Protein sprouty homolog 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein kinase binding Source: MGI
• protein serine/threonine kinase activator activity Source: MGI

GO - Biological processⁱ

• animal organ development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• branching morphogenesis of an epithelial tube Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.2

    "Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis."
    Tefft J.D., Lee M., Smith S., Leinwand M., Zhao J., Bringas P. Jr., Crowe D.L., Warburton D.
    Curr. Biol. 9:219-222(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• bud elongation involved in lung branching Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape."
    Tang N., Marshall W.F., McMahon M., Metzger R.J., Martin G.R.
    Science 333:342-345(2011) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling."
    Shim K., Minowada G., Coling D.E., Martin G.R.
    Dev Cell 8:553-564(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to leukemia inhibitory factor Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to vascular endothelial growth factor stimulus Source: MGI
• establishment of mitotic spindle orientation Source: MGIInferred from genetic interactionⁱ
  • "Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape."
    Tang N., Marshall W.F., McMahon M., Metzger R.J., Martin G.R.
    Science 333:342-345(2011) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling."
    Shim K., Minowada G., Coling D.E., Martin G.R.
    Dev Cell 8:553-564(2005) [PubMed] [Europe PMC] [Abstract]
• lung development Source: MGIInferred from mutant phenotypeⁱ
  • Ref.2

    "Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis."
    Tefft J.D., Lee M., Smith S., Leinwand M., Zhao J., Bringas P. Jr., Crowe D.L., Warburton D.
    Curr. Biol. 9:219-222(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• lung growth Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis."
    Mailleux A.A., Tefft D., Ndiaye D., Itoh N., Thiery J.P., Warburton D., Bellusci S.
    Mech Dev 102:81-94(2001) [PubMed] [Europe PMC] [Abstract]
• lung morphogenesis Source: MGIInferred from direct assayⁱ
  • "Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis."
    Mailleux A.A., Tefft D., Ndiaye D., Itoh N., Thiery J.P., Warburton D., Bellusci S.
    Mech Dev 102:81-94(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: MGI
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "A novel role of Sprouty 2 in regulating cellular apoptosis."
    Edwin F., Patel T.B.
    J Biol Chem 283:3181-3190(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: MGIInferred from direct assayⁱ
  • "Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation."
    Gross I., Bassit B., Benezra M., Licht J.D.
    J Biol Chem 276:46460-46468(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell projection organization Source: BHF-UCLInferred from direct assayⁱ
  • "MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths."
    Sayed D., Rane S., Lypowy J., He M., Chen I.Y., Vashistha H., Yan L., Malhotra A., Vatner D., Abdellatif M.
    Mol Biol Cell 19:3272-3282(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial to mesenchymal transition Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists."
    Zhao G., Wojciechowski M.C., Jee S., Boros J., McAvoy J.W., Lovicu F.J.
    Exp. Eye Res. 132:9-16(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of ERK1 and ERK2 cascade Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred."
    Zhao G., Bailey C.G., Feng Y., Rasko J., Lovicu F.J.
    Exp. Eye Res. 170:148-159(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, MUTAGENESIS OF TYR-55.
• negative regulation of fibroblast growth factor receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation."
    Gross I., Bassit B., Benezra M., Licht J.D.
    J Biol Chem 276:46460-46468(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of GTPase activity Source: MGIInferred from direct assayⁱ
  • "Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation."
    Gross I., Bassit B., Benezra M., Licht J.D.
    J Biol Chem 276:46460-46468(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of lens fiber cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred."
    Zhao G., Bailey C.G., Feng Y., Rasko J., Lovicu F.J.
    Exp. Eye Res. 170:148-159(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, MUTAGENESIS OF TYR-55.
• negative regulation of MAP kinase activity Source: MGIInferred from direct assayⁱ
  • "Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms."
    Ozaki K., Miyazaki S., Tanimura S., Kohno M.
    J Cell Sci 118:5861-5871(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurotrophin TRK receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation."
    Gross I., Bassit B., Benezra M., Licht J.D.
    J Biol Chem 276:46460-46468(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of peptidyl-threonine phosphorylation Source: MGI
• negative regulation of protein ubiquitination Source: UniProtKB
• negative regulation of Ras protein signal transduction Source: MGIInferred from direct assayⁱ
  • "Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation."
    Gross I., Bassit B., Benezra M., Licht J.D.
    J Biol Chem 276:46460-46468(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists."
    Zhao G., Wojciechowski M.C., Jee S., Boros J., McAvoy J.W., Lovicu F.J.
    Exp. Eye Res. 132:9-16(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
• positive regulation of cell migration Source: MGI
• positive regulation of ERK1 and ERK2 cascade Source: MGI
• positive regulation of gene expression Source: MGI
• positive regulation of peptidyl-serine phosphorylation Source: MGI
• positive regulation of protein kinase B signaling Source: MGI
• respiratory system development Source: MGIInferred from direct assayⁱ
  • "Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis."
    Mailleux A.A., Tefft D., Ndiaye D., Itoh N., Thiery J.P., Warburton D., Bellusci S.
    Mech Dev 102:81-94(2001) [PubMed] [Europe PMC] [Abstract]
• sensory perception of sound Source: MGIInferred from mutant phenotypeⁱ
  • "Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling."
    Shim K., Minowada G., Coling D.E., Martin G.R.
    Dev Cell 8:553-564(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR 
        60         70         80         90        100
NTNEYTEGPT VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH 
       110        120        130        140        150
SSRAPLSRSI STVSSGSRSS TRTSTSSSSS EQRLLGPSFS HGPAAADGII 
       160        170        180        190        200
RVQPKSELKP GDVKPLSKDD LGLHAYRCED CGKCKCKECT YPRPLPSDWI 
       210        220        230        240        250
CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN PCSCSQSHCC 
       260        270        280        290        300
TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 
       310 
CKVPTVPPRN FEKPT                                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families