UniProtKB - Q9QX27 (ST18_RAT)
Protein
Suppression of tumorigenicity 18 protein
Gene
St18
Organism
Rattus norvegicus (Rat)
Status
Functioni
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 344 – 387 | CCHHC-type 1PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 388 – 431 | CCHHC-type 2PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 700 – 743 | CCHHC-type 3PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 744 – 787 | CCHHC-type 4PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 792 – 835 | CCHHC-type 5PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 845 – 888 | CCHHC-type 6PROSITE-ProRule annotationAdd BLAST | 44 |
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- zinc ion binding Source: InterPro
GO - Biological processi
- interleukin-1-mediated signaling pathway Source: RGD
- interleukin-6-mediated signaling pathway Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- tumor necrosis factor-mediated signaling pathway Source: RGD
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Suppression of tumorigenicity 18 proteinAlternative name(s): C2-HC type zinc finger protein r-MyT3 Neural zinc finger factor 3 Short name: NZF-3 |
Gene namesi | Name:St18 Synonyms:Nzf3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708566, St18 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: RGD
Other locations
- protein-DNA complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234032 | 1 – 1032 | Suppression of tumorigenicity 18 proteinAdd BLAST | 1032 |
Proteomic databases
PaxDbi | Q9QX27 |
PRIDEi | Q9QX27 |
Expressioni
Tissue specificityi
Detected in brain.1 Publication
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 905 – 974 | Sequence analysisAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the MYT1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 344 – 387 | CCHHC-type 1PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 388 – 431 | CCHHC-type 2PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 700 – 743 | CCHHC-type 3PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 744 – 787 | CCHHC-type 4PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 792 – 835 | CCHHC-type 5PROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 845 – 888 | CCHHC-type 6PROSITE-ProRule annotationAdd BLAST | 44 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3803, Eukaryota |
InParanoidi | Q9QX27 |
PhylomeDBi | Q9QX27 |
Family and domain databases
InterProi | View protein in InterPro IPR013681, Myelin_TF IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF08474, MYT1, 1 hit PF01530, zf-C2HC, 6 hits |
SUPFAMi | SSF103637, SSF103637, 6 hits |
PROSITEi | View protein in PROSITE PS51802, ZF_CCHHC, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9QX27-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQRLKIKRCI LSQKEPKVAY DCSMAKKRRA EEQALGVPVN KRKSLLMKPR
60 70 80 90 100
HYSPDMDCKE NPDNRNEDDG LETNDHSTAD EIVVKPMDKT LHLPAQESSL
110 120 130 140 150
PKEDQYACYP ELMVKSLMHL GKFEESESVQ TVGENLNGNG IQSLKAECDE
160 170 180 190 200
ANECFMVHSD DGRDKVHHSQ PPFCSSGDSE SDSDNTENGW GSGSNSSEDT
210 220 230 240 250
DTHKGPKRKL TYNRKDLLEV PEIKAEDDKF IPCENRCDSD TSGRDPQNSH
260 270 280 290 300
MEPLAVKVQP SFPEVEESES LATVIAESAE VEKAKGSLSL LEQAIALQAE
310 320 330 340 350
RGSVFHHTYK ELDRFLLDHL ARQRRQPKVT DASGRQIFNN KHSPRPERRE
360 370 380 390 400
AKCPIPGCDG TGHVTGLYPH HRSLSGCPHK VRVPLEILAM HENVLKCPTP
410 420 430 440 450
GCTGRGHVNS NRNTHRSLSG CPIAAAEKLA MTQDKSQLDS SQTGQGPEQA
460 470 480 490 500
HRVNLVKQIE FNFRSQAITS PRASASKEQE KFGKVPFDYA SFDAQVFGKR
510 520 530 540 550
PLLQTGQGQK APPFPESKHF SNPVKFSNGL PSAGAHTQST VRASSYGHGQ
560 570 580 590 600
YSEDTHIAAA AAILNLSTRC REATDILSNK PQSLRAKGAE IEVDENGTLD
610 620 630 640 650
LSMKKNRILD KSIPPTSSHT TIATPSSSPF KASSLLVNAA FYQALCDQEG
660 670 680 690 700
WNVPINYSKS HGKTEEEKEK DPVNSLENLE EKKFAGEASI PSPKPKLHTR
710 720 730 740 750
DLKKELITCP TPGCDGSGHV TGNYASHRSV SGCPLADKTL KSLMAANSQE
760 770 780 790 800
LKCPTPGCDG SGHVTGNYAS HRSLSGCPRA RKGGIKMTPT KEEKEDSELR
810 820 830 840 850
CPVIGCDGQG HISGKYTSHR TASGCPLAAK RQKENPLNGT PLSWKLNKQE
860 870 880 890 900
LPHCPLPGCN GLGHVNNVFV THRSLSGCPL NAQAIKKVKV SEELMTIKLK
910 920 930 940 950
ATGGIEGDEE IRHLDEEIKE LNESNLKIEA DMMKLQTQIT SMESNLKTIE
960 970 980 990 1000
EENKLIEQSN ESLLKELAGL SQALISSLAD IQLPQMGPIN EQNFEAYVNT
1010 1020 1030
LTDMYSNLER DYSPECKALL ESIKQAVKGI HV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3ZTP6 | D3ZTP6_RAT | Suppression of tumorigenicity 18 pr... | St18 rCG_30431 | 1,044 | Annotation score: | ||
A0A0G2KAF8 | A0A0G2KAF8_RAT | Suppression of tumorigenicity 18 pr... | St18 | 1,032 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | G → N in AAC40048 (PubMed:8980226).Curated | 1 | |
Sequence conflicti | 74 | N → P in AAC40048 (PubMed:8980226).Curated | 1 | |
Sequence conflicti | 157 | V → E in AAB40717 (PubMed:9478997).Curated | 1 | |
Sequence conflicti | 255 | A → S in AAB40717 (PubMed:9478997).Curated | 1 | |
Sequence conflicti | 606 | N → H in AAC40048 (PubMed:8980226).Curated | 1 | |
Sequence conflicti | 614 – 615 | PP → GG in AAB40717 (PubMed:9478997).Curated | 2 | |
Sequence conflicti | 751 | L → V in AAB40717 (PubMed:9478997).Curated | 1 | |
Sequence conflicti | 840 | Missing in AAB40717 (PubMed:9478997).Curated | 1 | |
Sequence conflicti | 1027 | V → A in AAC40048 (PubMed:8980226).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018195 | 1 – 17 | MQRLK…QKEPK → MDSLIPELR in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67080 mRNA Translation: AAB40717.1 AF031942 mRNA Translation: AAC40048.1 |
PIRi | T14124 T31669 |
RefSeqi | NP_695222.2, NM_153310.2 |
Genome annotation databases
GeneIDi | 266680 |
KEGGi | rno:266680 |
UCSCi | RGD:708566, rat [Q9QX27-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67080 mRNA Translation: AAB40717.1 AF031942 mRNA Translation: AAC40048.1 |
PIRi | T14124 T31669 |
RefSeqi | NP_695222.2, NM_153310.2 |
3D structure databases
SMRi | Q9QX27 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000056380 |
Proteomic databases
PaxDbi | Q9QX27 |
PRIDEi | Q9QX27 |
Genome annotation databases
GeneIDi | 266680 |
KEGGi | rno:266680 |
UCSCi | RGD:708566, rat [Q9QX27-1] |
Organism-specific databases
CTDi | 9705 |
RGDi | 708566, St18 |
Phylogenomic databases
eggNOGi | KOG3803, Eukaryota |
InParanoidi | Q9QX27 |
PhylomeDBi | Q9QX27 |
Miscellaneous databases
PROi | PR:Q9QX27 |
Family and domain databases
InterProi | View protein in InterPro IPR013681, Myelin_TF IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF08474, MYT1, 1 hit PF01530, zf-C2HC, 6 hits |
SUPFAMi | SSF103637, SSF103637, 6 hits |
PROSITEi | View protein in PROSITE PS51802, ZF_CCHHC, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ST18_RAT | |
Accessioni | Q9QX27Primary (citable) accession number: Q9QX27 Secondary accession number(s): P70588 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | May 2, 2006 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families