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Protein

Protein canopy homolog 2

Gene

Cnpy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein ZSIG9
Transmembrane protein 4
Gene namesi
Name:Cnpy2
Synonyms:Msap, Tmem4, Zsig9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1928477 Cnpy2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003166721 – 182Protein canopy homolog 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
Modified residuei115PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9QXT0
MaxQBiQ9QXT0
PaxDbiQ9QXT0
PeptideAtlasiQ9QXT0
PRIDEiQ9QXT0
TopDownProteomicsiQ9QXT0

2D gel databases

REPRODUCTION-2DPAGEiIPI00135512

PTM databases

iPTMnetiQ9QXT0
PhosphoSitePlusiQ9QXT0
SwissPalmiQ9QXT0

Expressioni

Gene expression databases

BgeeiENSMUSG00000025381 Expressed in 281 organ(s), highest expression level in pancreas
CleanExiMM_CNPY2
ExpressionAtlasiQ9QXT0 baseline and differential
GenevisibleiQ9QXT0 MM

Interactioni

Subunit structurei

Interacts with MYLIP/MIR.By similarity

Protein-protein interaction databases

BioGridi208040, 1 interactor
IntActiQ9QXT0, 5 interactors
MINTiQ9QXT0
STRINGi10090.ENSMUSP00000026446

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 175Saposin B-typePROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 182Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the canopy family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3782 Eukaryota
ENOG4111XSQ LUCA
GeneTreeiENSGT00390000009749
HOGENOMiHOG000233996
HOVERGENiHBG052514
InParanoidiQ9QXT0
OMAiNVKDRLC
OrthoDBiEOG091G0HOQ
PhylomeDBiQ9QXT0
TreeFamiTF318578

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50015 SAP_B, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QXT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGWGWLALL LGVLLGTAWA RRSQDLHCGA CRALVDELEW EIARVDPKKT
60 70 80 90 100
IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEVCDRMK EYGEQIDPST
110 120 130 140 150
HRKNYVRVVS RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE
160 170 180
FFSREADNVK DKLCSKRTDL CDHALHRSHD EL
Length:182
Mass (Da):20,767
Last modified:May 1, 2000 - v1
Checksum:i83E54E7F01EE9B87
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P729A0A1W2P729_MOUSE
Protein canopy homolog 2
Cnpy2
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186115 mRNA Translation: AAF01433.1
AK007914 mRNA Translation: BAB25346.1
AK013014 mRNA Translation: BAB28597.1
AK013568 mRNA Translation: BAB28909.1
AK019927 mRNA Translation: BAB31921.1
AK150953 mRNA Translation: BAE29986.1
BC008261 mRNA Translation: AAH08261.1
CCDSiCCDS24272.1
RefSeqiNP_064337.1, NM_019953.1
XP_006513965.1, XM_006513902.3
UniGeneiMm.44220
Mm.486792

Genome annotation databases

EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381
ENSMUST00000219037; ENSMUSP00000151918; ENSMUSG00000025381
GeneIDi56530
KEGGimmu:56530
UCSCiuc007hmi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186115 mRNA Translation: AAF01433.1
AK007914 mRNA Translation: BAB25346.1
AK013014 mRNA Translation: BAB28597.1
AK013568 mRNA Translation: BAB28909.1
AK019927 mRNA Translation: BAB31921.1
AK150953 mRNA Translation: BAE29986.1
BC008261 mRNA Translation: AAH08261.1
CCDSiCCDS24272.1
RefSeqiNP_064337.1, NM_019953.1
XP_006513965.1, XM_006513902.3
UniGeneiMm.44220
Mm.486792

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208040, 1 interactor
IntActiQ9QXT0, 5 interactors
MINTiQ9QXT0
STRINGi10090.ENSMUSP00000026446

PTM databases

iPTMnetiQ9QXT0
PhosphoSitePlusiQ9QXT0
SwissPalmiQ9QXT0

2D gel databases

REPRODUCTION-2DPAGEiIPI00135512

Proteomic databases

EPDiQ9QXT0
MaxQBiQ9QXT0
PaxDbiQ9QXT0
PeptideAtlasiQ9QXT0
PRIDEiQ9QXT0
TopDownProteomicsiQ9QXT0

Protocols and materials databases

DNASUi56530
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381
ENSMUST00000219037; ENSMUSP00000151918; ENSMUSG00000025381
GeneIDi56530
KEGGimmu:56530
UCSCiuc007hmi.1 mouse

Organism-specific databases

CTDi10330
MGIiMGI:1928477 Cnpy2

Phylogenomic databases

eggNOGiKOG3782 Eukaryota
ENOG4111XSQ LUCA
GeneTreeiENSGT00390000009749
HOGENOMiHOG000233996
HOVERGENiHBG052514
InParanoidiQ9QXT0
OMAiNVKDRLC
OrthoDBiEOG091G0HOQ
PhylomeDBiQ9QXT0
TreeFamiTF318578

Miscellaneous databases

PROiPR:Q9QXT0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025381 Expressed in 281 organ(s), highest expression level in pancreas
CleanExiMM_CNPY2
ExpressionAtlasiQ9QXT0 baseline and differential
GenevisibleiQ9QXT0 MM

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50015 SAP_B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNPY2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT0
Secondary accession number(s): Q3UBH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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