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UniProtKB - Q9QX96 (SALL2_MOUSE)
Protein
Sal-like protein 2
Gene
Sall2
Organism
Mus musculus (Mouse)
Status
Functioni
Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 34 – 56 | C2H2-type 1; atypical1 PublicationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 629 – 651 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 657 – 679 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 689 – 711 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 908 – 930 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 937 – 961 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- eye development Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neural tube development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Sal-like protein 2Alternative name(s): Spalt-like protein 2 Zinc finger protein Spalt-2 Short name: Sal-2 Short name: mSal-2 |
Gene namesi | Name:Sall2 Synonyms:Sal2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354373, Sall2 |
VEuPathDBi | HostDB:ENSMUSG00000049532 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
No overt phenotypic abnormalities. Histologic analysis of the eyes reveales a colobomatous phenotype, with delayed apposition of the optic fissure margins and persistence of an anterior retinal coloboma phenotype after birth. Deficient embryos display correct posterior closure toward the optic nerve head, and upon contact of the fissure margins, dissolution of the basal lamina occurs and PAX2, known to be critical for this process, is expressed normally. Anterior closure is disrupted with the fissure margins failing to meet, or in some cases misaligning leading to a retinal lesion.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047023 | 1 – 1004 | Sal-like protein 2Add BLAST | 1004 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 243 | PhosphoserineBy similarity | 1 | |
Modified residuei | 794 | PhosphoserineBy similarity | 1 | |
Modified residuei | 799 | PhosphoserineBy similarity | 1 | |
Modified residuei | 803 | PhosphoserineCombined sources | 1 | |
Cross-linki | 908 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9QX96 |
MaxQBi | Q9QX96 |
PaxDbi | Q9QX96 |
PRIDEi | Q9QX96 |
ProteomicsDBi | 256829 |
PTM databases
iPTMneti | Q9QX96 |
PhosphoSitePlusi | Q9QX96 |
Expressioni
Tissue specificityi
Expressed throughout embryonic development. In adult predominantly in brain.
Gene expression databases
Bgeei | ENSMUSG00000049532, Expressed in cochlea and 275 other tissues |
ExpressionAtlasi | Q9QX96, baseline and differential |
Genevisiblei | Q9QX96, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 206051, 2 interactors |
IntActi | Q9QX96, 3 interactors |
MINTi | Q9QX96 |
STRINGi | 10090.ENSMUSP00000056401 |
Miscellaneous databases
RNActi | Q9QX96, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9QX96 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 51 – 122 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 137 – 177 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 220 – 270 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 285 – 307 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 712 – 910 | DisorderedSequence analysisAdd BLAST | 199 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 68 – 85 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 151 – 174 | Pro residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 249 – 268 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 727 – 756 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 757 – 777 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 830 – 845 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 871 – 885 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the sal C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 34 – 56 | C2H2-type 1; atypical1 PublicationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 629 – 651 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 657 – 679 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 689 – 711 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 908 – 930 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 937 – 961 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1074, Eukaryota |
GeneTreei | ENSGT00940000162245 |
HOGENOMi | CLU_013111_0_0_1 |
InParanoidi | Q9QX96 |
OMAi | ENGSEQC |
OrthoDBi | 244207at2759 |
TreeFami | TF317003 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9QX96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL
60 70 80 90 100
AHQNSCCTDP PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP
110 120 130 140 150
DSGSSGAPDP TWGPERRGEE SSGQFLVAAT GTAAGGGGGL ILASPKLGAT
160 170 180 190 200
PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT
210 220 230 240 250
EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP LFSPIKPAQT
260 270 280 290 300
GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA
310 320 330 340 350
PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK
360 370 380 390 400
NGSGELGYGE VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY
410 420 430 440 450
KCNVCGNRFT TRGNLKVHFH RHREKYPHVQ MNPHPVPEHL DYVITSSGLP
460 470 480 490 500
YGMSVPPEKA EEEAGTPGGG VERKPLVAST TALSATESLT LLSTGTSTAV
510 520 530 540 550
APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD SGSATRMQLS
560 570 580 590 600
KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR
610 620 630 640 650
QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ
660 670 680 690 700
HGGERPFKCK VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN
710 720 730 740 750
AVTLQQHVRM HLGGQIPNGG SALSEGGGAA QENSSEQSTA SGPGSFPQPQ
760 770 780 790 800
SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL AGRGSESGGE KAISVRGDSE
810 820 830 840 850
EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP DNLDHPQPME
860 870 880 890 900
QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD
910 920 930 940 950
PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA
960 970 980 990 1000
TLKKHMLLAH HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD
PTMP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BQV4 | A0A2I3BQV4_MOUSE | Sal-like protein 2 | Sall2 | 1,002 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | R → K in CAB65274 (PubMed:10602995).Curated | 1 | |
Sequence conflicti | 31 | D → H in CAB65274 (PubMed:10602995).Curated | 1 | |
Sequence conflicti | 107 | A → P in CAB65274 (PubMed:10602995).Curated | 1 | |
Sequence conflicti | 225 | E → K in CAB65274 (PubMed:10602995).Curated | 1 | |
Sequence conflicti | 869 | T → I in CAB65274 (PubMed:10602995).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007396 mRNA Translation: CAB65274.1 BC085361 mRNA Translation: AAH85361.1 |
CCDSi | CCDS27054.1 |
RefSeqi | NP_001231845.1, NM_001244916.1 NP_056587.2, NM_015772.3 |
Genome annotation databases
Ensembli | ENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532 |
GeneIDi | 50524 |
KEGGi | mmu:50524 |
UCSCi | uc007tpf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007396 mRNA Translation: CAB65274.1 BC085361 mRNA Translation: AAH85361.1 |
CCDSi | CCDS27054.1 |
RefSeqi | NP_001231845.1, NM_001244916.1 NP_056587.2, NM_015772.3 |
3D structure databases
AlphaFoldDBi | Q9QX96 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 206051, 2 interactors |
IntActi | Q9QX96, 3 interactors |
MINTi | Q9QX96 |
STRINGi | 10090.ENSMUSP00000056401 |
PTM databases
iPTMneti | Q9QX96 |
PhosphoSitePlusi | Q9QX96 |
Proteomic databases
jPOSTi | Q9QX96 |
MaxQBi | Q9QX96 |
PaxDbi | Q9QX96 |
PRIDEi | Q9QX96 |
ProteomicsDBi | 256829 |
Protocols and materials databases
Antibodypediai | 22191, 93 antibodies from 20 providers |
DNASUi | 50524 |
Genome annotation databases
Ensembli | ENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532 |
GeneIDi | 50524 |
KEGGi | mmu:50524 |
UCSCi | uc007tpf.2, mouse |
Organism-specific databases
CTDi | 6297 |
MGIi | MGI:1354373, Sall2 |
VEuPathDBi | HostDB:ENSMUSG00000049532 |
Phylogenomic databases
eggNOGi | KOG1074, Eukaryota |
GeneTreei | ENSGT00940000162245 |
HOGENOMi | CLU_013111_0_0_1 |
InParanoidi | Q9QX96 |
OMAi | ENGSEQC |
OrthoDBi | 244207at2759 |
TreeFami | TF317003 |
Miscellaneous databases
BioGRID-ORCSi | 50524, 5 hits in 71 CRISPR screens |
ChiTaRSi | Sall2, mouse |
PROi | PR:Q9QX96 |
RNActi | Q9QX96, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049532, Expressed in cochlea and 275 other tissues |
ExpressionAtlasi | Q9QX96, baseline and differential |
Genevisiblei | Q9QX96, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SALL2_MOUSE | |
Accessioni | Q9QX96Primary (citable) accession number: Q9QX96 Secondary accession number(s): Q5U3X1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families