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UniProtKB - Q9QX74 (SHAN2_RAT)

Entry version 165 (07 Oct 2020)
Sequence version 2 (26 Jul 2002)
Previous versions | rss
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Protein

SH3 and multiple ankyrin repeat domains protein 2

Gene

Shank2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 2
Short name:
Shank2
Alternative name(s):
Cortactin-binding protein 1
Short name:
CortBP1
GKAP/SAPAP-interacting protein
Proline-rich synapse-associated protein 1
Short name:
ProSAP1
SPANK-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shank2
Synonyms:Cortbp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		628772, Shank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001746741 – 1474SH3 and multiple ankyrin repeat domains protein 2Add BLAST1474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei457PhosphoserineBy similarity1
Modified residuei486PhosphothreonineBy similarity1
Modified residuei586PhosphoserineBy similarity1
Modified residuei724PhosphoserineBy similarity1
Modified residuei903PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1292O-linked (GlcNAc) threonineBy similarity1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1338PhosphoserineBy similarity1
Isoform 4 (identifier: Q9QX74-4)
Modified residuei162PhosphoserineCombined sources1
Isoform 5 (identifier: Q9QX74-5)
Modified residuei162PhosphoserineCombined sources1
Isoform 6 (identifier: Q9QX74-6)
Modified residuei162PhosphoserineCombined sources1
Isoform 2 (identifier: Q9QX74-2)
Modified residuei373PhosphoserineCombined sources1
Isoform 3 (identifier: Q9QX74-3)
Modified residuei373PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9QX74

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QX74

PRoteomics IDEntifications database

More...PRIDEi		Q9QX74

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9QX74, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QX74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QX74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells (at protein level). All isoforms except isoform 7 are expressed predominantly in brain, with highest levels in olfactory bulb, cerebral cortex, cerebellum, central gray matter and hippocampus. Moderate levels of expression are seen in the caudate putamen, thalamic nuclei and brain stem. In cerebellum primarily expressed in Purkinje cells. Isoform 7 is not expressed in brain but expressed in liver, cholangiocytes and thymus. Isoform 7 is present in pancreas, colonic mucosa and thymocytes (at protein level).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during early postnatal brain development, especially in the caudate putamen and thalamic nuclei. Expression in the cerebral cortex, the hippocampus and the cerebellum is moderate to high at P5 and shows a stable expression throughout development. Isoforms 1, 2, 4 and 6 are predominantly expressed in cerebellum up to the age of approximately 3 weeks. Isoform 1 expression decreases during development of cortex but slightly increases in cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000050206, Expressed in frontal cortex and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9QX74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QX74, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP.

Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1.

Interacts with DNM2, DBNL, GRID2, BAIAP2, SLC9A3, PLCB3 and CFTR.

Interacts with ABI1 (via SH3 domain).

Interacts (via proline-rich region) with PDE4D isoform 5 (via N-terminal region).

Interacts with PDE4D isoform 33, isoform 4, isoform 7, isoform 8 and isoform 9 but not isoform 32 and isoform 6.

Interacts weakly with PDE4D isoform 31.

Interacts with ABI1.

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		251104, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9QX74

Protein interaction database and analysis system

More...IntActi		Q9QX74, 12 interactors

Molecular INTeraction database

More...MINTi		Q9QX74

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000067841

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QX74

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 207SH3PROSITE-ProRule annotationAdd BLAST60
Domaini248 – 342PDZPROSITE-ProRule annotationAdd BLAST95
Domaini1411 – 1474SAMPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1169 – 1175SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 27Poly-Arg4
Compositional biasi521 – 529Poly-Pro9
Compositional biasi1203 – 1211Poly-Pro9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain is required for interaction with GRID2, PLCB3, SLC9A3 and CFTR.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHANK family.Curated

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504, Eukaryota
KOG4375, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153561

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QX74

KEGG Orthology (KO)

More...KOi		K15009

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17820, PDZ_6, 1 hit
PF00536, SAM_1, 1 hit
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: So far detected are complete isoforms 2 to 5. Experimental confirmation may be lacking for some isoforms.

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QX74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAG 
        60         70         80         90        100
APEWAVCSAA TSHRSLSPQL LQQTPSKPDG ATKSLGSYAP GPRSRSPSLN 
       110        120        130        140        150
RLGGAGEDGK RPQPPHWHVG SPFTPGANKD SLSTFEYPGP RRKLYSAVPG 
       160        170        180        190        200
RLFVAIKPYQ PQVDGEIPLH RGDRVKVLSI GEGGFWEGSA RGHIGWFPAE 
       210        220        230        240        250
CVEEVQCKPR DSQAETRADR SKKLFRHYTV GSYDSFDAAS DCIIEDKTVV 
       260        270        280        290        300
LQKKDNEGFG FVLRGAKADT PIEEFTPTPA FPALQYLESV DEGGVAWQAG 
       310        320        330        340        350
LRTGDFLIEV NNENVVKVGH RQVVNMIRQG GNHLVLKVVT VTRNLDPDDT 
       360        370        380        390        400
ARKKAPPPPK RAPTTALTLR SKSMTAELEE LGLSLVDKAS VRKKKDKPEE 
       410        420        430        440        450
IVPASKPSRT AENVAIESRV ATIKQRPTSR CFPAASDVNS VYERQGIAVM 
       460        470        480        490        500
TPTVPGSPKG PFLGLPRGTM RRQKSIDSRI FLSGITEEER QFLAPPMLKF 
       510        520        530        540        550
TRSLSMPDTS EDIPPPPQSV PPSPPPPSPT TYNCPRSPTP RVYGTIKPAF 
       560        570        580        590        600
NQNPVAKVPP ATRSDTVATM MREKGMFYRR ELDRFSLDSE DVYSRSPAPQ 
       610        620        630        640        650
AAFRTKRGQM PENPYSEVGK IASKAVYVPA KPARRKGMLV KQSNVEDSPE 
       660        670        680        690        700
KTCSIPIPTI IVKEPSTSSS GKSSQGSSME IDPQATEPGQ LRPDDSLTVS 
       710        720        730        740        750
SPFAAAIAGA VRDREKRLEA RRNSPAFLST DLGDEDVGLG PPAPRMQPSK 
       760        770        780        790        800
FPEEGGFGDE DETEQPLLPT PGAAPRELEN HFLGGGEAGA QGEAGGPLSS 
       810        820        830        840        850
TSKAKGPESG PAAALKSSSP ASPENYVHPL TGRLLDPSSP LALALSARDR 
       860        870        880        890        900
AMQESQQGHK GEAPKADLNK PLYIDTKMRP SVESGFPPVT RQNTRGPLRR 
       910        920        930        940        950
QETENKYETD LSKDRRADDK KNMLINIVDT AQQKSAGLLM VHTVDIPVAG 
       960        970        980        990       1000
PPLEEEEDRE DGDTKPDHSP STVPEGVPKT EGALQISAAP EPAAAPGRTI 
      1010       1020       1030       1040       1050
VAAGSVEEAV ILPFRIPPPP LASVDLDEDF LFTEPLPPPL EFANSFDIPD 
      1060       1070       1080       1090       1100
DRAASVPALA DLVKQKKSDT PQPPSLNSSQ PANSTDSKKP AGISNCLPSS 
      1110       1120       1130       1140       1150
FLPPPESFDA VTDSGIEEVD SRSSSDHHLE TTSTISTVSS ISTLSSEGGE 
      1160       1170       1180       1190       1200
SMDTCTVYAD GQAFVVDKPP VPPKPKMKPI VHKSNALYQD TLPEEDTDGF 
      1210       1220       1230       1240       1250
VIPPPAPPPP PGSAQAGVAK VIQPRTSKLW GDVTEVKSPI LSGPKANVIS 
      1260       1270       1280       1290       1300
ELNSILQQMN RGKSVKPGEG LELPVGAKSA NLAPRSPEVM STVSGTRSTT 
      1310       1320       1330       1340       1350
VTFTVRPGTS QPITLQSRPP DYESRTSGPR RAPSPVVSPT ELSKEILPTP 
      1360       1370       1380       1390       1400
PSAAAASPSP TLSDVFSLPS QSPAGDLFGL NPAGRSRSPS PSILQQPISN 
      1410       1420       1430       1440       1450
KPFTTKPVHL WTKPDVADWL ESLNLGEHKE TFMDNEIDGS HLPNLQKEDL 
      1460       1470 
IDLGVTRVGH RMNIERALKQ LLDR
Length:1,474
Mass (Da):158,684
Last modified:July 26, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF503D44D0D9AB7C1
GO
Isoform 2 (identifier: Q9QX74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-385: Missing.

Show »
Length:1,470
Mass (Da):158,313
Checksum:i3243014B3C11A193
GO
Isoform 3 (identifier: Q9QX74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-385: Missing.
     388-394: Missing.
     468-483: Missing.

Show »
Length:1,447
Mass (Da):155,638
Checksum:i6C88FEB1E3AAB067
GO
Isoform 4 (identifier: Q9QX74-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     212-239: SQAETRADRSKKLFRHYTVGSYDSFDAA → MMSVPGGGAATVMMTGYNNGRYPRNSLY
     382-385: Missing.

Show »
Length:1,259
Mass (Da):135,093
Checksum:i1C367EBC2AFCA2D2
GO
Isoform 5 (identifier: Q9QX74-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     212-239: SQAETRADRSKKLFRHYTVGSYDSFDAA → MMSVPGGGAATVMMTGYNNGRYPRNSLY
     382-385: Missing.
     388-394: Missing.

Show »
Length:1,252
Mass (Da):134,295
Checksum:iB636E33D36CFA29B
GO
Isoform 6 (identifier: Q9QX74-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.
     212-239: SQAETRADRSKKLFRHYTVGSYDSFDAA → MMSVPGGGAATVMMTGYNNGRYPRNSLY
     382-385: Missing.
     468-476: Missing.

Show »
Length:1,250
Mass (Da):134,035
Checksum:i39E4227E05938C9A
GO
Isoform 7 (identifier: Q9QX74-7) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLLNAFTKKE → MPRSPTSSED...YIKNHKETDI
     382-395: Missing.

Note: Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.Curated
Show »
Length:1,839
Mass (Da):199,855
Checksum:i0A44ABEE5F37FCBE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R5T5M0R5T5_RAT
SH3 and multiple ankyrin repeat dom...
Shank2
1,842Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRR2A0A0U1RRR2_RAT
SH3 and multiple ankyrin repeat dom...
Shank2
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RS17A0A0U1RS17_RAT
SH3 and multiple ankyrin repeat dom...
Shank2
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD42977 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35 – 41PRVLLRS → QKNLGAA (PubMed:10506216).Curated7
Sequence conflicti152L → F in AAF02497 (PubMed:14977424).Curated1
Sequence conflicti369L → V in AAC62226 (PubMed:9742101).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0060811 – 211Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST211
Alternative sequenceiVSP_0200491 – 12MKSLL…FTKKE → MPRSPTSSEDEMAQSFSDYS VGSESDSSKEETIYDTIRAT TEKPGGVKMEDLQGNTLVIR VVIQDLQQTKCIRFNPDATV WVAKQRILCTLNQGLKDVLN YGLFQPASNGRDGKFLDEER LLREYPQPMGQGVPSLEFRY KKRVYKQSNLDEKQLARLHT KTNLKKFMDHTQHRSVEKLV KLLDRGLDPNFHDLETGETP LTLAAQLDGSMEVIKALRNG GAHLDFRSRDGMTALHKAAR MRNQVALKTLLELGASPDYK DSYGLTPLYHTAIVGGDPYC CELLLHEHASVCCKDENGWH EIHQACRYGHVQHLEHLLFY GADMSAQNASGNTALHICAL YNQDSCARVLLFRGGDKELK NYNSQTPFQVAIIAGNFELA EYIKNHKETDI in isoform 7. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_006082212 – 239SQAET…SFDAA → MMSVPGGGAATVMMTGYNNG RYPRNSLY in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_020050382 – 395Missing in isoform 7. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_006083382 – 385Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 Publications4
Alternative sequenceiVSP_006084388 – 394Missing in isoform 3 and isoform 5. 3 Publications7
Alternative sequenceiVSP_006086468 – 483Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_006085468 – 476Missing in isoform 6. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF060116 mRNA Translation: AAC62226.1
AJ249562 mRNA Translation: CAB56522.1
AJ131899 mRNA Translation: CAB44314.1
AJ131899 mRNA Translation: CAB44312.1
AJ131899 mRNA Translation: CAB44313.1
AY298755 mRNA Translation: AAP85236.1
AF141903 mRNA Translation: AAF02497.1
AF159048 mRNA Translation: AAD42977.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...PIRi		T14272

NCBI Reference Sequences

More...RefSeqi		NP_001004133.1, NM_001004133.1
NP_597684.1, NM_133440.1 [Q9QX74-4]
NP_597685.1, NM_133441.1 [Q9QX74-2]
NP_958738.1, NM_201350.1 [Q9QX74-7]
XP_017444213.1, XM_017588724.1 [Q9QX74-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000071741; ENSRNOP00000067841; ENSRNOG00000050206 [Q9QX74-1]
ENSRNOT00000075078; ENSRNOP00000065891; ENSRNOG00000050206 [Q9QX74-7]
ENSRNOT00000092357; ENSRNOP00000075800; ENSRNOG00000050206 [Q9QX74-5]
ENSRNOT00000092386; ENSRNOP00000075919; ENSRNOG00000050206 [Q9QX74-4]
ENSRNOT00000092516; ENSRNOP00000075839; ENSRNOG00000050206 [Q9QX74-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		171093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:171093

UCSC genome browser

More...UCSCi		RGD:628772, rat [Q9QX74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060116 mRNA Translation: AAC62226.1
AJ249562 mRNA Translation: CAB56522.1
AJ131899 mRNA Translation: CAB44314.1
AJ131899 mRNA Translation: CAB44312.1
AJ131899 mRNA Translation: CAB44313.1
AY298755 mRNA Translation: AAP85236.1
AF141903 mRNA Translation: AAF02497.1
AF159048 mRNA Translation: AAD42977.1 Frameshift.
PIRiT14272
RefSeqiNP_001004133.1, NM_001004133.1
NP_597684.1, NM_133440.1 [Q9QX74-4]
NP_597685.1, NM_133441.1 [Q9QX74-2]
NP_958738.1, NM_201350.1 [Q9QX74-7]
XP_017444213.1, XM_017588724.1 [Q9QX74-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CPJNMR-A148-206[»]
SMRiQ9QX74
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi251104, 4 interactors
CORUMiQ9QX74
IntActiQ9QX74, 12 interactors
MINTiQ9QX74
STRINGi10116.ENSRNOP00000067841

PTM databases

GlyGeniQ9QX74, 1 site
iPTMnetiQ9QX74
PhosphoSitePlusiQ9QX74

Proteomic databases

jPOSTiQ9QX74
PaxDbiQ9QX74
PRIDEiQ9QX74

Genome annotation databases

EnsembliENSRNOT00000071741; ENSRNOP00000067841; ENSRNOG00000050206 [Q9QX74-1]
ENSRNOT00000075078; ENSRNOP00000065891; ENSRNOG00000050206 [Q9QX74-7]
ENSRNOT00000092357; ENSRNOP00000075800; ENSRNOG00000050206 [Q9QX74-5]
ENSRNOT00000092386; ENSRNOP00000075919; ENSRNOG00000050206 [Q9QX74-4]
ENSRNOT00000092516; ENSRNOP00000075839; ENSRNOG00000050206 [Q9QX74-2]
GeneIDi171093
KEGGirno:171093
UCSCiRGD:628772, rat [Q9QX74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22941
RGDi628772, Shank2

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
KOG4375, Eukaryota
GeneTreeiENSGT00940000153561
InParanoidiQ9QX74
KOiK15009

Enzyme and pathway databases

ReactomeiR-RNO-6794361, Neurexins and neuroligins

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9QX74

Gene expression databases

BgeeiENSRNOG00000050206, Expressed in frontal cortex and 18 other tissues
ExpressionAtlasiQ9QX74, baseline and differential
GenevisibleiQ9QX74, RN

Family and domain databases

Gene3Di1.10.150.50, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF17820, PDZ_6, 1 hit
PF00536, SAM_1, 1 hit
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHAN2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QX74
Secondary accession number(s): O70470
, Q6WB19, Q9QX93, Q9QZZ9, Q9WUV9, Q9WUW0, Q9WV46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: October 7, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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