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Entry version 154 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Activating signal cointegrator 1

Gene

Trip4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity). Also involved in androgen receptor transactivation (PubMed:12077347). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction (By similarity). May play a role in late myogenic differentiation (PubMed:27008887).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri167 – 219C4-typeAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activating signal cointegrator 11 Publication
Short name:
ASC-11 Publication
Alternative name(s):
Thyroid receptor-interacting protein 4Curated
Short name:
TR-interacting protein 4Curated
Short name:
TRIP-4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trip4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1928469, Trip4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656322 – 581Activating signal cointegrator 1Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei289PhosphotyrosineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)By similarity
Cross-linki334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK6.By similarity
Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9QXN3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QXN3

PRoteomics IDEntifications database

More...
PRIDEi
Q9QXN3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QXN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QXN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (PubMed:12390891). Expressed in the spinal cord, brain, paraspinal ganglia, thyroid, and submandibular glands (PubMed:26924529). Expressed at low level in all the muscles (at protein level) but with higher expression in axial than in limb muscles (PubMed:27008887).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in 17.5-day-old embryos.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032386, Expressed in pineal body and 300 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9QXN3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QXN3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (By similarity).

Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (By similarity).

Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (By similarity).

Interacts with UFSP2; competes with ligand-bound ESR1 (By similarity).

Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (By similarity).

Interacts with NCOA1 (By similarity).

Interacts with EP300 (By similarity). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347).

Interacts with NEK6 (By similarity).

Interacts with CSRP1 (By similarity).

Interacts with ZCCHC4 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207956, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112385

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9QXN3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QXN3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 300Mediates interaction with DDRGK1By similarityAdd BLAST101
Regioni300 – 400Mediates interaction with UFL1By similarityAdd BLAST101

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 219C4-typeAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2845, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005300

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025737_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QXN3

KEGG Orthology (KO)

More...
KOi
K23398

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDEADYF

Database of Orthologous Groups

More...
OrthoDBi
1132270at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314842

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007374, ASCH_domain
IPR015947, PUA-like_sf
IPR039128, TRIP4-like
IPR009349, Znf_C2HC5

The PANTHER Classification System

More...
PANTHERi
PTHR12963, PTHR12963, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04266, ASCH, 1 hit
PF06221, zf-C2HC5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01022, ASCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88697, SSF88697, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QXN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAGAAYRE PLVHWCTQQL QKTFALDVSE EIIQYVLSIE NAEEIREYVT
60 70 80 90 100
DLLQGNEGKK GQFIEDLITK WQKNDQEFIS DSFQQCLRKD EILDGQRSVD
110 120 130 140 150
QLKRSRRKGR NKQEVPAFPE PDVAVEVKTP LDLAKAQESN NSVKKKTRFV
160 170 180 190 200
NLYTREGQDK LAVLLPGRHP CDCLGQKHKL INNCLVCGRI VCEQEGSGPC
210 220 230 240 250
LFCGSLVCTN EEQDILQRDS NKSQKLLKKL MSGAETSGKV DVSTKDLLPH
260 270 280 290 300
QESRMKSGLE KAIKHKEKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK
310 320 330 340 350
VEREMLQKRE EELRELRHAS RLSKKVTIDF AGRKILEDEN PLAEYHSRLD
360 370 380 390 400
ETIQAIASGT LNQSLVTLDR SCEEPLGVLV NPNMYQASPQ WVDNTGSTPQ
410 420 430 440 450
KKTSLSAGPR LEPSLHQHQL RIQDQEFQEG FDGGWCLSMH QPWASLLVRG
460 470 480 490 500
IKRVEGRSWY TPHRGRLWIA ATGKRPSPQE VSELQATYRL LRGKDVEFPN
510 520 530 540 550
DYPSGCLLGC VDLIDCLSQK QFQEQFPDIS QESDSSFVFI CKNPQEMVVK
560 570 580
FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V
Length:581
Mass (Da):66,197
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CAB3512E3CEDDA7
GO
Isoform 2 (identifier: Q9QXN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-539: FPDISQESDSSFVF → GNWIPRSIKEQRRG
     540-581: Missing.

Show »
Length:539
Mass (Da):61,533
Checksum:iFF965B4855F43891
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3P3D3Z3P3_MOUSE
Activating signal cointegrator 1
Trip4
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7A → G in BAC30209 (PubMed:16141072).Curated1
Sequence conflicti388S → P in AAF18440 (PubMed:12077347).Curated1
Sequence conflicti388S → P in AAN23117 (PubMed:12390891).Curated1
Sequence conflicti388S → P in AAH21316 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011109526 – 539FPDIS…SSFVF → GNWIPRSIKEQRRG in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_011110540 – 581Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF197574 mRNA Translation: AAF18440.1
AF539614 mRNA Translation: AAN23117.1
AK039024 mRNA Translation: BAC30209.1
AC151906 Genomic DNA No translation available.
BC021316 mRNA Translation: AAH21316.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23298.1 [Q9QXN3-1]
CCDS52838.1 [Q9QXN3-2]

NCBI Reference Sequences

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RefSeqi
NP_001164378.1, NM_001170907.1 [Q9QXN3-2]
NP_062771.2, NM_019797.4 [Q9QXN3-1]
XP_006511359.1, XM_006511296.3 [Q9QXN3-1]
XP_006511361.1, XM_006511298.3 [Q9QXN3-1]
XP_006511362.1, XM_006511299.3
XP_017168981.1, XM_017313492.1 [Q9QXN3-1]
XP_017168982.1, XM_017313493.1 [Q9QXN3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000117083; ENSMUSP00000113949; ENSMUSG00000032386 [Q9QXN3-1]
ENSMUST00000119245; ENSMUSP00000112385; ENSMUSG00000032386 [Q9QXN3-1]
ENSMUST00000122410; ENSMUSP00000112866; ENSMUSG00000032386 [Q9QXN3-2]
ENSMUST00000179395; ENSMUSP00000137304; ENSMUSG00000032386 [Q9QXN3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56404

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56404

UCSC genome browser

More...
UCSCi
uc009qdz.2, mouse [Q9QXN3-2]
uc012gvn.1, mouse [Q9QXN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197574 mRNA Translation: AAF18440.1
AF539614 mRNA Translation: AAN23117.1
AK039024 mRNA Translation: BAC30209.1
AC151906 Genomic DNA No translation available.
BC021316 mRNA Translation: AAH21316.1
CCDSiCCDS23298.1 [Q9QXN3-1]
CCDS52838.1 [Q9QXN3-2]
RefSeqiNP_001164378.1, NM_001170907.1 [Q9QXN3-2]
NP_062771.2, NM_019797.4 [Q9QXN3-1]
XP_006511359.1, XM_006511296.3 [Q9QXN3-1]
XP_006511361.1, XM_006511298.3 [Q9QXN3-1]
XP_006511362.1, XM_006511299.3
XP_017168981.1, XM_017313492.1 [Q9QXN3-1]
XP_017168982.1, XM_017313493.1 [Q9QXN3-2]

3D structure databases

SMRiQ9QXN3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207956, 4 interactors
STRINGi10090.ENSMUSP00000112385

PTM databases

iPTMnetiQ9QXN3
PhosphoSitePlusiQ9QXN3

Proteomic databases

EPDiQ9QXN3
PaxDbiQ9QXN3
PRIDEiQ9QXN3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1761, 269 antibodies

Genome annotation databases

EnsembliENSMUST00000117083; ENSMUSP00000113949; ENSMUSG00000032386 [Q9QXN3-1]
ENSMUST00000119245; ENSMUSP00000112385; ENSMUSG00000032386 [Q9QXN3-1]
ENSMUST00000122410; ENSMUSP00000112866; ENSMUSG00000032386 [Q9QXN3-2]
ENSMUST00000179395; ENSMUSP00000137304; ENSMUSG00000032386 [Q9QXN3-2]
GeneIDi56404
KEGGimmu:56404
UCSCiuc009qdz.2, mouse [Q9QXN3-2]
uc012gvn.1, mouse [Q9QXN3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9325
MGIiMGI:1928469, Trip4

Phylogenomic databases

eggNOGiKOG2845, Eukaryota
GeneTreeiENSGT00390000005300
HOGENOMiCLU_025737_1_0_1
InParanoidiQ9QXN3
KOiK23398
OMAiDDEADYF
OrthoDBi1132270at2759
TreeFamiTF314842

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56404, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Trip4, mouse

Protein Ontology

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PROi
PR:Q9QXN3
RNActiQ9QXN3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032386, Expressed in pineal body and 300 other tissues
ExpressionAtlasiQ9QXN3, baseline and differential
GenevisibleiQ9QXN3, MM

Family and domain databases

InterProiView protein in InterPro
IPR007374, ASCH_domain
IPR015947, PUA-like_sf
IPR039128, TRIP4-like
IPR009349, Znf_C2HC5
PANTHERiPTHR12963, PTHR12963, 1 hit
PfamiView protein in Pfam
PF04266, ASCH, 1 hit
PF06221, zf-C2HC5, 1 hit
SMARTiView protein in SMART
SM01022, ASCH, 1 hit
SUPFAMiSSF88697, SSF88697, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIP4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXN3
Secondary accession number(s): E9QK64, Q8CAD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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