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Protein

F-box-like/WD repeat-containing protein TBL1X

Gene

Tbl1x

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • identical protein binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • fat cell differentiation Source: MGI
  • histone deacetylation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  • protein stabilization Source: UniProtKB
  • proteolysis Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • response to estrogen Source: MGI
  • response to steroid hormone Source: MGI
  • sensory perception of sound Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1X
Alternative name(s):
Transducin beta-like protein 1X
Gene namesi
Name:Tbl1x
Synonyms:Tbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1336172 Tbl1x

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi184E → A: Affects recruitment to heterochromatin by MECP2. 1 Publication1
Mutagenesisi326D → N: Affects recruitment to heterochromatin by MECP2. 1 Publication1
Mutagenesisi364E → A: Affects recruitment to heterochromatin by MECP2. 1 Publication1
Mutagenesisi382D → A: Affects recruitment to heterochromatin by MECP2. Does not interact with MECP2. Is efficiently incorporated in N-Cor repressor complex. 1 Publication1
Mutagenesisi457P → R: Does not interact with MECP2. Affects recruitment to heterochromatin by MECP2. Is efficiently incorporated in N-Cor repressor complex. 1 Publication1
Mutagenesisi459Y → F: Does not affect recruitment to heterochromatin by MECP2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000512652 – 527F-box-like/WD repeat-containing protein TBL1XAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei102N6-acetyllysineBy similarity1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9QXE7
MaxQBiQ9QXE7
PaxDbiQ9QXE7
PeptideAtlasiQ9QXE7
PRIDEiQ9QXE7

PTM databases

iPTMnetiQ9QXE7
PhosphoSitePlusiQ9QXE7

Expressioni

Tissue specificityi

Expressed in the cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000025246
CleanExiMM_TBL1X
GenevisibleiQ9QXE7 MM

Interactioni

Subunit structurei

Homotetramer; dimer of dimers (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with GPS2 (when sumoylated); leading to protect GPS2 against degradation by the proteasome (PubMed:26070566). Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4 (By similarity). Interacts with MECP2; recuits TBL1X to the heterochromatin foci (PubMed:28348241).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MECP2P516083EBI-8821270,EBI-1189067From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203977, 5 interactors
DIPiDIP-62055N
IntActiQ9QXE7, 3 interactors
MINTiQ9QXE7
STRINGi10090.ENSMUSP00000085549

Structurei

3D structure databases

ProteinModelPortaliQ9QXE7
SMRiQ9QXE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36LisHPROSITE-ProRule annotationAdd BLAST33
Domaini41 – 86F-box-likeAdd BLAST46
Repeati180 – 219WD 1Add BLAST40
Repeati236 – 275WD 2Add BLAST40
Repeati277 – 316WD 3Add BLAST40
Repeati319 – 359WD 4Add BLAST41
Repeati360 – 399WD 5Add BLAST40
Repeati402 – 450WD 6Add BLAST49
Repeati453 – 492WD 7Add BLAST40
Repeati494 – 526WD 8Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 121Poly-AlaAdd BLAST14
Compositional biasi130 – 133Poly-Ala4

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0273 Eukaryota
ENOG410XRSY LUCA
GeneTreeiENSGT00890000139430
HOGENOMiHOG000220902
InParanoidiQ9QXE7
KOiK04508
OMAiSMKQEVC
OrthoDBiEOG091G04MW
PhylomeDBiQ9QXE7
TreeFamiTF323190

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI
60 70 80 90 100
SILQKGLQYV EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR
110 120 130 140 150
EKLAQQQANA AAAAAAAAAT ATSTAATTPA AAAQQNPPKN GEATVNGEEN
160 170 180 190 200
GAHAINNHSK PMEIDGDVEI PPSKATVLRG HESEVFICAW NPVSDLLASG
210 220 230 240 250
SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNSDG
260 270 280 290 300
TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNKK GNYILSAGVD
310 320 330 340 350
KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG
360 370 380 390 400
CDRPVKTFQG HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQDACVHDL
410 420 430 440 450
QAHSKEIYTI KWSPTGPATS NPNSNIMLAS ASFDSTVRLW DVERGVCIHT
460 470 480 490 500
LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGSLV HSYRGTGGIF
510 520
EVCWNARGDK VGASASDGSV CVLDLRK
Length:527
Mass (Da):56,802
Last modified:April 26, 2004 - v2
Checksum:i146435A9C51DFDA6
GO

Sequence cautioni

The sequence CAB61534 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104A → T in BAC27015 (PubMed:16141072).Curated1
Sequence conflicti349L → H in BAC27612 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030547 mRNA Translation: BAC27015.1
AK031937 mRNA Translation: BAC27612.1
AK038674 mRNA Translation: BAC30092.1
BC043105 mRNA Translation: AAH43105.1
F38006 Genomic DNA Translation: CAB61534.1 Sequence problems.
CCDSiCCDS41036.1
RefSeqiNP_065626.1, NM_020601.2
XP_006528002.1, XM_006527939.2
UniGeneiMm.258476
Mm.392769

Genome annotation databases

EnsembliENSMUST00000088217; ENSMUSP00000085549; ENSMUSG00000025246
GeneIDi21372
KEGGimmu:21372
UCSCiuc009tqo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBL1X_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE7
Secondary accession number(s): Q8BMM0, Q8BYQ4, Q8C0A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 26, 2004
Last modified: June 20, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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