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Entry version 115 (02 Dec 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Na-K-Cl cotransporter

Gene

Slc12a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transportARBA annotation, SymportARBA annotation, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc12a2Imported
Synonyms:Nkcc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
620809, Slc12a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei308 – 334HelicalSequence analysisAdd BLAST27
Transmembranei355 – 379HelicalSequence analysisAdd BLAST25
Transmembranei399 – 418HelicalSequence analysisAdd BLAST20
Transmembranei427 – 448HelicalSequence analysisAdd BLAST22
Transmembranei478 – 500HelicalSequence analysisAdd BLAST23
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei590 – 613HelicalSequence analysisAdd BLAST24
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei672 – 690HelicalSequence analysisAdd BLAST19
Transmembranei702 – 721HelicalSequence analysisAdd BLAST20
Transmembranei727 – 742HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9QX10

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QX10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QX10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QX10, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini193 – 244AA_permease_NInterPro annotationAdd BLAST52
Domaini281 – 783AA_permeaseInterPro annotationAdd BLAST503
Domaini792 – 1203SLC12InterPro annotationAdd BLAST412

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 102DisorderedSequence analysisAdd BLAST102
Regioni107 – 126DisorderedSequence analysisAdd BLAST20
Regioni141 – 185DisorderedSequence analysisAdd BLAST45
Regioni953 – 982DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 185PolarSequence analysisAdd BLAST27
Compositional biasi953 – 979PolyampholyteSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
254933at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF58, PTHR11827:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930, 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QX10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG
60 70 80 90 100
GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA
110 120 130 140 150
AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS
160 170 180 190 200
DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY
210 220 230 240 250
LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF
260 270 280 290 300
ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS
310 320 330 340 350
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS
360 370 380 390 400
LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI
410 420 430 440 450
RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS
460 470 480 490 500
KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG
510 520 530 540 550
DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE
560 570 580 590 600
LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS
610 620 630 640 650
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF
660 670 680 690 700
LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK
710 720 730 740 750
YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG
760 770 780 790 800
SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH
810 820 830 840 850
DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH
860 870 880 890 900
ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD
910 920 930 940 950
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK
960 970 980 990 1000
SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL
1010 1020 1030 1040 1050
EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG
1060 1070 1080 1090 1100
GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE
1110 1120 1130 1140 1150
PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH
1160 1170 1180 1190 1200
SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT

FYS
Length:1,203
Mass (Da):130,352
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF59E4959A7E760FC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF051561 mRNA Translation: AAC27557.1

NCBI Reference Sequences

More...
RefSeqi
NP_113986.1, NM_031798.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:83629

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051561 mRNA Translation: AAC27557.1
RefSeqiNP_113986.1, NM_031798.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ9QX10
PhosphoSitePlusiQ9QX10

Proteomic databases

PRIDEiQ9QX10

Genome annotation databases

GeneIDi83629
KEGGirno:83629

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6558
RGDi620809, Slc12a2

Phylogenomic databases

OrthoDBi254933at2759

Gene expression databases

GenevisibleiQ9QX10, RN

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam
PANTHERiPTHR11827:SF58, PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit
PRINTSiPR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1
TIGRFAMsiTIGR00930, 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9QX10_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QX10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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