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UniProtKB - Q9QXL2 (KI21A_MOUSE)

Protein

Kinesin-like protein KIF21A

Gene

Kif21a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 95ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF21A
Gene namesi
Name:Kif21a
Synonyms:Kiaa1708
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109188 Kif21a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254631 – 1672Kinesin-like protein KIF21AAdd BLAST1672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei258PhosphoserineCombined sources1
Modified residuei524PhosphoserineBy similarity1
Modified residuei1227PhosphoserineBy similarity1
Modified residuei1231PhosphoserineBy similarity1
Modified residuei1241PhosphoserineBy similarity1
Modified residuei1660PhosphoserineCombined sources1
Modified residuei1662PhosphothreonineBy similarity1
Modified residuei1671PhosphoserineCombined sources1
Isoform 2 (identifier: Q9QXL2-2)
Modified residuei1101PhosphoserineCombined sources1
Modified residuei1102PhosphoserineCombined sources1
Modified residuei1207PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QXL2
PeptideAtlasiQ9QXL2
PRIDEiQ9QXL2

PTM databases

iPTMnetiQ9QXL2
PhosphoSitePlusiQ9QXL2

Expressioni

Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000022629 Expressed in 266 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_KIF21A
ExpressionAtlasiQ9QXL2 baseline and differential
GenevisibleiQ9QXL2 MM

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi200939, 4 interactors
IntActiQ9QXL2, 7 interactors
MINTiQ9QXL2
STRINGi10090.ENSMUSP00000085985

Structurei

Secondary structure

11672
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9QXL2
SMRiQ9QXL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 371Kinesin motorPROSITE-ProRule annotationAdd BLAST363
Repeati1343 – 1380WD 1Add BLAST38
Repeati1383 – 1421WD 2Add BLAST39
Repeati1447 – 1485WD 3Add BLAST39
Repeati1488 – 1530WD 4Add BLAST43
Repeati1539 – 1576WD 5Add BLAST38
Repeati1580 – 1619WD 6Add BLAST40
Repeati1622 – 1659WD 7Add BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili365 – 840Sequence analysisAdd BLAST476
Coiled coili933 – 1021Sequence analysisAdd BLAST89
Coiled coili1055 – 1085Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0244 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150846
HOGENOMiHOG000280728
HOVERGENiHBG052247
InParanoidiQ9QXL2
KOiK10395
OMAiAGAQQKM
PhylomeDBiQ9QXL2
TreeFamiTF105224

Family and domain databases

Gene3Di2.130.10.10, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QXL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT 
        60         70         80         90        100
FDYVFDIDSQ QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT 
       110        120        130        140        150
GFDVNIMEEE QGIISRAVRH LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE 
       160        170        180        190        200
LYNEEVLDLF DTTRDIDAKN KKSNIRIHED STGGIYTVGV TTRTVNTEPE 
       210        220        230        240        250
MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC PQTDAENATD 
       260        270        280        290        300
NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 
       310        320        330        340        350
LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP 
       360        370        380        390        400
SDRDFMETLN TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL 
       410        420        430        440        450
MEYKTGKRII DEEGVESIND MFHENAMLQT ENNNLRVRIK AMQETVDALR 
       460        470        480        490        500
ARITQLVSEQ ANQVLARAGE GNEEISNMIH SYIKEIEDLR AKLLESEAVN 
       510        520        530        540        550
ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL AKKDLEKLKR 
       560        570        580        590        600
KEKKKKKRLQ KLEESGREER SVAGKDDNAD TDQEKKEEKG VSEKENNELD 
       610        620        630        640        650
VEENQEVSDH EDEEEEEEDE EEEDDIEGEE SSDESDSESD EKANYQADLA 
       660        670        680        690        700
NITCEIAIKQ KLIDELENSQ KRLQTLKKQY EEKLMMLQHK IRDTQLERDQ 
       710        720        730        740        750
VLQNLGSVES YSEEKAKKVK CEYEKKLHAM NKELQRLQTA QKEHARLLKN 
       760        770        780        790        800
QSQYEKQLKK LQQDVMEMKK TKVRLMKQMK EEQEKARLTE SRRNREIAQL 
       810        820        830        840        850
KKDQRKRDHQ LRLLEAQKRN QEVVLRRKTE EVTALRRQVR PMSDKVAGKV 
       860        870        880        890        900
TRKLSSSESP APDTGSSAAS GEADTSRPGT QQKMRIPVAR VQALPTPTTN 
       910        920        930        940        950
GTRKKYQRKG FTGRVFTSKT ARMKWQLLER RVTDIIMQKM TISNMEADMN 
       960        970        980        990       1000
RLLRQREELT KRREKLSKRR EKIVKESGEG DKSVANIIEE MESLTANIDY 
      1010       1020       1030       1040       1050
INDSIADCQA NIMQMEEAKE EGETLDVTAV INACTLTEAR YLLDHFLSMG 
      1060       1070       1080       1090       1100
INKGLQAAQK EAQIKVLEGR LKQTEITSAT QNQLLFHMLK EKAELNPELD 
      1110       1120       1130       1140       1150
ALLGHALQDL DGAPPENEED SSEEDGPLHS PGSEGSTLSS DLMKLCGEVK 
      1160       1170       1180       1190       1200
PKNKARRRTT TQMELLYADS SEVASDTSAG DASLSGPLAP VAEGQEIGMN 
      1210       1220       1230       1240       1250
TETSGTSARD KELLAPSGLP SKIGSISRQS SLSEKKVPEP SPVTRRKAYE 
      1260       1270       1280       1290       1300
KADKPKAKEH KHSDSGASET SLSPPSSPPS RPRNELNVFN RLTVPQGTPS 
      1310       1320       1330       1340       1350
VQQDKSDESD SSLSEVHRGI INPFPACKGV RASPLQCVHI AEGHTKAVLC 
      1360       1370       1380       1390       1400
VDSTDDLLFT GSKDRTCKVW NLVTGQEIMS LGVHPNNVVS VKYCNYTSLV 
      1410       1420       1430       1440       1450
FTVSTSYIKV WDIRESAKCI RTLTSSGQVT LGEACSASTS RTVAIPSGES 
      1460       1470       1480       1490       1500
QINQIALNPT GTFLYAASGN AVRMWDLKRF QSTGKLTGHL GPVMCLTVDQ 
      1510       1520       1530       1540       1550
ISNGQDLIIT GSKDHYIKMF DVTEGALGTV SPTHNFEPPH YDGIEALAIQ 
      1560       1570       1580       1590       1600
GDNLFSGSRD NGIKKWDLAQ KGLLQQVPNA HKDWVCALGL VPGHPVLLSG 
      1610       1620       1630       1640       1650
CRGGILKLWN VDTFVPVGEM RGHDSPINAI CVNSTHVFTA ADDRTVRIWK 
      1660       1670 
AHNLQDGQLS DTGDLGEDIA SN
Length:1,672
Mass (Da):186,536
Last modified:July 19, 2004 - v2
Checksum:i1B2480E5129105AB
GO
Isoform 2 (identifier: Q9QXL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-570: Missing.
     1109-1115: Missing.
     1226-1305: ISRQSSLSEK...QGTPSVQQDK → M

Show »
Length:1,573
Mass (Da):175,588
Checksum:iD64D0EEBF5E9888B
GO
Isoform 3 (identifier: Q9QXL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-570: Missing.
     1227-1318: Missing.

Show »
Length:1,567
Mass (Da):174,806
Checksum:iC4AC29837E0FC17C
GO
Isoform 4 (identifier: Q9QXL2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1262-1318: HSDSGASETSLSPPSSPPSRPRNELNVFNRLTVPQGTPSVQQDKSDESDSSLSEVHR → Q

Show »
Length:1,616
Mass (Da):180,550
Checksum:i430FD674A10FFB34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGN6F8WGN6_MOUSE
Kinesin-like protein KIF21A
Kif21a
1,628Annotation score:
E9Q0J5E9Q0J5_MOUSE
Kinesin-like protein KIF21A
Kif21a
1,672Annotation score:
A0A2R8VKM5A0A2R8VKM5_MOUSE
Kinesin-like protein KIF21A
Kif21a
250Annotation score:
A0A2R8VJN0A0A2R8VJN0_MOUSE
Kinesin-like protein KIF21A
Kif21a
221Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1127P → A in AAF17083 (PubMed:10225949).Curated1
Sequence conflicti1311S → F (PubMed:10225949).Curated1
Sequence conflicti1321I → L (PubMed:10225949).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010873558 – 570Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0108741109 – 1115Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_0108751226 – 1305ISRQS…VQQDK → M in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0108761227 – 1318Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0108771262 – 1318HSDSG…SEVHR → Q in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202892 mRNA Translation: AAF17083.1
BC060698 mRNA Translation: AAH60698.1
BC062896 mRNA Translation: AAH62896.1
AK129426 mRNA Translation: BAC98236.1
AK049303 mRNA Translation: BAC33669.1
AK047350 mRNA Translation: BAC33031.1
CCDSiCCDS37179.1 [Q9QXL2-2]
CCDS49706.1 [Q9QXL2-3]
CCDS49708.1 [Q9QXL2-1]
RefSeqiNP_001102510.1, NM_001109040.2 [Q9QXL2-1]
NP_001102511.1, NM_001109041.2
NP_001102512.1, NM_001109042.2 [Q9QXL2-3]
NP_057914.2, NM_016705.4 [Q9QXL2-2]
UniGeneiMm.41379

Genome annotation databases

EnsembliENSMUST00000088614; ENSMUSP00000085985; ENSMUSG00000022629 [Q9QXL2-1]
ENSMUST00000109287; ENSMUSP00000104910; ENSMUSG00000022629 [Q9QXL2-3]
ENSMUST00000109288; ENSMUSP00000104911; ENSMUSG00000022629 [Q9QXL2-2]
GeneIDi16564
KEGGimmu:16564
UCSCiuc007xhs.3 mouse [Q9QXL2-1]
uc007xht.3 mouse [Q9QXL2-2]
uc007xhv.3 mouse [Q9QXL2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202892 mRNA Translation: AAF17083.1
BC060698 mRNA Translation: AAH60698.1
BC062896 mRNA Translation: AAH62896.1
AK129426 mRNA Translation: BAC98236.1
AK049303 mRNA Translation: BAC33669.1
AK047350 mRNA Translation: BAC33031.1
CCDSiCCDS37179.1 [Q9QXL2-2]
CCDS49706.1 [Q9QXL2-3]
CCDS49708.1 [Q9QXL2-1]
RefSeqiNP_001102510.1, NM_001109040.2 [Q9QXL2-1]
NP_001102511.1, NM_001109041.2
NP_001102512.1, NM_001109042.2 [Q9QXL2-3]
NP_057914.2, NM_016705.4 [Q9QXL2-2]
UniGeneiMm.41379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YAYX-ray1.55B1142-1169[»]
ProteinModelPortaliQ9QXL2
SMRiQ9QXL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200939, 4 interactors
IntActiQ9QXL2, 7 interactors
MINTiQ9QXL2
STRINGi10090.ENSMUSP00000085985

PTM databases

iPTMnetiQ9QXL2
PhosphoSitePlusiQ9QXL2

Proteomic databases

PaxDbiQ9QXL2
PeptideAtlasiQ9QXL2
PRIDEiQ9QXL2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088614; ENSMUSP00000085985; ENSMUSG00000022629 [Q9QXL2-1]
ENSMUST00000109287; ENSMUSP00000104910; ENSMUSG00000022629 [Q9QXL2-3]
ENSMUST00000109288; ENSMUSP00000104911; ENSMUSG00000022629 [Q9QXL2-2]
GeneIDi16564
KEGGimmu:16564
UCSCiuc007xhs.3 mouse [Q9QXL2-1]
uc007xht.3 mouse [Q9QXL2-2]
uc007xhv.3 mouse [Q9QXL2-3]

Organism-specific databases

CTDi55605
MGIiMGI:109188 Kif21a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0244 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150846
HOGENOMiHOG000280728
HOVERGENiHBG052247
InParanoidiQ9QXL2
KOiK10395
OMAiAGAQQKM
PhylomeDBiQ9QXL2
TreeFamiTF105224

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSiKif21a mouse
PROiPR:Q9QXL2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022629 Expressed in 266 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_KIF21A
ExpressionAtlasiQ9QXL2 baseline and differential
GenevisibleiQ9QXL2 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKI21A_MOUSE
AccessioniPrimary (citable) accession number: Q9QXL2
Secondary accession number(s): Q6P5H1
, Q6ZPJ8, Q8BWZ9, Q8BXF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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