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Protein

Tumor protein p53-inducible nuclear protein 1

Gene

Trp53inp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.4 Publications

GO - Molecular functioni

  • antioxidant activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Antioxidant
Biological processApoptosis, Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6804756 Regulation of TP53 Activity through Phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 1
Alternative name(s):
Stress-induced protein
Thymus-expressed acidic protein
Short name:
TEAP
p53-dependent damage-inducible nuclear protein 1
Short name:
p53DINP1
Gene namesi
Name:Trp53inp1
Synonyms:Sip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926609 Trp53inp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724071 – 239Tumor protein p53-inducible nuclear protein 1Add BLAST239

Proteomic databases

PaxDbiQ9QXE4
PRIDEiQ9QXE4

PTM databases

PhosphoSitePlusiQ9QXE4

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in the thymus.2 Publications

Inductioni

By adriamycin, methymethane sulfonate, ethanol, H2O2, ultraviolet irradiation and heat shock. Rapidly induced in acinar cells of the pancreas with acute pancreatitis upon caerulein treatment.1 Publication

Gene expression databases

BgeeiENSMUSG00000028211 Expressed in 292 organ(s), highest expression level in thymus
ExpressionAtlasiQ9QXE4 baseline and differential
GenevisibleiQ9QXE4 MM

Interactioni

Subunit structurei

Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029865

Structurei

3D structure databases

ProteinModelPortaliQ9QXE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi25 – 37LIRAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 52Poly-Glu7

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.By similarity

Phylogenomic databases

eggNOGiENOG410IJ9V Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
HOVERGENiHBG055647
InParanoidiQ9QXE4
KOiK15310
OMAiMFVGEVN
OrthoDBiEOG091G0FZC
PhylomeDBiQ9QXE4
TreeFamiTF333017

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9QXE4-1) [UniParc]FASTAAdd to basket
Also known as: SIP27, TEAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQRLNKMFV GEVTTSSSQE PEFSEKEDDE WILVDFIDTC PGFSAEEEEE
60 70 80 90 100
DEDIGEESSA EHTSVFSCLP ASLECLTDTS DSCFLQFESC PMEESWFITP
110 120 130 140 150
PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEASCGNDE
160 170 180 190 200
YNSSGPRMEA QSEMGKHIHC CVAALAAQAT FLEQPKSFRP SQWIKGHSER
210 220 230
QSLNRNGLRR QNLTRDCHTR QMKHSGWVVH QPCPRQYNY
Length:239
Mass (Da):26,935
Last modified:May 1, 2000 - v1
Checksum:i71F25DB7600D7C7B
GO
Isoform 2 (identifier: Q9QXE4-2) [UniParc]FASTAAdd to basket
Also known as: SIP18

The sequence of this isoform differs from the canonical sequence as follows:
     158-239: MEAQSEMGKH...HQPCPRQYNY → ARKSCL

Show »
Length:163
Mass (Da):18,010
Checksum:i2FAB1FFCEC07B936
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013177158 – 239MEAQS…RQYNY → ARKSCL in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131776 mRNA Translation: CAB66138.1
AY034611 mRNA Translation: AAK60419.1
AY034612 mRNA Translation: AAK60420.1
CCDSiCCDS17964.1 [Q9QXE4-1]
RefSeqiNP_001186034.1, NM_001199105.1 [Q9QXE4-2]
NP_068697.1, NM_021897.3 [Q9QXE4-1]
UniGeneiMm.393018
Mm.468195

Genome annotation databases

EnsembliENSMUST00000029865; ENSMUSP00000029865; ENSMUSG00000028211 [Q9QXE4-1]
GeneIDi60599
KEGGimmu:60599
UCSCiuc008ryz.1 mouse [Q9QXE4-1]
uc008rzb.1 mouse [Q9QXE4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131776 mRNA Translation: CAB66138.1
AY034611 mRNA Translation: AAK60419.1
AY034612 mRNA Translation: AAK60420.1
CCDSiCCDS17964.1 [Q9QXE4-1]
RefSeqiNP_001186034.1, NM_001199105.1 [Q9QXE4-2]
NP_068697.1, NM_021897.3 [Q9QXE4-1]
UniGeneiMm.393018
Mm.468195

3D structure databases

ProteinModelPortaliQ9QXE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029865

PTM databases

PhosphoSitePlusiQ9QXE4

Proteomic databases

PaxDbiQ9QXE4
PRIDEiQ9QXE4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029865; ENSMUSP00000029865; ENSMUSG00000028211 [Q9QXE4-1]
GeneIDi60599
KEGGimmu:60599
UCSCiuc008ryz.1 mouse [Q9QXE4-1]
uc008rzb.1 mouse [Q9QXE4-2]

Organism-specific databases

CTDi60599
MGIiMGI:1926609 Trp53inp1

Phylogenomic databases

eggNOGiENOG410IJ9V Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
HOVERGENiHBG055647
InParanoidiQ9QXE4
KOiK15310
OMAiMFVGEVN
OrthoDBiEOG091G0FZC
PhylomeDBiQ9QXE4
TreeFamiTF333017

Enzyme and pathway databases

ReactomeiR-MMU-6804756 Regulation of TP53 Activity through Phosphorylation

Miscellaneous databases

ChiTaRSiTrp53inp1 mouse
PROiPR:Q9QXE4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028211 Expressed in 292 organ(s), highest expression level in thymus
ExpressionAtlasiQ9QXE4 baseline and differential
GenevisibleiQ9QXE4 MM

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT53I1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE4
Secondary accession number(s): Q923I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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