Amyloid-beta A4 precursor protein-binding family B member 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage."
    Minopoli G., Stante M., Napolitano F., Telese F., Aloia L., De Felice M., Di Lauro R., Pacelli R., Brunetti A., Zambrano N., Russo T.
    J. Biol. Chem. 282:831-835(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, DISRUPTION PHENOTYPE.
• chromatin binding Source: MGI
• histone acetyltransferase binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• histone binding Source: MGI
• proline-rich region binding Source: MGI
• protein-containing complex binding Source: MGI
• tau protein binding Source: MGI
• transcription factor binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.9

    "Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157."
    Matz A., Lee S.J., Schwedhelm-Domeyer N., Zanini D., Holubowska A., Kannan M., Farnworth M., Jahn O., Goepfert M.C., Stegmueller J.
    Cell Death Differ. 22:626-642(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH RNF157, UBIQUITINATION BY RNF157, FUNCTION.

GO - Biological processⁱ

• actin filament-based movement Source: UniProtKBNon-traceable author statementⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: UniProtKB-KW
• axon guidance Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development."
    Guenette S., Chang Y., Hiesberger T., Richardson J.A., Eckman C.B., Eckman E.A., Hammer R.E., Herz J.
    EMBO J. 25:420-431(2006) [PubMed] [Europe PMC] [Abstract]
• cell cycle arrest Source: UniProtKBInferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to DNA damage stimulus Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage."
    Minopoli G., Stante M., Napolitano F., Telese F., Aloia L., De Felice M., Di Lauro R., Pacelli R., Brunetti A., Zambrano N., Russo T.
    J. Biol. Chem. 282:831-835(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, DISRUPTION PHENOTYPE.
• double-strand break repair Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage."
    Minopoli G., Stante M., Napolitano F., Telese F., Aloia L., De Felice M., Di Lauro R., Pacelli R., Brunetti A., Zambrano N., Russo T.
    J. Biol. Chem. 282:831-835(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, DISRUPTION PHENOTYPE.
• extracellular matrix organization Source: MGIInferred from genetic interactionⁱ
  • "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development."
    Guenette S., Chang Y., Hiesberger T., Richardson J.A., Eckman C.B., Eckman E.A., Hammer R.E., Herz J.
    EMBO J. 25:420-431(2006) [PubMed] [Europe PMC] [Abstract]
• histone H4 acetylation Source: UniProtKB
• negative regulation of cell growth Source: UniProtKBInferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis."
    Ma Q.H., Futagawa T., Yang W.L., Jiang X.D., Zeng L., Takeda Y., Xu R.X., Bagnard D., Schachner M., Furley A.J., Karagogeos D., Watanabe K., Dawe G.S., Xiao Z.C.
    Nat. Cell Biol. 10:283-294(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of thymidylate synthase biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• neuron migration Source: MGIInferred from genetic interactionⁱ
  • "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development."
    Guenette S., Chang Y., Hiesberger T., Richardson J.A., Eckman C.B., Eckman E.A., Hammer R.E., Herz J.
    EMBO J. 25:420-431(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of DNA repair Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage."
    Minopoli G., Stante M., Napolitano F., Telese F., Aloia L., De Felice M., Di Lauro R., Pacelli R., Brunetti A., Zambrano N., Russo T.
    J. Biol. Chem. 282:831-835(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, DISRUPTION PHENOTYPE.
• positive regulation of neuron projection development Source: MGI
• positive regulation of protein secretion Source: MGI
• positive regulation of transcription, DNA-templated Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP."
    Pardossi-Piquard R., Petit A., Kawarai T., Sunyach C., Alves da Costa C., Vincent B., Ring S., D'Adamio L., Shen J., Muller U., St George Hyslop P., Checler F.
    Neuron 46:541-554(2005) [PubMed] [Europe PMC] [Abstract]
• protein stabilization Source: UniProtKBNon-traceable author statementⁱ
  • "The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner."
    Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J.
    J. Biol. Chem. 276:40288-40292(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• synapse organization Source: SynGOInferred from direct assayⁱ
  • "FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation."
    Strecker P., Ludewig S., Rust M., Mundinger T.A., Gorlich A., Krachan E.G., Mehrfeld C., Herz J., Korte M., Guenette S.Y., Kins S.
    Sci Rep 6:25652-25652(2016) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: MGIInferred from mutant phenotypeⁱ
  • "Isoform-specific knockout of FE65 leads to impaired learning and memory."
    Wang B., Hu Q., Hearn M.G., Shimizu K., Ware C.B., Liggitt D.H., Jin L.W., Cool B.H., Storm D.R., Martin G.M.
    J. Neurosci. Res. 75:12-24(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• histone acetyltransferase binding Source: UniProtKBNon-traceable author statementⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• histone binding Source: MGI
• proline-rich region binding Source: MGI
• tau protein binding Source: MGI
• transcription factor binding Source: UniProtKBInferred from direct assayⁱ
  • "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression."
    Bruni P., Minopoli G., Brancaccio T., Napolitano M., Faraonio R., Zambrano N., Hansen U., Russo T.
    J. Biol. Chem. 277:35481-35488(2002) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.9

    "Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157."
    Matz A., Lee S.J., Schwedhelm-Domeyer N., Zanini D., Holubowska A., Kannan M., Farnworth M., Jahn O., Goepfert M.C., Stegmueller J.
    Cell Death Differ. 22:626-642(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH RNF157, UBIQUITINATION BY RNF157, FUNCTION.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL 
        60         70         80         90        100
RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS 
       110        120        130        140        150
QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE 
       160        170        180        190        200
EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR 
       210        220        230        240        250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE 
       260        270        280        290        300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
       310        320        330        340        350
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP 
       360        370        380        390        400
VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ 
       410        420        430        440        450
LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI 
       460        470        480        490        500
RVWGVGRDSG SNRDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS 
       510        520        530        540        550
KIMSERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN 
       560        570        580        590        600
VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV 
       610        620        630        640        650
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV 
       660        670        680        690        700
QAACMLRYQK CLDARSQTST SCLPAPPAES VARRVGWTVR RGVQSLWGSL 
       710
KPKRLGSQTP                                             

        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL 
        60         70         80         90        100
RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS 
       110        120        130        140        150
QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE 
       160        170        180        190        200
EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR 
       210        220        230        240        250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE 
       260        270        280        290        300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
       310        320        330        340        350
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP 
       360        370        380        390        400
VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ 
       410        420        430        440        450
LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI 
       460        470        480        490        500
RVWGVGRDSG SDFAYVARDK LTQMLKCHVF RCEAPAKNIA TSLHEICSKI 
       510        520        530        540        550
MSERRNARCL VNGLSLDHSK LVDVPFQVEF PAPKNELVQK FQVYYLGNVP 
       560        570        580        590        600
VAKPVGVDVI NGALESVLSS SSREQWTPSH VSVAPATLTI LHQQTEAVLG 
       610        620        630        640        650
ECRVRFLSFL AVGRDVHTFA FIMAAGPASF CCHMFWCEPN AASLSEAVQA 
       660        670        680        690        700
ACMLRYQKCL DARSQTSTSC LPAPPAESVA RRVGWTVRRG VQSLWGSLKP 

KRLGSQTP                                               

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot