Trpc5

Functionⁱ

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

Activity regulationⁱ

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.By similarity

GO - Molecular functionⁱ

actin binding Source: MGI
actinin binding Source: MGI
ATPase binding Source: MGI
calcium channel activity Source: MGI
clathrin binding Source: MGI
inositol 1,4,5 trisphosphate binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 14505576
store-operated calcium channel activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

manganese ion transport Source: GO_Central
negative regulation of dendrite morphogenesis Source: MGI
neuron differentiation Source: Ensembl
positive regulation of axon extension Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of cytosolic calcium ion concentration Source: MGI
positive regulation of neuron differentiation Source: MGI
positive regulation of peptidyl-threonine phosphorylation Source: MGI
regulation of cytosolic calcium ion concentration Source: GO_Central
regulation of membrane hyperpolarization Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calcium channel, Ion channel
Biological process	Calcium transport, Ion transport, Transport
Ligand	Calcium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3295583 TRP channels

Reactomeⁱ

R-MMU-3295583 TRP channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Short transient receptor potential channel 5 Short name: TrpC5 Alternative name(s): Capacitative calcium entry channel 2 Short name: CCE2 Transient receptor protein 5 Short name: TRP-5 Short name: mTRP5 Trp-related protein 5
Gene namesⁱ	Name:Trpc5 Synonyms:Trp5, Trrp5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:109524 Trpc5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 330	CytoplasmicSequence analysisAdd BLAST	330
Transmembraneⁱ	331 – 351	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	352 – 398	ExtracellularSequence analysisAdd BLAST	47
Transmembraneⁱ	399 – 419	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	420 – 437	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	438 – 458	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	459 – 470	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	471 – 491	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	492 – 512	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	513 – 533	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	534 – 603	ExtracellularSequence analysisAdd BLAST	70
Transmembraneⁱ	604 – 624	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	625 – 975	CytoplasmicSequence analysisAdd BLAST	351

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	490

GuidetoPHARMACOLOGYⁱ

490

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215319	1 – 975	Short transient receptor potential channel 5Add BLAST		975

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	461	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QX29
PaxDbⁱ	Q9QX29
PRIDEⁱ	Q9QX29

PTM databases

iPTMnetⁱ	Q9QX29
PhosphoSitePlusⁱ	Q9QX29

Expressionⁱ

Tissue specificityⁱ

Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000041710 Expressed in 61 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasⁱ	Q9QX29 baseline and differential
Genevisibleⁱ	Q9QX29 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts (via C-terminus) with CABP1. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP.By similarity2 Publications

GO - Molecular functionⁱ

actin binding Source: MGI
actinin binding Source: MGI
ATPase binding Source: MGI
clathrin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204331, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-40847N
IntActⁱ	Q9QX29, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9QX29
STRINGⁱ	10090.ENSMUSP00000049063

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QX29
SMRⁱ	Q9QX29
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	31 – 60	ANK 1Add BLAST	30
Repeatⁱ	69 – 97	ANK 2Add BLAST	29
Repeatⁱ	98 – 124	ANK 3Add BLAST	27
Repeatⁱ	141 – 170	ANK 4Add BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	971 – 973	Essential for binding to NHERF PDZ domainBy similarity		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	690 – 693	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3609 Eukaryota ENOG410XQ0Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119180
HOGENOMⁱ	HOG000020589
HOVERGENⁱ	HBG068337
InParanoidⁱ	Q9QX29
KEGG Orthology (KO) More...KOⁱ	K04968
OMAⁱ	SCMKWRR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029I
PhylomeDBⁱ	Q9QX29
TreeFamⁱ	TF313147

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR005821 Ion_trans_dom IPR004729 TRP_channel IPR013555 TRP_dom IPR005461 TRPC5_channel IPR002153 TRPC_channel
PANTHERⁱ	PTHR10117 PTHR10117, 1 hit PTHR10117:SF24 PTHR10117:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00520 Ion_trans, 1 hit PF08344 TRP_2, 1 hit
PRINTSⁱ	PR01097 TRNSRECEPTRP PR01646 TRPCHANNEL5
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
TIGRFAMsⁱ	TIGR00870 trp, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QX29-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ 
        60         70         80         90        100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL 
       110        120        130        140        150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA 
       160        170        180        190        200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY 
       210        220        230        240        250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL 
       260        270        280        290        300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE 
       310        320        330        340        350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI 
       360        370        380        390        400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP 
       410        420        430        440        450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI 
       460        470        480        490        500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN 
       510        520        530        540        550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP 
       560        570        580        590        600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV 
       610        620        630        640        650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY 
       660        670        680        690        700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT 
       710        720        730        740        750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI 
       760        770        780        790        800
SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ RDDTNDGSGG ARAKSKSVSF 
       810        820        830        840        850
NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG PSFKKLGLFF 
       860        870        880        890        900
SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM 
       910        920        930        940        950
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE 
       960        970 
TWGEACDLLM HKWGDGQEEQ VTTRL

Length:975

Mass (Da):111,458

Last modified:June 20, 2001 - v2

Checksum:ⁱDF9248168D3D2D62

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029983 mRNA Translation: AAC13550.1 AF060107 mRNA Translation: AAF02200.1 AJ006204 mRNA Translation: CAA06912.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30457.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033454.1, NM_009428.3
UniGeneⁱ	Mm.328378 Mm.82621

Genome annotation databases

Ensemblⁱ	ENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710
GeneIDⁱ	22067
KEGGⁱ	mmu:22067
UCSC genome browser More...UCSCⁱ	uc009umv.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QX29	Transient receptor potential cation channel, subfamily C, member 5		MOUSE		975	UniRef100_Q9QX29

Protein	Similar proteins		Species	Score	Length	Source
Q9QX29	Short transient receptor potential channel 5		HUMAN		973	UniRef90_Q9UL62
Short transient receptor potential channel 5		RABIT		974
TRPC5 isoform 1		PANTR		973
Uncharacterized protein		PANPA		973
Transient receptor potential cation channel, subfamily C, member 5		MOUSE		975
+97

Protein	Similar proteins		Species	Score	Length	Source
Q9QX29	Short transient receptor potential channel 4		HUMAN		977	UniRef50_Q9UBN4
Short transient receptor potential channel 4		BOVIN		979
Short transient receptor potential channel 4		RAT		977
Short transient receptor potential channel 4	)	MOUSE		974
Short transient receptor potential channel 5		RABIT		974
+760

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029983 mRNA Translation: AAC13550.1 AF060107 mRNA Translation: AAF02200.1 AJ006204 mRNA Translation: CAA06912.1
CCDSⁱ	CCDS30457.1
RefSeqⁱ	NP_033454.1, NM_009428.3
UniGeneⁱ	Mm.328378 Mm.82621

3D structure databases

ProteinModelPortalⁱ	Q9QX29
SMRⁱ	Q9QX29
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204331, 1 interactor
DIPⁱ	DIP-40847N
IntActⁱ	Q9QX29, 2 interactors
MINTⁱ	Q9QX29
STRINGⁱ	10090.ENSMUSP00000049063

Chemistry databases

GuidetoPHARMACOLOGYⁱ	490

GuidetoPHARMACOLOGYⁱ

490

PTM databases

iPTMnetⁱ	Q9QX29
PhosphoSitePlusⁱ	Q9QX29

Proteomic databases

MaxQBⁱ	Q9QX29
PaxDbⁱ	Q9QX29
PRIDEⁱ	Q9QX29

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710
GeneIDⁱ	22067
KEGGⁱ	mmu:22067
UCSCⁱ	uc009umv.1 mouse

Organism-specific databases

CTDⁱ	7224
MGIⁱ	MGI:109524 Trpc5

Phylogenomic databases

eggNOGⁱ	KOG3609 Eukaryota ENOG410XQ0Y LUCA
GeneTreeⁱ	ENSGT00760000119180
HOGENOMⁱ	HOG000020589
HOVERGENⁱ	HBG068337
InParanoidⁱ	Q9QX29
KOⁱ	K04968
OMAⁱ	SCMKWRR
OrthoDBⁱ	EOG091G029I
PhylomeDBⁱ	Q9QX29
TreeFamⁱ	TF313147

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3295583 TRP channels

Reactomeⁱ

R-MMU-3295583 TRP channels

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QX29
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000041710 Expressed in 61 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasⁱ	Q9QX29 baseline and differential
Genevisibleⁱ	Q9QX29 MM

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR005821 Ion_trans_dom IPR004729 TRP_channel IPR013555 TRP_dom IPR005461 TRPC5_channel IPR002153 TRPC_channel
PANTHERⁱ	PTHR10117 PTHR10117, 1 hit PTHR10117:SF24 PTHR10117:SF24, 1 hit
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00520 Ion_trans, 1 hit PF08344 TRP_2, 1 hit
PRINTSⁱ	PR01097 TRNSRECEPTRP PR01646 TRPCHANNEL5
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
TIGRFAMsⁱ	TIGR00870 trp, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRPC5_MOUSE
Accessionⁱ	Q9QX29Primary (citable) accession number: Q9QX29 Secondary accession number(s): Q61059, Q9QWT1, Q9R0D4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	June 20, 2001
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QX29 (TRPC5_MOUSE)

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Short transient receptor potential channel 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ