UniProtKB - Q9QXJ2 (Q9QXJ2_MOUSE)
Protein
Signal transducer and activator of transcription
Gene
Stat2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
- identical protein binding Source: Ensembl
- ubiquitin-like protein ligase binding Source: Ensembl
GO - Biological processi
- defense response to virus Source: Ensembl
- regulation of mitochondrial fission Source: Ensembl
- regulation of protein phosphorylation Source: Ensembl
- type I interferon signaling pathway Source: Ensembl
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Gene namesi | Name:Stat2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103039, Stat2 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Ensembl
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinUniRule annotationARBA annotationProteomic databases
PRIDEi | Q9QXJ2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040033, Expressed in head and 236 other tissues |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- identical protein binding Source: Ensembl
- ubiquitin-like protein ligase binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q9QXJ2, 15 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 570 – 708 | SH2InterPro annotationAdd BLAST | 139 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT01010000222348 |
HOGENOMi | CLU_014189_0_0_1 |
OrthoDBi | 327469at2759 |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9QXJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG
60 70 80 90 100
SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP
110 120 130 140 150
TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG
160 170 180 190 200
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA
210 220 230 240 250
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP
260 270 280 290 300
PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ
310 320 330 340 350
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL
360 370 380 390 400
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG
410 420 430 440 450
FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP
460 470 480 490 500
VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW
510 520 530 540 550
QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP
560 570 580 590 600
FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF
610 620 630 640 650
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA
660 670 680 690 700
EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ
710 720 730 740 750
VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI
760 770 780 790 800
LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE
810 820 830 840 850
PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA
860 870 880 890 900
HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE
910 920
TSIPYHSHFD ADGLLGWTLD TF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9WVL2 | STAT2_MOUSE | Signal transducer and activator of ... | Stat2 | 923 | Annotation score: | ||
E9QJX9 | E9QJX9_MOUSE | Signal transducer and activator of ... | Stat2 | 923 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC135859 Genomic DNA No translation available. AF206162 mRNA Translation: AAF17096.1 AK150070 mRNA Translation: BAE29282.1 |
RefSeqi | NP_064347.1, NM_019963.1 |
Genome annotation databases
Ensembli | ENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033 |
GeneIDi | 20847 |
KEGGi | mmu:20847 |
UCSCi | uc007hma.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC135859 Genomic DNA No translation available. AF206162 mRNA Translation: AAF17096.1 AK150070 mRNA Translation: BAE29282.1 |
RefSeqi | NP_064347.1, NM_019963.1 |
3D structure databases
SMRi | Q9QXJ2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9QXJ2, 15 interactors |
Proteomic databases
PRIDEi | Q9QXJ2 |
Protocols and materials databases
Antibodypediai | 3552, 988 antibodies |
DNASUi | 20847 |
Genome annotation databases
Ensembli | ENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033 |
GeneIDi | 20847 |
KEGGi | mmu:20847 |
UCSCi | uc007hma.1, mouse |
Organism-specific databases
CTDi | 6773 |
MGIi | MGI:103039, Stat2 |
Phylogenomic databases
GeneTreei | ENSGT01010000222348 |
HOGENOMi | CLU_014189_0_0_1 |
OrthoDBi | 327469at2759 |
Miscellaneous databases
BioGRID-ORCSi | 20847, 3 hits in 17 CRISPR screens |
ChiTaRSi | Stat2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040033, Expressed in head and 236 other tissues |
Family and domain databases
CDDi | cd10373, SH2_STAT2, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR022756, STAT2_C IPR035854, STAT2_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12188, STAT2_C, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9QXJ2_MOUSE | |
Accessioni | Q9QXJ2Primary (citable) accession number: Q9QXJ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |