Neuropilin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase activator activity Source: Ensembl
• heparin binding Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• protein kinase binding Source: Ensembl
• semaphorin receptor activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9288754
• vascular endothelial growth factor-activated receptor activity Source: Ensembl
• vascular endothelial growth factor binding Source: Ensembl

GO - Biological processⁱ

• actin cytoskeleton reorganization Source: Ensembl
• angiogenesis involved in coronary vascular morphogenesis Source: Ensembl
• axonal fasciculation Source: Ensembl
• axon extension involved in axon guidance Source: Ensembl
• axonogenesis involved in innervation Source: Ensembl
• basal dendrite arborization Source: Ensembl
• branching involved in blood vessel morphogenesis Source: Ensembl
• branchiomotor neuron axon guidance Source: Ensembl
• cell migration involved in sprouting angiogenesis Source: Ensembl
• cellular response to hepatocyte growth factor stimulus Source: Ensembl
• commissural neuron axon guidance Source: Ensembl
• coronary artery morphogenesis Source: Ensembl
• dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
• dorsal root ganglion morphogenesis Source: Ensembl
• endothelial cell chemotaxis Source: Ensembl
• facial nerve structural organization Source: Ensembl
• facioacoustic ganglion development Source: Ensembl
• gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
• hepatocyte growth factor receptor signaling pathway Source: Ensembl
• integrin-mediated signaling pathway Source: Ensembl
• motor neuron migration Source: UniProtKB
• negative regulation of axon extension involved in axon guidance Source: RGDInferred from mutant phenotypeⁱ
  • 9288754
• negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• nervous system development Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9288754
• neural crest cell migration involved in autonomic nervous system development Source: Ensembl
• otic placode development Source: Ensembl
• outflow tract septum morphogenesis Source: Ensembl
• platelet-derived growth factor receptor signaling pathway Source: Ensembl
• positive chemotaxis Source: Ensembl
• positive regulation of actin cytoskeleton reorganization Source: Ensembl
• positive regulation of axon extension involved in axon guidance Source: Ensembl
• positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of filopodium assembly Source: Ensembl
• positive regulation of focal adhesion assembly Source: Ensembl
• positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
• positive regulation of retinal ganglion cell axon guidance Source: Ensembl
• positive regulation of stress fiber assembly Source: Ensembl
• positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
• postsynapse organization Source: Ensembl
• protein localization to early endosome Source: Ensembl
• regulation of Cdc42 protein signal transduction Source: Ensembl
• renal artery morphogenesis Source: Ensembl
• response to wounding Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 15906313
• retinal ganglion cell axon guidance Source: Ensembl
• retina vasculature morphogenesis in camera-type eye Source: Ensembl
• semaphorin-plexin signaling pathway involved in axon guidance Source: Ensembl
• sensory neuron axon guidance Source: Ensembl
• substrate adhesion-dependent cell spreading Source: Ensembl
• substrate-dependent cell migration, cell extension Source: Ensembl
• sympathetic ganglion development Source: Ensembl
• sympathetic neuron projection extension Source: Ensembl
• sympathetic neuron projection guidance Source: Ensembl
• toxin transport Source: Ensembl
• trigeminal ganglion development Source: Ensembl
• trigeminal nerve structural organization Source: Ensembl
• vascular endothelial growth factor receptor signaling pathway Source: Ensembl
• VEGF-activated neuropilin signaling pathway involved in axon guidance Source: Ensembl
• ventral trunk neural crest cell migration Source: Ensembl
• vestibulocochlear nerve structural organization Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: Ensembl
• vascular endothelial growth factor binding Source: Ensembl

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP 
        60         70         80         90        100
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW 
       110        120        130        140        150
GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN 
       160        170        180        190        200
YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP 
       210        220        230        240        250
PGGVFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD 
       260        270        280        290        300
SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 
       310        320        330        340        350
WSVERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK 
       360        370        380        390        400
KKYYVKTYRV DISSNGEDWI TLKEGNKAII FQGNTNPTDV VFGVFPKPLI 
       410        420        430        440        450
TRFVRIKPAS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS 
       460        470        480        490        500
NQGDRNWMPE NIRLVTSRTG WALPPSPHPY INEWLQVDLG DEKIVRGVII 
       510        520        530        540        550
QGGKHRENKV FMRKFKIAYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE 
       560        570        580        590        600
LRAFTPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEVPTA GPTTPNGNPV 
       610        620        630        640        650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC 
       660        670        680        690        700
EFGWGSHKTF CHWEHDSHAQ LRWRVLTSKT GPIQDHTGDG NFIYSQADEN 
       710        720        730        740        750
QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL HYQKPEEYDQ 
       760        770        780        790        800
LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI 
       810        820        830        840        850
NNHIPQEDCA KPTDLDKKNT EIKIDETGST PGYEEGKGDK NISRKPGNVL 
       860        870        880        890        900
KTLDPILITI IAMSALGVLL GAVCGVVLYC ACWHNGMSER NLSALENYNF 
       910        920 
ELVDGVKLKK DKLNPQSNYS EA                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references