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Protein

Transcription elongation factor A protein 2

Gene

Tcea2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Protein S-II-T1
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
Gene namesi
Name:Tcea2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107368 Tcea2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214501 – 299Transcription elongation factor A protein 2Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei59PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QVN7
PaxDbiQ9QVN7
PRIDEiQ9QVN7

PTM databases

PhosphoSitePlusiQ9QVN7

Expressioni

Tissue specificityi

Testis and ovary specific. Specific to testicular germ cells.

Developmental stagei

Expressed in testicular germ cells during and after meiosis in the course of spermatogenesis, while it is not expressed in premeiotic or early meiotic testicular germ cells.

Gene expression databases

BgeeiENSMUSG00000059540 Expressed in 194 organ(s), highest expression level in testis
CleanExiMM_TCEA2
ExpressionAtlasiQ9QVN7 baseline and differential
GenevisibleiQ9QVN7 MM

Interactioni

Subunit structurei

Interacts with the basal transcription factor GTF2B. Interacts with REXO1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099331

Structurei

3D structure databases

ProteinModelPortaliQ9QVN7
SMRiQ9QVN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 82TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini138 – 254TFIIS centralPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the TFS-II family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000017794
HOGENOMiHOG000195015
HOVERGENiHBG055022
InParanoidiQ9QVN7
KOiK03145
OMAiCEHIAAQ
OrthoDBiEOG091G10EJ
PhylomeDBiQ9QVN7
TreeFamiTF314970

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100 TF_IIS-typ
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR017923 TFIIS_N
IPR006289 TFSII
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF01096 TFIIS_C, 1 hit
PF07500 TFIIS_M, 1 hit
PIRSFiPIRSF006704 TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510 TFS2M, 1 hit
SM00509 TFS2N, 1 hit
SM00440 ZnF_C2C2, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF47676 SSF47676, 1 hit
TIGRFAMsiTIGR01385 TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS51319 TFIIS_N, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QVN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEEEIARI ARRLDKMVTR KNAEGAMDLL RELKNMPITL HLLQSTRVGM
60 70 80 90 100
SVNALRKQSS DEELIALAKS LIKSWKKLLD VSDGKSRNQG RGTPLPTSSS
110 120 130 140 150
KDASRTTDLS CKKPDPPRTP STPRITTFPQ VPITCDAVRN KCREMLTLAL
160 170 180 190 200
QTDHDHVAVG VNCEHLSSQI EECIFLDVGN TDMKYKNRVR SRISNLKDAK
210 220 230 240 250
NPGLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR
260 270 280 290
TGGTQTDLFT CNKCRKKNCT YTQVQTRSSD EPMTTYVVCN ECGNRWKFC
Length:299
Mass (Da):33,663
Last modified:February 12, 2003 - v2
Checksum:iF89A30B7984EEDDB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCS4B7ZCS4_MOUSE
Transcription elongation factor A p...
Tcea2
292Annotation score:
F6XMY4F6XMY4_MOUSE
Transcription elongation factor A p...
Tcea2
297Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86081 mRNA Translation: BAA19752.1
AB010271 mRNA Translation: BAA82313.1
CCDSiCCDS17219.1
PIRiJC5430
RefSeqiNP_033352.1, NM_009326.2
UniGeneiMm.24245

Genome annotation databases

EnsembliENSMUST00000103042; ENSMUSP00000099331; ENSMUSG00000059540
GeneIDi21400
KEGGimmu:21400
UCSCiuc012cmu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86081 mRNA Translation: BAA19752.1
AB010271 mRNA Translation: BAA82313.1
CCDSiCCDS17219.1
PIRiJC5430
RefSeqiNP_033352.1, NM_009326.2
UniGeneiMm.24245

3D structure databases

ProteinModelPortaliQ9QVN7
SMRiQ9QVN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099331

PTM databases

PhosphoSitePlusiQ9QVN7

Proteomic databases

MaxQBiQ9QVN7
PaxDbiQ9QVN7
PRIDEiQ9QVN7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103042; ENSMUSP00000099331; ENSMUSG00000059540
GeneIDi21400
KEGGimmu:21400
UCSCiuc012cmu.2 mouse

Organism-specific databases

CTDi6919
MGIiMGI:107368 Tcea2

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000017794
HOGENOMiHOG000195015
HOVERGENiHBG055022
InParanoidiQ9QVN7
KOiK03145
OMAiCEHIAAQ
OrthoDBiEOG091G10EJ
PhylomeDBiQ9QVN7
TreeFamiTF314970

Miscellaneous databases

PROiPR:Q9QVN7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059540 Expressed in 194 organ(s), highest expression level in testis
CleanExiMM_TCEA2
ExpressionAtlasiQ9QVN7 baseline and differential
GenevisibleiQ9QVN7 MM

Family and domain databases

Gene3Di1.10.472.30, 1 hit
1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035100 TF_IIS-typ
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR003618 TFIIS_cen_dom
IPR036575 TFIIS_cen_dom_sf
IPR017923 TFIIS_N
IPR006289 TFSII
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF01096 TFIIS_C, 1 hit
PF07500 TFIIS_M, 1 hit
PIRSFiPIRSF006704 TF_IIS, 1 hit
SMARTiView protein in SMART
SM00510 TFS2M, 1 hit
SM00509 TFS2N, 1 hit
SM00440 ZnF_C2C2, 1 hit
SUPFAMiSSF46942 SSF46942, 1 hit
SSF47676 SSF47676, 1 hit
TIGRFAMsiTIGR01385 TFSII, 1 hit
PROSITEiView protein in PROSITE
PS51321 TFIIS_CENTRAL, 1 hit
PS51319 TFIIS_N, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCEA2_MOUSE
AccessioniPrimary (citable) accession number: Q9QVN7
Secondary accession number(s): O08667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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