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Entry version 128 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Integrin alpha-X

Gene

Itgax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi158MagnesiumBy similarity1
Metal bindingi160MagnesiumBy similarity1
Metal bindingi162MagnesiumBy similarity1
Metal bindingi260MagnesiumBy similarity1
Metal bindingi467Calcium 2By similarity1
Metal bindingi469Calcium 2By similarity1
Metal bindingi471Calcium 2By similarity1
Metal bindingi473Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi533Calcium 3By similarity1
Metal bindingi535Calcium 3By similarity1
Metal bindingi537Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi594Calcium 1By similarity1
Metal bindingi596Calcium 1By similarity1
Metal bindingi598Calcium 1By similarity1
Metal bindingi600Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi602Calcium 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi467 – 475By similarity9
Calcium bindingi531 – 539By similarity9
Calcium bindingi594 – 602By similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itgax
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96609 Itgax

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1116ExtracellularSequence analysisAdd BLAST1097
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1169CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001629520 – 1169Integrin alpha-XAdd BLAST1150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 76By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 126By similarity
Disulfide bondi116 ↔ 146By similarity
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi496 ↔ 507By similarity
Disulfide bondi640 ↔ 721By similarity
Disulfide bondi656 ↔ 711By similarity
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi770 ↔ 776By similarity
Disulfide bondi858 ↔ 873By similarity
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1007 ↔ 1031By similarity
Disulfide bondi1036 ↔ 1041By similarity
Glycosylationi1059N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9QXH4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QXH4

PRoteomics IDEntifications database

More...
PRIDEi
Q9QXH4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QXH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030789 Expressed in 70 organ(s), highest expression level in camera-type eye

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9QXH4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QXH4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3134 Integrin alphaX-beta2 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9QXH4

Protein interaction database and analysis system

More...
IntActi
Q9QXH4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9QXH4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033053

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9QXH4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QXH4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 78FG-GAP 1PROSITE-ProRule annotationAdd BLAST56
Repeati79 – 138FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 330VWFAPROSITE-ProRule annotationAdd BLAST179
Repeati341 – 392FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati393 – 444FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati445 – 505FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati508 – 566FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati571 – 631FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1140 – 1144GFFKR motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBA Eukaryota
ENOG410ZFBE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154838

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100530

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QXH4

KEGG Orthology (KO)

More...
KOi
K06462

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNPSIQC

Database of Orthologous Groups

More...
OrthoDBi
73876at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QXH4

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QXH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV
60 70 80 90 100
VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT
110 120 130 140 150
NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD
160 170 180 190 200
QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV
210 220 230 240 250
HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD
260 270 280 290 300
ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ
310 320 330 340 350
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL
360 370 380 390 400
EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED
410 420 430 440 450
MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV
460 470 480 490 500
RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG
510 520 530 540 550
VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN
560 570 580 590 600
RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL
610 620 630 640 650
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL
660 670 680 690 700
SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT
710 720 730 740 750
RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP
760 770 780 790 800
MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL
810 820 830 840 850
NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG
860 870 880 890 900
QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL
910 920 930 940 950
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF
960 970 980 990 1000
STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP
1010 1020 1030 1040 1050
QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD
1060 1070 1080 1090 1100
ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA
1110 1120 1130 1140 1150
QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML
1160
EEANGQFVSD GTPTPQVAQ
Length:1,169
Mass (Da):129,151
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC616412033C219A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNJ3A0A0U1RNJ3_MOUSE
Integrin alpha-X
Itgax
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF211864 mRNA Translation: AAF23492.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40150.1

NCBI Reference Sequences

More...
RefSeqi
NP_067309.1, NM_021334.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.22378

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789

Database of genes from NCBI RefSeq genomes

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GeneIDi
16411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16411

UCSC genome browser

More...
UCSCi
uc009jyc.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA Translation: AAF23492.1
CCDSiCCDS40150.1
RefSeqiNP_067309.1, NM_021334.2
UniGeneiMm.22378

3D structure databases

ProteinModelPortaliQ9QXH4
SMRiQ9QXH4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3134 Integrin alphaX-beta2 complex
CORUMiQ9QXH4
IntActiQ9QXH4, 1 interactor
MINTiQ9QXH4
STRINGi10090.ENSMUSP00000033053

PTM databases

PhosphoSitePlusiQ9QXH4

Proteomic databases

MaxQBiQ9QXH4
PaxDbiQ9QXH4
PRIDEiQ9QXH4

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
16411
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789
GeneIDi16411
KEGGimmu:16411
UCSCiuc009jyc.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3687
MGIiMGI:96609 Itgax

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00940000154838
HOVERGENiHBG100530
InParanoidiQ9QXH4
KOiK06462
OMAiQNPSIQC
OrthoDBi73876at2759
PhylomeDBiQ9QXH4
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9QXH4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030789 Expressed in 70 organ(s), highest expression level in camera-type eye
ExpressionAtlasiQ9QXH4 baseline and differential
GenevisibleiQ9QXH4 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITAX_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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