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Entry version 152 (18 Sep 2019)
Sequence version 2 (28 Jun 2011)
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Protein

Protein SON

Gene

Son

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processCell cycle, mRNA processing, mRNA splicing, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SON
Alternative name(s):
Negative regulatory element-binding protein
Short name:
NRE-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Son
Synonyms:Nrebp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:98353 Son

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000720382 – 2444Protein SONAdd BLAST2443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei16N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei94PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei150PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1
Modified residuei284N6-acetyllysineBy similarity1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei945Omega-N-methylarginineBy similarity1
Modified residuei954PhosphothreonineBy similarity1
Modified residuei993PhosphoserineCombined sources1
Modified residuei1002Asymmetric dimethylarginineCombined sources1
Modified residuei1017Asymmetric dimethylarginineCombined sources1
Modified residuei1030PhosphoserineBy similarity1
Modified residuei1038PhosphoserineBy similarity1
Modified residuei1055PhosphoserineBy similarity1
Modified residuei1063PhosphoserineBy similarity1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1678PhosphoserineBy similarity1
Modified residuei1723PhosphoserineCombined sources1
Modified residuei1727PhosphoserineBy similarity1
Modified residuei1772PhosphoserineBy similarity1
Modified residuei1784PhosphoserineBy similarity1
Modified residuei1791PhosphoserineBy similarity1
Modified residuei1794PhosphoserineBy similarity1
Modified residuei1807PhosphoserineBy similarity1
Modified residuei1808PhosphoserineBy similarity1
Modified residuei1973PhosphoserineBy similarity1
Modified residuei1975PhosphoserineBy similarity1
Modified residuei1977PhosphoserineBy similarity1
Modified residuei2027PhosphoserineBy similarity1
Modified residuei2029PhosphoserineBy similarity1
Modified residuei2031PhosphoserineBy similarity1
Modified residuei2047PhosphoserineBy similarity1
Modified residuei2049PhosphoserineBy similarity1
Modified residuei2073N6-acetyllysine; alternateCombined sources1
Cross-linki2073Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki2110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2147PhosphoserineCombined sources1
Cross-linki2167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2181PhosphothreonineBy similarity1
Modified residuei2256PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QX47

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9QX47

PeptideAtlas

More...
PeptideAtlasi
Q9QX47

PRoteomics IDEntifications database

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PRIDEi
Q9QX47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QX47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QX47

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9QX47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By leptin. Highly expressed in hypothalamus following leptin injection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022961 Expressed in 339 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9QX47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9QX47 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SRSF2. Associates with the spliceosome (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RUNX1T1Q064554EBI-643037,EBI-743342From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203390, 2 interactors

Database of interacting proteins

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DIPi
DIP-49510N

Protein interaction database and analysis system

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IntActi
Q9QX47, 7 interactors

Molecular INTeraction database

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MINTi
Q9QX47

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000109671

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9QX47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1001 – 10061-16
Repeati1009 – 10141-26
Repeati1016 – 10211-36
Repeati1025 – 10301-46
Repeati1033 – 10381-56
Repeati1041 – 10461-66
Repeati1050 – 10551-76
Repeati1058 – 10631-86
Repeati1066 – 10711-96
Repeati1075 – 10801-106
Repeati1084 – 10891-116
Repeati1095 – 11001-126
Repeati1106 – 11111-136
Repeati1115 – 11201-146
Repeati1950 – 19562-17
Repeati1959 – 19773-1Add BLAST19
Repeati1978 – 19842-27
Repeati1985 – 19912-37
Repeati1992 – 19982-47
Repeati1999 – 20052-57
Repeati2006 – 20122-67
Repeati2013 – 20192-7; approximate7
Repeati2020 – 20303-2; approximateAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2323 – 2369G-patchPROSITE-ProRule annotationAdd BLAST47
Domaini2389 – 2444DRBMPROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni721 – 85013 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQMAdd BLAST130
Regioni907 – 98311 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]Add BLAST77
Regioni1001 – 112014 X 6 AA repeats of [ED]-R-S-M-M-SAdd BLAST120
Regioni1141 – 11733 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]Add BLAST33
Regioni1950 – 20197 X 7 AA repeats of P-S-R-R-S-R-[TS]Add BLAST70
Regioni1959 – 20302 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-SAdd BLAST72
Regioni2031 – 20573 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-RAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEDZ Eukaryota
ENOG410ZUK5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111141

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9QX47

Database of Orthologous Groups

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OrthoDBi
30934at2759

TreeFam database of animal gene trees

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TreeFami
TF330344

Family and domain databases

Conserved Domains Database

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CDDi
cd00048 DSRM, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014720 dsRBD_dom
IPR000467 G_patch_dom
IPR032922 SON
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR46528 PTHR46528, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF01585 G-patch, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00443 G_patch, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 1 hit
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QX47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADIEQVFR SFVVSKFREI QQELSSGRSE GQLNGETNPP IEGNQAGDTA
60 70 80 90 100
ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEASRKS RCVSVQTDPT
110 120 130 140 150
DEVPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKL KSHHDGNLES
160 170 180 190 200
DSFLKFDSEP SAAALEHPVR AFGLSEASET ALVLEPPVVS MEVQESHVLE
210 220 230 240 250
TLKPATKAAE LSVVSTSVIS EQSEQPMPGM LEPSMTKILD SFTAAPVPMS
260 270 280 290 300
TAALKSPEPV VTMSVEYQKS VLKSLETMPP ETSKTTLVEL PIAKVVEPSE
310 320 330 340 350
TLTIVSETPT EVHPEPSPST MDFPESSTTD VQRLPEQPVE APSEIADSSM
360 370 380 390 400
TRPQESLELP KTTAVELQES TVASALELPG PPATSILELQ GPPVTPVPEL
410 420 430 440 450
PGPSATPVPE LSGPLSTPVP ELPGPPATVV PELPGPSVTP VPQLSQELPG
460 470 480 490 500
PPAPSMGLEP PQEVPEPPVM AQELSGVPAV SAAIELTGQP AVTVAMELTE
510 520 530 540 550
QPVTTTEFEQ PVAMTTVEHP GHPEVTTATG LLGQPEAAMV LELPGQPVAT
560 570 580 590 600
TALELSGQPS VTGVPELSGL PSATRALELS GQSVATGALE LPGQLMATGA
610 620 630 640 650
LEFSGQSGAA GALELLGQPL ATGVLELPGQ PGAPELPGQP VATVALEISV
660 670 680 690 700
QSVVTTSELS TMTVSQSLEV PSTTALESYN TVAQELPTTL VGETSVTVGV
710 720 730 740 750
DPLMAQESHM LASNTMETHM LASNTMDSQM LASNTMDSQM LASNTMDSQM
760 770 780 790 800
LASSTMDSQM LASSTMDSQM LATSTMDSQM LATSSMDSQM LATSSMDSQM
810 820 830 840 850
LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM
860 870 880 890 900
LATSSMDSQM LASGAMDSQM LASGTMDAQM LASGTMDAQM LASSTQDSAM
910 920 930 940 950
MGSKSPDPYR LAQDPYRLAQ DPYRLGHDPY RLGHDAYRLG QDPYRLGHDP
960 970 980 990 1000
YRLTPDPYRV SPRPYRIAPR SYRIAPRPYR LAPRPLMLAS RRSMMMSYAA
1010 1020 1030 1040 1050
ERSMMSSYER SMMSYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAE
1060 1070 1080 1090 1100
RSMMSAYERS MMSAYERSMM SPMADRSMMS MGADRSMMSS YSAADRSMMS
1110 1120 1130 1140 1150
SYSAADRSMM SSYTDRSMMS MAADSYTDSY TDSYTEAYMV PPLPPEEPPT
1160 1170 1180 1190 1200
MPPLPPEEPP MTPPLPPEEP PEGPALSTEQ SALTADNTWS TEVTLSTGES
1210 1220 1230 1240 1250
LSQPEPPVSQ SEISEPMAVP ANYSMSESET SMLASEAVMT VPEPAREPES
1260 1270 1280 1290 1300
SVTSAPVESA VVAEHEMVPE RPMTYMVSET TMSVEPAVLT SEASVISETS
1310 1320 1330 1340 1350
ETYDSMRPSG HAISEVTMSL LEPAVTISQP AENSLELPSM TVPAPSTMTT
1360 1370 1380 1390 1400
TESPVVAVTE IPPVAVPEPP IMAVPELPTM AVVKTPAVAV PEPLVAAPEP
1410 1420 1430 1440 1450
PTMATPELCS LSVSEPPVAV SELPALADPE HAITAVSGVS SLEPSVPILE
1460 1470 1480 1490 1500
PAVSVLQPVM IVSEPSVPVQ EPTVAVSEPA VIVSEHTQIT SPEMAVESSP
1510 1520 1530 1540 1550
VIVDSSVMSS QIMKGMNLLG GDENLGPEVG MQETLLHPGE EPRDGGHLKS
1560 1570 1580 1590 1600
DLYENEYDRN ADLTVNSHLI VKDAEHNTVC ATTVGPVGEA SEEKILPISE
1610 1620 1630 1640 1650
TKEITELATC AAVSEADIGR SLSSQLALEL DTVGTSKGFE FVTASALISE
1660 1670 1680 1690 1700
SKYDVEVSVT TQDTEHDMVI STSPSGGSEA DIEGPLPAKD IHLDLPSTNF
1710 1720 1730 1740 1750
VCKDVEDSLP IKESAQAVAV ALSPKESSED TEVPLPNKEI VPESGYSASI
1760 1770 1780 1790 1800
DEINEADLVR PLLPKDMERL TSLRAGIEGP LLASEVERDK SAASPVVISI
1810 1820 1830 1840 1850
PERASESSSE EKDDYEIFVK VKDTHEKSKK NKNRDKGEKE KKRDSSLRSR
1860 1870 1880 1890 1900
SKRSKSSEHK SRKRTSESRS RARKRSSKSK SHRSQTRSRS RSRRRRRSSR
1910 1920 1930 1940 1950
SRSKSRGRRS VSKEKRKRSP KHRSKSRERK RKRSSSRDNR KAARARSRTP
1960 1970 1980 1990 2000
SRRSRSHTPS RRRRSRSVGR RRSFSISPSR RSRTPSRRSR TPSRRSRTPS
2010 2020 2030 2040 2050
RRSRTPSRRS RTPSRRRRSR SAVRRRSFSI SPVRLRRSRT PLRRRFSRSP
2060 2070 2080 2090 2100
IRRKRSRSSE RGRSPKRLTD LDKAQLLEIA KANAAAMCAK AGVPLPPNLK
2110 2120 2130 2140 2150
PAPPPTIEEK VAKKSGGATI EELTEKCKQI AQSKEDDDVI VNKPHVSDEE
2160 2170 2180 2190 2200
EEEPPFYHHP FKLSEPKPIF FNLNIAAAKP TPPKSQVTLT KEFPVSSGSQ
2210 2220 2230 2240 2250
HRKKEADSVY GEWVPVEKNG EESKDDDNVF SSSLPSEPVD ISTAMSERAL
2260 2270 2280 2290 2300
AQKRLSENAF DLEAMSMLNR AQERIDAWAQ LNSIPGQFTG STGVQVLTQE
2310 2320 2330 2340 2350
QLANTGAQAW IKKDQFLRAA PVTGGMGAVL MRKMGWREGE GLGKNKEGNK
2360 2370 2380 2390 2400
EPILVDFKTD RKGLVAVGER AQKRSGNFSA AMKDLSGKHP VSALMEICNK
2410 2420 2430 2440
RRWQPPEFLL VHDSGPDHRK HFLFRVLRNG SPYQPNCMFF LNRY
Length:2,444
Mass (Da):265,651
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE873ADCB51B7123B
GO
Isoform 2 (identifier: Q9QX47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2126-2126: K → F
     2127-2444: Missing.

Show »
Length:2,126
Mass (Da):230,022
Checksum:iD977785966267327
GO
Isoform 3 (identifier: Q9QX47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-815: Missing.

Show »
Length:2,404
Mass (Da):261,443
Checksum:i6163EBD3D5E8FB95
GO
Isoform 4 (identifier: Q9QX47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-815: Missing.
     2238-2444: PVDISTAMSE...PNCMFFLNRY → GRVKRQGRVK...SRLYSSRFWW

Show »
Length:2,281
Mass (Da):247,971
Checksum:i10ABA0C4E10F6C03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV00H9KV00_MOUSE
Protein SON
Son
2,477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV01H9KV01_MOUSE
Protein SON
Son
2,321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV02H9KV02_MOUSE
Protein SON
Son
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV15H9KV15_MOUSE
Protein SON
Son
2,343Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CU80F7CU80_MOUSE
Protein SON
Son
478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH46419 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti857D → E in AAF23120 (PubMed:10950926).Curated1
Sequence conflicti857D → E in AAF23121 (PubMed:10950926).Curated1
Sequence conflicti857D → E in BAJ40169 (PubMed:20876580).Curated1
Sequence conflicti1333N → D in AAF23120 (PubMed:10950926).Curated1
Sequence conflicti1333N → D in AAF23121 (PubMed:10950926).Curated1
Sequence conflicti1734P → L in AAF23120 (PubMed:10950926).Curated1
Sequence conflicti1734P → L in AAF23121 (PubMed:10950926).Curated1
Sequence conflicti1966R → I in AAF23120 (PubMed:10950926).Curated1
Sequence conflicti1966R → I in AAF23121 (PubMed:10950926).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041557776 – 815Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_0044162126K → F in isoform 2. Curated1
Alternative sequenceiVSP_0044172127 – 2444Missing in isoform 2. CuratedAdd BLAST318
Alternative sequenceiVSP_0415582238 – 2444PVDIS…FLNRY → GRVKRQGRVKRQMKQPAASH LTVTRCNSLCGTKPQSEKHR IAEKSVITSLPNIGPSMHLW EGSPRYNYLASRFASRLYSS RFWW in isoform 4. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF193606
, AF193595, AF193596, AF193597, AF193598, AF193599, AF193600, AF193601, AF193602, AF193603, AF193604, AF193605 Genomic DNA Translation: AAF23120.1
AF193607 mRNA Translation: AAF23121.1
AB546195 mRNA Translation: BAJ40169.1
AC131691 Genomic DNA No translation available.
BC046419 mRNA Translation: AAH46419.1 Sequence problems.
AK019312 mRNA Translation: BAB31659.1
AK019081 mRNA Translation: BAB31536.1
AK008478 mRNA Translation: BAB25691.1
AK008256 mRNA Translation: BAB25562.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37399.1 [Q9QX47-1]
CCDS37400.1 [Q9QX47-2]

NCBI Reference Sequences

More...
RefSeqi
NP_849211.3, NM_178880.4 [Q9QX47-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000114036; ENSMUSP00000109670; ENSMUSG00000022961 [Q9QX47-2]
ENSMUST00000114037; ENSMUSP00000109671; ENSMUSG00000022961 [Q9QX47-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20658

UCSC genome browser

More...
UCSCi
uc007zxy.1 mouse [Q9QX47-2]
uc007zxz.1 mouse [Q9QX47-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193606
, AF193595, AF193596, AF193597, AF193598, AF193599, AF193600, AF193601, AF193602, AF193603, AF193604, AF193605 Genomic DNA Translation: AAF23120.1
AF193607 mRNA Translation: AAF23121.1
AB546195 mRNA Translation: BAJ40169.1
AC131691 Genomic DNA No translation available.
BC046419 mRNA Translation: AAH46419.1 Sequence problems.
AK019312 mRNA Translation: BAB31659.1
AK019081 mRNA Translation: BAB31536.1
AK008478 mRNA Translation: BAB25691.1
AK008256 mRNA Translation: BAB25562.1
CCDSiCCDS37399.1 [Q9QX47-1]
CCDS37400.1 [Q9QX47-2]
RefSeqiNP_849211.3, NM_178880.4 [Q9QX47-1]

3D structure databases

SMRiQ9QX47
ModBaseiSearch...

Protein-protein interaction databases

BioGridi203390, 2 interactors
DIPiDIP-49510N
IntActiQ9QX47, 7 interactors
MINTiQ9QX47
STRINGi10090.ENSMUSP00000109671

PTM databases

iPTMnetiQ9QX47
PhosphoSitePlusiQ9QX47
SwissPalmiQ9QX47

Proteomic databases

jPOSTiQ9QX47
PaxDbiQ9QX47
PeptideAtlasiQ9QX47
PRIDEiQ9QX47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114036; ENSMUSP00000109670; ENSMUSG00000022961 [Q9QX47-2]
ENSMUST00000114037; ENSMUSP00000109671; ENSMUSG00000022961 [Q9QX47-1]
GeneIDi20658
KEGGimmu:20658
UCSCiuc007zxy.1 mouse [Q9QX47-2]
uc007zxz.1 mouse [Q9QX47-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6651
MGIiMGI:98353 Son

Phylogenomic databases

eggNOGiENOG410IEDZ Eukaryota
ENOG410ZUK5 LUCA
GeneTreeiENSGT00730000111141
InParanoidiQ9QX47
OrthoDBi30934at2759
TreeFamiTF330344

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Son mouse

Protein Ontology

More...
PROi
PR:Q9QX47

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022961 Expressed in 339 organ(s), highest expression level in retina
ExpressionAtlasiQ9QX47 baseline and differential
GenevisibleiQ9QX47 MM

Family and domain databases

CDDicd00048 DSRM, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR000467 G_patch_dom
IPR032922 SON
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR46528 PTHR46528, 2 hits
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSON_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QX47
Secondary accession number(s): E3WC91
, E9PXW2, E9Q3H8, E9Q3I0, E9Q6M4, E9Q7G2, E9QAR8, E9QMT0, Q811G3, Q9CQ12, Q9CQK6, Q9QXP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 28, 2011
Last modified: September 18, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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