Na-K-Cl cotransporter

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ammonium transmembrane transporter activity Source: RGD
• cation:chloride symporter activity Source: RGD
• chaperone binding Source: RGD
• Hsp90 protein binding Source: RGD
• metal ion transmembrane transporter activity Source: RGD
• potassium:chloride symporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• potassium ion transmembrane transporter activity Source: RGD
• protein kinase binding Source: RGD
• sodium:chloride symporter activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium:potassium:chloride symporter activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1)."
    Dehaye J.P., Nagy A., Premkumar A., Turner R.J.
    J Biol Chem 278:11811-11817(2003) [PubMed] [Europe PMC] [Abstract]
• sodium ion transmembrane transporter activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension."
    Cho H.M., Lee H.A., Kim H.Y., Han H.S., Kim I.K.
    Am J Hypertens 24:1286-1293(2011) [PubMed] [Europe PMC] [Abstract]
• ammonium transport Source: RGD
• branching involved in mammary gland duct morphogenesis Source: RGD
• cellular chloride ion homeostasis Source: RGD
• cellular potassium ion homeostasis Source: RGD
• cellular response to chemokine Source: RGD
• cellular response to potassium ion Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Contribution of Na(+)-K(+)-Cl(-) cotransporter to high-[K(+)](o)- induced swelling and EAA release in astrocytes."
    Su G., Kintner D.B., Sun D.
    Am J Physiol Cell Physiol 282:C1136-46(2002) [PubMed] [Europe PMC] [Abstract]
• cellular sodium ion homeostasis Source: RGD
• cell volume homeostasis Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Contribution of Na(+)-K(+)-Cl(-) cotransporter to high-[K(+)](o)- induced swelling and EAA release in astrocytes."
    Su G., Kintner D.B., Sun D.
    Am J Physiol Cell Physiol 282:C1136-46(2002) [PubMed] [Europe PMC] [Abstract]
• chloride ion homeostasis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chloride transmembrane transport Source: RGD
• chloride transport Source: RGDInferred from mutant phenotypeⁱ
  • "Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1)."
    Dehaye J.P., Nagy A., Premkumar A., Turner R.J.
    J Biol Chem 278:11811-11817(2003) [PubMed] [Europe PMC] [Abstract]
• detection of mechanical stimulus involved in sensory perception of sound Source: RGD
• gamma-aminobutyric acid signaling pathway Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "NKCC1 transporter facilitates seizures in the developing brain."
    Dzhala V.I., Talos D.M., Sdrulla D.A., Brumback A.C., Mathews G.C., Benke T.A., Delpire E., Jensen F.E., Staley K.J.
    Nat Med 11:1205-1213(2005) [PubMed] [Europe PMC] [Abstract]
• hyperosmotic response Source: RGDInferred from mutant phenotypeⁱ
  • "Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells."
    Zhao H., Hyde R., Hundal H.S.
    J Physiol 560:123-136(2004) [PubMed] [Europe PMC] [Abstract]
• inorganic anion import across plasma membrane Source: RGD
• inorganic cation import across plasma membrane Source: RGD
• maintenance of blood-brain barrier Source: RGD
• mammary duct terminal end bud growth Source: RGD
• multicellular organism growth Source: RGD
• negative regulation of vascular wound healing Source: RGD
• positive regulation of aspartate secretion Source: RGD
• positive regulation of cell volume Source: RGDInferred from mutant phenotypeⁱ
  • "Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells."
    Zhao H., Hyde R., Hundal H.S.
    J Physiol 560:123-136(2004) [PubMed] [Europe PMC] [Abstract]
• potassium ion homeostasis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• potassium ion import across plasma membrane Source: RGD
• potassium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1)."
    Dehaye J.P., Nagy A., Premkumar A., Turner R.J.
    J Biol Chem 278:11811-11817(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of matrix metallopeptidase secretion Source: RGD
• regulation of spontaneous synaptic transmission Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "NKCC1 transporter facilitates seizures in the developing brain."
    Dzhala V.I., Talos D.M., Sdrulla D.A., Brumback A.C., Mathews G.C., Benke T.A., Delpire E., Jensen F.E., Staley K.J.
    Nat Med 11:1205-1213(2005) [PubMed] [Europe PMC] [Abstract]
• sodium ion homeostasis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium ion import across plasma membrane Source: RGD
• sodium ion transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1)."
    Dehaye J.P., Nagy A., Premkumar A., Turner R.J.
    J Biol Chem 278:11811-11817(2003) [PubMed] [Europe PMC] [Abstract]
• T cell chemotaxis Source: RGD
• transepithelial ammonium transport Source: RGD
• transepithelial chloride transport Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• chaperone binding Source: RGD
• Hsp90 protein binding Source: RGD
• protein kinase binding Source: RGD

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG 
        60         70         80         90        100
GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA 
       110        120        130        140        150
AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS 
       160        170        180        190        200
DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY 
       210        220        230        240        250
LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF 
       260        270        280        290        300
ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS 
       310        320        330        340        350
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS 
       360        370        380        390        400
LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI 
       410        420        430        440        450
RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS 
       460        470        480        490        500
KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG 
       510        520        530        540        550
DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE 
       560        570        580        590        600
LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS 
       610        620        630        640        650
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF 
       660        670        680        690        700
LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK 
       710        720        730        740        750
YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG 
       760        770        780        790        800
SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH 
       810        820        830        840        850
DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH 
       860        870        880        890        900
ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD 
       910        920        930        940        950
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK 
       960        970        980        990       1000
SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL 
      1010       1020       1030       1040       1050
EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG 
      1060       1070       1080       1090       1100
GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE 
      1110       1120       1130       1140       1150
PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH 
      1160       1170       1180       1190       1200
SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT 

FYS                                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ