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Protein

Homer protein homolog 2

Gene

Homer2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation through negative regulation of IL2 expression by inhibiting calcineurin-NFAT pathway activation through interaction with NFATC2 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 2Curated
Short name:
Homer-2
Alternative name(s):
Cupidin1 Publication
VASP/Ena-related gene up-regulated during seizure and LTP 2
Short name:
Vesl-2
Gene namesi
Name:Homer2Imported
Synonyms:Vesl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347354 Homer2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Homozygous knockout mice exhibit early onset progressive hearing loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910091 – 354Homer protein homolog 2Add BLAST354

Proteomic databases

PaxDbiQ9QWW1
PeptideAtlasiQ9QWW1
PRIDEiQ9QWW1

PTM databases

iPTMnetiQ9QWW1
PhosphoSitePlusiQ9QWW1

Expressioni

Tissue specificityi

Expressed in olfactory bulb, hippocampus, thalamus and heart (PubMed:9808459). Expressed in the cochlea, organ of Corti. Expression is particularly enriched in the tips of stereocilia of both inner and outer hair cells (PubMed:25816005).2 Publications

Gene expression databases

BgeeiENSMUSG00000025813 Expressed in 272 organ(s), highest expression level in lacrimal gland
CleanExiMM_HOMER2
ExpressionAtlasiQ9QWW1 baseline and differential
GenevisibleiQ9QWW1 MM

Interactioni

Subunit structurei

Forms coiled-coil structures coiled-coil structures that mediate homo- and heteromultimerization. Interacts with NFATC2; interaction is reduced by AKT activation. Interacts with NFATC1 and NFATC4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205015, 13 interactors
IntActiQ9QWW1, 1 interactor
STRINGi10090.ENSMUSP00000026922

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9QWW1
SMRiQ9QWW1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QWW1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110WH1PROSITE-ProRule annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili160 – 329Sequence analysisAdd BLAST170

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ9QWW1
KOiK15010
OMAiREKCNDQ
OrthoDBiEOG091G0CQ0
PhylomeDBiQ9QWW1
TreeFamiTF325627

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QWW1-1) [UniParc]FASTAAdd to basket
Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEQPIFTTR AHVFQIDPST KKNWVPASKQ AVTVSYFYDV TRNSYRIISV
60 70 80 90 100
DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSELQLTKFA
110 120 130 140 150
EKFQEVREAA RLARDKSQEK TETSSNHSQE SGCETPSSTQ ASSVNGTDDE
160 170 180 190 200
KASHASPADT HLKSENDKLK IALTQSAANV KKWEMELQTL RESNARLTTA
210 220 230 240 250
LQESAASVEQ WKRQFSICRD ENDRLRSKIE ELEEQCSEIN REKEKNTQLK
260 270 280 290 300
RRIEELESEV RDKEMELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
310 320 330 340 350
LEDKVRSLKT DIEESKYRQR HLKGELKSFL EVLDGKIDDL HDFRRGLSKL

GTDN
Length:354
Mass (Da):40,570
Last modified:May 1, 2000 - v1
Checksum:i18AF2F22EA8E1D06
GO
Isoform 2 (identifier: Q9QWW1-2) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Show »
Length:343
Mass (Da):39,463
Checksum:i417769609B7D655E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4F9E9Q4F9_MOUSE
Homer protein homolog 2
Homer2
290Annotation score:
A0A140LHR9A0A140LHR9_MOUSE
Homer protein homolog 2
Homer2
179Annotation score:
A0A140LJ06A0A140LJ06_MOUSE
Homer protein homolog 2
Homer2
252Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 192RE → VP in CAA09909 (Ref. 3) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009071130 – 140Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093259 mRNA Translation: AAC71023.1
AF093260 mRNA Translation: AAC71024.1
AB017136 mRNA Translation: BAA37088.1
AJ012076 mRNA Translation: CAA09909.1
CCDSiCCDS40009.1 [Q9QWW1-1]
CCDS85329.1 [Q9QWW1-2]
RefSeqiNP_001157558.1, NM_001164086.1 [Q9QWW1-2]
NP_001157559.1, NM_001164087.1
NP_036113.1, NM_011983.2 [Q9QWW1-1]
UniGeneiMm.228

Genome annotation databases

EnsembliENSMUST00000026922; ENSMUSP00000026922; ENSMUSG00000025813 [Q9QWW1-2]
ENSMUST00000207983; ENSMUSP00000146787; ENSMUSG00000025813 [Q9QWW1-1]
GeneIDi26557
KEGGimmu:26557
UCSCiuc009ich.2 mouse [Q9QWW1-1]
uc009ici.2 mouse [Q9QWW1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093259 mRNA Translation: AAC71023.1
AF093260 mRNA Translation: AAC71024.1
AB017136 mRNA Translation: BAA37088.1
AJ012076 mRNA Translation: CAA09909.1
CCDSiCCDS40009.1 [Q9QWW1-1]
CCDS85329.1 [Q9QWW1-2]
RefSeqiNP_001157558.1, NM_001164086.1 [Q9QWW1-2]
NP_001157559.1, NM_001164087.1
NP_036113.1, NM_011983.2 [Q9QWW1-1]
UniGeneiMm.228

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I7AX-ray2.24A/B/C/D1-111[»]
ProteinModelPortaliQ9QWW1
SMRiQ9QWW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205015, 13 interactors
IntActiQ9QWW1, 1 interactor
STRINGi10090.ENSMUSP00000026922

PTM databases

iPTMnetiQ9QWW1
PhosphoSitePlusiQ9QWW1

Proteomic databases

PaxDbiQ9QWW1
PeptideAtlasiQ9QWW1
PRIDEiQ9QWW1

Protocols and materials databases

DNASUi26557
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026922; ENSMUSP00000026922; ENSMUSG00000025813 [Q9QWW1-2]
ENSMUST00000207983; ENSMUSP00000146787; ENSMUSG00000025813 [Q9QWW1-1]
GeneIDi26557
KEGGimmu:26557
UCSCiuc009ich.2 mouse [Q9QWW1-1]
uc009ici.2 mouse [Q9QWW1-2]

Organism-specific databases

CTDi9455
MGIiMGI:1347354 Homer2

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ9QWW1
KOiK15010
OMAiREKCNDQ
OrthoDBiEOG091G0CQ0
PhylomeDBiQ9QWW1
TreeFamiTF325627

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiHomer2 mouse
EvolutionaryTraceiQ9QWW1
PROiPR:Q9QWW1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025813 Expressed in 272 organ(s), highest expression level in lacrimal gland
CleanExiMM_HOMER2
ExpressionAtlasiQ9QWW1 baseline and differential
GenevisibleiQ9QWW1 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHOME2_MOUSE
AccessioniPrimary (citable) accession number: Q9QWW1
Secondary accession number(s): O89025, Q9Z0E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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