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Protein

Zinc finger protein 354B

Gene

Znf354b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354B
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 2
Gene namesi
Name:Znf354b
Synonyms:Kid2, Zfp354b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351476 Zfp354b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804071 – 601Zinc finger protein 354BAdd BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9QXT9
PRIDEiQ9QXT9

PTM databases

iPTMnetiQ9QXT9
PhosphoSitePlusiQ9QXT9

Expressioni

Tissue specificityi

Expressed in brain and kidney. Lower levels in lung, muscle, heart, testis, tongue and eye.1 Publication

Developmental stagei

Expressed at E16.5 in brain, heart, lung, kidney and gut.1 Publication

Gene expression databases

BgeeiENSMUSG00000020335 Expressed in 195 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExiMM_ZFP354B
GenevisibleiQ9QXT9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104752

Structurei

3D structure databases

ProteinModelPortaliQ9QXT9
SMRiQ9QXT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144148
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9QXT9
KOiK09228
OMAiHIEEDAL
OrthoDBiEOG091G02KC
PhylomeDBiQ9QXT9
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q9QXT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPEQREGKS QVSVTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFPFTKP KMISVLQQGE EPWKSEKESH GCSPLGCHGS LQTTKSTQTK
110 120 130 140 150
ESLFQELKRK QLKRDEAWDF TSGKSCRPDN SFRTQDTNES LEIISINHTK
160 170 180 190 200
ILTIDKSRKN FKFGPSVGLK SIGKQKIAGE KTQRNSLEEN STLLSQPKLK
210 220 230 240 250
TVEKRYKCST CEKAFIHNSS LRKHLKNHTG ERLFQCKDCL KAFSQSSALI
260 270 280 290 300
QHQRTHTGEK PYICKECGKA FSHSASLCKH LRTHTLEKSY TCKECGKSFS
310 320 330 340 350
RRSGLFLHQK IHARENPHKY NPGRKASTSL SGCQRIHSRK KTYLCNECGN
360 370 380 390 400
TFKSSSSLRY HQRIHTGEKP FKCSECGRAF SQSASLIQHE RIHTGEKPYR
410 420 430 440 450
CSECGKGFTS ISRLNRHRII HTGEKFYNCN ECGKALSSHS TLIIHERIHT
460 470 480 490 500
GEKPCKCKVC GKAFRQSSAL IQHQRMHTGE RPYKCNECGK TFRCNSSLSN
510 520 530 540 550
HQRTHTGEKP YRCQECGMSF GQSAALIQHR RIHTGEKPFK CNTCGKSFRQ
560 570 580 590 600
SSSLIAHQRI HTGEKPYECS ACGKLFSQRS SLTNHYRIHI EEDALNIDLH

E
Length:601
Mass (Da):68,664
Last modified:May 1, 2000 - v1
Checksum:i4CE1540A8FF8E8B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184112 mRNA Translation: AAF01034.1
AL627215 Genomic DNA No translation available.
BC107400 mRNA Translation: AAI07401.1
BC107401 mRNA Translation: AAI07402.1
AK010007 mRNA Translation: BAB26638.1
CCDSiCCDS24641.1
RefSeqiNP_038772.1, NM_013744.3
UniGeneiMm.74670

Genome annotation databases

EnsembliENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335
ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335
GeneIDi27274
KEGGimmu:27274
UCSCiuc007itd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184112 mRNA Translation: AAF01034.1
AL627215 Genomic DNA No translation available.
BC107400 mRNA Translation: AAI07401.1
BC107401 mRNA Translation: AAI07402.1
AK010007 mRNA Translation: BAB26638.1
CCDSiCCDS24641.1
RefSeqiNP_038772.1, NM_013744.3
UniGeneiMm.74670

3D structure databases

ProteinModelPortaliQ9QXT9
SMRiQ9QXT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104752

PTM databases

iPTMnetiQ9QXT9
PhosphoSitePlusiQ9QXT9

Proteomic databases

PaxDbiQ9QXT9
PRIDEiQ9QXT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335
ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335
GeneIDi27274
KEGGimmu:27274
UCSCiuc007itd.2 mouse

Organism-specific databases

CTDi27274
MGIiMGI:1351476 Zfp354b

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144148
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9QXT9
KOiK09228
OMAiHIEEDAL
OrthoDBiEOG091G02KC
PhylomeDBiQ9QXT9
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZfp354b mouse
PROiPR:Q9QXT9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020335 Expressed in 195 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExiMM_ZFP354B
GenevisibleiQ9QXT9 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ354B_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT9
Secondary accession number(s): Q9CV15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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