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Entry version 142 (12 Aug 2020)
Sequence version 2 (11 Sep 2007)
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Protein

Kinesin-like protein KIFC1

Gene

Kifc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:16638812). May contribute to movement of early endocytic vesicles (PubMed:17360972). Regulates cilium formation and structure (PubMed:23807208).3 Publications

Miscellaneous

Purified early endocytic vesicles bind minus end-directed Kifc1 as well as plus end-directed Kif5b. Addition of anti-Kifc1 antibodies leads to a decrease in minus end-directed vesicle motility in vitro.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi411 – 418ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2132295, MHC class II antigen presentation
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIFC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kifc1Imported
Synonyms:Kifc41 Publication, Kifc5a1 Publication, Kifc5b1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109596, Kifc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Centrosome amplification as well as multipolar spindles. Cells overexpressing Kifc1 show a single microtubule aster and growth arrest in prometaphase.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020891 – 674Kinesin-like protein KIFC1Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei360PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9QWT9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9QWT9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QWT9

PeptideAtlas

More...
PeptideAtlasi
Q9QWT9

PRoteomics IDEntifications database

More...
PRIDEi
Q9QWT9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QWT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QWT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in 14 dpc embryos, spleen and NIH3T3 cells. Also expressed in testis, brain, lung, kidney and cultured astrocytes. Very low levels in skeletal muscle and heart.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in hippocampus of 13 dpc embryos declining to low levels by 18 dpc and to undetectable levels in juvenile and adult hippocampus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000079553, Expressed in bone marrow and 106 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9QWT9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QWT9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds NUBP1 and NUBP2 (PubMed:16638812).

Interacts with PPP1R42 (PubMed:18237440).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
200952, 8 interactors
224976, 49 interactors

Protein interaction database and analysis system

More...
IntActi
Q9QWT9, 9 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000134572

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9QWT9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QWT9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini311 – 664Kinesin motorPROSITE-ProRule annotationAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili146 – 315Sequence analysisAdd BLAST170

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0239, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001485_12_4_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9QWT9

KEGG Orthology (KO)

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KOi
K10405

Identification of Orthologs from Complete Genome Data

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OMAi
RHIFKEM

Database of Orthologous Groups

More...
OrthoDBi
364605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9QWT9

TreeFam database of animal gene trees

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TreeFami
TF105237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9QWT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVQAQRPPL LEVKRNVELK AALVKSSSRV PLSASRLKRG PDQMEDALEP
60 70 80 90 100
AKKRTRVMGA VTKVDTSRPR GPLLSTVSQT QGHTAAQKGP KKTGPRGCSA
110 120 130 140 150
IGTVLRSQKP VPAAPAQKPG TSTAPVVVGK RAGKRPAWDL KGQLCDLNEE
160 170 180 190 200
LKRYREKTQT LELENRGLRE QLREVQEQAT TLGTERNTLE GELASVRSRA
210 220 230 240 250
EQDQQRLETL SARVLELEEC LGTRERLLQE LQGERLQLQE ERSTLSTQLE
260 270 280 290 300
EQERRFQATE AALSSSQEEV VCLRQKTEAQ VTLLAEQGDR LYGLEMERRR
310 320 330 340 350
LHNQLQELKG NIRVFCRVRP VLEGESTPSP GFLVFPPGPA GPSDPPTGLS
360 370 380 390 400
LSRSDDRRST LTGAPAPTVR HDFSFDRVFP PGSKQEEVFE EIAMLVQSAL
410 420 430 440 450
DGYPVCIFAY GQTGSGKTFT MEGGPRGDPQ LEGLIPRAMR HLFSVAQEMS
460 470 480 490 500
GQGWTYSFVA SYVEIYNETV RDLLATGPRK GQGGECEIRR ASPGSEELTV
510 520 530 540 550
TNARYVPVSC EKEVEALLHL AHQNRAVAHT AQNKRSSRSH SVFQLQISGE
560 570 580 590 600
HAARGLQCGA PLNLVDLAGS ERLDPGLHLG PGERDRLRET QAINSSLSTL
610 620 630 640 650
GLVIMALSNK ESHVPYRNSK LTYLLQNSLG GSAKMLMFVN ISPLEENVSE
660 670
SLNSLRFASK VNQCVIGTAQ ANKK
Length:674
Mass (Da):74,153
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA99B6FB6F9BC1B03
GO
Isoform 21 Publication (identifier: Q9QWT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:631
Mass (Da):69,401
Checksum:iE74F26745611BCB4
GO
Isoform 31 Publication (identifier: Q9QWT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     203-222: Missing.

Show »
Length:611
Mass (Da):67,117
Checksum:iBF5B0CA4DE84A5C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UXN2G3UXN2_MOUSE
Kinesin-like protein KIFC1
Kifc1
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX22G3UX22_MOUSE
Kinesin-like protein KIFC1
Kifc1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA19676 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101I → V in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti101I → V in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti101I → V in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti101I → V in AAH03753 (PubMed:15489334).Curated1
Sequence conflicti101I → V in AAH57162 (PubMed:15489334).Curated1
Sequence conflicti101I → V in AAI00329 (PubMed:15489334).Curated1
Sequence conflicti111V → A in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti111V → A in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti111V → A in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti111V → A in AAH03753 (PubMed:15489334).Curated1
Sequence conflicti111V → A in AAH57162 (PubMed:15489334).Curated1
Sequence conflicti111V → A in AAI00329 (PubMed:15489334).Curated1
Sequence conflicti160T → M in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti160T → M in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti160T → M in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti253E → K in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti253E → K in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti253E → K in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti253E → K in AAH03753 (PubMed:15489334).Curated1
Sequence conflicti271V → L in AAH57162 (PubMed:15489334).Curated1
Sequence conflicti315F → L in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti323E → A in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti323E → A in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti323E → A in CAJ19646 (PubMed:16638812).Curated1
Sequence conflicti323E → A in AAH03753 (PubMed:15489334).Curated1
Sequence conflicti323E → A in AAI00329 (PubMed:15489334).Curated1
Sequence conflicti345P → L in AAI00329 (PubMed:15489334).Curated1
Sequence conflicti432E → A in BAC38230 (PubMed:16141072).Curated1
Sequence conflicti478P → L in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti503A → V in BAA19676 (PubMed:9115736).Curated1
Sequence conflicti566D → G in AAF34646 (PubMed:10775188).Curated1
Sequence conflicti578H → P in BAC38230 (PubMed:16141072).Curated1
Sequence conflicti619S → R in BAA19676 (PubMed:9115736).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0525261 – 43Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_052527203 – 222Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49544 mRNA Translation: BAA19676.1 Frameshift.
AF221102 mRNA Translation: AAF34646.1
AM051187 mRNA Translation: CAJ19646.1
AF110520 Genomic DNA Translation: AAC97970.1
BC003753 mRNA Translation: AAH03753.1
BC057162 mRNA Translation: AAH57162.1
BC100328 mRNA Translation: AAI00329.1
AK081484 mRNA Translation: BAC38230.1
AF013117 mRNA Translation: AAC39966.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS57065.1 [Q9QWT9-1]

NCBI Reference Sequences

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RefSeqi
NP_001182227.1, NM_001195298.1 [Q9QWT9-1]
NP_444403.2, NM_053173.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000114361; ENSMUSP00000110001; ENSMUSG00000079553 [Q9QWT9-3]
ENSMUST00000173492; ENSMUSP00000134572; ENSMUSG00000079553 [Q9QWT9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100502766
16580

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100502766
mmu:16580

UCSC genome browser

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UCSCi
uc008bzw.2, mouse [Q9QWT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49544 mRNA Translation: BAA19676.1 Frameshift.
AF221102 mRNA Translation: AAF34646.1
AM051187 mRNA Translation: CAJ19646.1
AF110520 Genomic DNA Translation: AAC97970.1
BC003753 mRNA Translation: AAH03753.1
BC057162 mRNA Translation: AAH57162.1
BC100328 mRNA Translation: AAI00329.1
AK081484 mRNA Translation: BAC38230.1
AF013117 mRNA Translation: AAC39966.1
CCDSiCCDS57065.1 [Q9QWT9-1]
RefSeqiNP_001182227.1, NM_001195298.1 [Q9QWT9-1]
NP_444403.2, NM_053173.2

3D structure databases

SMRiQ9QWT9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200952, 8 interactors
224976, 49 interactors
IntActiQ9QWT9, 9 interactors
STRINGi10090.ENSMUSP00000134572

PTM databases

iPTMnetiQ9QWT9
PhosphoSitePlusiQ9QWT9

Proteomic databases

EPDiQ9QWT9
jPOSTiQ9QWT9
PaxDbiQ9QWT9
PeptideAtlasiQ9QWT9
PRIDEiQ9QWT9

Genome annotation databases

EnsembliENSMUST00000114361; ENSMUSP00000110001; ENSMUSG00000079553 [Q9QWT9-3]
ENSMUST00000173492; ENSMUSP00000134572; ENSMUSG00000079553 [Q9QWT9-1]
GeneIDi100502766
16580
KEGGimmu:100502766
mmu:16580
UCSCiuc008bzw.2, mouse [Q9QWT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
16580
3833
MGIiMGI:109596, Kifc1

Phylogenomic databases

eggNOGiKOG0239, Eukaryota
GeneTreeiENSGT00940000161735
HOGENOMiCLU_001485_12_4_1
InParanoidiQ9QWT9
KOiK10405
OMAiRHIFKEM
OrthoDBi364605at2759
PhylomeDBiQ9QWT9
TreeFamiTF105237

Enzyme and pathway databases

ReactomeiR-MMU-2132295, MHC class II antigen presentation
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
100502766, 1 hit in 18 CRISPR screens
16580, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Kifc1, mouse

Protein Ontology

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PROi
PR:Q9QWT9
RNActiQ9QWT9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079553, Expressed in bone marrow and 106 other tissues
ExpressionAtlasiQ9QWT9, baseline and differential
GenevisibleiQ9QWT9, MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIFC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QWT9
Secondary accession number(s): O08671
, O35230, Q497Y3, Q4A1N2, Q6PG90, Q8BV06, Q99L84, Q9JKZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: August 12, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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