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UniProtKB - Q9QXU2 (SURF1_RAT)
Protein
Surfeit locus protein 1
Gene
Surf1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
By similarityGO - Molecular functioni
- cytochrome-c oxidase activity Source: RGD
GO - Biological processi
- mitochondrial cytochrome c oxidase assembly Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Surfeit locus protein 1 |
Gene namesi | Name:Surf1 Synonyms:Surf-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620527, Surf1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 86 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 280 – 300 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215654 | 1 – 306 | Surfeit locus protein 1Add BLAST | 306 |
Proteomic databases
PaxDbi | Q9QXU2 |
PTM databases
iPTMneti | Q9QXU2 |
PhosphoSitePlusi | Q9QXU2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000005247, Expressed in heart and 20 other tissues |
Genevisiblei | Q9QXU2, RN |
Interactioni
Subunit structurei
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14.
Interacts with COA3.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000057954 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the SURF1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1563, Eukaryota KOG3998, Eukaryota |
GeneTreei | ENSGT00530000064194 |
HOGENOMi | CLU_047737_4_0_1 |
InParanoidi | Q9QXU2 |
OMAi | THIAHIK |
OrthoDBi | 923657at2759 |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 IPR045214, Surf1/Surf4 |
PANTHERi | PTHR23427, PTHR23427, 1 hit |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9QXU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVMALTVL RSRITRWPQW ACAGPAPFCA VRRSVFGFSV RSGMVCRPHR
60 70 80 90 100
CCSSTAETAA AKAEDDSFLQ WFLLFIPATA FGLGTWQVQR RKWKLKLIAE
110 120 130 140 150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV
160 170 180 190 200
REARDAGRLS STESGAYVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQQ
210 220 230 240 250
GQVLGEVDLV GIVRLTENRK PFVPENNPER SLWYYRDLDA MAKRTGTDPI
260 270 280 290 300
FIDADFNSTT PGGPIGGQTR VTLRNEHMQY IITWYGLCAA TSYLWFRKFV
RRTPGV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182952 mRNA Translation: AAF19608.1 |
RefSeqi | NP_742065.1, NM_172068.1 XP_006233790.1, XM_006233728.3 |
Genome annotation databases
Ensembli | ENSRNOT00000061242; ENSRNOP00000057954; ENSRNOG00000005247 |
GeneIDi | 64463 |
KEGGi | rno:64463 |
UCSCi | RGD:620527, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182952 mRNA Translation: AAF19608.1 |
RefSeqi | NP_742065.1, NM_172068.1 XP_006233790.1, XM_006233728.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000057954 |
PTM databases
iPTMneti | Q9QXU2 |
PhosphoSitePlusi | Q9QXU2 |
Proteomic databases
PaxDbi | Q9QXU2 |
Genome annotation databases
Ensembli | ENSRNOT00000061242; ENSRNOP00000057954; ENSRNOG00000005247 |
GeneIDi | 64463 |
KEGGi | rno:64463 |
UCSCi | RGD:620527, rat |
Organism-specific databases
CTDi | 6834 |
RGDi | 620527, Surf1 |
Phylogenomic databases
eggNOGi | KOG1563, Eukaryota KOG3998, Eukaryota |
GeneTreei | ENSGT00530000064194 |
HOGENOMi | CLU_047737_4_0_1 |
InParanoidi | Q9QXU2 |
OMAi | THIAHIK |
OrthoDBi | 923657at2759 |
Miscellaneous databases
PROi | PR:Q9QXU2 |
Gene expression databases
Bgeei | ENSRNOG00000005247, Expressed in heart and 20 other tissues |
Genevisiblei | Q9QXU2, RN |
Family and domain databases
CDDi | cd06662, SURF1, 1 hit |
InterProi | View protein in InterPro IPR002994, Surf1/Shy1 IPR045214, Surf1/Surf4 |
PANTHERi | PTHR23427, PTHR23427, 1 hit |
Pfami | View protein in Pfam PF02104, SURF1, 1 hit |
PROSITEi | View protein in PROSITE PS50895, SURF1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SURF1_RAT | |
Accessioni | Q9QXU2Primary (citable) accession number: Q9QXU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families