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Protein

Protein sprouty homolog 1

Gene

Spry1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-MMU-182971 EGFR downregulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:Spry1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1345139 Spry1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000768991 – 313Protein sprouty homolog 1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QXV9
PaxDbiQ9QXV9
PRIDEiQ9QXV9

PTM databases

iPTMnetiQ9QXV9
PhosphoSitePlusiQ9QXV9

Expressioni

Tissue specificityi

Expressed in the embryo and adult tissues including heart, brain, lung, kidney, and skeletal muscle.

Developmental stagei

At E8.5 expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain. At E9.5 continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud. At E10.5 expressed in the somites, frontonasal processes, tailbud, and hindlimb bud.

Inductioni

By FGF signaling.

Gene expression databases

BgeeiENSMUSG00000037211 Expressed in 245 organ(s), highest expression level in lung
CleanExiMM_SPRY1
ExpressionAtlasiQ9QXV9 baseline and differential
GenevisibleiQ9QXV9 MM

Interactioni

Protein-protein interaction databases

BioGridi204876, 7 interactors
STRINGi10090.ENSMUSP00000049292

Structurei

3D structure databases

ProteinModelPortaliQ9QXV9
SMRiQ9QXV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 289SPRPROSITE-ProRule annotationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 125Poly-Ser10
Compositional biasi175 – 304Cys-richAdd BLAST130

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

eggNOGiENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiQ9QXV9
KOiK04704
OMAiNNYEHRP
OrthoDBiEOG091G0DOQ
PhylomeDBiQ9QXV9
TreeFamiTF325070

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1
PANTHERiPTHR12365:SF10 PTHR12365:SF10, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPSQHGSH TSLVVIQPPA VEGRQRLDYD RDTQPATILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVA RRPAPRTAPR PEKQERTHEI IPANVNSSYE HRPASHPGNA
110 120 130 140 150
RGSVLSRSTS TGSAASSGSS SSVSSEQGLL GRSPPTRPIP GHRSDRVIRT
160 170 180 190 200
QPKQLLVEDL KASLKEDPTQ HKFICEQCGK CKCGECTAPR ALPSCLACDR
210 220 230 240 250
QCLCSAESMV EYGTCMCLVK GIFYHCSNDD DGGSYSDNPC SCSQSHCCSR
260 270 280 290 300
YLCMGALSLC LPCLLCYPPA KGCLKLCRGC YDWTHRPGCR CRNSNTVYCK
310
LESCPSRAQG KLS
Length:313
Mass (Da):34,004
Last modified:May 1, 2000 - v1
Checksum:iCD3C27F7022C0B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176903 mRNA Translation: AAD56004.1
BC053428 mRNA Translation: AAH53428.1
BC069914 mRNA Translation: AAH69914.1
CCDSiCCDS17322.1
RefSeqiNP_001292369.1, NM_001305440.1
NP_001292370.1, NM_001305441.1
NP_001292371.1, NM_001305442.1
NP_036026.1, NM_011896.3
UniGeneiMm.330986

Genome annotation databases

EnsembliENSMUST00000038569; ENSMUSP00000049292; ENSMUSG00000037211
ENSMUST00000108107; ENSMUSP00000103742; ENSMUSG00000037211
ENSMUST00000108109; ENSMUSP00000103744; ENSMUSG00000037211
GeneIDi24063
KEGGimmu:24063
UCSCiuc008pax.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176903 mRNA Translation: AAD56004.1
BC053428 mRNA Translation: AAH53428.1
BC069914 mRNA Translation: AAH69914.1
CCDSiCCDS17322.1
RefSeqiNP_001292369.1, NM_001305440.1
NP_001292370.1, NM_001305441.1
NP_001292371.1, NM_001305442.1
NP_036026.1, NM_011896.3
UniGeneiMm.330986

3D structure databases

ProteinModelPortaliQ9QXV9
SMRiQ9QXV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204876, 7 interactors
STRINGi10090.ENSMUSP00000049292

PTM databases

iPTMnetiQ9QXV9
PhosphoSitePlusiQ9QXV9

Proteomic databases

MaxQBiQ9QXV9
PaxDbiQ9QXV9
PRIDEiQ9QXV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038569; ENSMUSP00000049292; ENSMUSG00000037211
ENSMUST00000108107; ENSMUSP00000103742; ENSMUSG00000037211
ENSMUST00000108109; ENSMUSP00000103744; ENSMUSG00000037211
GeneIDi24063
KEGGimmu:24063
UCSCiuc008pax.2 mouse

Organism-specific databases

CTDi10252
MGIiMGI:1345139 Spry1

Phylogenomic databases

eggNOGiENOG410IJJB Eukaryota
ENOG410Z8F4 LUCA
GeneTreeiENSGT00390000003535
HOGENOMiHOG000233079
HOVERGENiHBG003544
InParanoidiQ9QXV9
KOiK04704
OMAiNNYEHRP
OrthoDBiEOG091G0DOQ
PhylomeDBiQ9QXV9
TreeFamiTF325070

Enzyme and pathway databases

ReactomeiR-MMU-182971 EGFR downregulation

Miscellaneous databases

PROiPR:Q9QXV9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037211 Expressed in 245 organ(s), highest expression level in lung
CleanExiMM_SPRY1
ExpressionAtlasiQ9QXV9 baseline and differential
GenevisibleiQ9QXV9 MM

Family and domain databases

InterProiView protein in InterPro
IPR007875 Sprouty
IPR030783 SPRY1
PANTHERiPTHR12365:SF10 PTHR12365:SF10, 1 hit
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PROSITEiView protein in PROSITE
PS51227 SPR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPY1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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