2. 1 PublicationAdd BLAST		44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF176520 mRNA Translation: AAF09130.1 AK019715 mRNA Translation: BAB31841.1 AK154911 mRNA Translation: BAE32921.1 AL732557 Genomic DNA Translation: CAM25629.1 AL732557 Genomic DNA Translation: CAM25630.1 Sequence problems. CH466542 Genomic DNA Translation: EDL08255.1 BC010776 mRNA Translation: AAH10776.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15778.1 [Q9QXW2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_038936.1, NM_013908.4 [Q9QXW2-1]
UniGeneⁱ	Mm.29170

Genome annotation databases

Ensemblⁱ	ENSMUST00000015239; ENSMUSP00000015239; ENSMUSG00000015095 [Q9QXW2-1]
GeneIDⁱ	30839
KEGGⁱ	mmu:30839
UCSC genome browser More...UCSCⁱ	uc008isj.1 mouse [Q9QXW2-1] uc008isk.1 mouse [Q9QXW2-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QXW2-2	F-box/WD repeat-containing protein 5		RAT		569	UniRef90_Q9QXW2-2
Isoform 2 of F-box/WD repeat-containing protein 5		RAT		624
UPI0003D071DC		RAT		491

Protein	Similar proteins		Species	Score	Length	Source
Q9QXW2	F-box/WD repeat-containing protein 5		HUMAN		566	UniRef50_Q969U6
F-box/WD repeat-containing protein 5		RAT		569
F-box/WD repeat-containing protein 5 isoform X1		Enhydra lutris kenyoni		683
F-box/WD repeat-containing protein 5 isoform X1		ODORO		620
F-box and WD repeat domain containing 5		CANLF		620
+186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF176520 mRNA Translation: AAF09130.1 AK019715 mRNA Translation: BAB31841.1 AK154911 mRNA Translation: BAE32921.1 AL732557 Genomic DNA Translation: CAM25629.1 AL732557 Genomic DNA Translation: CAM25630.1 Sequence problems. CH466542 Genomic DNA Translation: EDL08255.1 BC010776 mRNA Translation: AAH10776.1
CCDSⁱ	CCDS15778.1 [Q9QXW2-1]
RefSeqⁱ	NP_038936.1, NM_013908.4 [Q9QXW2-1]
UniGeneⁱ	Mm.29170

3D structure databases

ProteinModelPortalⁱ	Q9QXW2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205976, 4 interactors
DIPⁱ	DIP-60700N
IntActⁱ	Q9QXW2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000015239

PTM databases

iPTMnetⁱ	Q9QXW2
PhosphoSitePlusⁱ	Q9QXW2

Proteomic databases

PaxDbⁱ	Q9QXW2
PRIDEⁱ	Q9QXW2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000015239; ENSMUSP00000015239; ENSMUSG00000015095 [Q9QXW2-1]
GeneIDⁱ	30839
KEGGⁱ	mmu:30839
UCSCⁱ	uc008isj.1 mouse [Q9QXW2-1] uc008isk.1 mouse [Q9QXW2-2]

Organism-specific databases

CTDⁱ	54461
MGIⁱ	MGI:1354731 Fbxw5

Phylogenomic databases

eggNOGⁱ	ENOG410IEAX Eukaryota ENOG410XTK0 LUCA
GeneTreeⁱ	ENSGT00730000111276
HOGENOMⁱ	HOG000231549
HOVERGENⁱ	HBG051595
InParanoidⁱ	Q9QXW2
KOⁱ	K10263
OMAⁱ	VFGCWLT
OrthoDBⁱ	EOG091G04E0
TreeFamⁱ	TF324320

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-MMU-8951664 Neddylation R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSⁱ	Fbxw5 mouse
Protein Ontology More...PROⁱ	PR:Q9QXW2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015095 Expressed in 266 organ(s), highest expression level in testis
CleanExⁱ	MM_FBXW5
ExpressionAtlasⁱ	Q9QXW2 baseline and differential
Genevisibleⁱ	Q9QXW2 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF12937 F-box-like, 1 hit PF00400 WD40, 2 hits
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit SM00320 WD40, 3 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit PS50082 WD_REPEATS_2, 2 hits PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FBXW5_MOUSE
Accessionⁱ	Q9QXW2Primary (citable) accession number: Q9QXW2 Secondary accession number(s): A2AJ36 , A2AJ37, E9QMP0, Q3U368
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9QXW2 (FBXW5_MOUSE)

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F-box/WD repeat-containing protein 5

Fbxw5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ