UniProtKB - Q9QUS1 (NR1I3_RAT)
Nuclear receptor subfamily 1 group I member 3
Nr1i3
Functioni
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 18 – 93 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 21 – 41 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 57 – 81 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- nuclear receptor activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- osteoblast differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription, DNA-templated Source: RGD
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 1 group I member 3Alternative name(s): Constitutive androstane receptor Short name: CAR |
Gene namesi | Name:Nr1i3 Synonyms:Car |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621400, Nr1i3 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Recruited to the cytoplasm by DNAJC7.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053556 | 1 – 358 | Nuclear receptor subfamily 1 group I member 3Add BLAST | 358 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | Phosphothreonine; by PKCBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9QUS1 |
PTM databases
PhosphoSitePlusi | Q9QUS1 |
Interactioni
Subunit structurei
Heterodimer of NR1I3 and RXR.
Interacts with PSMC4.
Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity).
Interacts with CRY1 (By similarity).
Interacts with CRY2 in a ligand-dependent manner (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000048836 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 119 – 358 | NR LBDPROSITE-ProRule annotationAdd BLAST | 240 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 21 – 41 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 57 – 81 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
HOGENOMi | CLU_007368_12_0_1 |
InParanoidi | Q9QUS1 |
OrthoDBi | 297114at2759 |
PhylomeDBi | Q9QUS1 |
TreeFami | TF316304 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS
60 70 80 90 100
KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR
110 120 130 140 150
RARQARRRAQ KASLQLSQQQ KELIQTLLGA HTRHVGPMFD QFVQFRPPAY
160 170 180 190 200
LFSHHRPFQP LAPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ
210 220 230 240 250
ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV HVGFQYEFLE
260 270 280 290 300
LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL
310 320 330 340 350
ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM
PLLGEICS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ402C1 | Q402C1_RAT | Constitutive androstane receptor sp... | Nr1i3 NR1I3 | 316 | Annotation score: | ||
Q76FN2 | Q76FN2_RAT | Nuclear receptor subfamily 1 group ... | Nr1i3 CAR | 310 | Annotation score: | ||
A0A8I6AVD8 | A0A8I6AVD8_RAT | Nuclear receptor subfamily 1 group ... | Nr1i3 rCG_20357 | 286 | Annotation score: | ||
A0A8I6A462 | A0A8I6A462_RAT | Nuclear receptor subfamily 1 group ... | Nr1i3 | 311 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133095 mRNA Translation: AAF22567.1 AF133094 mRNA Translation: AAF22566.1 AB104736 mRNA Translation: BAC82431.1 AB105071 Genomic DNA Translation: BAC84955.1 |
RefSeqi | NP_075230.1, NM_022941.4 |
Genome annotation databases
Ensembli | ENSRNOT00000049873; ENSRNOP00000048836; ENSRNOG00000003260 |
GeneIDi | 65035 |
KEGGi | rno:65035 |
UCSCi | RGD:621400, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133095 mRNA Translation: AAF22567.1 AF133094 mRNA Translation: AAF22566.1 AB104736 mRNA Translation: BAC82431.1 AB105071 Genomic DNA Translation: BAC84955.1 |
RefSeqi | NP_075230.1, NM_022941.4 |
3D structure databases
AlphaFoldDBi | Q9QUS1 |
SMRi | Q9QUS1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000048836 |
Chemistry databases
ChEMBLi | CHEMBL3509594 |
PTM databases
PhosphoSitePlusi | Q9QUS1 |
Proteomic databases
PaxDbi | Q9QUS1 |
Genome annotation databases
Ensembli | ENSRNOT00000049873; ENSRNOP00000048836; ENSRNOG00000003260 |
GeneIDi | 65035 |
KEGGi | rno:65035 |
UCSCi | RGD:621400, rat |
Organism-specific databases
CTDi | 9970 |
RGDi | 621400, Nr1i3 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
HOGENOMi | CLU_007368_12_0_1 |
InParanoidi | Q9QUS1 |
OrthoDBi | 297114at2759 |
PhylomeDBi | Q9QUS1 |
TreeFami | TF316304 |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Miscellaneous databases
PROi | PR:Q9QUS1 |
Gene expression databases
Genevisiblei | Q9QUS1, RN |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NR1I3_RAT | |
Accessioni | Q9QUS1Primary (citable) accession number: Q9QUS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families