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Protein

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Gene

Dapp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Short name:
mDAPP1
Alternative name(s):
B lymphocyte adapter protein Bam32
B-cell adapter molecule of 32 kDa
Gene namesi
Name:Dapp1
Synonyms:Bam32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1347063 Dapp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797861 – 280Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139PhosphotyrosineCombined sources1
Modified residuei141PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXT1
MaxQBiQ9QXT1
PaxDbiQ9QXT1
PRIDEiQ9QXT1

PTM databases

iPTMnetiQ9QXT1
PhosphoSitePlusiQ9QXT1

Expressioni

Inductioni

Upon B-cell activation.By similarity

Gene expression databases

BgeeiENSMUSG00000028159 Expressed in 167 organ(s), highest expression level in blood
ExpressionAtlasiQ9QXT1 baseline and differential
GenevisibleiQ9QXT1 MM

Interactioni

Subunit structurei

Interacts with PtdIns(3,4,5)P3 and PLCG2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029806

Structurei

3D structure databases

ProteinModelPortaliQ9QXT1
SMRiQ9QXT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 129SH2PROSITE-ProRule annotationAdd BLAST95
Domaini164 – 259PHPROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IF6C Eukaryota
ENOG410XSW5 LUCA
GeneTreeiENSGT00910000144274
HOGENOMiHOG000112147
HOVERGENiHBG051297
InParanoidiQ9QXT1
KOiK12229
OMAiKVNCFCL
OrthoDBiEOG091G0HCX
PhylomeDBiQ9QXT1
TreeFamiTF105418

Family and domain databases

CDDicd10355 SH2_DAPP1_BAM32_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035843 DAPP1_SH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QXT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAELLGGN MSTQDPSELW GRADGGTDLL QDLGWYHGNL TRHAAEALLL
60 70 80 90 100
SNGRDGSYLL RDSNEQTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEYS
110 120 130 140 150
SLKDFVKHFA NQPLIGSETG TLMVLKHPYP REVEEPCIYE SVRVHTAMQT
160 170 180 190 200
GRTENDLVPT APSLGTKEGY LTKQGGLVKT WKTRWFTLQR NELKYFKDQM
210 220 230 240 250
SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC AKTGVEADEW
260 270 280
IKILRWKLSK IRKQLDQGED TVRSRSFIFK
Length:280
Mass (Da):32,167
Last modified:May 1, 2000 - v1
Checksum:iD15CF545A710F7F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TEK6Q3TEK6_MOUSE
Dual adapter for phosphotyrosine an...
Dapp1
239Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90Y → C in AAD49698 (PubMed:10432293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163255 mRNA Translation: AAD49698.1
AF186023 mRNA Translation: AAF14579.1
BC014759 mRNA Translation: AAH14759.1
CCDSiCCDS17864.1
RefSeqiNP_036062.1, NM_011932.3
UniGeneiMm.254835
Mm.470427

Genome annotation databases

EnsembliENSMUST00000029806; ENSMUSP00000029806; ENSMUSG00000028159
GeneIDi26377
KEGGimmu:26377
UCSCiuc008rmt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163255 mRNA Translation: AAD49698.1
AF186023 mRNA Translation: AAF14579.1
BC014759 mRNA Translation: AAH14759.1
CCDSiCCDS17864.1
RefSeqiNP_036062.1, NM_011932.3
UniGeneiMm.254835
Mm.470427

3D structure databases

ProteinModelPortaliQ9QXT1
SMRiQ9QXT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029806

PTM databases

iPTMnetiQ9QXT1
PhosphoSitePlusiQ9QXT1

Proteomic databases

EPDiQ9QXT1
MaxQBiQ9QXT1
PaxDbiQ9QXT1
PRIDEiQ9QXT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029806; ENSMUSP00000029806; ENSMUSG00000028159
GeneIDi26377
KEGGimmu:26377
UCSCiuc008rmt.1 mouse

Organism-specific databases

CTDi27071
MGIiMGI:1347063 Dapp1

Phylogenomic databases

eggNOGiENOG410IF6C Eukaryota
ENOG410XSW5 LUCA
GeneTreeiENSGT00910000144274
HOGENOMiHOG000112147
HOVERGENiHBG051297
InParanoidiQ9QXT1
KOiK12229
OMAiKVNCFCL
OrthoDBiEOG091G0HCX
PhylomeDBiQ9QXT1
TreeFamiTF105418

Enzyme and pathway databases

ReactomeiR-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

PROiPR:Q9QXT1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028159 Expressed in 167 organ(s), highest expression level in blood
ExpressionAtlasiQ9QXT1 baseline and differential
GenevisibleiQ9QXT1 MM

Family and domain databases

CDDicd10355 SH2_DAPP1_BAM32_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035843 DAPP1_SH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPP1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT1
Secondary accession number(s): Q9R178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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