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Protein

U6 snRNA-associated Sm-like protein LSm4

Gene

Lsm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

  • PH domain binding Source: MGI
  • RNA binding Source: GO_Central
  • U6 snRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm4
Gene namesi
Name:Lsm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354692 Lsm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255651 – 137U6 snRNA-associated Sm-like protein LSm4Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QXA5
MaxQBiQ9QXA5
PaxDbiQ9QXA5
PRIDEiQ9QXA5

PTM databases

iPTMnetiQ9QXA5
PhosphoSitePlusiQ9QXA5
SwissPalmiQ9QXA5

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60115N
IntActiQ9QXA5, 1 interactor
STRINGi10090.ENSMUSP00000034311

Structurei

3D structure databases

ProteinModelPortaliQ9QXA5
SMRiQ9QXA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3293 Eukaryota
ENOG4111TZU LUCA
HOVERGENiHBG000486
InParanoidiQ9QXA5
KOiK12623

Family and domain databases

CDDicd01723 LSm4, 1 hit
InterProiView protein in InterPro
IPR034101 Lsm4
IPR027141 LSm4/Sm_D1/D3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR23338 PTHR23338, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9QXA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG
60 70 80 90 100
DKFWRMPECY IRGSTIKYLR IPDEIIDMVR EEAAKGRGRG GPQQKQQKGR
110 120 130
GMGGAGRGVF GGRGRGGIPG AGRGQPEKKP GRQAGKQ
Length:137
Mass (Da):15,076
Last modified:May 1, 2000 - v1
Checksum:iA917E16E61467940
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CY46Q9CY46_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm4 LSM4, mCG_14793
138Annotation score:
D3YTP8D3YTP8_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm4 LSM4
96Annotation score:
A0A1B0GQZ9A0A1B0GQZ9_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm4 LSM4
103Annotation score:
A0A1B0GRR9A0A1B0GRR9_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm4
105Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249439 mRNA Translation: CAB65729.1
RefSeqiNP_056631.2, NM_015816.4
UniGeneiMm.248188

Genome annotation databases

GeneIDi50783
KEGGimmu:50783

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249439 mRNA Translation: CAB65729.1
RefSeqiNP_056631.2, NM_015816.4
UniGeneiMm.248188

3D structure databases

ProteinModelPortaliQ9QXA5
SMRiQ9QXA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60115N
IntActiQ9QXA5, 1 interactor
STRINGi10090.ENSMUSP00000034311

PTM databases

iPTMnetiQ9QXA5
PhosphoSitePlusiQ9QXA5
SwissPalmiQ9QXA5

Proteomic databases

EPDiQ9QXA5
MaxQBiQ9QXA5
PaxDbiQ9QXA5
PRIDEiQ9QXA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50783
KEGGimmu:50783

Organism-specific databases

CTDi25804
MGIiMGI:1354692 Lsm4

Phylogenomic databases

eggNOGiKOG3293 Eukaryota
ENOG4111TZU LUCA
HOVERGENiHBG000486
InParanoidiQ9QXA5
KOiK12623

Miscellaneous databases

PROiPR:Q9QXA5
SOURCEiSearch...

Family and domain databases

CDDicd01723 LSm4, 1 hit
InterProiView protein in InterPro
IPR034101 Lsm4
IPR027141 LSm4/Sm_D1/D3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR23338 PTHR23338, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM4_MOUSE
AccessioniPrimary (citable) accession number: Q9QXA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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