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Protein

Drebrin

Gene

Dbn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin
Alternative name(s):
Developmentally-regulated brain protein
Gene namesi
Name:Dbn1
Synonyms:Drba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1931838 Dbn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000800092 – 706DrebrinAdd BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei141PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Modified residuei344PhosphoserineBy similarity1
Modified residuei379PhosphothreonineBy similarity1
Modified residuei383PhosphothreonineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei387PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei394PhosphothreonineCombined sources1
Modified residuei468PhosphoserineBy similarity1
Modified residuei550PhosphothreonineBy similarity1
Modified residuei658PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QXS6
PeptideAtlasiQ9QXS6
PRIDEiQ9QXS6

PTM databases

iPTMnetiQ9QXS6
PhosphoSitePlusiQ9QXS6
SwissPalmiQ9QXS6

Expressioni

Tissue specificityi

Highly expressed in brain. Also present in stomach and to a lesser degree in kidney, colon, and urinary bladder. The E2 isoform is specifically expressed in adult stomach, kidney, and cultured cells.

Gene expression databases

BgeeiENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain
CleanExiMM_DBN1
ExpressionAtlasiQ9QXS6 baseline and differential
GenevisibleiQ9QXS6 MM

Interactioni

Subunit structurei

Interacts with RUFY3 (PubMed:24720729). Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207900, 14 interactors
IntActiQ9QXS6, 21 interactors
MINTiQ9QXS6
STRINGi10090.ENSMUSP00000021950

Structurei

3D structure databases

ProteinModelPortaliQ9QXS6
SMRiQ9QXS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 134ADF-HPROSITE-ProRule annotationAdd BLAST132

Phylogenomic databases

eggNOGiENOG410IP00 Eukaryota
ENOG410YAV7 LUCA
GeneTreeiENSGT00530000062953
HOGENOMiHOG000015304
HOVERGENiHBG000823
InParanoidiQ9QXS6
OMAiPCSHLDS
OrthoDBiEOG091G05KP
PhylomeDBiQ9QXS6
TreeFamiTF318935

Family and domain databases

Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR028438 Drebrin
PANTHERiPTHR10829:SF1 PTHR10829:SF1, 2 hits
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9QXS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG
60 70 80 90 100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS
110 120 130 140 150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR
260 270 280 290 300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV
310 320 330 340 350
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF
360 370 380 390 400
PYITCHRTPN LSSSLPCSHL DSHRRMAPTP IPTRSPSDSS TASTPIAEQI
410 420 430 440 450
ERALDEVTSS QPPPPPPPPP PTQEAQETTP SLDEELSKEA KVTAAPEVWA
460 470 480 490 500
GCAAEPPQAQ EPPLLQSSPL EDSMCTESPE QAALAAPAEP AASVTSVADV
510 520 530 540 550
HAADTIETTT ATTDTTIANN VTPAAASLID LWPGNGEEAS TLQAEPRVPT
560 570 580 590 600
PPSGAEASLA EVPLLNEAAQ EPLPPVGEGC ANLLNFDELP EPPATFCDPE
610 620 630 640 650
EEVGETLAAS QVLTMPSALE EVDQVLEQEL EPEPHLLTNG ETTQKEGTQA
660 670 680 690 700
SEGYFSQSQE EEFAQSEEPC AKVPPPVFYN KPPEIDITCW DADPVPEEEE

GFEGGD
Length:706
Mass (Da):77,287
Last modified:January 23, 2007 - v4
Checksum:i39E542D2BB859346
GO
Isoform A2 (identifier: Q9QXS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: S → R
     369-706: Missing.

Show »
Length:368
Mass (Da):41,718
Checksum:i585010710EA49488
GO
Isoform E2 (identifier: Q9QXS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-367: Missing.

Show »
Length:660
Mass (Da):72,416
Checksum:i95375DD52994C689
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1E3A0A0R4J1E3_MOUSE
Drebrin
Dbn1
661Annotation score:
F7CPL2F7CPL2_MOUSE
Drebrin
Dbn1
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79K → T in AAF25189 (PubMed:10633083).Curated1
Sequence conflicti79K → T in AAF25190 (PubMed:10633083).Curated1
Sequence conflicti79K → T in BAB86904 (PubMed:11991718).Curated1
Sequence conflicti649Q → QQ in BAE20965 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004198322 – 367Missing in isoform E2. 3 PublicationsAdd BLAST46
Alternative sequenceiVSP_004199368S → R in isoform A2. 1 Publication1
Alternative sequenceiVSP_004200369 – 706Missing in isoform A2. 1 PublicationAdd BLAST338

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187147 mRNA Translation: AAF25189.1
AF187148 mRNA Translation: AAF25190.1
AB064321 mRNA Translation: BAB86904.1
AK132060 mRNA Translation: BAE20965.1
CT009762 Genomic DNA Translation: CAM17636.1
BC006714 mRNA Translation: AAH06714.1
AB028740 Genomic DNA Translation: BAB87811.1
CCDSiCCDS36677.1 [Q9QXS6-3]
CCDS49274.1 [Q9QXS6-1]
RefSeqiNP_001170842.1, NM_001177371.1 [Q9QXS6-1]
NP_001170843.1, NM_001177372.1
NP_062787.2, NM_019813.4 [Q9QXS6-3]
UniGeneiMm.19016

Genome annotation databases

EnsembliENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1]
ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3]
GeneIDi56320
KEGGimmu:56320
UCSCiuc007qrc.2 mouse [Q9QXS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187147 mRNA Translation: AAF25189.1
AF187148 mRNA Translation: AAF25190.1
AB064321 mRNA Translation: BAB86904.1
AK132060 mRNA Translation: BAE20965.1
CT009762 Genomic DNA Translation: CAM17636.1
BC006714 mRNA Translation: AAH06714.1
AB028740 Genomic DNA Translation: BAB87811.1
CCDSiCCDS36677.1 [Q9QXS6-3]
CCDS49274.1 [Q9QXS6-1]
RefSeqiNP_001170842.1, NM_001177371.1 [Q9QXS6-1]
NP_001170843.1, NM_001177372.1
NP_062787.2, NM_019813.4 [Q9QXS6-3]
UniGeneiMm.19016

3D structure databases

ProteinModelPortaliQ9QXS6
SMRiQ9QXS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207900, 14 interactors
IntActiQ9QXS6, 21 interactors
MINTiQ9QXS6
STRINGi10090.ENSMUSP00000021950

PTM databases

iPTMnetiQ9QXS6
PhosphoSitePlusiQ9QXS6
SwissPalmiQ9QXS6

Proteomic databases

PaxDbiQ9QXS6
PeptideAtlasiQ9QXS6
PRIDEiQ9QXS6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675 [Q9QXS6-1]
ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675 [Q9QXS6-3]
GeneIDi56320
KEGGimmu:56320
UCSCiuc007qrc.2 mouse [Q9QXS6-1]

Organism-specific databases

CTDi1627
MGIiMGI:1931838 Dbn1

Phylogenomic databases

eggNOGiENOG410IP00 Eukaryota
ENOG410YAV7 LUCA
GeneTreeiENSGT00530000062953
HOGENOMiHOG000015304
HOVERGENiHBG000823
InParanoidiQ9QXS6
OMAiPCSHLDS
OrthoDBiEOG091G05KP
PhylomeDBiQ9QXS6
TreeFamiTF318935

Miscellaneous databases

ChiTaRSiDbn1 mouse
PROiPR:Q9QXS6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034675 Expressed in 255 organ(s), highest expression level in forebrain
CleanExiMM_DBN1
ExpressionAtlasiQ9QXS6 baseline and differential
GenevisibleiQ9QXS6 MM

Family and domain databases

Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR028438 Drebrin
PANTHERiPTHR10829:SF1 PTHR10829:SF1, 2 hits
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDREB_MOUSE
AccessioniPrimary (citable) accession number: Q9QXS6
Secondary accession number(s): A2CG16
, Q3V234, Q922X1, Q9QXS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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