Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin alpha-X

Gene

Itgax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi158MagnesiumBy similarity1
Metal bindingi160MagnesiumBy similarity1
Metal bindingi162MagnesiumBy similarity1
Metal bindingi260MagnesiumBy similarity1
Metal bindingi467Calcium 2By similarity1
Metal bindingi469Calcium 2By similarity1
Metal bindingi471Calcium 2By similarity1
Metal bindingi473Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi533Calcium 3By similarity1
Metal bindingi535Calcium 3By similarity1
Metal bindingi537Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi594Calcium 1By similarity1
Metal bindingi596Calcium 1By similarity1
Metal bindingi598Calcium 1By similarity1
Metal bindingi600Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi602Calcium 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi467 – 475By similarity9
Calcium bindingi531 – 539By similarity9
Calcium bindingi594 – 602By similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
Gene namesi
Name:Itgax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96609 Itgax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1116ExtracellularSequence analysisAdd BLAST1097
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1169CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001629520 – 1169Integrin alpha-XAdd BLAST1150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 76By similarity
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 126By similarity
Disulfide bondi116 ↔ 146By similarity
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi496 ↔ 507By similarity
Disulfide bondi640 ↔ 721By similarity
Disulfide bondi656 ↔ 711By similarity
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi770 ↔ 776By similarity
Disulfide bondi858 ↔ 873By similarity
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1007 ↔ 1031By similarity
Disulfide bondi1036 ↔ 1041By similarity
Glycosylationi1059N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QXH4
PaxDbiQ9QXH4
PRIDEiQ9QXH4

PTM databases

PhosphoSitePlusiQ9QXH4

Expressioni

Gene expression databases

BgeeiENSMUSG00000030789 Expressed in 70 organ(s), highest expression level in camera-type eye
CleanExiMM_ITGAX
ExpressionAtlasiQ9QXH4 baseline and differential
GenevisibleiQ9QXH4 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-3134 Integrin alphaX-beta2 complex
CORUMiQ9QXH4
IntActiQ9QXH4, 1 interactor
MINTiQ9QXH4
STRINGi10090.ENSMUSP00000033053

Structurei

3D structure databases

ProteinModelPortaliQ9QXH4
SMRiQ9QXH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 78FG-GAP 1PROSITE-ProRule annotationAdd BLAST56
Repeati79 – 138FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini152 – 330VWFAPROSITE-ProRule annotationAdd BLAST179
Repeati341 – 392FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati393 – 444FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati445 – 505FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati508 – 566FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati571 – 631FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1140 – 1144GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00930000150854
HOVERGENiHBG100530
InParanoidiQ9QXH4
KOiK06462
OMAiQNPSIQC
OrthoDBiEOG091G01BZ
PhylomeDBiQ9QXH4
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QXH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV
60 70 80 90 100
VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT
110 120 130 140 150
NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD
160 170 180 190 200
QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV
210 220 230 240 250
HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD
260 270 280 290 300
ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ
310 320 330 340 350
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL
360 370 380 390 400
EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED
410 420 430 440 450
MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV
460 470 480 490 500
RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG
510 520 530 540 550
VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN
560 570 580 590 600
RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL
610 620 630 640 650
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL
660 670 680 690 700
SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT
710 720 730 740 750
RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP
760 770 780 790 800
MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL
810 820 830 840 850
NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG
860 870 880 890 900
QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL
910 920 930 940 950
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF
960 970 980 990 1000
STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP
1010 1020 1030 1040 1050
QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD
1060 1070 1080 1090 1100
ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA
1110 1120 1130 1140 1150
QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML
1160
EEANGQFVSD GTPTPQVAQ
Length:1,169
Mass (Da):129,151
Last modified:May 1, 2000 - v1
Checksum:iC616412033C219A6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNJ3A0A0U1RNJ3_MOUSE
Integrin alpha-X
Itgax
257Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA Translation: AAF23492.1
CCDSiCCDS40150.1
RefSeqiNP_067309.1, NM_021334.2
UniGeneiMm.22378

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789
GeneIDi16411
KEGGimmu:16411
UCSCiuc009jyc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA Translation: AAF23492.1
CCDSiCCDS40150.1
RefSeqiNP_067309.1, NM_021334.2
UniGeneiMm.22378

3D structure databases

ProteinModelPortaliQ9QXH4
SMRiQ9QXH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3134 Integrin alphaX-beta2 complex
CORUMiQ9QXH4
IntActiQ9QXH4, 1 interactor
MINTiQ9QXH4
STRINGi10090.ENSMUSP00000033053

PTM databases

PhosphoSitePlusiQ9QXH4

Proteomic databases

MaxQBiQ9QXH4
PaxDbiQ9QXH4
PRIDEiQ9QXH4

Protocols and materials databases

DNASUi16411
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789
GeneIDi16411
KEGGimmu:16411
UCSCiuc009jyc.1 mouse

Organism-specific databases

CTDi3687
MGIiMGI:96609 Itgax

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00930000150854
HOVERGENiHBG100530
InParanoidiQ9QXH4
KOiK06462
OMAiQNPSIQC
OrthoDBiEOG091G01BZ
PhylomeDBiQ9QXH4
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q9QXH4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030789 Expressed in 70 organ(s), highest expression level in camera-type eye
CleanExiMM_ITGAX
ExpressionAtlasiQ9QXH4 baseline and differential
GenevisibleiQ9QXH4 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QXH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again