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UniProtKB - Q9QWJ9 (NRP1_RAT)

Entry version 169 (02 Dec 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Neuropilin-1

Gene

Nrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (By similarity). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi195CalciumBy similarity1
Metal bindingi209CalciumBy similarity1
Metal bindingi250CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processAngiogenesis, Differentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-194306, Neurophilin interactions with VEGF and VEGFR
R-RNO-399954, Sema3A PAK dependent Axon repulsion
R-RNO-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956, CRMPs in Sema3A signaling
R-RNO-445144, Signal transduction by L1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen: CD304
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Rat genome database

More...RGDi		621588, Nrp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 855ExtracellularSequence analysisAdd BLAST834
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei856 – 880HelicalSequence analysisAdd BLAST25
Topological domaini881 – 922CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3309098

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002186122 – 922Neuropilin-1Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 541 Publication
Disulfide bondi82 ↔ 1041 Publication
Disulfide bondi147 ↔ 173By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 228By similarity
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi275 ↔ 4241 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 5831 Publication
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612O-linked (Xyl...) (chondroitin sulfate) serine; alternateBy similarity1
Glycosylationi612O-linked (Xyl...) (heparan sulfate) serine; alternateBy similarity1
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei893PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QWJ9

PRoteomics IDEntifications database

More...PRIDEi		Q9QWJ9

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9QWJ9, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QWJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QWJ9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9QWJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the embryonic nervous system (PubMed:9288754). Expressed in dorsal root ganglia (PubMed:28270793).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Increased in dorsal root ganglia in response to injury caused by dorsal rhizotomy (PubMed:28270793). Increased in dorsal root ganglia in response to both sciatic nerve crush and transection injury (PubMed:28270793).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000010744, Expressed in lung and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QWJ9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with NRP2. Binds PLXNB1 (By similarity).

Interacts with FER.

Interacts with VEGFA (By similarity).

Interacts with ABCB8/MITOSUR in mitochondria (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		251596, 2 interactors

Database of interacting proteins

More...DIPi		DIP-44935N

Protein interaction database and analysis system

More...IntActi		Q9QWJ9, 2 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000014492

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9QWJ9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1922
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QWJ9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9QWJ9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini147 – 265CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini275 – 424F5/8 type C 1PROSITE-ProRule annotationAdd BLAST150
Domaini431 – 583F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153
Domaini645 – 811MAMPROSITE-ProRule annotationAdd BLAST167

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUEH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015228_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QWJ9

Identification of Orthologs from Complete Genome Data

More...OMAi		HPYTNEW

Database of Orthologous Groups

More...OrthoDBi		124611at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QWJ9

TreeFam database of animal gene trees

More...TreeFami		TF316506

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR46806:SF4, PTHR46806:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036960, Neuropilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00020, MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QWJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP 
        60         70         80         90        100
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW 
       110        120        130        140        150
GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN 
       160        170        180        190        200
YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP 
       210        220        230        240        250
PGGVFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD 
       260        270        280        290        300
SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 
       310        320        330        340        350
WSVERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK 
       360        370        380        390        400
KKYYVKTYRV DISSNGEDWI TLKEGNKAII FQGNTNPTDV VFGVFPKPLI 
       410        420        430        440        450
TRFVRIKPAS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS 
       460        470        480        490        500
NQGDRNWMPE NIRLVTSRTG WALPPSPHPY INEWLQVDLG DEKIVRGVII 
       510        520        530        540        550
QGGKHRENKV FMRKFKIAYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE 
       560        570        580        590        600
LRAFTPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEVPTA GPTTPNGNPV 
       610        620        630        640        650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC 
       660        670        680        690        700
EFGWGSHKTF CHWEHDSHAQ LRWRVLTSKT GPIQDHTGDG NFIYSQADEN 
       710        720        730        740        750
QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL HYQKPEEYDQ 
       760        770        780        790        800
LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI 
       810        820        830        840        850
NNHIPQEDCA KPTDLDKKNT EIKIDETGST PGYEEGKGDK NISRKPGNVL 
       860        870        880        890        900
KTLDPILITI IAMSALGVLL GAVCGVVLYC ACWHNGMSER NLSALENYNF 
       910        920 
ELVDGVKLKK DKLNPQSNYS EA
Length:922
Mass (Da):103,082
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC6F82AD098B0F2E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF016296 mRNA Translation: AAC53337.1
BC085689 mRNA Translation: AAH85689.1

NCBI Reference Sequences

More...RefSeqi		NP_659566.1, NM_145098.2
XP_006255887.1, XM_006255825.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000014492; ENSRNOP00000014492; ENSRNOG00000010744
ENSRNOT00000080465; ENSRNOP00000075034; ENSRNOG00000010744

Database of genes from NCBI RefSeq genomes

More...GeneIDi		246331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:246331

UCSC genome browser

More...UCSCi		RGD:621588, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016296 mRNA Translation: AAC53337.1
BC085689 mRNA Translation: AAH85689.1
RefSeqiNP_659566.1, NM_145098.2
XP_006255887.1, XM_006255825.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ORXX-ray2.40A273-586[»]
2ORZX-ray2.15A273-586[»]
SMRiQ9QWJ9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi251596, 2 interactors
DIPiDIP-44935N
IntActiQ9QWJ9, 2 interactors
STRINGi10116.ENSRNOP00000014492

Chemistry databases

BindingDBiQ9QWJ9
ChEMBLiCHEMBL3309098

PTM databases

GlyGeniQ9QWJ9, 6 sites
iPTMnetiQ9QWJ9
PhosphoSitePlusiQ9QWJ9
SwissPalmiQ9QWJ9

Proteomic databases

PaxDbiQ9QWJ9
PRIDEiQ9QWJ9

Genome annotation databases

EnsembliENSRNOT00000014492; ENSRNOP00000014492; ENSRNOG00000010744
ENSRNOT00000080465; ENSRNOP00000075034; ENSRNOG00000010744
GeneIDi246331
KEGGirno:246331
UCSCiRGD:621588, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8829
RGDi621588, Nrp1

Phylogenomic databases

eggNOGiENOG502QUEH, Eukaryota
GeneTreeiENSGT00940000157169
HOGENOMiCLU_015228_6_1_1
InParanoidiQ9QWJ9
OMAiHPYTNEW
OrthoDBi124611at2759
PhylomeDBiQ9QWJ9
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-RNO-194306, Neurophilin interactions with VEGF and VEGFR
R-RNO-399954, Sema3A PAK dependent Axon repulsion
R-RNO-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956, CRMPs in Sema3A signaling
R-RNO-445144, Signal transduction by L1

Miscellaneous databases

EvolutionaryTraceiQ9QWJ9

Protein Ontology

More...PROi		PR:Q9QWJ9

Gene expression databases

BgeeiENSRNOG00000010744, Expressed in lung and 20 other tissues
GenevisibleiQ9QWJ9, RN

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF4, PTHR46806:SF4, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit
PIRSFiPIRSF036960, Neuropilin, 1 hit
PRINTSiPR00020, MAMDOMAIN
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit
SUPFAMiSSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QWJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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