Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TERF1-interacting nuclear factor 2

Gene

Tinf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity).By similarity

GO - Molecular functioni

  • telomeric DNA binding Source: BHF-UCL

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
TERF1-interacting nuclear factor 2
Alternative name(s):
TRF1-interacting nuclear protein 2
Gene namesi
Name:Tinf2
Synonyms:Tin2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107246 Tinf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000725422 – 341TERF1-interacting nuclear factor 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QXG9
MaxQBiQ9QXG9
PaxDbiQ9QXG9
PeptideAtlasiQ9QXG9
PRIDEiQ9QXG9

PTM databases

iPTMnetiQ9QXG9
PhosphoSitePlusiQ9QXG9

Expressioni

Gene expression databases

CleanExiMM_TINF2

Interactioni

Subunit structurei

Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 (By similarity). Interacts with TERF1.By similarity1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-153 Shelterin complex
IntActiQ9QXG9, 2 interactors
MINTiQ9QXG9
STRINGi10090.ENSMUSP00000007733

Structurei

3D structure databases

SMRiQ9QXG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi243 – 265TBMAdd BLAST23
Motifi249 – 255Nuclear localization signalSequence analysis7

Domaini

The TBM domain mediates interaction with TERF1.By similarity

Phylogenomic databases

eggNOGiENOG410IHMP Eukaryota
ENOG410Z499 LUCA
HOVERGENiHBG057120
InParanoidiQ9QXG9

Family and domain databases

CDDicd11657 TIN2_N, 1 hit
InterProiView protein in InterPro
IPR039098 TINF2
IPR029400 TINF2_N
PANTHERiPTHR15512 PTHR15512, 1 hit
PfamiView protein in Pfam
PF14973 TINF2_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9QXG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC
60 70 80 90 100
YRHHERLCMS LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL
110 120 130 140 150
LEARENFCLL VKHLSEDPPS SLQELEQDYG ESFLVAMEKL LFEYLCQLEK
160 170 180 190 200
ALPPVRAQEL QDALSWSQPG SFITSSVALH QYGMDMGWTF PESSTSGSGN
210 220 230 240 250
LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL AGHRFNLAPL
260 270 280 290 300
GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS
310 320 330 340
AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAASRRT V
Length:341
Mass (Da):37,887
Last modified:July 27, 2011 - v2
Checksum:i41A07CE00DC2B4D7
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K1K3Q8K1K3_MOUSE
TERF1-interacting nuclear factor 2
Tinf2 mCG_22054
414Annotation score:
A0A2I3BRL3A0A2I3BRL3_MOUSE
TERF1-interacting nuclear factor 2
Tinf2
419Annotation score:
A0A2I3BPS4A0A2I3BPS4_MOUSE
TERF1-interacting nuclear factor 2
Tinf2
149Annotation score:
A0A2I3BRI7A0A2I3BRI7_MOUSE
TERF1-interacting nuclear factor 2
Tinf2
197Annotation score:
A0A2I3BRW2A0A2I3BRW2_MOUSE
TERF1-interacting nuclear factor 2
Tinf2
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337S → G in AAF23504 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214013 mRNA Translation: AAF23504.1
CT025679 Genomic DNA No translation available.
UniGeneiMm.29346

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214013 mRNA Translation: AAF23504.1
CT025679 Genomic DNA No translation available.
UniGeneiMm.29346

3D structure databases

SMRiQ9QXG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-153 Shelterin complex
IntActiQ9QXG9, 2 interactors
MINTiQ9QXG9
STRINGi10090.ENSMUSP00000007733

PTM databases

iPTMnetiQ9QXG9
PhosphoSitePlusiQ9QXG9

Proteomic databases

EPDiQ9QXG9
MaxQBiQ9QXG9
PaxDbiQ9QXG9
PeptideAtlasiQ9QXG9
PRIDEiQ9QXG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107246 Tinf2

Phylogenomic databases

eggNOGiENOG410IHMP Eukaryota
ENOG410Z499 LUCA
HOVERGENiHBG057120
InParanoidiQ9QXG9

Miscellaneous databases

PROiPR:Q9QXG9
SOURCEiSearch...

Gene expression databases

CleanExiMM_TINF2

Family and domain databases

CDDicd11657 TIN2_N, 1 hit
InterProiView protein in InterPro
IPR039098 TINF2
IPR029400 TINF2_N
PANTHERiPTHR15512 PTHR15512, 1 hit
PfamiView protein in Pfam
PF14973 TINF2_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTINF2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXG9
Secondary accession number(s): E9Q126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: July 18, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again