UniProtKB - Q9QXS6 (DREB_MOUSE)
Drebrin
Dbn1
Functioni
GO - Molecular functioni
- actin filament binding Source: MGI
- cytoskeletal protein binding Source: MGI
- profilin binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: MGI
- cell communication by chemical coupling Source: MGI
- cell communication by electrical coupling Source: MGI
- cellular response to transforming growth factor beta stimulus Source: MGI
- cellular response to tumor necrosis factor Source: MGI
- cytoplasmic sequestering of protein Source: UniProtKB
- generation of neurons Source: DFLAT
- in utero embryonic development Source: MGI
- maintenance of protein location in cell Source: MGI
- modulation of inhibitory postsynaptic potential Source: MGI
- negative regulation of actin-dependent ATPase activity Source: MGI
- negative regulation of actin filament bundle assembly Source: MGI
- negative regulation of locomotion involved in locomotory behavior Source: MGI
- negative regulation of muscle filament sliding Source: MGI
- neural precursor cell proliferation Source: DFLAT
- neuron projection morphogenesis Source: GO_Central
- positive regulation of axon extension Source: MGI
- positive regulation of cell-substrate adhesion Source: MGI
- positive regulation of dendritic spine morphogenesis Source: UniProtKB
- positive regulation of excitatory postsynaptic potential Source: MGI
- positive regulation of neuron projection development Source: MGI
- positive regulation of receptor localization to synapse Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: MGI
- positive regulation of synaptic plasticity Source: UniProtKB
- postsynaptic actin cytoskeleton organization Source: MGI
- prepulse inhibition Source: MGI
- regulation of actin filament polymerization Source: MGI
- regulation of filopodium assembly Source: MGI
- regulation of postsynaptic density protein 95 clustering Source: MGI
Keywordsi
Molecular function | Actin-binding, Developmental protein |
Biological process | Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: DrebrinAlternative name(s): Developmentally-regulated brain protein |
Gene namesi | Name:Dbn1 Synonyms:Drba |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1931838 Dbn1 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- dendrite By similarity
- cell cortex By similarity
- Cell junction By similarity
- Cell projection 1 Publication
- growth cone 1 Publication
Note: In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729).By similarity1 Publication
Cytoskeleton
- actin cytoskeleton Source: MGI
- cortical actin cytoskeleton Source: GO_Central
- cytoskeleton Source: MGI
- postsynaptic actin cytoskeleton Source: MGI
Cytosol
- postsynaptic cytosol Source: SynGO
Plasma Membrane
- plasma membrane Source: MGI
- postsynaptic membrane Source: SynGO
Other locations
- asymmetric synapse Source: MGI
- axonal growth cone Source: MGI
- axonal spine Source: MGI
- cell Source: GOC
- cell-cell junction Source: MGI
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- dendritic filopodium Source: MGI
- dendritic shaft Source: MGI
- dendritic spine Source: MGI
- excitatory synapse Source: MGI
- filopodium Source: MGI
- gap junction Source: MGI
- glutamatergic synapse Source: SynGO
- growth cone Source: UniProtKB
- lamellipodium Source: MGI
- membrane Source: MGI
- neuron spine Source: MGI
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
- postsynaptic density Source: SynGO
- site of polarized growth Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell projection, CytoplasmPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000080009 | 2 – 706 | DrebrinAdd BLAST | 705 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 141 | PhosphoserineBy similarity | 1 | |
Modified residuei | 142 | PhosphoserineBy similarity | 1 | |
Modified residuei | 241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineBy similarity | 1 | |
Modified residuei | 379 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 383 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources | 1 | |
Modified residuei | 387 | PhosphoserineBy similarity | 1 | |
Modified residuei | 393 | PhosphoserineCombined sources | 1 | |
Modified residuei | 394 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 468 | PhosphoserineBy similarity | 1 | |
Modified residuei | 550 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 658 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9QXS6 |
PaxDbi | Q9QXS6 |
PeptideAtlasi | Q9QXS6 |
PRIDEi | Q9QXS6 |
PTM databases
iPTMneti | Q9QXS6 |
PhosphoSitePlusi | Q9QXS6 |
SwissPalmi | Q9QXS6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q9QXS6 baseline and differential |
Genevisiblei | Q9QXS6 MM |
Interactioni
Subunit structurei
Interacts with RUFY3 (PubMed:24720729).
Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity).
Interacts (via ADF-H domain) with ZMYND8 (via PHD-type Zinc finger, Bromo and PWWP domains); the interaction leads to sequestering of ZMYND8 in the cytoplasm (By similarity).
By similarityGO - Molecular functioni
- actin filament binding Source: MGI
- cytoskeletal protein binding Source: MGI
- profilin binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 207900, 15 interactors |
IntActi | Q9QXS6, 21 interactors |
MINTi | Q9QXS6 |
STRINGi | 10090.ENSMUSP00000021950 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 134 | ADF-HPROSITE-ProRule annotationAdd BLAST | 132 |
Phylogenomic databases
eggNOGi | ENOG410IP00 Eukaryota ENOG410YAV7 LUCA |
GeneTreei | ENSGT00940000159431 |
HOGENOMi | HOG000015304 |
InParanoidi | Q9QXS6 |
OMAi | MSPIPPQ |
OrthoDBi | 885776at2759 |
PhylomeDBi | Q9QXS6 |
TreeFami | TF318935 |
Family and domain databases
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin |
PANTHERi | PTHR10829:SF1 PTHR10829:SF1, 1 hit |
Pfami | View protein in Pfam PF00241 Cofilin_ADF, 1 hit |
SMARTi | View protein in SMART SM00102 ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263 ADF_H, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG
60 70 80 90 100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS
110 120 130 140 150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR
260 270 280 290 300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV
310 320 330 340 350
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF
360 370 380 390 400
PYITCHRTPN LSSSLPCSHL DSHRRMAPTP IPTRSPSDSS TASTPIAEQI
410 420 430 440 450
ERALDEVTSS QPPPPPPPPP PTQEAQETTP SLDEELSKEA KVTAAPEVWA
460 470 480 490 500
GCAAEPPQAQ EPPLLQSSPL EDSMCTESPE QAALAAPAEP AASVTSVADV
510 520 530 540 550
HAADTIETTT ATTDTTIANN VTPAAASLID LWPGNGEEAS TLQAEPRVPT
560 570 580 590 600
PPSGAEASLA EVPLLNEAAQ EPLPPVGEGC ANLLNFDELP EPPATFCDPE
610 620 630 640 650
EEVGETLAAS QVLTMPSALE EVDQVLEQEL EPEPHLLTNG ETTQKEGTQA
660 670 680 690 700
SEGYFSQSQE EEFAQSEEPC AKVPPPVFYN KPPEIDITCW DADPVPEEEE
GFEGGD
The sequence of this isoform differs from the canonical sequence as follows:
368-368: S → R
369-706: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
322-367: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J1E3 | A0A0R4J1E3_MOUSE | Drebrin | Dbn1 | 661 | Annotation score: | ||
F7CPL2 | F7CPL2_MOUSE | Drebrin | Dbn1 | 169 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | K → T in AAF25189 (PubMed:10633083).Curated | 1 | |
Sequence conflicti | 79 | K → T in AAF25190 (PubMed:10633083).Curated | 1 | |
Sequence conflicti | 79 | K → T in BAB86904 (PubMed:11991718).Curated | 1 | |
Sequence conflicti | 649 | Q → QQ in BAE20965 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004198 | 322 – 367 | Missing in isoform E2. 3 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_004199 | 368 | S → R in isoform A2. 1 Publication | 1 | |
Alternative sequenceiVSP_004200 | 369 – 706 | Missing in isoform A2. 1 PublicationAdd BLAST | 338 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF187147 mRNA Translation: AAF25189.1 AF187148 mRNA Translation: AAF25190.1 AB064321 mRNA Translation: BAB86904.1 AK132060 mRNA Translation: BAE20965.1 CT009762 Genomic DNA No translation available. BC006714 mRNA Translation: AAH06714.1 AB028740 Genomic DNA Translation: BAB87811.1 |
CCDSi | CCDS36677.1 [Q9QXS6-3] CCDS49274.1 [Q9QXS6-1] |
RefSeqi | NP_001170842.1, NM_001177371.1 [Q9QXS6-1] NP_001170843.1, NM_001177372.1 NP_062787.2, NM_019813.4 [Q9QXS6-3] |
Genome annotation databases
Ensembli | ENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1] ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3] |
GeneIDi | 56320 |
KEGGi | mmu:56320 |
UCSCi | uc007qrc.2 mouse [Q9QXS6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF187147 mRNA Translation: AAF25189.1 AF187148 mRNA Translation: AAF25190.1 AB064321 mRNA Translation: BAB86904.1 AK132060 mRNA Translation: BAE20965.1 CT009762 Genomic DNA No translation available. BC006714 mRNA Translation: AAH06714.1 AB028740 Genomic DNA Translation: BAB87811.1 |
CCDSi | CCDS36677.1 [Q9QXS6-3] CCDS49274.1 [Q9QXS6-1] |
RefSeqi | NP_001170842.1, NM_001177371.1 [Q9QXS6-1] NP_001170843.1, NM_001177372.1 NP_062787.2, NM_019813.4 [Q9QXS6-3] |
3D structure databases
SMRi | Q9QXS6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 207900, 15 interactors |
IntActi | Q9QXS6, 21 interactors |
MINTi | Q9QXS6 |
STRINGi | 10090.ENSMUSP00000021950 |
PTM databases
iPTMneti | Q9QXS6 |
PhosphoSitePlusi | Q9QXS6 |
SwissPalmi | Q9QXS6 |
Proteomic databases
jPOSTi | Q9QXS6 |
PaxDbi | Q9QXS6 |
PeptideAtlasi | Q9QXS6 |
PRIDEi | Q9QXS6 |
Genome annotation databases
Ensembli | ENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1] ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3] |
GeneIDi | 56320 |
KEGGi | mmu:56320 |
UCSCi | uc007qrc.2 mouse [Q9QXS6-1] |
Organism-specific databases
CTDi | 1627 |
MGIi | MGI:1931838 Dbn1 |
Phylogenomic databases
eggNOGi | ENOG410IP00 Eukaryota ENOG410YAV7 LUCA |
GeneTreei | ENSGT00940000159431 |
HOGENOMi | HOG000015304 |
InParanoidi | Q9QXS6 |
OMAi | MSPIPPQ |
OrthoDBi | 885776at2759 |
PhylomeDBi | Q9QXS6 |
TreeFami | TF318935 |
Miscellaneous databases
ChiTaRSi | Dbn1 mouse |
PROi | PR:Q9QXS6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q9QXS6 baseline and differential |
Genevisiblei | Q9QXS6 MM |
Family and domain databases
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin |
PANTHERi | PTHR10829:SF1 PTHR10829:SF1, 1 hit |
Pfami | View protein in Pfam PF00241 Cofilin_ADF, 1 hit |
SMARTi | View protein in SMART SM00102 ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263 ADF_H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DREB_MOUSE | |
Accessioni | Q9QXS6Primary (citable) accession number: Q9QXS6 Secondary accession number(s): A2CG16 Q9QXS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 13, 2019 | |
This is version 158 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot