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Protein

Chromobox protein homolog 8

Gene

Cbx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 8
Alternative name(s):
Polycomb 3 homolog
Short name:
Pc3
Short name:
mPc3
Gene namesi
Name:Cbx8
Synonyms:Pc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353589 Cbx8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802161 – 362Chromobox protein homolog 8Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei164PhosphoserineBy similarity1
Modified residuei229PhosphoserineCombined sources1
Modified residuei234PhosphotyrosineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei284PhosphoserineCombined sources1
Modified residuei305PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXV1
MaxQBiQ9QXV1
PaxDbiQ9QXV1
PeptideAtlasiQ9QXV1
PRIDEiQ9QXV1

PTM databases

iPTMnetiQ9QXV1
PhosphoSitePlusiQ9QXV1

Expressioni

Gene expression databases

BgeeiENSMUSG00000025578 Expressed in 228 organ(s), highest expression level in thymus
CleanExiMM_CBX8
GenevisibleiQ9QXV1 MM

Interactioni

Subunit structurei

Component of a PRC1-like complex (PubMed:16359901). Interacts with RING1, RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6 and PHC2 (PubMed:16359901). Interacts with histone H3 (By similarity). Interacts with MLLT3 (Ref. 8). Interacts with PHC2 (By similarity). Interacts (via chromodomain) with single-stranded RNA (PubMed:16537902).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206027, 7 interactors
IntActiQ9QXV1, 5 interactors
STRINGi10090.ENSMUSP00000026663

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9QXV1
SMRiQ9QXV1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QXV1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG410IPQ7 Eukaryota
ENOG410XRRX LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000233642
HOVERGENiHBG003608
InParanoidiQ9QXV1
KOiK11455
OMAiQCGVASP
OrthoDBiEOG091G0MFV
PhylomeDBiQ9QXV1
TreeFamiTF106456

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD
60 70 80 90 100
ARLLAAFEER EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSTR
110 120 130 140 150
GIRIPYPGRS PQDLASTSRA REGLRNTGLP PPGSSTSTCR ADPPRDRDRE
160 170 180 190 200
RDRGTSRVDD KPSSPGDSSK KRGPKPRKEP LDPSQRPLGE PSAGLGEYLK
210 220 230 240 250
GRKLDETSSG TGKFPAGHSV IQLARRQDSD LVQYGVTSPS SAEASSKLAV
260 270 280 290 300
DTFPARVIKH RAAFLEAKGQ GALDPGGARV RHSSGTPASV GSLYRDMGAQ
310 320 330 340 350
GGRPSLIARI PVARILGDPE EESWSPSLTN LEKVVVTDVT SNFLTVTIKE
360
SNTDQGFFKE KR
Length:362
Mass (Da):39,860
Last modified:May 1, 2000 - v1
Checksum:iEE047F57483741B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180370 mRNA Translation: AAF25615.1
AF202116 Genomic DNA Translation: AAF26713.1
BC014815 mRNA Translation: AAH14815.1
CCDSiCCDS25709.1
RefSeqiNP_038954.1, NM_013926.1
UniGeneiMm.99953

Genome annotation databases

EnsembliENSMUST00000026663; ENSMUSP00000026663; ENSMUSG00000025578
GeneIDi30951
KEGGimmu:30951
UCSCiuc007mpu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180370 mRNA Translation: AAF25615.1
AF202116 Genomic DNA Translation: AAF26713.1
BC014815 mRNA Translation: AAH14815.1
CCDSiCCDS25709.1
RefSeqiNP_038954.1, NM_013926.1
UniGeneiMm.99953

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNVNMR-A8-58[»]
ProteinModelPortaliQ9QXV1
SMRiQ9QXV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206027, 7 interactors
IntActiQ9QXV1, 5 interactors
STRINGi10090.ENSMUSP00000026663

PTM databases

iPTMnetiQ9QXV1
PhosphoSitePlusiQ9QXV1

Proteomic databases

EPDiQ9QXV1
MaxQBiQ9QXV1
PaxDbiQ9QXV1
PeptideAtlasiQ9QXV1
PRIDEiQ9QXV1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026663; ENSMUSP00000026663; ENSMUSG00000025578
GeneIDi30951
KEGGimmu:30951
UCSCiuc007mpu.1 mouse

Organism-specific databases

CTDi57332
MGIiMGI:1353589 Cbx8

Phylogenomic databases

eggNOGiENOG410IPQ7 Eukaryota
ENOG410XRRX LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000233642
HOVERGENiHBG003608
InParanoidiQ9QXV1
KOiK11455
OMAiQCGVASP
OrthoDBiEOG091G0MFV
PhylomeDBiQ9QXV1
TreeFamiTF106456

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

EvolutionaryTraceiQ9QXV1
PROiPR:Q9QXV1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025578 Expressed in 228 organ(s), highest expression level in thymus
CleanExiMM_CBX8
GenevisibleiQ9QXV1 MM

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBX8_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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