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Entry version 134 (07 Apr 2021)
Sequence version 2 (01 May 2007)
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Protein

Protein Shroom3

Gene

Shroom3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:10589677, PubMed:14680628). Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628, PubMed:16249236, PubMed:16684770, PubMed:22493320). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processCell shape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Shroom3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shroom3
Synonyms:Kiaa1481, Shrm
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351655, Shroom3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death at birth due to defects in neural tube closure causing exencephaly, acrania, facial clefting and spina bifida.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1772 – 1776KKAEL → AKARA: Does not affect binding to ROCK1. 5
Mutagenesisi1838 – 1841LLSL → AASA: Loss of dimerization, binding to ROCK1 and ability to trigger apical constriction in cells. 1 Publication4
Mutagenesisi1840 – 1846SLSGRLA → ALEADLE: Reduces binding to ROCK1 and ability to trigger apical constriction in cells. 1 Publication7
Mutagenesisi1884 – 1891LKENLDRR → AAENLDDA: Loss of binding to ROCK1 and ability to trigger apical constriction in cells. 1 Publication8
Mutagenesisi1921 – 1928LLIEQRKL → ALIEQAKA: Loss of dimerization, binding to ROCK1 and ability to trigger apical constriction in cells. 1 Publication8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860671 – 1986Protein Shroom3Add BLAST1986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei212PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei888PhosphoserineBy similarity1
Modified residuei909PhosphothreonineCombined sources1
Modified residuei912PhosphoserineCombined sources1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1066PhosphoserineCombined sources1
Modified residuei1219PhosphoserineCombined sources1
Isoform 4 (identifier: Q9QXN0-4)
Modified residuei1175PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Isoform 3 (identifier: Q9QXN0-3)
Modified residuei1350PhosphoserineCombined sources1
Modified residuei1354PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9QXN0

PeptideAtlas

More...
PeptideAtlasi
Q9QXN0

PRoteomics IDEntifications database

More...
PRIDEi
Q9QXN0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
255419 [Q9QXN0-1]
255420 [Q9QXN0-2]
255421 [Q9QXN0-3]
255422 [Q9QXN0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QXN0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QXN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 8.75 dpc, strongly expressed in the cranial neuroepithelium, and also expressed in neural tube, paraxial mesoderm and gut. At 10.5 dpc, expressed in neural tube, forebrain, somites, ventral body wall, heart and gut. At 14.5 dpc, expression is restricted to skeletal muscle, tips of the digits and forebrain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F-actin (PubMed:10589677).

Interacts with ROCK1 (PubMed:22493320).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
205229, 5 interactors

Protein interaction database and analysis system

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IntActi
Q9QXN0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108678

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9QXN0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QXN0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 109PDZPROSITE-ProRule annotationAdd BLAST86
Domaini927 – 1023ASD1PROSITE-ProRule annotationAdd BLAST97
Domaini1659 – 1947ASD2PROSITE-ProRule annotationAdd BLAST289

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1844 – 1890Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 268Ser-richAdd BLAST78
Compositional biasi1351 – 1540Pro-richAdd BLAST190

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASD1 domain mediates F-actin binding.
The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the shroom family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUU2, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QXN0

Database of Orthologous Groups

More...
OrthoDBi
29607at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QXN0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030494, Shrm3
IPR027685, Shroom_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QXN0-1) [UniParc]FASTAAdd to basket
Also known as: L,a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTPENLEEP SATPNPSRTP TERFVYLEAL LEGGAPWGFT LKGGLERGEP
60 70 80 90 100
LIISKIEEGG KADSVSSGLQ AGDEVIHINE VALSSPRREA VSLVKGSYKT
110 120 130 140 150
LRLVVRRDVC AAPGHADPGT SKSLSSELLT CSPQHRKATW SGGVKLRLKQ
160 170 180 190 200
RCSEPATRPH SWHTTKFGET QPDVSMMQIS QGTMGPPWHQ SYHSSSSTSD
210 220 230 240 250
LSNYDHAYLR RSPDQCSSQG SMESLEPSGG YPPCHLLSPA KSTSSIDQLG
260 270 280 290 300
HLHNKRDSAY SSFSTSSSIF EYPPPGGSAR ERSGSMDVIS ARGGLLEGMR
310 320 330 340 350
QADIRYVKTV YDTRRGVSSE YEVNPSALLL QGRDAHASAD SQGCAKWHSI
360 370 380 390 400
PRGKGTPSPS WSQQCSGSLE TATDNLPQKA GAPLPPTRSD SYAAFRHRER
410 420 430 440 450
PSSWSSLDQK RFCRPQTNSS GSQKTPFAED QLHTVPERSP ENSPPVKSKH
460 470 480 490 500
NYTQKAQPGQ PLLPTGIYPV PSPEPHFAQV PQPSVSSNGT VYPALVKESG
510 520 530 540 550
YTAAQGTCNK MATLDENGNQ NEASRPGFAF CQPLEHNSVT PVEKRPEPTA
560 570 580 590 600
KYIYKVHFSS VPENEDSSLK RHITPPHGHS PYPSERKNIH GGSRACSNHH
610 620 630 640 650
SLSSPQAQAL HVGDDRRPSR LSQPWEGDFQ EDHNANLRQK VEREGQGQGL
660 670 680 690 700
SGNSGRTRSA FSSLQNIPES LRRQSNVELG EAQEVHPGGR SKVEDPGRKA
710 720 730 740 750
GASDIRGYLD RSVSYPRPEG KMNAVDSVHS ADSRYEESPA PALPQTSGAS
760 770 780 790 800
QRRLSSSSSA APQYRKPHCS VLEKVSRIEE REQGRHRPLS VGSSAYGPGY
810 820 830 840 850
RPGRTGPTPS TSSSDLDDPK AGSVHFSEST EHLRNGEQNP PNGEAKQEEA
860 870 880 890 900
SRPQCSHLIR RAPADGRGPP ARGGEPSRPE ARLLRSQSTF QLYSEAEREA
910 920 930 940 950
SWSEDRPGTP ESPLLDAPFS RAYRNSIKDA QSRVLGATSF RRRDLEPGTP
960 970 980 990 1000
ATSRPWRPRP ASAHVGMRSP EAAVPSSSPH TPRERHSVTP AAPQAARRGP
1010 1020 1030 1040 1050
RRRLTVEQKK RSYSEPEKMN EVGVSEEAEP TPCGPPRPAQ PRFSESTVAD
1060 1070 1080 1090 1100
RRRIFERDGK ACSTLSLSGP ELKQFQQSAL ADYIQRKTGK RPTGAACTPE
1110 1120 1130 1140 1150
AGLRERAQSA YLQAGPAAPD GPGLASACSL SSLREPEALP RKEHTHPSAA
1160 1170 1180 1190 1200
DGPQAPRDRS SSFASGRLVG ERRRWDPQVP RQLLSGANCE PRGVQRMDGA
1210 1220 1230 1240 1250
PGGPPSWGMV AGKAGKSKSA EDLLERSDTL AVPVHVRSRS SPTSDKKGQD
1260 1270 1280 1290 1300
VLLREGSNFG FVKDPCCLAG PGPRSLSCSD KGQNELALPL HHPTPCWNGS
1310 1320 1330 1340 1350
GCKATVASSA PPESSGAADH LKQRRAPGPR PLSAGMHGHF PDARAASLSS
1360 1370 1380 1390 1400
PLPSPVPSAS PVPSSYRSQL AMDQQTGQQP PSSPASAVTQ PTSPRSPELS
1410 1420 1430 1440 1450
SPAYGLGEGM WKRTSLPQRP PPPWVKWAHA VREDGLAEDT LAPEFANLKH
1460 1470 1480 1490 1500
YRNQPSRPSS CSTSDPDTPG RISLRISESA LQPSPPPRGD YDDEVFMKDL
1510 1520 1530 1540 1550
HPKVTSSPTF EALPPPPPPS PPSEEPLVNG TDDFPPPPPP QALCEVLLDG
1560 1570 1580 1590 1600
EASTEAGSGP CRIPRVMVTR EGHVPGAAHS EGSQIMTATP PQTSAKGSEA
1610 1620 1630 1640 1650
ESNTPSSASA QPQLNGSPGK QLCPSQTRNL TYEPVERTQD LGKKTHAEPQ
1660 1670 1680 1690 1700
KTSEDIRTEA LAKEIVHQDK SLADILDPDS RMKTTMDLME GLFPGDASVL
1710 1720 1730 1740 1750
MDSGAKRKAL DITARRAGCE AKASDHKEAV SVLVNCPAYY SVSAAKAELL
1760 1770 1780 1790 1800
NKIKDMPEEL QEEEGQEDVN EKKAELIGSL THKLESLQEA KGSLLTDIKL
1810 1820 1830 1840 1850
NNALGEEVEA LISELCKPNE FDKYKMFIGD LDKVVNLLLS LSGRLARVEN
1860 1870 1880 1890 1900
VLRGLGEDAS KEERSSLNEK RKVLAGQHED ARELKENLDR RERVVLDILA
1910 1920 1930 1940 1950
NYLSAEQLQD YQHFVKMKST LLIEQRKLDD KIKLGQEQVR CLLESLPSDF
1960 1970 1980
RPKAGAISLP PALTGHATPG GTSVFGGVFP TLTSPL
Length:1,986
Mass (Da):214,888
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52C7A4AF6390D547
GO
Isoform 2 (identifier: Q9QXN0-2) [UniParc]FASTAAdd to basket
Also known as: S,b

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:1,811
Mass (Da):195,981
Checksum:iDE2A33086EE355F8
GO
Isoform 3 (identifier: Q9QXN0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1359: Missing.

Show »
Length:1,980
Mass (Da):214,349
Checksum:i18B675C987AAC60B
GO
Isoform 4 (identifier: Q9QXN0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     1354-1359: Missing.

Show »
Length:1,805
Mass (Da):195,442
Checksum:iB8099FC19E506415
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QMY5E9QMY5_MOUSE
Protein Shroom3
Shroom3
1,980Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6I3E9Q6I3_MOUSE
Protein Shroom3
Shroom3
1,849Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1H8A0A0R4J1H8_MOUSE
Protein Shroom3
Shroom3
1,805Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDQ8A0A286YDQ8_MOUSE
Protein Shroom3
Shroom3
1,899Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UXH3G3UXH3_MOUSE
Protein Shroom3
Shroom3
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF13269 differs from that shown. Reason: Frameshift.Curated
The sequence AAF13270 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti409Q → H in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti409Q → H in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti617R → K in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti617R → K in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti683Q → P in BAC98181 (PubMed:14621295).Curated1
Sequence conflicti800Y → N in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti800Y → N in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1078S → N in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti1078S → N in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1239R → K in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti1239R → K in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1293P → H in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti1293P → H in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1318A → S in BAC98181 (PubMed:14621295).Curated1
Sequence conflicti1397P → L in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti1397P → L in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1407 – 1408GE → EK in BAC98181 (PubMed:14621295).Curated2
Sequence conflicti1419R → Q in BAC98181 (PubMed:14621295).Curated1
Sequence conflicti1423P → L in BAC98181 (PubMed:14621295).Curated1
Sequence conflicti1457R → L in BAC98181 (PubMed:14621295).Curated1
Sequence conflicti1770N → Y in AAF13270 (PubMed:10589677).Curated1
Sequence conflicti1770N → Y in AAF13269 (PubMed:10589677).Curated1
Sequence conflicti1967A → G in BAE27948 (PubMed:16141072).Curated1
Sequence conflicti1967A → G in BAE37966 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249691 – 175Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST175
Alternative sequenceiVSP_0249701354 – 1359Missing in isoform 3 and isoform 4. 2 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF199421 mRNA Translation: AAF13269.1 Frameshift.
AF199422 mRNA Translation: AAF13270.1 Frameshift.
AK147493 mRNA Translation: BAE27948.1
AK164918 mRNA Translation: BAE37966.1
AK129371 mRNA Translation: BAC98181.1
BC003909 mRNA Translation: AAH03909.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS39154.1 [Q9QXN0-3]
CCDS39155.1 [Q9QXN0-4]

NCBI Reference Sequences

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RefSeqi
NP_001071063.1, NM_001077595.2
NP_001071064.1, NM_001077596.2
NP_056571.2, NM_015756.2
XP_006535031.1, XM_006534968.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
27428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:27428

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199421 mRNA Translation: AAF13269.1 Frameshift.
AF199422 mRNA Translation: AAF13270.1 Frameshift.
AK147493 mRNA Translation: BAE27948.1
AK164918 mRNA Translation: BAE37966.1
AK129371 mRNA Translation: BAC98181.1
BC003909 mRNA Translation: AAH03909.1
CCDSiCCDS39154.1 [Q9QXN0-3]
CCDS39155.1 [Q9QXN0-4]
RefSeqiNP_001071063.1, NM_001077595.2
NP_001071064.1, NM_001077596.2
NP_056571.2, NM_015756.2
XP_006535031.1, XM_006534968.2

3D structure databases

SMRiQ9QXN0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205229, 5 interactors
IntActiQ9QXN0, 1 interactor
STRINGi10090.ENSMUSP00000108678

PTM databases

iPTMnetiQ9QXN0
PhosphoSitePlusiQ9QXN0

Proteomic databases

PaxDbiQ9QXN0
PeptideAtlasiQ9QXN0
PRIDEiQ9QXN0
ProteomicsDBi255419 [Q9QXN0-1]
255420 [Q9QXN0-2]
255421 [Q9QXN0-3]
255422 [Q9QXN0-4]

Genome annotation databases

GeneIDi27428
KEGGimmu:27428

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57619
MGIiMGI:1351655, Shroom3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QUU2, Eukaryota
InParanoidiQ9QXN0
OrthoDBi29607at2759
PhylomeDBiQ9QXN0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
27428, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Shroom3, mouse

Protein Ontology

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PROi
PR:Q9QXN0
RNActiQ9QXN0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR014800, ASD1_dom
IPR014799, ASD2_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030494, Shrm3
IPR027685, Shroom_fam
PANTHERiPTHR15012, PTHR15012, 1 hit
PTHR15012:SF33, PTHR15012:SF33, 1 hit
PfamiView protein in Pfam
PF08688, ASD1, 1 hit
PF08687, ASD2, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51306, ASD1, 1 hit
PS51307, ASD2, 1 hit
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHRM3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXN0
Secondary accession number(s): Q3TNX1
, Q6ZPP9, Q99L16, Q9QXM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 7, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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