Cyclic nucleotide-gated channel

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cGMP binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes."
    Lee H.M., Park Y.S., Kim W., Park C.S.
    J Neurophysiol 85:2335-2349(2001) [PubMed] [Europe PMC] [Abstract]
• intracellular cAMP-activated cation channel activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intracellular cGMP-activated cation channel activity Source: RGDInferred from direct assayⁱ
  • "Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes."
    Lee H.M., Park Y.S., Kim W., Park C.S.
    J Neurophysiol 85:2335-2349(2001) [PubMed] [Europe PMC] [Abstract]
• intracellular cyclic nucleotide activated cation channel activity Source: RGD
• protein C-terminus binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction."
    Selvakumar D., Drescher M.J., Drescher D.G.
    J Biol Chem 288:7215-7229(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cation transport Source: RGD
• inorganic cation import across plasma membrane Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Taste buds have a cyclic nucleotide-activated channel, CNGgust."
    Misaka T., Kusakabe Y., Emori Y., Gonoi T., Arai S., Abe K.
    J. Biol. Chem. 272:22623-22629(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• ion transmembrane transport Source: RGDInferred from direct assayⁱ
  • "Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes."
    Lee H.M., Park Y.S., Kim W., Park C.S.
    J Neurophysiol 85:2335-2349(2001) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from direct assayⁱ
  • "Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes."
    Lee H.M., Park Y.S., Kim W., Park C.S.
    J Neurophysiol 85:2335-2349(2001) [PubMed] [Europe PMC] [Abstract]
• response to corticosteroid Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Modulation of renal CNG-A3 sodium channel in rats subjected to low- and high-sodium diets."
    Novaira H.J., Botelho B.F., Goldenberg R.C., Guggino S.E., Morales M.M.
    Biochim Biophys Acta 1665:101-110(2004) [PubMed] [Europe PMC] [Abstract]
• response to magnesium ion Source: RGDInferred from direct assayⁱ
  • "Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes."
    Lee H.M., Park Y.S., Kim W., Park C.S.
    J Neurophysiol 85:2335-2349(2001) [PubMed] [Europe PMC] [Abstract]
• retinal cone cell development Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein C-terminus binding Source: RGDInferred from physical interactionⁱ
  • "Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction."
    Selvakumar D., Drescher M.J., Drescher D.G.
    J Biol Chem 288:7215-7229(2013) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MHQMETSTMV QDNRVSRFII SIRAWAARHL HHEDPTPDSF LDRFHGAEPK 
        60         70         80         90        100
EVSSQERNAQ PNPGGQEPPE GGKGRKKDPI VVDPSSNIYY RWLTAIALPV 
       110        120        130        140        150
FYNWCLLVCR ACFDELQSEH LTLWLVLDYS ADALYVVDML VRARTGFLEQ 
       160        170        180        190        200
GLMVRDTKRL WKHYTKTLHF KLDILSLIPT DLAYLKLGMN YPELRFNRLL 
       210        220        230        240        250
RFSRLFEFFD RTETRTNYPN VFRIGNLVLY TLIIIHWNAC IYFAISKFIG 
       260        270        280        290        300
FGTDSWVYPN TSKPEYGRLS RKYIYSLYWS TLTLTTIGET PPPVKDEEYL 
       310        320        330        340        350
FVVIDFLVGV LIFATIVGNV GSMISNMNAS RAEFQAKIDS IKQYMQFRKV 
       360        370        380        390        400
TKDLETRVIR WFDYLWANRK TVDEKEVLKN LPDKLKAEIA INVHLDTLKK 
       410        420        430        440        450
VRIFQDCEAG LLVELVLKLR PAVFSPGDYI CKKGDIGREM YIIKEGKLAV 
       460        470        480        490        500
VADDGVTQFV VLSDGSYFGE ISILNIKGSK SGNRRTANIR SIGYSDLFCL 
       510        520        530        540        550
SKDDLMETLT EYPDAKRALE EKGRQILMKD NLIDDDLVTA RADARNIEEK 
       560        570        580        590        600
VEYLESSLDG LQTRFARLLA EYSASQMKLK QRLSQLESQM TRRGHGFSPD 
       610 
RENSEDASKA D                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ