Phc2

Functionⁱ

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	625 – 659	FCS-typePROSITE-ProRule annotationAdd BLAST		35

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
identical protein binding Source: MGI
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
spermatogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 17215307

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-3108214 SUMOylation of DNA damage response and repair proteins R-MMU-3899300 SUMOylation of transcription cofactors R-MMU-4551638 SUMOylation of chromatin organization proteins R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polyhomeotic-like protein 2 Short name: mPH2 Alternative name(s): Early development regulatory protein 2 p36
Gene namesⁱ	Name:Phc2 Synonyms:Edr2, Ph2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1860454 Phc2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile but show posterior transformations of the axial skeleton and premature senescence of mouse embryonic fibroblast associated with derepression of Hox cluster genes and Cdkn2a genes, respectively. Mice lacking Phc2 and Phc1 die at an early gestational stage. Mice mutant for Phc1 and/or Phc2 demonstrate that Phc1 and Phc2 mutations affect synergistically the survival of embryos in a gene dosage-dependent manner and thus show functional redundancy of Phc1 and Phc2.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076287	1 – 850	Polyhomeotic-like protein 2Add BLAST		850

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	590	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	592	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	611	PhosphothreonineBy similarity	1
Modified residueⁱ	613	PhosphoserineBy similarity	1
Cross-linkⁱ	624	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	694	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	743	PhosphoserineBy similarity	1
Cross-linkⁱ	839	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9QWH1
PeptideAtlas More...PeptideAtlasⁱ	Q9QWH1
PRIDEⁱ	Q9QWH1

PTM databases

iPTMnetⁱ	Q9QWH1
PhosphoSitePlusⁱ	Q9QWH1

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is ubiquitously expressed in embryos and adult tissues at much higher level than isoform 1.1 Publication

Developmental stageⁱ

Detected at E11.5 in the developing brain, in the ventricular zones of the cortex and ganglionic eminences as well as in adult, in mature structures such as the granule cell layer of the dentate gyrus and cerebellum.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000028796 Expressed in 299 organ(s), highest expression level in neocortex
CleanExⁱ	MM_PHC2
ExpressionAtlasⁱ	Q9QWH1 baseline and differential
Genevisibleⁱ	Q9QWH1 MM

Interactionⁱ

Subunit structureⁱ

Component of a PRC1-like complex. Interacts with CBX4 (By similarity). Interacts with BMI1, PCGF2, PHC1 and RNF2 (PubMed:9627119, PubMed:16024804, PubMed:27827373). Interacts with CHTOP (PubMed:22872859). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Bmi1	P25916	3	EBI-642357,EBI-927401
MAPKAPK2	P49137	2	EBI-642357,EBI-993299	From Homo sapiens.
Mapkapk2	P49138	5	EBI-642357,EBI-298776
Pcgf2	P23798	5	EBI-642357,EBI-926857
Phc1	Q64028	2	EBI-642357,EBI-927346
Ring1	O35730	2	EBI-642357,EBI-929310
Rnf2	Q9CQJ4	7	EBI-642357,EBI-927321

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207636, 9 interactors
IntActⁱ	Q9QWH1, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9QWH1
STRINGⁱ	10090.ENSMUSP00000030588

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	560 – 565	Combined sources	6
Beta strandⁱ	568 – 573	Combined sources	6
Turnⁱ	578 – 580	Combined sources	3
Helixⁱ	583 – 586	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9QWH1
SMRⁱ	Q9QWH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	786 – 850	SAMPROSITE-ProRule annotationAdd BLAST		65

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 79	Intrinsically disordered1 PublicationAdd BLAST		79
Regionⁱ	33 – 56	Interaction with BMI11 PublicationAdd BLAST		24

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	550 – 579	HD1Add BLAST		30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	34 – 41	Poly-Gly		8
Compositional biasⁱ	58 – 114	Gln-richAdd BLAST		57

Domainⁱ

HD1 motif interacts with SAM domain of PHC1.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	625 – 659	FCS-typePROSITE-ProRule annotationAdd BLAST		35

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IDZN Eukaryota ENOG4111F0Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074459
HOGENOMⁱ	HOG000236275
HOVERGENⁱ	HBG039325
InParanoidⁱ	Q9QWH1
KEGG Orthology (KO) More...KOⁱ	K11457
OMAⁱ	PQQCAPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02VS
PhylomeDBⁱ	Q9QWH1
TreeFamⁱ	TF331299

Family and domain databases

Gene3Dⁱ	3.30.60.160, 1 hit
InterProⁱ	View protein in InterPro IPR001660 SAM IPR013761 SAM/pointed_sf IPR012313 Znf_FCS IPR038603 Znf_FCS_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00536 SAM_1, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 1 hit PS51024 ZF_FCS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9QWH1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENELPVPHT SNRASVTTNT SGTNSSSGCI SSSGGGGGSG GRPTAPQISV 
        60         70         80         90        100
YSGIPDRQTV QVIQQALHRQ PSTAAQYLQQ MYAAQQQHLM LQTAALQQQH 
       110        120        130        140        150
LSSAQLQSLA AVQQASLVAN RQGSTPGSSV SSQAPAQSSS LNLAASPAAA 
       160        170        180        190        200
QLINRAQSVN SAAASGLAQQ AVLLGNTSSP ALTASQAQMY LRAQMLIFTP 
       210        220        230        240        250
TATVATVQPE LCTGSPARPP TPAQVQNLTL RTQQTPAAAA SGPPPTQPVL 
       260        270        280        290        300
PSLALKPTPS SSQPLPAPPQ GRTMAQGSPA GAKPSGTDNA PETLKAGDGN 
       310        320        330        340        350
CNMEGRPGPG RAVPAVATHP LIAPAYAHLQ SHQLLPQPPA KHPQPQFVAQ 
       360        370        380        390        400
QQPQPPRPAP QVQSQPQLAS VSPSLALQSS PEDHALPLGS VTQALPLQCS 
       410        420        430        440        450
TTHVHKPGNS QQCHLPTLDT GSQNGHPEGG SHPPQRRFQH TSAVILQVQP 
       460        470        480        490        500
ASPVTPQQCA PDDWKEVVPA EKSVPVARPG PSPHQQAIIP AIPGGLPGPK 
       510        520        530        540        550
SPNIQQCPAH ETGQGIVHAL TDLSSPGMTS GNGNSASSIA GTAPQNGENK 
       560        570        580        590        600
PPQAIVKPQI LTHVIEGFVI QEGAEPFPVG RSSLLVGNLK KKYAQGFLPE 
       610        620        630        640        650
KPPQQDHTTT TDSEMEEPYL QESKEEGTPL KLKCELCGRV DFAYKFKRSK 
       660        670        680        690        700
RFCSMACAKR YNVGCTKRVG LFHSDRSKLQ KAGTTTHNRR RASKASLPTL 
       710        720        730        740        750
TKDTKKQPSG TVPLSVTAAL QLAHSQEDSS RCSDNSSYEE PLSPISASSS 
       760        770        780        790        800
TSRRRQGQRD LDLPDMHMRD LVGVGHHFLP SEPTKWNVED VYEFIRSLPG 
       810        820        830        840        850
CQEIAEEFRA QEIDGQALLL LKEDHLMSAM NIKLGPALKI YARISMLKDS

Length:850

Mass (Da):89,799

Last modified:May 1, 2000 - v1

Checksum:ⁱ87746AFD7808DC7B

GO

Isoform 2 (identifier: Q9QWH1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-527: Missing.

« Hide

        10         20         30         40         50
MTSGNGNSAS SIAGTAPQNG ENKPPQAIVK PQILTHVIEG FVIQEGAEPF 
        60         70         80         90        100
PVGRSSLLVG NLKKKYAQGF LPEKPPQQDH TTTTDSEMEE PYLQESKEEG 
       110        120        130        140        150
TPLKLKCELC GRVDFAYKFK RSKRFCSMAC AKRYNVGCTK RVGLFHSDRS 
       160        170        180        190        200
KLQKAGTTTH NRRRASKASL PTLTKDTKKQ PSGTVPLSVT AALQLAHSQE 
       210        220        230        240        250
DSSRCSDNSS YEEPLSPISA SSSTSRRRQG QRDLDLPDMH MRDLVGVGHH 
       260        270        280        290        300
FLPSEPTKWN VEDVYEFIRS LPGCQEIAEE FRAQEIDGQA LLLLKEDHLM 
       310        320 
SAMNIKLGPA LKIYARISML KDS

Show »

Length:323

Mass (Da):35,748

Checksum:ⁱECEA73FEA72710E1

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1ASA3	B1ASA3_MOUSE	Polyhomeotic-like 2 (Drosophila) Polyhomeotic-like 2 (Drosophila) (Polyhomeotic-like protein 2)	Phc2 RP23-467J23.1-008	202	Annotation score:
B1ASA2	B1ASA2_MOUSE	Polyhomeotic-like 2 (Drosophila) Polyhomeotic-like 2 (Drosophila) (Polyhomeotic-like protein 2)	Phc2 RP23-467J23.1-009	143	Annotation score:
B1AS97	B1AS97_MOUSE	Polyhomeotic-like 2 (Drosophila) Polyhomeotic-like 2 (Drosophila) (Polyhomeotic-like protein 2)	Phc2 RP23-467J23.1-002	269	Annotation score:
B1ASA1	B1ASA1_MOUSE	Polyhomeotic-like protein 2 Polyhomeotic-like protein 2	Phc2	53	Annotation score:
B1ASA0	B1ASA0_MOUSE	Polyhomeotic-like 2 (Drosophila) Polyhomeotic-like 2 (Drosophila) (Polyhomeotic-like protein 2)	Phc2 RP23-467J23.1-011	22	Annotation score:
D6REH8	D6REH8_MOUSE	Polyhomeotic-like protein 2 Polyhomeotic-like protein 2	Phc2	40	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016919	1 – 527	Missing in isoform 2. 2 PublicationsAdd BLAST		527

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB062362 mRNA Translation: BAB93527.1 U81491 mRNA Translation: AAD00519.1 AL611969, AL611983 Genomic DNA Translation: CAM23052.1 AL611983 Genomic DNA Translation: CAM25248.1 AL611983, AL611969 Genomic DNA Translation: CAM25252.1 BC057571 mRNA Translation: AAH57571.1 BC071246 mRNA Translation: AAH71246.1 AF060076 mRNA Translation: AAC23570.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18674.1 [Q9QWH1-1] CCDS57297.1 [Q9QWH1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182012.1, NM_001195083.1 [Q9QWH1-2] NP_001182059.1, NM_001195130.1 [Q9QWH1-1] NP_061244.1, NM_018774.4 [Q9QWH1-1] XP_006503300.1, XM_006503237.3 [Q9QWH1-2] XP_006503301.1, XM_006503238.1 [Q9QWH1-2] XP_017175809.1, XM_017320320.1 [Q9QWH1-1]
UniGeneⁱ	Mm.473738 Mm.490300

Genome annotation databases

Ensemblⁱ	ENSMUST00000030588; ENSMUSP00000030588; ENSMUSG00000028796 [Q9QWH1-1] ENSMUST00000106079; ENSMUSP00000101689; ENSMUSG00000028796 [Q9QWH1-2] ENSMUST00000106080; ENSMUSP00000101690; ENSMUSG00000028796 [Q9QWH1-1]
GeneIDⁱ	54383
KEGGⁱ	mmu:54383
UCSC genome browser More...UCSCⁱ	uc008uvh.2 mouse [Q9QWH1-1] uc008uvk.2 mouse [Q9QWH1-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QWH1	Polyhomeotic-like 2 (Drosophila) (Fragment)		MOUSE		269	UniRef100_Q9QWH1
Isoform 2 of Polyhomeotic-like protein 2		MOUSE		323
Polyhomeotic-like 2 (Drosophila) (Fragment)		MOUSE		143
Polyhomeotic-like 2 (Drosophila) (Fragment)		MOUSE		202

Protein	Similar proteins		Species	Score	Length	Source
Q9QWH1	Polyhomeotic-like 2 (Drosophila) (Fragment)		MOUSE		269	UniRef90_Q9QWH1
polyhomeotic-like protein 2 isoform X1		MESAU		858
Polyhomeotic homolog 2		RAT		850
Polyhomeotic-like protein 2		CRIGR		800
UPI00077DB82D		PERMB		860
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9QWH1	Polyhomeotic-like protein 2		HUMAN		858	UniRef50_Q8IXK0
Uncharacterized protein		MACFA		860
Polyhomeotic homolog 2		GORGO		859
Uncharacterized protein		COLAP		859
Polyhomeotic homolog 2		PANTR		859
+356

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB062362 mRNA Translation: BAB93527.1 U81491 mRNA Translation: AAD00519.1 AL611969, AL611983 Genomic DNA Translation: CAM23052.1 AL611983 Genomic DNA Translation: CAM25248.1 AL611983, AL611969 Genomic DNA Translation: CAM25252.1 BC057571 mRNA Translation: AAH57571.1 BC071246 mRNA Translation: AAH71246.1 AF060076 mRNA Translation: AAC23570.1
CCDSⁱ	CCDS18674.1 [Q9QWH1-1] CCDS57297.1 [Q9QWH1-2]
RefSeqⁱ	NP_001182012.1, NM_001195083.1 [Q9QWH1-2] NP_001182059.1, NM_001195130.1 [Q9QWH1-1] NP_061244.1, NM_018774.4 [Q9QWH1-1] XP_006503300.1, XM_006503237.3 [Q9QWH1-2] XP_006503301.1, XM_006503238.1 [Q9QWH1-2] XP_017175809.1, XM_017320320.1 [Q9QWH1-1]
UniGeneⁱ	Mm.473738 Mm.490300

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2NA1	NMR	-	A	557-590	[»]
ProteinModelPortalⁱ	Q9QWH1
SMRⁱ	Q9QWH1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207636, 9 interactors
IntActⁱ	Q9QWH1, 9 interactors
MINTⁱ	Q9QWH1
STRINGⁱ	10090.ENSMUSP00000030588

PTM databases

iPTMnetⁱ	Q9QWH1
PhosphoSitePlusⁱ	Q9QWH1

Proteomic databases

PaxDbⁱ	Q9QWH1
PeptideAtlasⁱ	Q9QWH1
PRIDEⁱ	Q9QWH1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030588; ENSMUSP00000030588; ENSMUSG00000028796 [Q9QWH1-1] ENSMUST00000106079; ENSMUSP00000101689; ENSMUSG00000028796 [Q9QWH1-2] ENSMUST00000106080; ENSMUSP00000101690; ENSMUSG00000028796 [Q9QWH1-1]
GeneIDⁱ	54383
KEGGⁱ	mmu:54383
UCSCⁱ	uc008uvh.2 mouse [Q9QWH1-1] uc008uvk.2 mouse [Q9QWH1-2]

Organism-specific databases

CTDⁱ	1912
MGIⁱ	MGI:1860454 Phc2

Phylogenomic databases

eggNOGⁱ	ENOG410IDZN Eukaryota ENOG4111F0Y LUCA
GeneTreeⁱ	ENSGT00550000074459
HOGENOMⁱ	HOG000236275
HOVERGENⁱ	HBG039325
InParanoidⁱ	Q9QWH1
KOⁱ	K11457
OMAⁱ	PQQCAPD
OrthoDBⁱ	EOG091G02VS
PhylomeDBⁱ	Q9QWH1
TreeFamⁱ	TF331299

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-3108214 SUMOylation of DNA damage response and repair proteins R-MMU-3899300 SUMOylation of transcription cofactors R-MMU-4551638 SUMOylation of chromatin organization proteins R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

ChiTaRSⁱ	Phc2 mouse
Protein Ontology More...PROⁱ	PR:Q9QWH1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028796 Expressed in 299 organ(s), highest expression level in neocortex
CleanExⁱ	MM_PHC2
ExpressionAtlasⁱ	Q9QWH1 baseline and differential
Genevisibleⁱ	Q9QWH1 MM

Family and domain databases

Gene3Dⁱ	3.30.60.160, 1 hit
InterProⁱ	View protein in InterPro IPR001660 SAM IPR013761 SAM/pointed_sf IPR012313 Znf_FCS IPR038603 Znf_FCS_sf
Pfamⁱ	View protein in Pfam PF00536 SAM_1, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 1 hit PS51024 ZF_FCS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PHC2_MOUSE
Accessionⁱ	Q9QWH1Primary (citable) accession number: Q9QWH1 Secondary accession number(s): B1AS98 , B1ASA4, O88463, Q8K5D9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QWH1 (PHC2_MOUSE)

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Polyhomeotic-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ