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UniProtKB - Q9QWH1 (PHC2_MOUSE)

Entry version 170 (25 May 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Polyhomeotic-like protein 2

Gene

Phc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi634ZincPROSITE-ProRule annotation1
Metal bindingi637ZincPROSITE-ProRule annotation1
Metal bindingi653ZincPROSITE-ProRule annotation1
Metal bindingi657ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri625 – 659FCS-typePROSITE-ProRule annotationAdd BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2559580, Oxidative Stress Induced Senescence
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-3899300, SUMOylation of transcription cofactors
R-MMU-4551638, SUMOylation of chromatin organization proteins
R-MMU-4570464, SUMOylation of RNA binding proteins
R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724, Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyhomeotic-like protein 2
Short name:
mPH2
Alternative name(s):
Early development regulatory protein 2
p36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phc2
Synonyms:Edr2, Ph2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1860454, Phc2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000028796

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile but show posterior transformations of the axial skeleton and premature senescence of mouse embryonic fibroblast associated with derepression of Hox cluster genes and Cdkn2a genes, respectively. Mice lacking Phc2 and Phc1 die at an early gestational stage. Mice mutant for Phc1 and/or Phc2 demonstrate that Phc1 and Phc2 mutations affect synergistically the survival of embryos in a gene dosage-dependent manner and thus show functional redundancy of Phc1 and Phc2.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762871 – 850Polyhomeotic-like protein 2Add BLAST850

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei611PhosphothreonineBy similarity1
Modified residuei613PhosphoserineBy similarity1
Cross-linki624Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki694Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei743PhosphoserineBy similarity1
Cross-linki839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9QWH1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9QWH1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QWH1

PeptideAtlas

More...PeptideAtlasi		Q9QWH1

PRoteomics IDEntifications database

More...PRIDEi		Q9QWH1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		289489 [Q9QWH1-1]
289490 [Q9QWH1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QWH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QWH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is ubiquitously expressed in embryos and adult tissues at much higher level than isoform 1.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 11.5 dpc in the developing brain, in the ventricular zones of the cortex and ganglionic eminences as well as in adult, in mature structures such as the granule cell layer of the dentate gyrus and cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028796, Expressed in neocortex and 322 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9QWH1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QWH1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a PRC1-like complex.

Interacts with CBX4 (By similarity).

Interacts with BMI1, PCGF2, PHC1 and RNF2 (PubMed:9627119, PubMed:16024804, PubMed:27827373).

Interacts with CHTOP (PubMed:22872859).

Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		207636, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9QWH1, 8 interactors

Molecular INTeraction database

More...MINTi		Q9QWH1

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000101690

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9QWH1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1850
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9QWH1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QWH1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini786 – 850SAMPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79Disordered1 PublicationAdd BLAST79
Regioni33 – 56Interaction with BMI11 PublicationAdd BLAST24
Regioni233 – 314DisorderedSequence analysisAdd BLAST82
Regioni335 – 386DisorderedSequence analysisAdd BLAST52
Regioni402 – 436DisorderedSequence analysisAdd BLAST35
Regioni528 – 553DisorderedSequence analysisAdd BLAST26
Regioni597 – 624DisorderedSequence analysisAdd BLAST28
Regioni676 – 712DisorderedSequence analysisAdd BLAST37
Regioni725 – 764DisorderedSequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi550 – 579HD1Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 38Polar residuesSequence analysisAdd BLAST38
Compositional biasi338 – 362Pro residuesSequence analysisAdd BLAST25
Compositional biasi363 – 379Polar residuesSequence analysisAdd BLAST17
Compositional biasi528 – 549Polar residuesSequence analysisAdd BLAST22
Compositional biasi610 – 624Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi689 – 712Polar residuesSequence analysisAdd BLAST24
Compositional biasi725 – 754Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

HD1 motif interacts with SAM domain of PHC1.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri625 – 659FCS-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS5Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012048_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QWH1

Identification of Orthologs from Complete Genome Data

More...OMAi		PTPNQVQ

Database of Orthologous Groups

More...OrthoDBi		298184at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QWH1

TreeFam database of animal gene trees

More...TreeFami		TF331299

Family and domain databases

Database of protein disorder

More...DisProti		DP01315

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
3.30.60.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR012313, Znf_FCS
IPR038603, Znf_FCS_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QWH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENELPVPHT SNRASVTTNT SGTNSSSGCI SSSGGGGGSG GRPTAPQISV 
        60         70         80         90        100
YSGIPDRQTV QVIQQALHRQ PSTAAQYLQQ MYAAQQQHLM LQTAALQQQH 
       110        120        130        140        150
LSSAQLQSLA AVQQASLVAN RQGSTPGSSV SSQAPAQSSS LNLAASPAAA 
       160        170        180        190        200
QLINRAQSVN SAAASGLAQQ AVLLGNTSSP ALTASQAQMY LRAQMLIFTP 
       210        220        230        240        250
TATVATVQPE LCTGSPARPP TPAQVQNLTL RTQQTPAAAA SGPPPTQPVL 
       260        270        280        290        300
PSLALKPTPS SSQPLPAPPQ GRTMAQGSPA GAKPSGTDNA PETLKAGDGN 
       310        320        330        340        350
CNMEGRPGPG RAVPAVATHP LIAPAYAHLQ SHQLLPQPPA KHPQPQFVAQ 
       360        370        380        390        400
QQPQPPRPAP QVQSQPQLAS VSPSLALQSS PEDHALPLGS VTQALPLQCS 
       410        420        430        440        450
TTHVHKPGNS QQCHLPTLDT GSQNGHPEGG SHPPQRRFQH TSAVILQVQP 
       460        470        480        490        500
ASPVTPQQCA PDDWKEVVPA EKSVPVARPG PSPHQQAIIP AIPGGLPGPK 
       510        520        530        540        550
SPNIQQCPAH ETGQGIVHAL TDLSSPGMTS GNGNSASSIA GTAPQNGENK 
       560        570        580        590        600
PPQAIVKPQI LTHVIEGFVI QEGAEPFPVG RSSLLVGNLK KKYAQGFLPE 
       610        620        630        640        650
KPPQQDHTTT TDSEMEEPYL QESKEEGTPL KLKCELCGRV DFAYKFKRSK 
       660        670        680        690        700
RFCSMACAKR YNVGCTKRVG LFHSDRSKLQ KAGTTTHNRR RASKASLPTL 
       710        720        730        740        750
TKDTKKQPSG TVPLSVTAAL QLAHSQEDSS RCSDNSSYEE PLSPISASSS 
       760        770        780        790        800
TSRRRQGQRD LDLPDMHMRD LVGVGHHFLP SEPTKWNVED VYEFIRSLPG 
       810        820        830        840        850
CQEIAEEFRA QEIDGQALLL LKEDHLMSAM NIKLGPALKI YARISMLKDS
Length:850
Mass (Da):89,799
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87746AFD7808DC7B
GO
Isoform 2 (identifier: Q9QWH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-527: Missing.

Show »
Length:323
Mass (Da):35,748
Checksum:iECEA73FEA72710E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASA3B1ASA3_MOUSE
Polyhomeotic-like 2 (Drosophila)
Phc2 RP23-467J23.1-008
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ASA2B1ASA2_MOUSE
Polyhomeotic-like 2 (Drosophila)
Phc2 RP23-467J23.1-009
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AS97B1AS97_MOUSE
Polyhomeotic-like 2 (Drosophila)
Phc2 RP23-467J23.1-002
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ASA1B1ASA1_MOUSE
Polyhomeotic-like protein 2
Phc2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REH8D6REH8_MOUSE
Polyhomeotic-like protein 2
Phc2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ASA0B1ASA0_MOUSE
Polyhomeotic-like 2 (Drosophila)
Phc2 RP23-467J23.1-011
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0169191 – 527Missing in isoform 2. 2 PublicationsAdd BLAST527

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB062362 mRNA Translation: BAB93527.1
U81491 mRNA Translation: AAD00519.1
AL611969 Genomic DNA No translation available.
AL611983 Genomic DNA No translation available.
BC057571 mRNA Translation: AAH57571.1
BC071246 mRNA Translation: AAH71246.1
AF060076 mRNA Translation: AAC23570.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS18674.1 [Q9QWH1-1]
CCDS57297.1 [Q9QWH1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001182012.1, NM_001195083.1 [Q9QWH1-2]
NP_001182059.1, NM_001195130.1 [Q9QWH1-1]
NP_061244.1, NM_018774.4 [Q9QWH1-1]
XP_006503300.1, XM_006503237.3 [Q9QWH1-2]
XP_006503301.1, XM_006503238.1 [Q9QWH1-2]
XP_017175809.1, XM_017320320.1 [Q9QWH1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000030588; ENSMUSP00000030588; ENSMUSG00000028796 [Q9QWH1-1]
ENSMUST00000106079; ENSMUSP00000101689; ENSMUSG00000028796 [Q9QWH1-2]
ENSMUST00000106080; ENSMUSP00000101690; ENSMUSG00000028796 [Q9QWH1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54383

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:54383

UCSC genome browser

More...UCSCi		uc008uvh.2, mouse [Q9QWH1-1]
uc008uvk.2, mouse [Q9QWH1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062362 mRNA Translation: BAB93527.1
U81491 mRNA Translation: AAD00519.1
AL611969 Genomic DNA No translation available.
AL611983 Genomic DNA No translation available.
BC057571 mRNA Translation: AAH57571.1
BC071246 mRNA Translation: AAH71246.1
AF060076 mRNA Translation: AAC23570.1
CCDSiCCDS18674.1 [Q9QWH1-1]
CCDS57297.1 [Q9QWH1-2]
RefSeqiNP_001182012.1, NM_001195083.1 [Q9QWH1-2]
NP_001182059.1, NM_001195130.1 [Q9QWH1-1]
NP_061244.1, NM_018774.4 [Q9QWH1-1]
XP_006503300.1, XM_006503237.3 [Q9QWH1-2]
XP_006503301.1, XM_006503238.1 [Q9QWH1-2]
XP_017175809.1, XM_017320320.1 [Q9QWH1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NA1NMR-A557-590[»]
AlphaFoldDBiQ9QWH1
SMRiQ9QWH1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi207636, 16 interactors
IntActiQ9QWH1, 8 interactors
MINTiQ9QWH1
STRINGi10090.ENSMUSP00000101690

PTM databases

iPTMnetiQ9QWH1
PhosphoSitePlusiQ9QWH1

Proteomic databases

EPDiQ9QWH1
MaxQBiQ9QWH1
PaxDbiQ9QWH1
PeptideAtlasiQ9QWH1
PRIDEiQ9QWH1
ProteomicsDBi289489 [Q9QWH1-1]
289490 [Q9QWH1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31416, 111 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		54383

Genome annotation databases

EnsembliENSMUST00000030588; ENSMUSP00000030588; ENSMUSG00000028796 [Q9QWH1-1]
ENSMUST00000106079; ENSMUSP00000101689; ENSMUSG00000028796 [Q9QWH1-2]
ENSMUST00000106080; ENSMUSP00000101690; ENSMUSG00000028796 [Q9QWH1-1]
GeneIDi54383
KEGGimmu:54383
UCSCiuc008uvh.2, mouse [Q9QWH1-1]
uc008uvk.2, mouse [Q9QWH1-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1912
MGIiMGI:1860454, Phc2
VEuPathDBiHostDB:ENSMUSG00000028796

Phylogenomic databases

eggNOGiENOG502QS5Q, Eukaryota
GeneTreeiENSGT00940000160840
HOGENOMiCLU_012048_0_0_1
InParanoidiQ9QWH1
OMAiPTPNQVQ
OrthoDBi298184at2759
PhylomeDBiQ9QWH1
TreeFamiTF331299

Enzyme and pathway databases

ReactomeiR-MMU-2559580, Oxidative Stress Induced Senescence
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-3899300, SUMOylation of transcription cofactors
R-MMU-4551638, SUMOylation of chromatin organization proteins
R-MMU-4570464, SUMOylation of RNA binding proteins
R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724, Regulation of PTEN gene transcription

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54383, 1 hit in 70 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Phc2, mouse

Protein Ontology

More...PROi		PR:Q9QWH1
RNActiQ9QWH1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028796, Expressed in neocortex and 322 other tissues
ExpressionAtlasiQ9QWH1, baseline and differential
GenevisibleiQ9QWH1, MM

Family and domain databases

DisProtiDP01315
Gene3Di1.10.150.50, 1 hit
3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR012313, Znf_FCS
IPR038603, Znf_FCS_sf
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHC2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QWH1
Secondary accession number(s): B1AS98
, B1ASA4, O88463, Q8K5D9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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