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Protein

Fetuin-B

Gene

Fetub

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.1 Publication

GO - Molecular functioni

GO - Biological processi

  • binding of sperm to zona pellucida Source: UniProtKB
  • negative regulation of endopeptidase activity Source: UniProtKB
  • single fertilization Source: UniProtKB

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological processFertilization

Protein family/group databases

MEROPSiI25.061

Names & Taxonomyi

Protein namesi
Recommended name:
Fetuin-B
Alternative name(s):
Fetuin-like protein IRL685
Gene namesi
Name:Fetub
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1890221 Fetub

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Female infertility due to a block early in fertilization. Oocytes undergo premature zona pellucida hardening.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000890019 – 388Fetuin-BAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 107PROSITE-ProRule annotation
Disulfide bondi120 ↔ 140PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi154 ↔ 157PROSITE-ProRule annotation
Disulfide bondi217 ↔ 224PROSITE-ProRule annotation
Disulfide bondi237 ↔ 263PROSITE-ProRule annotation
Glycosylationi292O-linked (GalNAc...) threonineBy similarity1
Glycosylationi295O-linked (GalNAc...) threonineBy similarity1
Modified residuei321PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QXC1
PaxDbiQ9QXC1
PRIDEiQ9QXC1

PTM databases

iPTMnetiQ9QXC1
PhosphoSitePlusiQ9QXC1

Expressioni

Tissue specificityi

Liver, lung and tongue.

Gene expression databases

BgeeiENSMUSG00000022871 Expressed in 73 organ(s), highest expression level in liver
CleanExiMM_FETUB
ExpressionAtlasiQ9QXC1 baseline and differential
GenevisibleiQ9QXC1 MM

Interactioni

Protein-protein interaction databases

BioGridi208524, 2 interactors
IntActiQ9QXC1, 1 interactor
MINTiQ9QXC1
STRINGi10090.ENSMUSP00000023587

Structurei

3D structure databases

ProteinModelPortaliQ9QXC1
SMRiQ9QXC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 141Cystatin fetuin-B-type 1PROSITE-ProRule annotationAdd BLAST114
Domaini152 – 264Cystatin fetuin-B-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEMR Eukaryota
ENOG4111K2W LUCA
GeneTreeiENSGT00530000063413
HOGENOMiHOG000059646
HOVERGENiHBG051608
InParanoidiQ9QXC1
OMAiSQWVFGP
OrthoDBiEOG091G0Y4O
PhylomeDBiQ9QXC1
TreeFamiTF333729

Family and domain databases

CDDicd00042 CY, 2 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR025764 Cystatin_Fetuin_B
IPR001363 Prot_inh_fetuin_CS
PfamiView protein in Pfam
PF00031 Cystatin, 2 hits
SMARTiView protein in SMART
SM00043 CY, 2 hits
PROSITEiView protein in PROSITE
PS51530 CYSTATIN_FETUIN_B, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QXC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLRLLVLC TLAACCMARS PPAPPLPQRP LSPLHPLGCN DSEVLAVAGF
60 70 80 90 100
ALQNINRDQK DGYMLSLNRV HDVREHYQED MGSLFYLTLD VLETDCHVLS
110 120 130 140 150
RKAQKDCKPR MFYESVYGQC KAMFHINKPR RVLYLPAYNC TLRPVSKRKT
160 170 180 190 200
HTTCPDCPSP IDLSNPSALE AATESLAKFN SKSPSKKYEL VKVTKAMNQW
210 220 230 240 250
VSGPAYYVEY LIKEAPCTKS QASCSLQHSD SEPVGICQGS TVQSSLRHVP
260 270 280 290 300
LIQPVEKSVT VTCEFFESQA QVPGDENPAV TQGPQKLPQK NTAPTSSPSV
310 320 330 340 350
TAPRGSIQHL PELDDEKPEE SKGGSPEEAF PVQLDLTTNP QGDTLDVSFL
360 370 380
YLEPGDKKLV VLPFPGKEQR SAECPGPEKE NNPLVLPP
Length:388
Mass (Da):42,713
Last modified:May 1, 2000 - v1
Checksum:i39CFAD76A9D8DC2B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6YJU1Q6YJU1_MOUSE
Fetuin-B
Fetub Gugu
308Annotation score:
A0A338P7B8A0A338P7B8_MOUSE
Fetuin-B
Fetub
232Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242927 mRNA Translation: CAB62541.1
BC018341 mRNA Translation: AAH18341.1
CCDSiCCDS37300.1
RefSeqiNP_001077373.1, NM_001083904.1
NP_001077374.1, NM_001083905.1
NP_067539.1, NM_021564.2
UniGeneiMm.28461

Genome annotation databases

EnsembliENSMUST00000023587; ENSMUSP00000023587; ENSMUSG00000022871
ENSMUST00000167399; ENSMUSP00000128745; ENSMUSG00000022871
ENSMUST00000170805; ENSMUSP00000128989; ENSMUSG00000022871
ENSMUST00000231768; ENSMUSP00000156347; ENSMUSG00000022871
ENSMUST00000232097; ENSMUSP00000155898; ENSMUSG00000022871
GeneIDi59083
KEGGimmu:59083
UCSCiuc007yss.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242927 mRNA Translation: CAB62541.1
BC018341 mRNA Translation: AAH18341.1
CCDSiCCDS37300.1
RefSeqiNP_001077373.1, NM_001083904.1
NP_001077374.1, NM_001083905.1
NP_067539.1, NM_021564.2
UniGeneiMm.28461

3D structure databases

ProteinModelPortaliQ9QXC1
SMRiQ9QXC1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208524, 2 interactors
IntActiQ9QXC1, 1 interactor
MINTiQ9QXC1
STRINGi10090.ENSMUSP00000023587

Protein family/group databases

MEROPSiI25.061

PTM databases

iPTMnetiQ9QXC1
PhosphoSitePlusiQ9QXC1

Proteomic databases

MaxQBiQ9QXC1
PaxDbiQ9QXC1
PRIDEiQ9QXC1

Protocols and materials databases

DNASUi59083
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023587; ENSMUSP00000023587; ENSMUSG00000022871
ENSMUST00000167399; ENSMUSP00000128745; ENSMUSG00000022871
ENSMUST00000170805; ENSMUSP00000128989; ENSMUSG00000022871
ENSMUST00000231768; ENSMUSP00000156347; ENSMUSG00000022871
ENSMUST00000232097; ENSMUSP00000155898; ENSMUSG00000022871
GeneIDi59083
KEGGimmu:59083
UCSCiuc007yss.1 mouse

Organism-specific databases

CTDi26998
MGIiMGI:1890221 Fetub

Phylogenomic databases

eggNOGiENOG410IEMR Eukaryota
ENOG4111K2W LUCA
GeneTreeiENSGT00530000063413
HOGENOMiHOG000059646
HOVERGENiHBG051608
InParanoidiQ9QXC1
OMAiSQWVFGP
OrthoDBiEOG091G0Y4O
PhylomeDBiQ9QXC1
TreeFamiTF333729

Miscellaneous databases

PROiPR:Q9QXC1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022871 Expressed in 73 organ(s), highest expression level in liver
CleanExiMM_FETUB
ExpressionAtlasiQ9QXC1 baseline and differential
GenevisibleiQ9QXC1 MM

Family and domain databases

CDDicd00042 CY, 2 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR025764 Cystatin_Fetuin_B
IPR001363 Prot_inh_fetuin_CS
PfamiView protein in Pfam
PF00031 Cystatin, 2 hits
SMARTiView protein in SMART
SM00043 CY, 2 hits
PROSITEiView protein in PROSITE
PS51530 CYSTATIN_FETUIN_B, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFETUB_MOUSE
AccessioniPrimary (citable) accession number: Q9QXC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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