UniProtKB - Q9QXS6 (DREB_MOUSE)

BLAST

>sp|Q9QXS6|DREB_MOUSE Drebrin OS=Mus musculus OX=10090 GN=Dbn1 PE=1 SV=4
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFEN
QKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASS
VEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQF
WEQAKKEEELRKEEERKKALDARLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQ
SLEAEEAKRRLKEQSIFGDQRDEEEESQMKKSESEVEEAAAIIAQRPDNPREFFRQQERV
ASASGGSCDAPAPAPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPN
LSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPIAEQIERALDEVTSSQPPPPPPPPP
PTQEAQETTPSLDEELSKEAKVTAAPEVWAGCAAEPPQAQEPPLLQSSPLEDSMCTESPE
QAALAAPAEPAASVTSVADVHAADTIETTTATTDTTIANNVTPAAASLIDLWPGNGEEAS
TLQAEPRVPTPPSGAEASLAEVPLLNEAAQEPLPPVGEGCANLLNFDELPEPPATFCDPE
EEVGETLAASQVLTMPSALEEVDQVLEQELEPEPHLLTNGETTQKEGTQASEGYFSQSQE
EEFAQSEEPCAKVPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

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History
Entry version 148 (12 Sep 2018)
Sequence version 4 (23 Jan 2007)
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Protein

Drebrin

Gene

Dbn1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.By similarity

GO - Molecular functionⁱ

actin filament binding Source: MGI
cytoskeletal protein binding Source: MGI
profilin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization
Source: MGI
Inferred from direct assayⁱ
- 11991718
cell communication by chemical coupling
Source: MGI
Inferred from mutant phenotypeⁱ
- 15084279
cell communication by electrical coupling
Source: MGI
Inferred from mutant phenotypeⁱ
- 15084279
cellular response to transforming growth factor beta stimulus Source: MGI
cellular response to tumor necrosis factor Source: MGI
generation of neurons
Source: DFLAT
Inferred from expression patternⁱ
- 20882566
maintenance of protein location in cell
Source: MGI
Inferred from mutant phenotypeⁱ
- 15084279
modulation of inhibitory postsynaptic potential Source: MGI
negative regulation of actin-dependent ATPase activity Source: MGI
negative regulation of actin filament bundle assembly Source: MGI
negative regulation of locomotion involved in locomotory behavior Source: MGI
negative regulation of muscle filament sliding Source: MGI
neural precursor cell proliferation
Source: DFLAT
Inferred from expression patternⁱ
- 20882566
positive regulation of axon extension Source: MGI
positive regulation of cell-substrate adhesion Source: MGI
positive regulation of dendritic spine morphogenesis Source: MGI
positive regulation of excitatory postsynaptic potential Source: MGI
positive regulation of neuron projection development Source: MGI
positive regulation of substrate adhesion-dependent cell spreading Source: MGI
prepulse inhibition Source: MGI
regulation of actin filament polymerization Source: MGI
regulation of filopodium assembly Source: MGI
regulation of postsynaptic density protein 95 clustering Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Developmental protein
Biological process	Differentiation, Neurogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Drebrin Alternative name(s): Developmentally-regulated brain protein
Gene namesⁱ	Name:Dbn1 Synonyms:Drba
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:1931838 Dbn1

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000080009	2 – 706	DrebrinAdd BLAST		705

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Modified residueⁱ	141	PhosphoserineBy similarity	1
Modified residueⁱ	142	PhosphoserineBy similarity	1
Modified residueⁱ	241	PhosphoserineCombined sources	1
Modified residueⁱ	344	PhosphoserineBy similarity	1
Modified residueⁱ	379	PhosphothreonineBy similarity	1
Modified residueⁱ	383	PhosphothreonineCombined sources	1
Modified residueⁱ	385	PhosphoserineCombined sources	1
Modified residueⁱ	387	PhosphoserineBy similarity	1
Modified residueⁱ	393	PhosphoserineCombined sources	1
Modified residueⁱ	394	PhosphothreonineCombined sources	1
Modified residueⁱ	468	PhosphoserineBy similarity	1
Modified residueⁱ	550	PhosphothreonineBy similarity	1
Modified residueⁱ	658	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9QXS6
PeptideAtlas More...PeptideAtlasⁱ	Q9QXS6
PRIDEⁱ	Q9QXS6

PTM databases

iPTMnetⁱ	Q9QXS6
PhosphoSitePlusⁱ	Q9QXS6
SwissPalmⁱ	Q9QXS6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain. Also present in stomach and to a lesser degree in kidney, colon, and urinary bladder. The E2 isoform is specifically expressed in adult stomach, kidney, and cultured cells.

Gene expression databases

Bgeeⁱ	ENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain
CleanExⁱ	MM_DBN1
ExpressionAtlasⁱ	Q9QXS6 baseline and differential
Genevisibleⁱ	Q9QXS6 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RUFY3 (PubMed:24720729). Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

actin filament binding Source: MGI
cytoskeletal protein binding Source: MGI
profilin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207900, 14 interactors
IntActⁱ	Q9QXS6, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q9QXS6
STRINGⁱ	10090.ENSMUSP00000021950

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QXS6
SMRⁱ	Q9QXS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 134	ADF-HPROSITE-ProRule annotationAdd BLAST		132

Phylogenomic databases

eggNOGⁱ	ENOG410IP00 Eukaryota ENOG410YAV7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062953
HOGENOMⁱ	HOG000015304
HOVERGENⁱ	HBG000823
InParanoidⁱ	Q9QXS6
OMAⁱ	PCSHLDS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05KP
PhylomeDBⁱ	Q9QXS6
TreeFamⁱ	TF318935

Family and domain databases

Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin
PANTHERⁱ	PTHR10829:SF1 PTHR10829:SF1, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: Q9QXS6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG 
        60         70         80         90        100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 
       110        120        130        140        150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 
       160        170        180        190        200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 
       210        220        230        240        250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR 
       260        270        280        290        300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV 
       310        320        330        340        350
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF 
       360        370        380        390        400
PYITCHRTPN LSSSLPCSHL DSHRRMAPTP IPTRSPSDSS TASTPIAEQI 
       410        420        430        440        450
ERALDEVTSS QPPPPPPPPP PTQEAQETTP SLDEELSKEA KVTAAPEVWA 
       460        470        480        490        500
GCAAEPPQAQ EPPLLQSSPL EDSMCTESPE QAALAAPAEP AASVTSVADV 
       510        520        530        540        550
HAADTIETTT ATTDTTIANN VTPAAASLID LWPGNGEEAS TLQAEPRVPT 
       560        570        580        590        600
PPSGAEASLA EVPLLNEAAQ EPLPPVGEGC ANLLNFDELP EPPATFCDPE 
       610        620        630        640        650
EEVGETLAAS QVLTMPSALE EVDQVLEQEL EPEPHLLTNG ETTQKEGTQA 
       660        670        680        690        700
SEGYFSQSQE EEFAQSEEPC AKVPPPVFYN KPPEIDITCW DADPVPEEEE 

GFEGGD

Length:706

Mass (Da):77,287

Last modified:January 23, 2007 - v4

Checksum:ⁱ39E542D2BB859346

Isoform A2 (identifier: Q9QXS6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
368-368: S → R
369-706: Missing.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG 
        60         70         80         90        100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 
       110        120        130        140        150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 
       160        170        180        190        200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 
       210        220        230        240        250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR 
       260        270        280        290        300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV 
       310        320        330        340        350
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF 
       360 
PYITCHRTPN LSSSLPCR

Show »

Length:368

Mass (Da):41,718

Checksum:ⁱ585010710EA49488

Isoform E2 (identifier: Q9QXS6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
322-367: Missing.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG 
        60         70         80         90        100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 
       110        120        130        140        150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 
       160        170        180        190        200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 
       210        220        230        240        250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR 
       260        270        280        290        300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV 
       310        320        330        340        350
ASASGGSCDA PAPAPFNHRP GSHLDSHRRM APTPIPTRSP SDSSTASTPI 
       360        370        380        390        400
AEQIERALDE VTSSQPPPPP PPPPPTQEAQ ETTPSLDEEL SKEAKVTAAP 
       410        420        430        440        450
EVWAGCAAEP PQAQEPPLLQ SSPLEDSMCT ESPEQAALAA PAEPAASVTS 
       460        470        480        490        500
VADVHAADTI ETTTATTDTT IANNVTPAAA SLIDLWPGNG EEASTLQAEP 
       510        520        530        540        550
RVPTPPSGAE ASLAEVPLLN EAAQEPLPPV GEGCANLLNF DELPEPPATF 
       560        570        580        590        600
CDPEEEVGET LAASQVLTMP SALEEVDQVL EQELEPEPHL LTNGETTQKE 
       610        620        630        640        650
GTQASEGYFS QSQEEEFAQS EEPCAKVPPP VFYNKPPEID ITCWDADPVP 
       660
EEEEGFEGGD

Show »

Length:660

Mass (Da):72,416

Checksum:ⁱ95375DD52994C689

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0R4J1E3	A0A0R4J1E3_MOUSE	Drebrin Drebrin	Dbn1	661	Annotation score:
F7CPL2	F7CPL2_MOUSE	Drebrin Drebrin	Dbn1	169	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	K → T in AAF25189 (PubMed:10633083).Curated	1
Sequence conflictⁱ	79	K → T in AAF25190 (PubMed:10633083).Curated	1
Sequence conflictⁱ	79	K → T in BAB86904 (PubMed:11991718).Curated	1
Sequence conflictⁱ	649	Q → QQ in BAE20965 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004198	322 – 367	Missing in isoform E2. 3 PublicationsAdd BLAST	46
Alternative sequenceⁱVSP_004199	368	S → R in isoform A2. 1 Publication	1
Alternative sequenceⁱVSP_004200	369 – 706	Missing in isoform A2. 1 PublicationAdd BLAST	338

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF187147 mRNA Translation: AAF25189.1 AF187148 mRNA Translation: AAF25190.1 AB064321 mRNA Translation: BAB86904.1 AK132060 mRNA Translation: BAE20965.1 CT009762 Genomic DNA Translation: CAM17636.1 BC006714 mRNA Translation: AAH06714.1 AB028740 Genomic DNA Translation: BAB87811.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36677.1 [Q9QXS6-3] CCDS49274.1 [Q9QXS6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001170842.1, NM_001177371.1 [Q9QXS6-1] NP_001170843.1, NM_001177372.1 NP_062787.2, NM_019813.4 [Q9QXS6-3]
UniGeneⁱ	Mm.19016

Genome annotation databases

Ensemblⁱ	ENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1] ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3]
GeneIDⁱ	56320
KEGGⁱ	mmu:56320
UCSC genome browser More...UCSCⁱ	uc007qrc.2 mouse [Q9QXS6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QXS6	drebrin isoform X1		MESAU		708	UniRef90_Q9QXS6
Drebrin (Fragment)		HUMAN		124
DBN1 isoform 10 (Fragment)		PONAB		124
UPI000024DB29		MOUSE		707
UPI000A3091CB		MUSPA		707
+1
Q9QXS6-3	Drebrin		MOUSE		661	UniRef90_A0A0R4J1E3
drebrin isoform X2		MESAU		662
Drebrin E		RAT		661
UPI000A3146C2		MUSCR		662
UPI000A30CFE6		MUSPA		661
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9QXS6	Drebrin		RAT		707	UniRef50_Q07266
Drebrin	)	HUMAN		649
drebrin isoform X1		DELLE		699
drebrin isoform X1		ODORO		698
Uncharacterized protein		PROCO		696
+287

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF187147 mRNA Translation: AAF25189.1 AF187148 mRNA Translation: AAF25190.1 AB064321 mRNA Translation: BAB86904.1 AK132060 mRNA Translation: BAE20965.1 CT009762 Genomic DNA Translation: CAM17636.1 BC006714 mRNA Translation: AAH06714.1 AB028740 Genomic DNA Translation: BAB87811.1
CCDSⁱ	CCDS36677.1 [Q9QXS6-3] CCDS49274.1 [Q9QXS6-1]
RefSeqⁱ	NP_001170842.1, NM_001177371.1 [Q9QXS6-1] NP_001170843.1, NM_001177372.1 NP_062787.2, NM_019813.4 [Q9QXS6-3]
UniGeneⁱ	Mm.19016

3D structure databases

ProteinModelPortalⁱ	Q9QXS6
SMRⁱ	Q9QXS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207900, 14 interactors
IntActⁱ	Q9QXS6, 21 interactors
MINTⁱ	Q9QXS6
STRINGⁱ	10090.ENSMUSP00000021950

PTM databases

iPTMnetⁱ	Q9QXS6
PhosphoSitePlusⁱ	Q9QXS6
SwissPalmⁱ	Q9QXS6

Proteomic databases

PaxDbⁱ	Q9QXS6
PeptideAtlasⁱ	Q9QXS6
PRIDEⁱ	Q9QXS6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1] ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3]
GeneIDⁱ	56320
KEGGⁱ	mmu:56320
UCSCⁱ	uc007qrc.2 mouse [Q9QXS6-1]

Organism-specific databases

CTDⁱ	1627
MGIⁱ	MGI:1931838 Dbn1

Phylogenomic databases

eggNOGⁱ	ENOG410IP00 Eukaryota ENOG410YAV7 LUCA
GeneTreeⁱ	ENSGT00530000062953
HOGENOMⁱ	HOG000015304
HOVERGENⁱ	HBG000823
InParanoidⁱ	Q9QXS6
OMAⁱ	PCSHLDS
OrthoDBⁱ	EOG091G05KP
PhylomeDBⁱ	Q9QXS6
TreeFamⁱ	TF318935

Miscellaneous databases

ChiTaRSⁱ	Dbn1 mouse
Protein Ontology More...PROⁱ	PR:Q9QXS6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain
CleanExⁱ	MM_DBN1
ExpressionAtlasⁱ	Q9QXS6 baseline and differential
Genevisibleⁱ	Q9QXS6 MM

Family and domain databases

Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin
PANTHERⁱ	PTHR10829:SF1 PTHR10829:SF1, 2 hits
Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DREB_MOUSE
Accessionⁱ	Q9QXS6Primary (citable) accession number: Q9QXS6 Secondary accession number(s): A2CG16 , Q3V234, Q922X1, Q9QXS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QXS6 (DREB_MOUSE)

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Drebrin

Dbn1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ