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UniProtKB - Q9QXT9 (Z354B_MOUSE)
Protein
Zinc finger protein 354B
Gene
Znf354b
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 206 – 228 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 234 – 256 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 262 – 284 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 290 – 312 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 539 – 561 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 567 – 589 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 354BAlternative name(s): Kidney, ischemia, and developmentally-regulated protein 2 |
Gene namesi | Name:Znf354b Synonyms:Kid2, Zfp354b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1351476, Zfp354b |
VEuPathDBi | HostDB:ENSMUSG00000020335 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280407 | 1 – 601 | Zinc finger protein 354BAdd BLAST | 601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 150 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q9QXT9 |
PaxDbi | Q9QXT9 |
PRIDEi | Q9QXT9 |
ProteomicsDBi | 275332 |
PTM databases
iPTMneti | Q9QXT9 |
PhosphoSitePlusi | Q9QXT9 |
Expressioni
Tissue specificityi
Expressed in brain and kidney. Lower levels in lung, muscle, heart, testis, tongue and eye.1 Publication
Developmental stagei
Expressed at 16.5 dpc in brain, heart, lung, kidney and gut.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020335, Expressed in male associated reproductive structure (mouse) and 228 other tissues |
Genevisiblei | Q9QXT9, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104752 |
Miscellaneous databases
RNActi | Q9QXT9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 206 – 228 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 234 – 256 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 262 – 284 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 290 – 312 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 539 – 561 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 567 – 589 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162570 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9QXT9 |
OMAi | HYTHYLE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9QXT9 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
i Sequence
Sequence statusi: Complete.
Q9QXT9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPEQREGKS QVSVTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFPFTKP KMISVLQQGE EPWKSEKESH GCSPLGCHGS LQTTKSTQTK
110 120 130 140 150
ESLFQELKRK QLKRDEAWDF TSGKSCRPDN SFRTQDTNES LEIISINHTK
160 170 180 190 200
ILTIDKSRKN FKFGPSVGLK SIGKQKIAGE KTQRNSLEEN STLLSQPKLK
210 220 230 240 250
TVEKRYKCST CEKAFIHNSS LRKHLKNHTG ERLFQCKDCL KAFSQSSALI
260 270 280 290 300
QHQRTHTGEK PYICKECGKA FSHSASLCKH LRTHTLEKSY TCKECGKSFS
310 320 330 340 350
RRSGLFLHQK IHARENPHKY NPGRKASTSL SGCQRIHSRK KTYLCNECGN
360 370 380 390 400
TFKSSSSLRY HQRIHTGEKP FKCSECGRAF SQSASLIQHE RIHTGEKPYR
410 420 430 440 450
CSECGKGFTS ISRLNRHRII HTGEKFYNCN ECGKALSSHS TLIIHERIHT
460 470 480 490 500
GEKPCKCKVC GKAFRQSSAL IQHQRMHTGE RPYKCNECGK TFRCNSSLSN
510 520 530 540 550
HQRTHTGEKP YRCQECGMSF GQSAALIQHR RIHTGEKPFK CNTCGKSFRQ
560 570 580 590 600
SSSLIAHQRI HTGEKPYECS ACGKLFSQRS SLTNHYRIHI EEDALNIDLH
E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF184112 mRNA Translation: AAF01034.1 AL627215 Genomic DNA No translation available. BC107400 mRNA Translation: AAI07401.1 BC107401 mRNA Translation: AAI07402.1 AK010007 mRNA Translation: BAB26638.1 |
CCDSi | CCDS24641.1 |
RefSeqi | NP_038772.1, NM_013744.3 |
Genome annotation databases
Ensembli | ENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335 ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335 |
GeneIDi | 27274 |
KEGGi | mmu:27274 |
UCSCi | uc007itd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF184112 mRNA Translation: AAF01034.1 AL627215 Genomic DNA No translation available. BC107400 mRNA Translation: AAI07401.1 BC107401 mRNA Translation: AAI07402.1 AK010007 mRNA Translation: BAB26638.1 |
CCDSi | CCDS24641.1 |
RefSeqi | NP_038772.1, NM_013744.3 |
3D structure databases
SMRi | Q9QXT9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104752 |
PTM databases
iPTMneti | Q9QXT9 |
PhosphoSitePlusi | Q9QXT9 |
Proteomic databases
jPOSTi | Q9QXT9 |
PaxDbi | Q9QXT9 |
PRIDEi | Q9QXT9 |
ProteomicsDBi | 275332 |
Protocols and materials databases
Antibodypediai | 29455, 16 antibodies from 9 providers |
DNASUi | 27274 |
Genome annotation databases
Ensembli | ENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335 ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335 |
GeneIDi | 27274 |
KEGGi | mmu:27274 |
UCSCi | uc007itd.2, mouse |
Organism-specific databases
CTDi | 27274 |
MGIi | MGI:1351476, Zfp354b |
VEuPathDBi | HostDB:ENSMUSG00000020335 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162570 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9QXT9 |
OMAi | HYTHYLE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9QXT9 |
TreeFami | TF341817 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 27274, 0 hits in 63 CRISPR screens |
ChiTaRSi | Zfp354b, mouse |
PROi | PR:Q9QXT9 |
RNActi | Q9QXT9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020335, Expressed in male associated reproductive structure (mouse) and 228 other tissues |
Genevisiblei | Q9QXT9, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Z354B_MOUSE | |
Accessioni | Q9QXT9Primary (citable) accession number: Q9QXT9 Secondary accession number(s): Q9CV15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families