UniProtKB - Q9QWG5 (INP4B_RAT)
Protein
Type II inositol 3,4-bisphosphate 4-phosphatase
Gene
Inpp4b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (PubMed:9295334). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity).By similarity1 Publication
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate1 PublicationEC:3.1.3.661 Publication
- 1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate1 Publication
Activity regulationi
Strongly inhibited by inositol hexakisphosphate.1 Publication
Kineticsi
- KM=39 µM for inositol 3,4-bisphosphate1 Publication
- KM=34 µM for inositol 1,3,4-trisphosphate1 Publication
- Vmax=26 µmol/min/mg enzyme with inositol 3,4-bisphosphate as substrate1 Publication
- Vmax=22 µmol/min/mg enzyme with inositol 1,3,4-trisphosphate as substrate1 Publication
pH dependencei
Optimum pH is 7-8.1 Publication
: phosphatidylinositol signaling pathway Pathwayi
This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.1 PublicationView all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.
GO - Molecular functioni
- lipid binding Source: RGD
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Source: RGD
- phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Source: UniProtKB-EC
- phosphatidylinositol bisphosphate phosphatase activity Source: RGD
- phosphatidylinositol trisphosphate phosphatase activity Source: RGD
GO - Biological processi
- cellular calcium ion homeostasis Source: RGD
- inositol phosphate dephosphorylation Source: MGI
- negative regulation of osteoclast differentiation Source: RGD
- phosphatidylinositol dephosphorylation Source: MGI
- regulation of bone remodeling Source: RGD
- regulation of nucleocytoplasmic transport Source: RGD
- regulation of protein kinase B signaling Source: RGD
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.66, 5301 |
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-1660516, Synthesis of PIPs at the early endosome membrane R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
UniPathwayi | UPA00944 |
Chemistry databases
SwissLipidsi | SLP:000000896 |
Names & Taxonomyi
Protein namesi | Recommended name: Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.661 Publication)Alternative name(s): Inositol polyphosphate 4-phosphatase type II |
Gene namesi | Name:Inpp4b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620470, Inpp4b |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: RGD
Other locations
- cytoplasm Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190239 | 1 – 928 | Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST | 928 |
Proteomic databases
PaxDbi | Q9QWG5 |
PRIDEi | Q9QWG5 |
PTM databases
iPTMneti | Q9QWG5 |
PhosphoSitePlusi | Q9QWG5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018382, Expressed in testis and 20 other tissues |
Genevisiblei | Q9QWG5, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 165 | C2PROSITE-ProRule annotationAdd BLAST | 143 |
Sequence similaritiesi
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG4428, Eukaryota |
GeneTreei | ENSGT00940000157587 |
HOGENOMi | CLU_007802_1_0_1 |
InParanoidi | Q9QWG5 |
OMAi | HITTDAQ |
OrthoDBi | 129165at2759 |
PhylomeDBi | Q9QWG5 |
TreeFami | TF325637 |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR039034, INPP4 |
PANTHERi | PTHR12187, PTHR12187, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9QWG5-1) [UniParc]FASTAAdd to basket
Also known as: Alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKSPNEPQ LEFILACKDL
60 70 80 90 100
VAPVSDRKLN TVVQVSVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPS
110 120 130 140 150
DYPIYEETRI KLTVYDVKDK PHDTIRTSVL PEHKDPPPEV ARSFLGCASF
160 170 180 190 200
KVGELLKSKE QLLSLSLRTS DGGKVVGTIE VSLVKMGEIE DGDTDHITTD
210 220 230 240 250
VQGQKCALVY DSTAPESLSG KENLPFMNAV LRNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QELKELGDLS PHWDNLRNNV
310 320 330 340 350
LSHCDQMVTM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSSINQL QPLVATHADL LLTSASQHSP DSLRSSLKLL
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILRKPPSPKV STEEKSSQHD
510 520 530 540 550
SPQQLRRQDS IPHHSDYDEE EWDRVWANVG KSLNCIIAKV DKLIERDSRN
560 570 580 590 600
DKSTGGDSSK DGDADPNLED SLTSHPREDW YEQLHPLILT LKECMAEVVN
610 620 630 640 650
RAKQSLTFVL LQELAYSLPQ CLMLTLRRDI VFSQALAGLV CGFIIKLHTS
660 670 680 690 700
LHDPGFLQQL HTVGLIVQYE GLLSTYSDEI GMLEDMAVGI SDLRKVAFKI
710 720 730 740 750
TEATSNDVLP VLTGRREHYV VEVKLPATVF ESLPLQIKEG QLLHVYPVLF
760 770 780 790 800
NVGINEQQTL AERFGDVSLQ ESINQENFEL VQEYYSIFME KMPPDYISHF
810 820 830 840 850
QEQNDLKGLL DNLHQNIQAK KRKNVEIMWL AATICRKLNG IRFTCCKSAK
860 870 880 890 900
DRTSMSVTLE QCSILRDEHQ LHKDFFIRAL DCMRREGCRI ENVLKNIKCR
910 920
RYAFNMLQLM AFPKCYRPPE GTYGKADT
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015249 | 885 – 928 | REGCR…GKADT → SRQTQGALNESDDPETGCLS DNKPTSRHFYPVALLLVSSH LLVVWLILSLALLLAKYQ in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96920 mRNA Translation: AAB72151.1 U96921 mRNA Translation: AAB72152.1 |
RefSeqi | NP_446369.1, NM_053917.1 [Q9QWG5-2] XP_008770684.1, XM_008772462.2 [Q9QWG5-2] XP_008770686.1, XM_008772464.2 [Q9QWG5-1] XP_017456652.1, XM_017601163.1 [Q9QWG5-2] XP_017456653.1, XM_017601164.1 [Q9QWG5-1] |
Genome annotation databases
Ensembli | ENSRNOT00000024981; ENSRNOP00000024981; ENSRNOG00000018382 [Q9QWG5-1] ENSRNOT00000025013; ENSRNOP00000025013; ENSRNOG00000018382 [Q9QWG5-2] |
GeneIDi | 116699 |
KEGGi | rno:116699 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96920 mRNA Translation: AAB72151.1 U96921 mRNA Translation: AAB72152.1 |
RefSeqi | NP_446369.1, NM_053917.1 [Q9QWG5-2] XP_008770684.1, XM_008772462.2 [Q9QWG5-2] XP_008770686.1, XM_008772464.2 [Q9QWG5-1] XP_017456652.1, XM_017601163.1 [Q9QWG5-2] XP_017456653.1, XM_017601164.1 [Q9QWG5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025013 |
Chemistry databases
SwissLipidsi | SLP:000000896 |
PTM databases
iPTMneti | Q9QWG5 |
PhosphoSitePlusi | Q9QWG5 |
Proteomic databases
PaxDbi | Q9QWG5 |
PRIDEi | Q9QWG5 |
Genome annotation databases
Ensembli | ENSRNOT00000024981; ENSRNOP00000024981; ENSRNOG00000018382 [Q9QWG5-1] ENSRNOT00000025013; ENSRNOP00000025013; ENSRNOG00000018382 [Q9QWG5-2] |
GeneIDi | 116699 |
KEGGi | rno:116699 |
Organism-specific databases
CTDi | 8821 |
RGDi | 620470, Inpp4b |
Phylogenomic databases
eggNOGi | KOG4428, Eukaryota |
GeneTreei | ENSGT00940000157587 |
HOGENOMi | CLU_007802_1_0_1 |
InParanoidi | Q9QWG5 |
OMAi | HITTDAQ |
OrthoDBi | 129165at2759 |
PhylomeDBi | Q9QWG5 |
TreeFami | TF325637 |
Enzyme and pathway databases
UniPathwayi | UPA00944 |
BRENDAi | 3.1.3.66, 5301 |
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-1660516, Synthesis of PIPs at the early endosome membrane R-RNO-1855183, Synthesis of IP2, IP, and Ins in the cytosol |
Miscellaneous databases
PROi | PR:Q9QWG5 |
Gene expression databases
Bgeei | ENSRNOG00000018382, Expressed in testis and 20 other tissues |
Genevisiblei | Q9QWG5, RN |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR039034, INPP4 |
PANTHERi | PTHR12187, PTHR12187, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INP4B_RAT | |
Accessioni | Q9QWG5Primary (citable) accession number: Q9QWG5 Secondary accession number(s): O35825 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families