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Protein

Developmentally-regulated GTP-binding protein 2

Gene

Drg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation, differentiation and death.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:Drg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342307 Drg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054281 – 364Developmentally-regulated GTP-binding protein 2Add BLAST364

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9QXB9
MaxQBiQ9QXB9
PaxDbiQ9QXB9
PeptideAtlasiQ9QXB9
PRIDEiQ9QXB9

PTM databases

iPTMnetiQ9QXB9
PhosphoSitePlusiQ9QXB9

Expressioni

Tissue specificityi

Fairly high levels in liver, heart, kidney, and brain. Very low levels in lung, spleen, testis and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000020537 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExiMM_DRG2
GenevisibleiQ9QXB9 MM

Interactioni

Subunit structurei

Interacts with RWDD1.1 Publication

Protein-protein interaction databases

BioGridi199311, 3 interactors
IntActiQ9QXB9, 2 interactors
MINTiQ9QXB9
STRINGi10090.ENSMUSP00000018568

Structurei

3D structure databases

ProteinModelPortaliQ9QXB9
SMRiQ9QXB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075059
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiQ9QXB9
KOiK06944
OMAiMIREDIT
OrthoDBiEOG091G0A12
PhylomeDBiQ9QXB9
TreeFamiTF105706

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS
60 70 80 90 100
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI
110 120 130 140 150
PGVIEYKGAN IQLLDLPGII EGAAQGRGRG RQVIAVARTA DVVVMMLDAT
160 170 180 190 200
KGDVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE
210 220 230 240 250
KLVQLILHEY KIFNAEVLFR EDCSPDDFID VIVGNRVYMP CLYVYNKIDQ
260 270 280 290 300
ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT
360
HTMEHEDVIQ IVKK
Length:364
Mass (Da):40,718
Last modified:May 1, 2000 - v1
Checksum:i932353C8FF257BE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243590 mRNA Translation: CAB65258.1
AL596090 Genomic DNA No translation available.
BC082564 mRNA Translation: AAH82564.1
CCDSiCCDS24791.1
RefSeqiNP_067329.1, NM_021354.1
UniGeneiMm.41803

Genome annotation databases

EnsembliENSMUST00000018568; ENSMUSP00000018568; ENSMUSG00000020537
GeneIDi13495
KEGGimmu:13495
UCSCiuc007jfy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243590 mRNA Translation: CAB65258.1
AL596090 Genomic DNA No translation available.
BC082564 mRNA Translation: AAH82564.1
CCDSiCCDS24791.1
RefSeqiNP_067329.1, NM_021354.1
UniGeneiMm.41803

3D structure databases

ProteinModelPortaliQ9QXB9
SMRiQ9QXB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199311, 3 interactors
IntActiQ9QXB9, 2 interactors
MINTiQ9QXB9
STRINGi10090.ENSMUSP00000018568

PTM databases

iPTMnetiQ9QXB9
PhosphoSitePlusiQ9QXB9

Proteomic databases

EPDiQ9QXB9
MaxQBiQ9QXB9
PaxDbiQ9QXB9
PeptideAtlasiQ9QXB9
PRIDEiQ9QXB9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018568; ENSMUSP00000018568; ENSMUSG00000020537
GeneIDi13495
KEGGimmu:13495
UCSCiuc007jfy.1 mouse

Organism-specific databases

CTDi1819
MGIiMGI:1342307 Drg2

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075059
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiQ9QXB9
KOiK06944
OMAiMIREDIT
OrthoDBiEOG091G0A12
PhylomeDBiQ9QXB9
TreeFamiTF105706

Miscellaneous databases

PROiPR:Q9QXB9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020537 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExiMM_DRG2
GenevisibleiQ9QXB9 MM

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXB9
Secondary accession number(s): Q5SX94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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