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Protein

Phosducin

Gene

Pdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Rod photoreceptor 1
Short name:
RPR-1
Gene namesi
Name:Pdc
Synonyms:Rpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98090 Pdc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637531 – 244PhosducinAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71Phosphoserine; by PKABy similarity1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QW08
PaxDbiQ9QW08
PRIDEiQ9QW08

PTM databases

iPTMnetiQ9QW08
PhosphoSitePlusiQ9QW08

Expressioni

Gene expression databases

BgeeiENSMUSG00000006007 Expressed in 103 organ(s), highest expression level in retina
CleanExiMM_PDC
ExpressionAtlasiQ9QW08 baseline and differential
GenevisibleiQ9QW08 MM

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131631

Structurei

3D structure databases

ProteinModelPortaliQ9QW08
SMRiQ9QW08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 244Thioredoxin foldBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiQ9QW08
KOiK08327
OMAiAAEYPMV
OrthoDBiEOG091G0ISM
PhylomeDBiQ9QW08
TreeFamiTF315179

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 2 hits
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QW08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL
60 70 80 90 100
RQMSSPQSRD DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH
110 120 130 140 150
QKLSFGPRYG FVYELETGEQ FLETIEKEQK VTTIVVNIYE DGVRGCDALN
160 170 180 190 200
SSLACLAVEY PMVKFCKIKA SNTGAGDRFS TDVLPTLLVY KGGELISNFI
210 220 230 240
SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED EDIE
Length:244
Mass (Da):28,016
Last modified:May 1, 2000 - v1
Checksum:iF42361EA25F0F254
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS02A0A087WS02_MOUSE
Phosducin
Pdc
185Annotation score:
A0A087WRK4A0A087WRK4_MOUSE
Phosducin
Pdc
82Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08075 mRNA Translation: AAK13559.1
BC012507 mRNA Translation: AAH12507.1
BC021920 mRNA Translation: AAH21920.1
CCDSiCCDS15354.1
PIRiJC2018
RefSeqiNP_001153202.1, NM_001159730.1
NP_077778.1, NM_024458.2
UniGeneiMm.440883

Genome annotation databases

EnsembliENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007
ENSMUST00000191228; ENSMUSP00000141136; ENSMUSG00000006007
GeneIDi20028
KEGGimmu:20028
UCSCiuc007cxw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08075 mRNA Translation: AAK13559.1
BC012507 mRNA Translation: AAH12507.1
BC021920 mRNA Translation: AAH21920.1
CCDSiCCDS15354.1
PIRiJC2018
RefSeqiNP_001153202.1, NM_001159730.1
NP_077778.1, NM_024458.2
UniGeneiMm.440883

3D structure databases

ProteinModelPortaliQ9QW08
SMRiQ9QW08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131631

PTM databases

iPTMnetiQ9QW08
PhosphoSitePlusiQ9QW08

Proteomic databases

MaxQBiQ9QW08
PaxDbiQ9QW08
PRIDEiQ9QW08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007
ENSMUST00000191228; ENSMUSP00000141136; ENSMUSG00000006007
GeneIDi20028
KEGGimmu:20028
UCSCiuc007cxw.1 mouse

Organism-specific databases

CTDi5132
MGIiMGI:98090 Pdc

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00930000150898
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiQ9QW08
KOiK08327
OMAiAAEYPMV
OrthoDBiEOG091G0ISM
PhylomeDBiQ9QW08
TreeFamiTF315179

Miscellaneous databases

PROiPR:Q9QW08
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006007 Expressed in 103 organ(s), highest expression level in retina
CleanExiMM_PDC
ExpressionAtlasiQ9QW08 baseline and differential
GenevisibleiQ9QW08 MM

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 2 hits
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_MOUSE
AccessioniPrimary (citable) accession number: Q9QW08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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