Znf354b

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	206 – 228	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	234 – 256	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	262 – 284	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	290 – 312	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	343 – 365	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	371 – 393	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	399 – 421	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	427 – 449	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	455 – 477	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	483 – 505	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	511 – 533	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	539 – 561	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	567 – 589	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 24105743
DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: GO_Central
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 24105743
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 354B Alternative name(s): Kidney, ischemia, and developmentally-regulated protein 2
Gene namesⁱ	Name:Znf354b Synonyms:Kid2, Zfp354b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1351476 Zfp354b

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280407	1 – 601	Zinc finger protein 354BAdd BLAST		601

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	150	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9QXT9
PRIDEⁱ	Q9QXT9

PTM databases

iPTMnetⁱ	Q9QXT9
PhosphoSitePlusⁱ	Q9QXT9

Expressionⁱ

Tissue specificityⁱ

Expressed in brain and kidney. Lower levels in lung, muscle, heart, testis, tongue and eye.1 Publication

Developmental stageⁱ

Expressed at E16.5 in brain, heart, lung, kidney and gut.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020335 Expressed in 195 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExⁱ	MM_ZFP354B
Genevisibleⁱ	Q9QXT9 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000104752

STRINGⁱ

10090.ENSMUSP00000104752

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QXT9
SMRⁱ	Q9QXT9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 85	KRABPROSITE-ProRule annotationAdd BLAST		72

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	206 – 228	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	234 – 256	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	262 – 284	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	290 – 312	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	343 – 365	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	371 – 393	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	399 – 421	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	427 – 449	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	455 – 477	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	483 – 505	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	511 – 533	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	539 – 561	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	567 – 589	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144148
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9QXT9
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	HIEEDAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9QXT9
TreeFamⁱ	TF341817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QXT9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPEQREGKS QVSVTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL 
        60         70         80         90        100
ASLGFPFTKP KMISVLQQGE EPWKSEKESH GCSPLGCHGS LQTTKSTQTK 
       110        120        130        140        150
ESLFQELKRK QLKRDEAWDF TSGKSCRPDN SFRTQDTNES LEIISINHTK 
       160        170        180        190        200
ILTIDKSRKN FKFGPSVGLK SIGKQKIAGE KTQRNSLEEN STLLSQPKLK 
       210        220        230        240        250
TVEKRYKCST CEKAFIHNSS LRKHLKNHTG ERLFQCKDCL KAFSQSSALI 
       260        270        280        290        300
QHQRTHTGEK PYICKECGKA FSHSASLCKH LRTHTLEKSY TCKECGKSFS 
       310        320        330        340        350
RRSGLFLHQK IHARENPHKY NPGRKASTSL SGCQRIHSRK KTYLCNECGN 
       360        370        380        390        400
TFKSSSSLRY HQRIHTGEKP FKCSECGRAF SQSASLIQHE RIHTGEKPYR 
       410        420        430        440        450
CSECGKGFTS ISRLNRHRII HTGEKFYNCN ECGKALSSHS TLIIHERIHT 
       460        470        480        490        500
GEKPCKCKVC GKAFRQSSAL IQHQRMHTGE RPYKCNECGK TFRCNSSLSN 
       510        520        530        540        550
HQRTHTGEKP YRCQECGMSF GQSAALIQHR RIHTGEKPFK CNTCGKSFRQ 
       560        570        580        590        600
SSSLIAHQRI HTGEKPYECS ACGKLFSQRS SLTNHYRIHI EEDALNIDLH 

E

Length:601

Mass (Da):68,664

Last modified:May 1, 2000 - v1

Checksum:ⁱ4CE1540A8FF8E8B1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184112 mRNA Translation: AAF01034.1 AL627215 Genomic DNA No translation available. BC107400 mRNA Translation: AAI07401.1 BC107401 mRNA Translation: AAI07402.1 AK010007 mRNA Translation: BAB26638.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24641.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038772.1, NM_013744.3
UniGeneⁱ	Mm.74670

Genome annotation databases

Ensemblⁱ	ENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335 ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335
GeneIDⁱ	27274
KEGGⁱ	mmu:27274
UCSC genome browser More...UCSCⁱ	uc007itd.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QXT9	Zinc finger protein 354B		RAT		540	UniRef90_Q9QXT9
UPI0003D09445		RAT		625

Protein	Similar proteins		Species	Score	Length	Source
Q9QXT9	Zinc finger protein 354A		RAT		576	UniRef50_Q02975
Zinc finger protein 354A		MOUSE		572
zinc finger protein 2 homolog isoform X5		MESAU		638
Zinc finger protein 354A		HETGA		489
Zinc finger protein 354B		TUPCH		527
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184112 mRNA Translation: AAF01034.1 AL627215 Genomic DNA No translation available. BC107400 mRNA Translation: AAI07401.1 BC107401 mRNA Translation: AAI07402.1 AK010007 mRNA Translation: BAB26638.1
CCDSⁱ	CCDS24641.1
RefSeqⁱ	NP_038772.1, NM_013744.3
UniGeneⁱ	Mm.74670

3D structure databases

ProteinModelPortalⁱ	Q9QXT9
SMRⁱ	Q9QXT9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000104752

STRINGⁱ

10090.ENSMUSP00000104752

PTM databases

iPTMnetⁱ	Q9QXT9
PhosphoSitePlusⁱ	Q9QXT9

Proteomic databases

PaxDbⁱ	Q9QXT9
PRIDEⁱ	Q9QXT9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000109124; ENSMUSP00000104752; ENSMUSG00000020335 ENSMUST00000164280; ENSMUSP00000127671; ENSMUSG00000020335
GeneIDⁱ	27274
KEGGⁱ	mmu:27274
UCSCⁱ	uc007itd.2 mouse

Organism-specific databases

CTDⁱ	27274
MGIⁱ	MGI:1351476 Zfp354b

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144148
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9QXT9
KOⁱ	K09228
OMAⁱ	HIEEDAL
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q9QXT9
TreeFamⁱ	TF341817

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	Zfp354b mouse
Protein Ontology More...PROⁱ	PR:Q9QXT9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020335 Expressed in 195 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExⁱ	MM_ZFP354B
Genevisibleⁱ	Q9QXT9 MM

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Z354B_MOUSE
Accessionⁱ	Q9QXT9Primary (citable) accession number: Q9QXT9 Secondary accession number(s): Q9CV15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	May 1, 2000
	Last modified:	October 10, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QXT9 (Z354B_MOUSE)

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Zinc finger protein 354B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ