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UniProtKB - Q9QWG5 (INP4B_RAT)

Entry version 122 (02 Dec 2020)
Sequence version 1 (01 May 2000)
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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

Inpp4b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (PubMed:9295334). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by inositol hexakisphosphate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=39 µM for inositol 3,4-bisphosphate1 Publication
  2. KM=34 µM for inositol 1,3,4-trisphosphate1 Publication
  1. Vmax=26 µmol/min/mg enzyme with inositol 3,4-bisphosphate as substrate1 Publication
  2. Vmax=22 µmol/min/mg enzyme with inositol 1,3,4-trisphosphate as substrate1 Publication

pH dependencei

Optimum pH is 7-8.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.1 Publication
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.66, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-1660516, Synthesis of PIPs at the early endosome membrane
R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00944

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000896

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.661 Publication)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Inpp4b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Rat genome database

More...RGDi		620470, Inpp4b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902391 – 928Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST928

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QWG5

PRoteomics IDEntifications database

More...PRIDEi		Q9QWG5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QWG5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QWG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000018382, Expressed in testis and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9QWG5, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000025013

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 165C2PROSITE-ProRule annotationAdd BLAST143

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4428, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007802_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QWG5

Identification of Orthologs from Complete Genome Data

More...OMAi		HITTDAQ

Database of Orthologous Groups

More...OrthoDBi		129165at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9QWG5

TreeFam database of animal gene trees

More...TreeFami		TF325637

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035892, C2_domain_sf
IPR039034, INPP4

The PANTHER Classification System

More...PANTHERi		PTHR12187, PTHR12187, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9QWG5-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKSPNEPQ LEFILACKDL 
        60         70         80         90        100
VAPVSDRKLN TVVQVSVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPS 
       110        120        130        140        150
DYPIYEETRI KLTVYDVKDK PHDTIRTSVL PEHKDPPPEV ARSFLGCASF 
       160        170        180        190        200
KVGELLKSKE QLLSLSLRTS DGGKVVGTIE VSLVKMGEIE DGDTDHITTD 
       210        220        230        240        250
VQGQKCALVY DSTAPESLSG KENLPFMNAV LRNPVCKLYR FPTSDNKWMR 
       260        270        280        290        300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QELKELGDLS PHWDNLRNNV 
       310        320        330        340        350
LSHCDQMVTM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ 
       360        370        380        390        400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI 
       410        420        430        440        450
YYSPENTAKA KEVLSSINQL QPLVATHADL LLTSASQHSP DSLRSSLKLL 
       460        470        480        490        500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILRKPPSPKV STEEKSSQHD 
       510        520        530        540        550
SPQQLRRQDS IPHHSDYDEE EWDRVWANVG KSLNCIIAKV DKLIERDSRN 
       560        570        580        590        600
DKSTGGDSSK DGDADPNLED SLTSHPREDW YEQLHPLILT LKECMAEVVN 
       610        620        630        640        650
RAKQSLTFVL LQELAYSLPQ CLMLTLRRDI VFSQALAGLV CGFIIKLHTS 
       660        670        680        690        700
LHDPGFLQQL HTVGLIVQYE GLLSTYSDEI GMLEDMAVGI SDLRKVAFKI 
       710        720        730        740        750
TEATSNDVLP VLTGRREHYV VEVKLPATVF ESLPLQIKEG QLLHVYPVLF 
       760        770        780        790        800
NVGINEQQTL AERFGDVSLQ ESINQENFEL VQEYYSIFME KMPPDYISHF 
       810        820        830        840        850
QEQNDLKGLL DNLHQNIQAK KRKNVEIMWL AATICRKLNG IRFTCCKSAK 
       860        870        880        890        900
DRTSMSVTLE QCSILRDEHQ LHKDFFIRAL DCMRREGCRI ENVLKNIKCR 
       910        920 
RYAFNMLQLM AFPKCYRPPE GTYGKADT
Length:928
Mass (Da):105,245
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i973EB2EEA58E6430
GO
Isoform 2 (identifier: Q9QWG5-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     885-928: REGCRIENVL...PEGTYGKADT → SRQTQGALNE...SLALLLAKYQ

Note: Inactive.Curated
Show »
Length:942
Mass (Da):106,485
Checksum:i65B9CB28D3AAC6E3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015249885 – 928REGCR…GKADT → SRQTQGALNESDDPETGCLS DNKPTSRHFYPVALLLVSSH LLVVWLILSLALLLAKYQ in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U96920 mRNA Translation: AAB72151.1
U96921 mRNA Translation: AAB72152.1

NCBI Reference Sequences

More...RefSeqi		NP_446369.1, NM_053917.1 [Q9QWG5-2]
XP_008770684.1, XM_008772462.2 [Q9QWG5-2]
XP_008770686.1, XM_008772464.2 [Q9QWG5-1]
XP_017456652.1, XM_017601163.1 [Q9QWG5-2]
XP_017456653.1, XM_017601164.1 [Q9QWG5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000024981; ENSRNOP00000024981; ENSRNOG00000018382 [Q9QWG5-1]
ENSRNOT00000025013; ENSRNOP00000025013; ENSRNOG00000018382 [Q9QWG5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:116699

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96920 mRNA Translation: AAB72151.1
U96921 mRNA Translation: AAB72152.1
RefSeqiNP_446369.1, NM_053917.1 [Q9QWG5-2]
XP_008770684.1, XM_008772462.2 [Q9QWG5-2]
XP_008770686.1, XM_008772464.2 [Q9QWG5-1]
XP_017456652.1, XM_017601163.1 [Q9QWG5-2]
XP_017456653.1, XM_017601164.1 [Q9QWG5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025013

Chemistry databases

SwissLipidsiSLP:000000896

PTM databases

iPTMnetiQ9QWG5
PhosphoSitePlusiQ9QWG5

Proteomic databases

PaxDbiQ9QWG5
PRIDEiQ9QWG5

Genome annotation databases

EnsembliENSRNOT00000024981; ENSRNOP00000024981; ENSRNOG00000018382 [Q9QWG5-1]
ENSRNOT00000025013; ENSRNOP00000025013; ENSRNOG00000018382 [Q9QWG5-2]
GeneIDi116699
KEGGirno:116699

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8821
RGDi620470, Inpp4b

Phylogenomic databases

eggNOGiKOG4428, Eukaryota
GeneTreeiENSGT00940000157587
HOGENOMiCLU_007802_1_0_1
InParanoidiQ9QWG5
OMAiHITTDAQ
OrthoDBi129165at2759
PhylomeDBiQ9QWG5
TreeFamiTF325637

Enzyme and pathway databases

UniPathwayiUPA00944
BRENDAi3.1.3.66, 5301
ReactomeiR-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-1660516, Synthesis of PIPs at the early endosome membrane
R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9QWG5

Gene expression databases

BgeeiENSRNOG00000018382, Expressed in testis and 20 other tissues
GenevisibleiQ9QWG5, RN

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892, C2_domain_sf
IPR039034, INPP4
PANTHERiPTHR12187, PTHR12187, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINP4B_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QWG5
Secondary accession number(s): O35825
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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