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UniProtKB - Q9QXJ1 (APBB1_MOUSE)

Entry version 166 (23 Feb 2022)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

Amyloid beta precursor protein binding family B member 1

Gene

Apbb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription coregulator that can have both coactivator and corepressor functions (PubMed:17121854, PubMed:25342469).

Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:17121854, PubMed:25342469).

Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity).

Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (By similarity).

Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity).

Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846).

Plays a role in the maintenance of lens transparency (PubMed:25757569).

May play a role in muscle cell strength (PubMed:25757569, PubMed:27734846).

By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processApoptosis, DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid beta precursor protein binding family B member 1By similarity
Alternative name(s):
Amyloid-beta A4 precursor protein-binding family B member 1Imported
Protein Fe651 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Apbb1Imported
Synonyms:Fe651 Publication, RirImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107765, Apbb1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000037032

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No phenotype in normal conditions (PubMed:17121854). Displays an increased sensitivity to genotoxic stress and exposure to DNA damaging agents (PubMed:17121854). Knockout mice have decreased muscle strength, however clasping ability is unaffected (PubMed:25757569). Impaired spatial memory retrieval and learning (PubMed:27734846). Reduced branching of hippocampal neurites and increased fragmentation of neuromuscular junctions (PubMed:27734846). APBB1 and APBB2 double knockout mice show progressive retinal lens disruption from 1 month of age, morphologically lenses show massive vacuolization, lens capsule rupture and disruption of the lens fiber cells organization (PubMed:25757569). Decreased muscle strength, however clasping ability is unaffected (PubMed:25757569, PubMed:27734846). Defects in peripheral motor function including balance and coordination, reduced environmental anxiety, reduced hippocampal basal synaptic transmission and synaptic plasticity (PubMed:27734846).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi280W → F: Abolishes ligand binding; when associated with A-283. 1 Publication1
Mutagenesisi283P → A: Abolishes ligand binding; when associated with F-280. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760501 – 710Amyloid beta precursor protein binding family B member 1Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135PhosphoserineCombined sources1
Modified residuei204N6-acetyllysineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei547Phosphotyrosine; by ABL1By similarity1
Modified residuei610Phosphoserine; by SGK1By similarity1
Modified residuei701N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitination by RNF157 leads to degradation by the proteasome (PubMed:25342469).1 Publication
Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-546 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1 (By similarity).By similarity
Acetylation at Lys-204 and Lys-701 by KAT5 promotes its transcription activator activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9QXJ1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9QXJ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QXJ1

PRoteomics IDEntifications database

More...PRIDEi		Q9QXJ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		296328 [Q9QXJ1-1]
296329 [Q9QXJ1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QXJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QXJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, retinal lens and muscle cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000037032, Expressed in primary motor cortex and 305 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QXJ1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP (By similarity).

Interacts (via PID domain 2) with APP (with the intracellular domain of the amyloid-beta precursor protein) (By similarity).

Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the transcription activation activity (By similarity).

Interacts (via PID domain 1) with KAT5/TIP60 (By similarity).

Interacts (via the WW domain) with the proline-rich region of APBB1IP (PubMed:9407065).

Interacts with TSHZ1 and TSHZ2 (PubMed:19343227).

Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142') and the proline-rich region of ENAH (PubMed:9407065).

Interacts with MAPK8 (By similarity).

Interacts (via PID domain 1) with TSHZ3 (via homeobox domain) (By similarity).

Interacts with SET (By similarity).

Found in a trimeric complex with HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 (By similarity).

Interacts (via WWW domain) with NEK6.

Interacts (via WWW domain) with ABL1.

Interacts with RNF157 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		198141, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9QXJ1

Protein interaction database and analysis system

More...IntActi		Q9QXJ1, 2 interactors

Molecular INTeraction database

More...MINTi		Q9QXJ1

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000140116

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9QXJ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9QXJ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QXJ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini253 – 285WWPROSITE-ProRule annotationAdd BLAST33
Domaini370 – 509PID 1PROSITE-ProRule annotationAdd BLAST140
Domaini542 – 699PID 2PROSITE-ProRule annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 256DisorderedSequence analysisAdd BLAST114
Regioni276 – 300DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 175Acidic residuesSequence analysisAdd BLAST24
Compositional biasi208 – 249Polar residuesSequence analysisAdd BLAST42

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT08, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000002

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QXJ1

Database of Orthologous Groups

More...OrthoDBi		437627at2759

TreeFam database of animal gene trees

More...TreeFami		TF314331

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039576, Fe65
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14058, PTHR14058, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00640, PID, 2 hits
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462, PTB, 2 hits
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179, PID, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QXJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL 
        60         70         80         90        100
RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS 
       110        120        130        140        150
QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE 
       160        170        180        190        200
EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR 
       210        220        230        240        250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE 
       260        270        280        290        300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
       310        320        330        340        350
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP 
       360        370        380        390        400
VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ 
       410        420        430        440        450
LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI 
       460        470        480        490        500
RVWGVGRDSG SNRDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS 
       510        520        530        540        550
KIMSERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN 
       560        570        580        590        600
VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV 
       610        620        630        640        650
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV 
       660        670        680        690        700
QAACMLRYQK CLDARSQTST SCLPAPPAES VARRVGWTVR RGVQSLWGSL 
       710
KPKRLGSQTP
Length:710
Mass (Da):77,384
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CFD571C50584979
GO
Isoform 2 (identifier: Q9QXJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-463: Missing.

Show »
Length:708
Mass (Da):77,114
Checksum:i234B7C6D9383B148
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J2C1A0A0R4J2C1_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
710Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR62A0A087WR62_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRP1A0A087WRP1_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2C6A0A0R4J2C6_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
708Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WNN4A0A087WNN4_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPF4A0A087WPF4_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSI3A0A1B0GSI3_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPI2A0A087WPI2_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPS7A0A087WPS7_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQH0A0A087WQH0_MOUSE
Amyloid beta precursor protein-bind...
Apbb1
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92T → A in AAF20141 (Ref. 1) Curated1
Sequence conflicti313E → D in AAF20141 (Ref. 1) Curated1
Sequence conflicti461 – 462SN → RE in BAC39033 (PubMed:16141072).Curated2
Sequence conflicti461 – 462SN → RE in BAE37645 (PubMed:16141072).Curated2
Sequence conflicti630A → S in BAC39033 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011659462 – 463Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF206720 mRNA Translation: AAF20141.1
AK030748 mRNA Translation: BAC27116.1
AK083830 mRNA Translation: BAC39033.1
AK164140 mRNA Translation: BAE37645.1
AC125227 Genomic DNA No translation available.
L77865 mRNA Translation: AAB51603.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS80775.1 [Q9QXJ1-2]
CCDS80776.1 [Q9QXJ1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001240814.1, NM_001253885.1
NP_001240815.1, NM_001253886.1
NP_033815.1, NM_009685.3
XP_006507293.1, XM_006507230.2
XP_006507294.1, XM_006507231.1
XP_017177435.1, XM_017321946.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000081165; ENSMUSP00000079932; ENSMUSG00000037032 [Q9QXJ1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11785

UCSC genome browser

More...UCSCi		uc009iyi.2, mouse [Q9QXJ1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206720 mRNA Translation: AAF20141.1
AK030748 mRNA Translation: BAC27116.1
AK083830 mRNA Translation: BAC39033.1
AK164140 mRNA Translation: BAE37645.1
AC125227 Genomic DNA No translation available.
L77865 mRNA Translation: AAB51603.1
CCDSiCCDS80775.1 [Q9QXJ1-2]
CCDS80776.1 [Q9QXJ1-1]
RefSeqiNP_001240814.1, NM_001253885.1
NP_001240815.1, NM_001253886.1
NP_033815.1, NM_009685.3
XP_006507293.1, XM_006507230.2
XP_006507294.1, XM_006507231.1
XP_017177435.1, XM_017321946.1

3D structure databases

BMRBiQ9QXJ1
SMRiQ9QXJ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198141, 6 interactors
CORUMiQ9QXJ1
IntActiQ9QXJ1, 2 interactors
MINTiQ9QXJ1
STRINGi10090.ENSMUSP00000140116

PTM databases

iPTMnetiQ9QXJ1
PhosphoSitePlusiQ9QXJ1

Proteomic databases

jPOSTiQ9QXJ1
MaxQBiQ9QXJ1
PaxDbiQ9QXJ1
PRIDEiQ9QXJ1
ProteomicsDBi296328 [Q9QXJ1-1]
296329 [Q9QXJ1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23808, 401 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		11785

Genome annotation databases

EnsembliENSMUST00000081165; ENSMUSP00000079932; ENSMUSG00000037032 [Q9QXJ1-1]
GeneIDi11785
KEGGimmu:11785
UCSCiuc009iyi.2, mouse [Q9QXJ1-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		322
MGIiMGI:107765, Apbb1
VEuPathDBiHostDB:ENSMUSG00000037032

Phylogenomic databases

eggNOGiENOG502QT08, Eukaryota
GeneTreeiENSGT00390000000002
InParanoidiQ9QXJ1
OrthoDBi437627at2759
TreeFamiTF314331

Enzyme and pathway databases

ReactomeiR-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11785, 1 hit in 94 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Apbb1, mouse

Protein Ontology

More...PROi		PR:Q9QXJ1
RNActiQ9QXJ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000037032, Expressed in primary motor cortex and 305 other tissues
GenevisibleiQ9QXJ1, MM

Family and domain databases

CDDicd00201, WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576, Fe65
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR14058, PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640, PID, 2 hits
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 2 hits
SM00456, WW, 1 hit
SUPFAMiSSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPBB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXJ1
Secondary accession number(s): E9QNW5
, O08642, Q3TPU0, Q8BNF4, Q8BSR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: February 23, 2022
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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