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Protein

Complement C1q tumor necrosis factor-related protein 1

Gene

C1qtnf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 1
Alternative name(s):
Putative secreted protein ZSIG37
Gene namesi
Name:C1qtnf1
Synonyms:Zsig37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919254 C1qtnf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000032008126 – 281Complement C1q tumor necrosis factor-related protein 1Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QXP7
PaxDbiQ9QXP7
PeptideAtlasiQ9QXP7
PRIDEiQ9QXP7

PTM databases

PhosphoSitePlusiQ9QXP7

Expressioni

Gene expression databases

BgeeiENSMUSG00000017446 Expressed in 167 organ(s), highest expression level in vibrissa unit
CleanExiMM_C1QTNF1
ExpressionAtlasiQ9QXP7 baseline and differential
GenevisibleiQ9QXP7 MM

Interactioni

Protein-protein interaction databases

IntActiQ9QXP7, 1 interactor
STRINGi10090.ENSMUSP00000017590

Structurei

3D structure databases

ProteinModelPortaliQ9QXP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 140Collagen-likeAdd BLAST42
Domaini141 – 281C1qPROSITE-ProRule annotationAdd BLAST141

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKX5 Eukaryota
ENOG410XQIM LUCA
GeneTreeiENSGT00900000140911
HOGENOMiHOG000101544
HOVERGENiHBG108220
InParanoidiQ9QXP7
OMAiRCCDPGT
OrthoDBiEOG091G0LRA
PhylomeDBiQ9QXP7
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QXP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSCAQGFML GCCLLLAITW GPILSLVPRV QEEQQEWEET EELPSPLDPV
60 70 80 90 100
TRPEETREKY SPRQGEDLPT SRCYRCCDPS TPVYQTIPPP QINITILKGE
110 120 130 140 150
KGDRGDRGLQ GKYGKIGSTG PRGHVGPKGQ KGSIGAPGNH CKSQYAAFSV
160 170 180 190 200
GRKKALHSND YFQPVVFDTE FVNLYKHFNM FTGKFYCYVP GIYFFSLNVH
210 220 230 240 250
TWNQKETYLH IMKNEEEVVI LYAQVSDRSI MQSQSLMMEL REEDEVWVRL
260 270 280
FKGERENAIF SDEFDTYITF SGYLVKPASE P
Length:281
Mass (Da):32,009
Last modified:May 1, 2000 - v1
Checksum:iC9816216DB6419E2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A4W2A2A4W2_MOUSE
Complement C1q tumor necrosis facto...
C1qtnf1
51Annotation score:
A2A4W1A2A4W1_MOUSE
Complement C1q tumor necrosis facto...
C1qtnf1
49Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9M → L in BAE26237 (PubMed:16141072).Curated1
Sequence conflicti9M → L in AAH49894 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002394 mRNA Translation: AAY21926.1
AF192499 mRNA Translation: AAF06664.1
AK005484 mRNA Translation: BAB24070.1
AK145104 mRNA Translation: BAE26237.1
AL591075 Genomic DNA No translation available.
BC049894 mRNA Translation: AAH49894.1
CCDSiCCDS25703.1
RefSeqiNP_001191058.1, NM_001204129.1
NP_001191059.1, NM_001204130.1
NP_064343.1, NM_019959.3
XP_006533884.1, XM_006533821.3
XP_006533885.1, XM_006533822.3
UniGeneiMm.23845

Genome annotation databases

EnsembliENSMUST00000017590; ENSMUSP00000017590; ENSMUSG00000017446
ENSMUST00000106286; ENSMUSP00000101893; ENSMUSG00000017446
GeneIDi56745
KEGGimmu:56745
UCSCiuc007mpg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002394 mRNA Translation: AAY21926.1
AF192499 mRNA Translation: AAF06664.1
AK005484 mRNA Translation: BAB24070.1
AK145104 mRNA Translation: BAE26237.1
AL591075 Genomic DNA No translation available.
BC049894 mRNA Translation: AAH49894.1
CCDSiCCDS25703.1
RefSeqiNP_001191058.1, NM_001204129.1
NP_001191059.1, NM_001204130.1
NP_064343.1, NM_019959.3
XP_006533884.1, XM_006533821.3
XP_006533885.1, XM_006533822.3
UniGeneiMm.23845

3D structure databases

ProteinModelPortaliQ9QXP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXP7, 1 interactor
STRINGi10090.ENSMUSP00000017590

PTM databases

PhosphoSitePlusiQ9QXP7

Proteomic databases

MaxQBiQ9QXP7
PaxDbiQ9QXP7
PeptideAtlasiQ9QXP7
PRIDEiQ9QXP7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017590; ENSMUSP00000017590; ENSMUSG00000017446
ENSMUST00000106286; ENSMUSP00000101893; ENSMUSG00000017446
GeneIDi56745
KEGGimmu:56745
UCSCiuc007mpg.2 mouse

Organism-specific databases

CTDi114897
MGIiMGI:1919254 C1qtnf1

Phylogenomic databases

eggNOGiENOG410IKX5 Eukaryota
ENOG410XQIM LUCA
GeneTreeiENSGT00900000140911
HOGENOMiHOG000101544
HOVERGENiHBG108220
InParanoidiQ9QXP7
OMAiRCCDPGT
OrthoDBiEOG091G0LRA
PhylomeDBiQ9QXP7
TreeFamiTF329591

Miscellaneous databases

ChiTaRSiC1qtnf1 mouse
PROiPR:Q9QXP7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017446 Expressed in 167 organ(s), highest expression level in vibrissa unit
CleanExiMM_C1QTNF1
ExpressionAtlasiQ9QXP7 baseline and differential
GenevisibleiQ9QXP7 MM

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1QT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXP7
Secondary accession number(s): Q80VI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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