UniProtKB - Q9QXJ1 (APBB1_MOUSE)

BLAST

>sp|Q9QXJ1|APBB1_MOUSE Amyloid-beta A4 precursor protein-binding family B member 1 OS=Mus musculus OX=10090 GN=Apbb1 PE=1 SV=3
MSVPSSLSQSAINANSHGGPALSFPLPLHAAHNQLLNAKLQATAVVPKDLRSAMGEGSVP
EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEAETAPLGPKGLMHLYSEL
ELSAHNAANRGLHGSALIINTQEQGPDEGEEKAAGEAEEDDEDEEEEEEEEDLSSPPGLP
EPLENVEVPSGPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
TWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQ
RNANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEGK
DLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGSNRDFAYVARDKLTQMLKCH
VFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELV
QKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAV
LGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQK
CLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP

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History
Entry version 146 (12 Sep 2018)
Sequence version 3 (27 Jul 2011)
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Protein

Amyloid-beta A4 precursor protein-binding family B member 1

Gene

Apbb1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).2 Publications

GO - Molecular functionⁱ

amyloid-beta binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17121854
chromatin binding Source: MGI
histone acetyltransferase binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12089154
histone binding Source: MGI
proline-rich region binding Source: MGI
protein-containing complex binding Source: MGI
tau protein binding Source: MGI
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament-based movement
Source: UniProtKB
Non-traceable author statementⁱ
- 12089154
apoptotic process Source: UniProtKB-KW
axon guidance
Source: MGI
Inferred from genetic interactionⁱ
- 16407979
cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17121854
double-strand break repair
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17121854
extracellular matrix organization
Source: MGI
Inferred from genetic interactionⁱ
- 16407979
histone H4 acetylation Source: UniProtKB
negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154
negative regulation of neuron differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 18278038
negative regulation of thymidylate synthase biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154
negative regulation of transcription by RNA polymerase II Source: MGI
neuron migration
Source: MGI
Inferred from genetic interactionⁱ
- 16407979
positive regulation of apoptotic process Source: UniProtKB
positive regulation of DNA repair
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17121854
positive regulation of neuron projection development Source: MGI
positive regulation of protein secretion Source: MGI
positive regulation of transcription, DNA-templated Source: MGI
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 15944124
protein stabilization
Source: UniProtKB
Non-traceable author statementⁱ
- 11544248
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154
transcription, DNA-templated Source: UniProtKB-KW
visual learning
Source: MGI
Inferred from mutant phenotypeⁱ
- 14689444

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator, Repressor
Biological process	Apoptosis, DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Reactomeⁱ

R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid-beta A4 precursor protein-binding family B member 1 Alternative name(s): Protein Fe65
Gene namesⁱ	Name:Apbb1 Synonyms:Fe65
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:107765 Apbb1

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

No phenotype in normal conditions. Displays an increased sensitivity to genotoxic stress and exposur to DNA damaging agents.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	280	W → F: Abolishes ligand binding; when associated with A-283. 1 Publication		1
Mutagenesisⁱ	283	P → A: Abolishes ligand binding; when associated with F-280. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076050	1 – 710	Amyloid-beta A4 precursor protein-binding family B member 1Add BLAST		710

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	135	PhosphoserineCombined sources	1
Modified residueⁱ	517	PhosphoserineCombined sources	1
Modified residueⁱ	547	Phosphotyrosine; by ABL1By similarity	1
Modified residueⁱ	610	Phosphoserine; by SGK1By similarity	1

Post-translational modificationⁱ

Polyubiquitination by RNF157 leads to degradation by the proteasome (PubMed:25342469).1 Publication

Phosphorylated following nuclear translocation. Phosphorylation at Tyr-546 enhances the transcription activation activity and reduces the affinity with RASD1/DEXRAS1. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9QXJ1
PRIDEⁱ	Q9QXJ1

PTM databases

iPTMnetⁱ	Q9QXJ1
PhosphoSitePlusⁱ	Q9QXJ1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037032 Expressed in 281 organ(s), highest expression level in primary motor cortex
ExpressionAtlasⁱ	Q9QXJ1 baseline and differential
Genevisibleⁱ	Q9QXJ1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SET. Found in a trimeric complex with HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 (By similarity). Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (with the intracellular domain of the amyloid-beta precursor protein). Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the transcription activation activity. Interacts (via PID domain 1) with KAT5/TIP60. Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142'). Interacts with MAPK8 (By similarity). Interacts (via the WW domain) with proline-rich regions of APBB1IP and ENAH. Interacts (via PID domain 1) with TSHZ3 (via homeobox domain). Interacts with TSHZ1 and TSHZ2. Interacts (via WWW domain) with NEK6. Interacts (via WWW domain) with ABL1 (By similarity). Interacts with RNF157 (PubMed:25342469).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
App	P12023	2	EBI-81338,EBI-78814

With

Entry

#Exp.

IntAct

Notes

App

P12023

EBI-81338,EBI-78814

GO - Molecular functionⁱ

histone acetyltransferase binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12089154
histone binding Source: MGI
proline-rich region binding Source: MGI
tau protein binding Source: MGI
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12089154

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198141, 6 interactors
IntActⁱ	Q9QXJ1, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9QXJ1
STRINGⁱ	10090.ENSMUSP00000079932

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QXJ1
SMRⁱ	Q9QXJ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	253 – 285	WWPROSITE-ProRule annotationAdd BLAST	33
Domainⁱ	370 – 509	PID 1PROSITE-ProRule annotationAdd BLAST	140
Domainⁱ	542 – 699	PID 2PROSITE-ProRule annotationAdd BLAST	158

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	158 – 171	Glu-richAdd BLAST		14

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000033983
HOVERGENⁱ	HBG050524
InParanoidⁱ	Q9QXJ1
KEGG Orthology (KO) More...KOⁱ	K04529
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04HV
TreeFamⁱ	TF314331

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 2 hits PF00397 WW, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9QXJ1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL 
        60         70         80         90        100
RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS 
       110        120        130        140        150
QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE 
       160        170        180        190        200
EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR 
       210        220        230        240        250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE 
       260        270        280        290        300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
       310        320        330        340        350
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP 
       360        370        380        390        400
VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ 
       410        420        430        440        450
LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI 
       460        470        480        490        500
RVWGVGRDSG SNRDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS 
       510        520        530        540        550
KIMSERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN 
       560        570        580        590        600
VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV 
       610        620        630        640        650
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV 
       660        670        680        690        700
QAACMLRYQK CLDARSQTST SCLPAPPAES VARRVGWTVR RGVQSLWGSL 
       710
KPKRLGSQTP

Length:710

Mass (Da):77,384

Last modified:July 27, 2011 - v3

Checksum:ⁱ9CFD571C50584979

Isoform 2 (identifier: Q9QXJ1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
462-463: Missing.

« Hide

        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSFPLPLHA AHNQLLNAKL QATAVVPKDL 
        60         70         80         90        100
RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS 
       110        120        130        140        150
QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQEQGPDEGE 
       160        170        180        190        200
EKAAGEAEED DEDEEEEEEE EDLSSPPGLP EPLENVEVPS GPQALTDGPR 
       210        220        230        240        250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE 
       260        270        280        290        300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL 
       310        320        330        340        350
TWTGFAHQEG FEEGEFWKDE PSEEAPMELG LKDPEEATLS FPAQSLSPEP 
       360        370        380        390        400
VPQEEEKLSQ RNANPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ 
       410        420        430        440        450
LSYHKNNLHD PMAGGWGEGK DLLLQLEDET LKLVEPQNQT LLHAQPIVSI 
       460        470        480        490        500
RVWGVGRDSG SDFAYVARDK LTQMLKCHVF RCEAPAKNIA TSLHEICSKI 
       510        520        530        540        550
MSERRNARCL VNGLSLDHSK LVDVPFQVEF PAPKNELVQK FQVYYLGNVP 
       560        570        580        590        600
VAKPVGVDVI NGALESVLSS SSREQWTPSH VSVAPATLTI LHQQTEAVLG 
       610        620        630        640        650
ECRVRFLSFL AVGRDVHTFA FIMAAGPASF CCHMFWCEPN AASLSEAVQA 
       660        670        680        690        700
ACMLRYQKCL DARSQTSTSC LPAPPAESVA RRVGWTVRRG VQSLWGSLKP 

KRLGSQTP

Show »

Length:708

Mass (Da):77,114

Checksum:ⁱ234B7C6D9383B148

Computationally mapped potential isoform sequencesⁱ

There are 16 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0R4J2C1	A0A0R4J2C1_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	710	Annotation score:
	A0A087WPS7	A0A087WPS7_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	485	Annotation score:
	A0A087WPI2	A0A087WPI2_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	487	Annotation score:
	A0A087WR62	A0A087WR62_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	451	Annotation score:
	A0A0R4J2C6	A0A0R4J2C6_MOUSE	Amyloid beta (A4) protein-binding, ... Amyloid beta (A4) protein-binding, family B, member 1, isoform CRA_e (Amyloid-beta A4 precursor protein-binding family B member 1)	Apbb1 mCG_19725	708	Annotation score:
	A0A087WRP1	A0A087WRP1_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	223	Annotation score:
	A0A087WQH0	A0A087WQH0_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	260	Annotation score:
	A0A087WQC5	A0A087WQC5_MOUSE	Amyloid beta (A4) protein-binding, ... Amyloid beta (A4) protein-binding, family B, member 1, isoform CRA_b (Amyloid-beta A4 precursor protein-binding family B member 1)	Apbb1 mCG_19725	235	Annotation score:
	A0A087WNN4	A0A087WNN4_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	158	Annotation score:
	A0A087WQ58	A0A087WQ58_MOUSE	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family B member 1	Apbb1	105	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	92	T → A in AAF20141 (Ref. 1) Curated	1
Sequence conflictⁱ	313	E → D in AAF20141 (Ref. 1) Curated	1
Sequence conflictⁱ	461 – 462	SN → RE in BAC39033 (PubMed:16141072).Curated	2
Sequence conflictⁱ	461 – 462	SN → RE in BAE37645 (PubMed:16141072).Curated	2
Sequence conflictⁱ	630	A → S in BAC39033 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011659	462 – 463	Missing in isoform 2. 2 Publications		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF206720 mRNA Translation: AAF20141.1 AK030748 mRNA Translation: BAC27116.1 AK083830 mRNA Translation: BAC39033.1 AK164140 mRNA Translation: BAE37645.1 AC125227 Genomic DNA No translation available. L77865 mRNA Translation: AAB51603.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS80775.1 [Q9QXJ1-2] CCDS80776.1 [Q9QXJ1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001240814.1, NM_001253885.1 NP_001240815.1, NM_001253886.1 NP_033815.1, NM_009685.3 XP_006507293.1, XM_006507230.2 XP_006507294.1, XM_006507231.1 XP_017177435.1, XM_017321946.1
UniGeneⁱ	Mm.38469 Mm.490092

Genome annotation databases

Ensemblⁱ	ENSMUST00000081165; ENSMUSP00000079932; ENSMUSG00000037032 [Q9QXJ1-1]
GeneIDⁱ	11785
KEGGⁱ	mmu:11785
UCSC genome browser More...UCSCⁱ	uc009iyi.2 mouse [Q9QXJ1-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QXJ1	Amyloid-beta A4 precursor protein-binding family B member 1 (Fragment)		MOUSE		120	UniRef100_Q9QXJ1
Amyloid-beta A4 precursor protein-binding family B member 1 (Fragment)		MOUSE		105
Amyloid-beta A4 precursor protein-binding family B member 1 (Fragment)		MOUSE		158
Amyloid-beta A4 precursor protein-binding family B member 1 (Fragment)		MOUSE		145

Protein	Similar proteins		Species	Score	Length	Source
Q9QXJ1	Isoform 2 of Amyloid-beta A4 precursor protein-binding family B member 1		HUMAN		708	UniRef90_O00213-2
Amyloid-beta A4 precursor protein-binding family B member 1		RAT		711
Uncharacterized protein		FELCA		775
Uncharacterized protein		RABIT		762
Uncharacterized protein		PIG		734
+323

Protein	Similar proteins		Species	Score	Length	Source
Q9QXJ1	Amyloid-beta A4 precursor protein-binding family B member 1	)	HUMAN		710	UniRef50_O00213
Amyloid-beta A4 precursor protein-binding family B member 1		RAT		711
APBB1 isoform 10		PANTR		451
APBB1 isoform 10		PONAB		451
Uncharacterized protein		AOTNA		718
+400

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF206720 mRNA Translation: AAF20141.1 AK030748 mRNA Translation: BAC27116.1 AK083830 mRNA Translation: BAC39033.1 AK164140 mRNA Translation: BAE37645.1 AC125227 Genomic DNA No translation available. L77865 mRNA Translation: AAB51603.1
CCDSⁱ	CCDS80775.1 [Q9QXJ1-2] CCDS80776.1 [Q9QXJ1-1]
RefSeqⁱ	NP_001240814.1, NM_001253885.1 NP_001240815.1, NM_001253886.1 NP_033815.1, NM_009685.3 XP_006507293.1, XM_006507230.2 XP_006507294.1, XM_006507231.1 XP_017177435.1, XM_017321946.1
UniGeneⁱ	Mm.38469 Mm.490092

3D structure databases

ProteinModelPortalⁱ	Q9QXJ1
SMRⁱ	Q9QXJ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198141, 6 interactors
IntActⁱ	Q9QXJ1, 2 interactors
MINTⁱ	Q9QXJ1
STRINGⁱ	10090.ENSMUSP00000079932

PTM databases

iPTMnetⁱ	Q9QXJ1
PhosphoSitePlusⁱ	Q9QXJ1

Proteomic databases

PaxDbⁱ	Q9QXJ1
PRIDEⁱ	Q9QXJ1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000081165; ENSMUSP00000079932; ENSMUSG00000037032 [Q9QXJ1-1]
GeneIDⁱ	11785
KEGGⁱ	mmu:11785
UCSCⁱ	uc009iyi.2 mouse [Q9QXJ1-2]

Organism-specific databases

CTDⁱ	322
MGIⁱ	MGI:107765 Apbb1

Phylogenomic databases

eggNOGⁱ	ENOG410IEKA Eukaryota ENOG410YEVS LUCA
GeneTreeⁱ	ENSGT00390000000002
HOGENOMⁱ	HOG000033983
HOVERGENⁱ	HBG050524
InParanoidⁱ	Q9QXJ1
KOⁱ	K04529
OrthoDBⁱ	EOG091G04HV
TreeFamⁱ	TF314331

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Reactomeⁱ

R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Miscellaneous databases

ChiTaRSⁱ	Apbb1 mouse
Protein Ontology More...PROⁱ	PR:Q9QXJ1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037032 Expressed in 281 organ(s), highest expression level in primary motor cortex
ExpressionAtlasⁱ	Q9QXJ1 baseline and differential
Genevisibleⁱ	Q9QXJ1 MM

Family and domain databases

CDDⁱ	cd00201 WW, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR001202 WW_dom IPR036020 WW_dom_sf
Pfamⁱ	View protein in Pfam PF00640 PID, 2 hits PF00397 WW, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 2 hits SM00456 WW, 1 hit
SUPFAMⁱ	SSF51045 SSF51045, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 2 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APBB1_MOUSE
Accessionⁱ	Q9QXJ1Primary (citable) accession number: Q9QXJ1 Secondary accession number(s): E9QNW5 , O08642, Q3TPU0, Q8BNF4, Q8BSR9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Keywords - Technical termⁱ

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Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9QXJ1 (APBB1_MOUSE)

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Amyloid-beta A4 precursor protein-binding family B member 1

Apbb1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Mutagenesis

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Proteomic databases

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Gene expression databases

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3D structure databases

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ