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UniProtKB - Q9QXN4 (MIOX_RAT)
Protein
Inositol oxygenase
Gene
Miox
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:1.13.99.1
Cofactori
Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity
: myo-inositol degradation into D-glucuronate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol. This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 29 | SubstrateBy similarity | 1 | |
Metal bindingi | 98 | Iron 1By similarity | 1 | |
Metal bindingi | 123 | Iron 1By similarity | 1 | |
Metal bindingi | 124 | Iron 1By similarity | 1 | |
Metal bindingi | 124 | Iron 2By similarity | 1 | |
Binding sitei | 127 | SubstrateBy similarity | 1 | |
Metal bindingi | 194 | Iron 2By similarity | 1 | |
Metal bindingi | 220 | Iron 2By similarity | 1 | |
Metal bindingi | 253 | Iron 1By similarity | 1 |
GO - Molecular functioni
- aldo-keto reductase (NADP) activity Source: UniProtKB
- ferric iron binding Source: UniProtKB
- inositol oxygenase activity Source: UniProtKB
- NADP binding Source: RGD
- oxidoreductase activity, acting on NAD(P)H Source: RGD
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: UniProtKB
GO - Biological processi
- inositol catabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.13.99.1, 5301 |
Reactomei | R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
SABIO-RKi | Q9QXN4 |
UniPathwayi | UPA00111;UER00527 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol oxygenase (EC:1.13.99.1)Alternative name(s): Aldehyde reductase-like 6 Kidney-specific protein 32 Myo-inositol oxygenase Short name: MI oxygenase Renal-specific oxidoreductase |
Gene namesi | Name:Miox Synonyms:Aldrl6, Ksp32, Rsor |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628739, Miox |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
- inclusion body Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079152 | 1 – 285 | Inositol oxygenaseAdd BLAST | 285 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9QXN4 |
PRIDEi | Q9QXN4 |
PTM databases
iPTMneti | Q9QXN4 |
PhosphoSitePlusi | Q9QXN4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 87 | Substrate bindingBy similarity | 3 | |
Regioni | 141 – 142 | Substrate bindingBy similarity | 2 | |
Regioni | 220 – 221 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the myo-inositol oxygenase family.Curated
Phylogenomic databases
eggNOGi | KOG1573, Eukaryota |
HOGENOMi | CLU_050259_1_0_1 |
InParanoidi | Q9QXN4 |
OrthoDBi | 1436589at2759 |
PhylomeDBi | Q9QXN4 |
TreeFami | TF300089 |
Family and domain databases
InterProi | View protein in InterPro IPR018170, Aldo/ket_reductase_CS IPR007828, Inositol_oxygenase |
PANTHERi | PTHR12588, PTHR12588, 1 hit |
Pfami | View protein in Pfam PF05153, MIOX, 1 hit |
PROSITEi | View protein in PROSITE PS00063, ALDOKETO_REDUCTASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9QXN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVDLGPDPS LVYRPDVDPE MAKSKGSFRN YTSGPLLDRV FTTYKLMHTH
60 70 80 90 100
QTVDFVMRKR IQFGSFSYKK MTVMEAVDML DDLVDESDPD VDFPNSFHAF
110 120 130 140 150
QTAEGIRKAH PDKDWFHLVG LLHDLGKILA LWGEPQWAVV GDTFPVGCRP
160 170 180 190 200
QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLENVLM SWGHDEYLYQ
210 220 230 240 250
MMKFNKFSLP SEAFYMVRFH SFYPWHTGGD YRQLCSQQDL DMLPWVQEFN
260 270 280
KFDLYTKCPD LPEVKSLRPY YQGLIDKYCP GILSW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHH0 | A0A0H2UHH0_RAT | Inositol oxygenase | Miox | 289 | Annotation score: | ||
A0A8I6GFH1 | A0A8I6GFH1_RAT | Inositol oxygenase | Miox | 285 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 – 5 | DL → TV in AAK00767 (Ref. 2) Curated | 2 | |
Sequence conflicti | 21 | M → V in AAK00767 (Ref. 2) Curated | 1 | |
Sequence conflicti | 24 – 26 | SKG → DKA in AAK00767 (Ref. 2) Curated | 3 | |
Sequence conflicti | 57 | M → R (Ref. 2) Curated | 1 | |
Sequence conflicti | 57 | M → V in AAV65817 (PubMed:15504367).Curated | 1 | |
Sequence conflicti | 58 – 61 | RKRI → SKHA (Ref. 2) Curated | 4 | |
Sequence conflicti | 282 | I → T (PubMed:10944187).Curated | 1 | |
Sequence conflicti | 282 | I → T (PubMed:15504367).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF197128 mRNA Translation: AAF25203.1 AF230096 mRNA Translation: AAK00767.1 AY738259 mRNA Translation: AAV65817.1 BC078840 mRNA Translation: AAH78840.1 |
RefSeqi | NP_665714.2, NM_145771.2 |
Genome annotation databases
Ensembli | ENSRNOT00000011941; ENSRNOP00000011941; ENSRNOG00000008694 |
GeneIDi | 252899 |
KEGGi | rno:252899 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF197128 mRNA Translation: AAF25203.1 AF230096 mRNA Translation: AAK00767.1 AY738259 mRNA Translation: AAV65817.1 BC078840 mRNA Translation: AAH78840.1 |
RefSeqi | NP_665714.2, NM_145771.2 |
3D structure databases
AlphaFoldDBi | Q9QXN4 |
SMRi | Q9QXN4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011941 |
PTM databases
iPTMneti | Q9QXN4 |
PhosphoSitePlusi | Q9QXN4 |
Proteomic databases
PaxDbi | Q9QXN4 |
PRIDEi | Q9QXN4 |
Protocols and materials databases
DNASUi | 252899 |
Genome annotation databases
Ensembli | ENSRNOT00000011941; ENSRNOP00000011941; ENSRNOG00000008694 |
GeneIDi | 252899 |
KEGGi | rno:252899 |
Organism-specific databases
CTDi | 55586 |
RGDi | 628739, Miox |
Phylogenomic databases
eggNOGi | KOG1573, Eukaryota |
HOGENOMi | CLU_050259_1_0_1 |
InParanoidi | Q9QXN4 |
OrthoDBi | 1436589at2759 |
PhylomeDBi | Q9QXN4 |
TreeFami | TF300089 |
Enzyme and pathway databases
UniPathwayi | UPA00111;UER00527 |
BRENDAi | 1.13.99.1, 5301 |
Reactomei | R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
SABIO-RKi | Q9QXN4 |
Miscellaneous databases
PROi | PR:Q9QXN4 |
Gene expression databases
Genevisiblei | Q9QXN4, RN |
Family and domain databases
InterProi | View protein in InterPro IPR018170, Aldo/ket_reductase_CS IPR007828, Inositol_oxygenase |
PANTHERi | PTHR12588, PTHR12588, 1 hit |
Pfami | View protein in Pfam PF05153, MIOX, 1 hit |
PROSITEi | View protein in PROSITE PS00063, ALDOKETO_REDUCTASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MIOX_RAT | |
Accessioni | Q9QXN4Primary (citable) accession number: Q9QXN4 Secondary accession number(s): Q5S8C8, Q68G06, Q99PN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | November 8, 2005 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families