UniProtKB - Q9QX29 (TRPC5_MOUSE)
Short transient receptor potential channel 5
Trpc5
Functioni
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity).
Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (PubMed:32110987).
By similarity1 PublicationActivity regulationi
GO - Molecular functioni
- actin binding Source: MGI
- actinin binding Source: MGI
- ATPase binding Source: MGI
- calcium channel activity Source: MGI
- clathrin binding Source: MGI
- inositol 1,4,5 trisphosphate binding Source: BHF-UCL
- store-operated calcium channel activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- manganese ion transport Source: GO_Central
- negative regulation of dendrite morphogenesis Source: MGI
- neuron apoptotic process Source: UniProtKB
- neuron differentiation Source: Ensembl
- phosphatidylserine exposure on apoptotic cell surface Source: UniProtKB
- positive regulation of axon extension Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of peptidyl-threonine phosphorylation Source: MGI
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of membrane hyperpolarization Source: MGI
Keywordsi
Molecular function | Calcium channel, Ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-MMU-3295583, TRP channels |
Names & Taxonomyi
Protein namesi | Recommended name: Short transient receptor potential channel 5Short name: TrpC5 Alternative name(s): Capacitative calcium entry channel 2 Short name: CCE2 Transient receptor protein 5 Short name: TRP-5 Short name: mTRP5 Trp-related protein 5 |
Gene namesi | Name:Trpc5 Synonyms:Trp5, Trrp5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109524, Trpc5 |
VEuPathDBi | HostDB:ENSMUSG00000041710 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- calcium channel complex Source: MGI
- cation channel complex Source: GO_Central
- cytoplasm Source: MGI
- dendrite Source: MGI
- growth cone Source: MGI
- membrane raft Source: MGI
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 330 | CytoplasmicSequence analysisAdd BLAST | 330 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 352 – 398 | ExtracellularSequence analysisAdd BLAST | 47 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 420 – 437 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 438 – 458 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 459 – 470 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 471 – 491 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 492 – 512 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 513 – 533 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 534 – 603 | ExtracellularSequence analysisAdd BLAST | 70 | |
Transmembranei | 604 – 624 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 625 – 975 | CytoplasmicSequence analysisAdd BLAST | 351 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215319 | 1 – 975 | Short transient receptor potential channel 5Add BLAST | 975 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q9QX29 |
PaxDbi | Q9QX29 |
PRIDEi | Q9QX29 |
ProteomicsDBi | 300017 |
PTM databases
GlyGeni | Q9QX29, 1 site |
iPTMneti | Q9QX29 |
PhosphoSitePlusi | Q9QX29 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000041710, Expressed in supraoptic nucleus and 85 other tissues |
ExpressionAtlasi | Q9QX29, baseline and differential |
Genevisiblei | Q9QX29, MM |
Interactioni
Subunit structurei
Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity).
Interacts (via C-terminus) with CABP1 (PubMed:15895247).
Interacts with SLC9A3R1/NHERF (PubMed:10980202).
Interacts with MX1 and RNF24 (By similarity).
Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity).
Interacts with TRPC4AP (PubMed:20458742).
Interacts with PLSCR1 (PubMed:32110987).
By similarity4 PublicationsGO - Molecular functioni
- actin binding Source: MGI
- actinin binding Source: MGI
- ATPase binding Source: MGI
- clathrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204331, 2 interactors |
DIPi | DIP-40847N |
IntActi | Q9QX29, 2 interactors |
MINTi | Q9QX29 |
STRINGi | 10090.ENSMUSP00000049063 |
Chemistry databases
BindingDBi | Q9QX29 |
Miscellaneous databases
RNActi | Q9QX29, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9QX29 |
SMRi | Q9QX29 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 31 – 60 | ANK 1Add BLAST | 30 | |
Repeati | 69 – 97 | ANK 2Add BLAST | 29 | |
Repeati | 98 – 124 | ANK 3Add BLAST | 27 | |
Repeati | 141 – 170 | ANK 4Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 766 – 795 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 816 – 838 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 971 – 973 | Essential for binding to SLC9A3R1 PDZ domain1 Publication | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 767 – 795 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3609, Eukaryota |
GeneTreei | ENSGT00990000203600 |
HOGENOMi | CLU_005716_4_1_1 |
InParanoidi | Q9QX29 |
OMAi | ACSQSEM |
OrthoDBi | 824310at2759 |
PhylomeDBi | Q9QX29 |
TreeFami | TF313147 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005461, TRPC5_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit PTHR10117:SF76, PTHR10117:SF76, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP PR01646, TRPCHANNEL5 |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT
710 720 730 740 750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ RDDTNDGSGG ARAKSKSVSF
810 820 830 840 850
NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG PSFKKLGLFF
860 870 880 890 900
SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM
910 920 930 940 950
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE
960 970
TWGEACDLLM HKWGDGQEEQ VTTRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029983 mRNA Translation: AAC13550.1 AF060107 mRNA Translation: AAF02200.1 AJ006204 mRNA Translation: CAA06912.1 |
CCDSi | CCDS30457.1 |
RefSeqi | NP_033454.1, NM_009428.3 |
Genome annotation databases
Ensembli | ENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710 |
GeneIDi | 22067 |
KEGGi | mmu:22067 |
UCSCi | uc009umv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029983 mRNA Translation: AAC13550.1 AF060107 mRNA Translation: AAF02200.1 AJ006204 mRNA Translation: CAA06912.1 |
CCDSi | CCDS30457.1 |
RefSeqi | NP_033454.1, NM_009428.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AEI | electron microscopy | 2.89 | A/B/C/D | 1-765 | [»] | |
AlphaFoldDBi | Q9QX29 | |||||
SMRi | Q9QX29 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204331, 2 interactors |
DIPi | DIP-40847N |
IntActi | Q9QX29, 2 interactors |
MINTi | Q9QX29 |
STRINGi | 10090.ENSMUSP00000049063 |
Chemistry databases
BindingDBi | Q9QX29 |
ChEMBLi | CHEMBL4523481 |
GuidetoPHARMACOLOGYi | 490 |
PTM databases
GlyGeni | Q9QX29, 1 site |
iPTMneti | Q9QX29 |
PhosphoSitePlusi | Q9QX29 |
Proteomic databases
MaxQBi | Q9QX29 |
PaxDbi | Q9QX29 |
PRIDEi | Q9QX29 |
ProteomicsDBi | 300017 |
Protocols and materials databases
ABCDi | Q9QX29, 1 sequenced antibody |
Antibodypediai | 356, 304 antibodies from 31 providers |
DNASUi | 22067 |
Genome annotation databases
Ensembli | ENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710 |
GeneIDi | 22067 |
KEGGi | mmu:22067 |
UCSCi | uc009umv.1, mouse |
Organism-specific databases
CTDi | 7224 |
MGIi | MGI:109524, Trpc5 |
VEuPathDBi | HostDB:ENSMUSG00000041710 |
Phylogenomic databases
eggNOGi | KOG3609, Eukaryota |
GeneTreei | ENSGT00990000203600 |
HOGENOMi | CLU_005716_4_1_1 |
InParanoidi | Q9QX29 |
OMAi | ACSQSEM |
OrthoDBi | 824310at2759 |
PhylomeDBi | Q9QX29 |
TreeFami | TF313147 |
Enzyme and pathway databases
Reactomei | R-MMU-3295583, TRP channels |
Miscellaneous databases
BioGRID-ORCSi | 22067, 0 hits in 72 CRISPR screens |
PROi | PR:Q9QX29 |
RNActi | Q9QX29, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041710, Expressed in supraoptic nucleus and 85 other tissues |
ExpressionAtlasi | Q9QX29, baseline and differential |
Genevisiblei | Q9QX29, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005461, TRPC5_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit PTHR10117:SF76, PTHR10117:SF76, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP PR01646, TRPCHANNEL5 |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPC5_MOUSE | |
Accessioni | Q9QX29Primary (citable) accession number: Q9QX29 Secondary accession number(s): Q61059, Q9QWT1, Q9R0D4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | June 20, 2001 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families