UniProtKB - Q9QWN7 (Q9QWN7_RAT)
Protein
Submitted name:
Cyclic nucleotide-gated channel
Gene
Cnga3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- cGMP binding Source: RGD
- intracellular cAMP-activated cation channel activity Source: GO_Central
- intracellular cGMP-activated cation channel activity Source: RGD
- intracellular cyclic nucleotide activated cation channel activity Source: RGD
- protein C-terminus binding Source: RGD
GO - Biological processi
- cation transport Source: RGD
- inorganic cation import across plasma membrane Source: RGD
- ion transmembrane transport Source: RGD
- response to cAMP Source: RGD
- response to corticosteroid Source: RGD
- response to magnesium ion Source: RGD
- retinal cone cell development Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelARBA annotation |
Biological process | Ion transport, Sensory transductionARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclic nucleotide-gated channelImported |
Gene namesi | Name:Cnga3Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 70948, Cnga3 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- axon initial segment Source: RGD
- cytoplasm Source: RGD
- dendrite Source: RGD
- glial cell projection Source: RGD
- neuronal cell body Source: RGD
- perikaryon Source: RGD
- photoreceptor outer segment Source: RGD
- transmembrane transporter complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 227 – 245 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 299 – 321 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 403 – 517 | Cyclic nucleotide-bindingInterPro annotationAdd BLAST | 115 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 79 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 585 – 611 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 544 – 564 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 594 – 611 | PolyampholyteSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032406, CLZ_dom IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF16526, CLZ, 1 hit PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9QWN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHQMETSTMV QDNRVSRFII SIRAWAARHL HHEDPTPDSF LDRFHGAEPK
60 70 80 90 100
EVSSQERNAQ PNPGGQEPPE GGKGRKKDPI VVDPSSNIYY RWLTAIALPV
110 120 130 140 150
FYNWCLLVCR ACFDELQSEH LTLWLVLDYS ADALYVVDML VRARTGFLEQ
160 170 180 190 200
GLMVRDTKRL WKHYTKTLHF KLDILSLIPT DLAYLKLGMN YPELRFNRLL
210 220 230 240 250
RFSRLFEFFD RTETRTNYPN VFRIGNLVLY TLIIIHWNAC IYFAISKFIG
260 270 280 290 300
FGTDSWVYPN TSKPEYGRLS RKYIYSLYWS TLTLTTIGET PPPVKDEEYL
310 320 330 340 350
FVVIDFLVGV LIFATIVGNV GSMISNMNAS RAEFQAKIDS IKQYMQFRKV
360 370 380 390 400
TKDLETRVIR WFDYLWANRK TVDEKEVLKN LPDKLKAEIA INVHLDTLKK
410 420 430 440 450
VRIFQDCEAG LLVELVLKLR PAVFSPGDYI CKKGDIGREM YIIKEGKLAV
460 470 480 490 500
VADDGVTQFV VLSDGSYFGE ISILNIKGSK SGNRRTANIR SIGYSDLFCL
510 520 530 540 550
SKDDLMETLT EYPDAKRALE EKGRQILMKD NLIDDDLVTA RADARNIEEK
560 570 580 590 600
VEYLESSLDG LQTRFARLLA EYSASQMKLK QRLSQLESQM TRRGHGFSPD
610
RENSEDASKA D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002801 mRNA Translation: BAA24353.1 |
RefSeqi | NP_445947.1, NM_053495.1 |
Genome annotation databases
GeneIDi | 85257 |
KEGGi | rno:85257 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002801 mRNA Translation: BAA24353.1 |
RefSeqi | NP_445947.1, NM_053495.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 85257 |
KEGGi | rno:85257 |
Organism-specific databases
CTDi | 1261 |
RGDi | 70948, Cnga3 |
Gene expression databases
Genevisiblei | Q9QWN7, RN |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032406, CLZ_dom IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF16526, CLZ, 1 hit PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9QWN7_RAT | |
Accessioni | Q9QWN7Primary (citable) accession number: Q9QWN7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |