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Protein

Peroxisomal acyl-coenzyme A oxidase 2

Gene

Acox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids.By similarity

Catalytic activityi

(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-389887 Beta-oxidation of pristanoyl-CoA
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 2By similarity (EC:1.17.99.3By similarity)
Alternative name(s):
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidaseBy similarity
Trihydroxycoprostanoyl-CoA oxidaseBy similarityImported
Short name:
THCA-CoA oxidaseBy similarity
Short name:
THCCox
Gene namesi
Name:Acox2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1934852 Acox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046821 – 681Peroxisomal acyl-coenzyme A oxidase 2Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei66N6-succinyllysineCombined sources1
Modified residuei137N6-succinyllysineCombined sources1
Modified residuei303N6-succinyllysineCombined sources1
Modified residuei453N6-succinyllysineCombined sources1
Modified residuei561N6-succinyllysineCombined sources1
Modified residuei667N6-succinyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-667 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QXD1
PaxDbiQ9QXD1
PeptideAtlasiQ9QXD1
PRIDEiQ9QXD1

PTM databases

CarbonylDBiQ9QXD1
iPTMnetiQ9QXD1
PhosphoSitePlusiQ9QXD1
SwissPalmiQ9QXD1

Expressioni

Gene expression databases

BgeeiENSMUSG00000021751 Expressed in 78 organ(s), highest expression level in liver
CleanExiMM_ACOX2
ExpressionAtlasiQ9QXD1 baseline and differential
GenevisibleiQ9QXD1 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QXD1, 2 interactors
MINTiQ9QXD1
STRINGi10090.ENSMUSP00000022271

Structurei

3D structure databases

ProteinModelPortaliQ9QXD1
SMRiQ9QXD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi679 – 681Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000181256
HOVERGENiHBG050451
InParanoidiQ9QXD1
KOiK10214
OMAiQKACVIA
OrthoDBiEOG091G0A1P
TreeFamiTF300672

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QXD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNPGDRVSL GETWSREVHP DIDSERHSPS FSVERLTNIL DGGIPNTELR
60 70 80 90 100
RRVESLIQRD PVFNLKHLYF MTRDELYEDA VQKRFHLEKL AWSLGWSEDG
110 120 130 140 150
PERIYADRVL AGYNNLNLHG IAMNAIRSLG SDEQIAKWGQ LGKNFQIITT
160 170 180 190 200
YAQTELGHGT YLQGLETEAT YDATTQEFVI HSPTMTSIKW WPGDLGRTVT
210 220 230 240 250
HAVVLAHLIC LGARHGMHAF IVPIRSLEDH TPLPGITVGD IGPKMGFENI
260 270 280 290 300
DNGFLRLNHV RVPRENMLSR FAEVLPDGTY QRLGTPQSNY LGMLVTRVQL
310 320 330 340 350
LYKGFLPTLQ KACTIAVRYA VIRHQSRLRP SDPEAKILEY QTQQQKLLPQ
360 370 380 390 400
LAVSYALHFM TTSLLQFFHS SYSDILKRDF SLLPELHALS TGMKAMSSDF
410 420 430 440 450
CAQGTEICRR ACGGHGYSKL SGLPTLVTQA IASCTYEGEN TVLYLQVARF
460 470 480 490 500
LMKSYLQAQV SPGSIPQKPL PQSVMYLATP RPARCPAQTA ADFRCPEVYT
510 520 530 540 550
TAWAYVSARL IRDATQHTQT LMRSGVDQYD AWNQTSVIHL QAAKAHCYFL
560 570 580 590 600
TVRNFKEAVE KLDNEPEIQR VLQNLCDLYA LNGILTNSGD FLHDGFLSGA
610 620 630 640 650
QVDMARTAFL DLLPLIRKDA ILLTDAFDFS DHCLNSALGC YDGHVYQRLF
660 670 680
EWAQKSPANT QENPAYKKYI RPLMQSWKPK L
Length:681
Mass (Da):76,863
Last modified:July 27, 2011 - v2
Checksum:i32C65231326BA0FB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5T5E9Q5T5_MOUSE
Peroxisomal acyl-coenzyme A oxidase...
Acox2
201Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26R → W in CAB65251 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238492 mRNA Translation: CAB65251.1
BC021339 mRNA Translation: AAH21339.1
CCDSiCCDS36801.1
RefSeqiNP_001155139.1, NM_001161667.1
NP_444345.2, NM_053115.2
XP_006518171.1, XM_006518108.3
UniGeneiMm.28700

Genome annotation databases

EnsembliENSMUST00000022271; ENSMUSP00000022271; ENSMUSG00000021751
ENSMUST00000164598; ENSMUSP00000126464; ENSMUSG00000021751
GeneIDi93732
KEGGimmu:93732
UCSCiuc007sey.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238492 mRNA Translation: CAB65251.1
BC021339 mRNA Translation: AAH21339.1
CCDSiCCDS36801.1
RefSeqiNP_001155139.1, NM_001161667.1
NP_444345.2, NM_053115.2
XP_006518171.1, XM_006518108.3
UniGeneiMm.28700

3D structure databases

ProteinModelPortaliQ9QXD1
SMRiQ9QXD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXD1, 2 interactors
MINTiQ9QXD1
STRINGi10090.ENSMUSP00000022271

PTM databases

CarbonylDBiQ9QXD1
iPTMnetiQ9QXD1
PhosphoSitePlusiQ9QXD1
SwissPalmiQ9QXD1

Proteomic databases

MaxQBiQ9QXD1
PaxDbiQ9QXD1
PeptideAtlasiQ9QXD1
PRIDEiQ9QXD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022271; ENSMUSP00000022271; ENSMUSG00000021751
ENSMUST00000164598; ENSMUSP00000126464; ENSMUSG00000021751
GeneIDi93732
KEGGimmu:93732
UCSCiuc007sey.2 mouse

Organism-specific databases

CTDi8309
MGIiMGI:1934852 Acox2

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000181256
HOVERGENiHBG050451
InParanoidiQ9QXD1
KOiK10214
OMAiQKACVIA
OrthoDBiEOG091G0A1P
TreeFamiTF300672

Enzyme and pathway databases

ReactomeiR-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-389887 Beta-oxidation of pristanoyl-CoA
R-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSiAcox2 mouse
PROiPR:Q9QXD1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021751 Expressed in 78 organ(s), highest expression level in liver
CleanExiMM_ACOX2
ExpressionAtlasiQ9QXD1 baseline and differential
GenevisibleiQ9QXD1 MM

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACOX2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXD1
Secondary accession number(s): Q8VCB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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