Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Short transient receptor potential channel 5

Gene

Trpc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

Activity regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
TrpC5
Alternative name(s):
Capacitative calcium entry channel 2
Short name:
CCE2
Transient receptor protein 5
Short name:
TRP-5
Short name:
mTRP5
Trp-related protein 5
Gene namesi
Name:Trpc5
Synonyms:Trp5, Trrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:109524 Trpc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 330CytoplasmicSequence analysisAdd BLAST330
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 398ExtracellularSequence analysisAdd BLAST47
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 470ExtracellularSequence analysisAdd BLAST12
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 512CytoplasmicSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 603ExtracellularSequence analysisAdd BLAST70
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 975CytoplasmicSequence analysisAdd BLAST351

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153191 – 975Short transient receptor potential channel 5Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QX29
PaxDbiQ9QX29
PRIDEiQ9QX29

PTM databases

iPTMnetiQ9QX29
PhosphoSitePlusiQ9QX29

Expressioni

Tissue specificityi

Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus.1 Publication

Gene expression databases

BgeeiENSMUSG00000041710 Expressed in 61 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ9QX29 baseline and differential
GenevisibleiQ9QX29 MM

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts (via C-terminus) with CABP1. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204331, 1 interactor
DIPiDIP-40847N
IntActiQ9QX29, 2 interactors
MINTiQ9QX29
STRINGi10090.ENSMUSP00000049063

Structurei

3D structure databases

ProteinModelPortaliQ9QX29
SMRiQ9QX29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati69 – 97ANK 2Add BLAST29
Repeati98 – 124ANK 3Add BLAST27
Repeati141 – 170ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni971 – 973Essential for binding to NHERF PDZ domainBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi690 – 693Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiQ9QX29
KOiK04968
OMAiSCMKWRR
OrthoDBiEOG091G029I
PhylomeDBiQ9QX29
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005461 TRPC5_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF24 PTHR10117:SF24, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01646 TRPCHANNEL5
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QX29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT
710 720 730 740 750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ RDDTNDGSGG ARAKSKSVSF
810 820 830 840 850
NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG PSFKKLGLFF
860 870 880 890 900
SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM
910 920 930 940 950
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE
960 970
TWGEACDLLM HKWGDGQEEQ VTTRL
Length:975
Mass (Da):111,458
Last modified:June 20, 2001 - v2
Checksum:iDF9248168D3D2D62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029983 mRNA Translation: AAC13550.1
AF060107 mRNA Translation: AAF02200.1
AJ006204 mRNA Translation: CAA06912.1
CCDSiCCDS30457.1
RefSeqiNP_033454.1, NM_009428.3
UniGeneiMm.328378
Mm.82621

Genome annotation databases

EnsembliENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710
GeneIDi22067
KEGGimmu:22067
UCSCiuc009umv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029983 mRNA Translation: AAC13550.1
AF060107 mRNA Translation: AAF02200.1
AJ006204 mRNA Translation: CAA06912.1
CCDSiCCDS30457.1
RefSeqiNP_033454.1, NM_009428.3
UniGeneiMm.328378
Mm.82621

3D structure databases

ProteinModelPortaliQ9QX29
SMRiQ9QX29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204331, 1 interactor
DIPiDIP-40847N
IntActiQ9QX29, 2 interactors
MINTiQ9QX29
STRINGi10090.ENSMUSP00000049063

Chemistry databases

GuidetoPHARMACOLOGYi490

PTM databases

iPTMnetiQ9QX29
PhosphoSitePlusiQ9QX29

Proteomic databases

MaxQBiQ9QX29
PaxDbiQ9QX29
PRIDEiQ9QX29

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710
GeneIDi22067
KEGGimmu:22067
UCSCiuc009umv.1 mouse

Organism-specific databases

CTDi7224
MGIiMGI:109524 Trpc5

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiQ9QX29
KOiK04968
OMAiSCMKWRR
OrthoDBiEOG091G029I
PhylomeDBiQ9QX29
TreeFamiTF313147

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Miscellaneous databases

PROiPR:Q9QX29
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041710 Expressed in 61 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ9QX29 baseline and differential
GenevisibleiQ9QX29 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005461 TRPC5_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF24 PTHR10117:SF24, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01646 TRPCHANNEL5
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC5_MOUSE
AccessioniPrimary (citable) accession number: Q9QX29
Secondary accession number(s): Q61059, Q9QWT1, Q9R0D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 12, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again