Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear receptor subfamily 1 group I member 3

Gene

Nr1i3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 93Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri21 – 41NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri57 – 81NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 3
Alternative name(s):
Constitutive androstane receptor
Short name:
CAR
Gene namesi
Name:Nr1i3
Synonyms:Car
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621400 Nr1i3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3509594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535561 – 358Nuclear receptor subfamily 1 group I member 3Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Phosphothreonine; by PKCBy similarity1

Post-translational modificationi

Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QUS1
PRIDEiQ9QUS1

PTM databases

PhosphoSitePlusiQ9QUS1

Expressioni

Gene expression databases

GenevisibleiQ9QUS1 RN

Interactioni

Subunit structurei

Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048836

Structurei

3D structure databases

ProteinModelPortaliQ9QUS1
SMRiQ9QUS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 358NR LBDPROSITE-ProRule annotationAdd BLAST240

Domaini

Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 41NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri57 – 81NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiQ9QUS1
KOiK08541
OrthoDBiEOG091G0DMU
PhylomeDBiQ9QUS1
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9QUS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS
60 70 80 90 100
KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR
110 120 130 140 150
RARQARRRAQ KASLQLSQQQ KELIQTLLGA HTRHVGPMFD QFVQFRPPAY
160 170 180 190 200
LFSHHRPFQP LAPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ
210 220 230 240 250
ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV HVGFQYEFLE
260 270 280 290 300
LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL
310 320 330 340 350
ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM

PLLGEICS
Length:358
Mass (Da):40,923
Last modified:May 1, 2000 - v1
Checksum:i13691F49CAD8F1ED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q402C1Q402C1_RAT
Constitutive androstane receptor sp...
Nr1i3 NR1I3
316Annotation score:
Q76FN2Q76FN2_RAT
Nuclear receptor subfamily 1 group ...
Nr1i3 CAR
310Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133095 mRNA Translation: AAF22567.1
AF133094 mRNA Translation: AAF22566.1
AB104736 mRNA Translation: BAC82431.1
AB105071 Genomic DNA Translation: BAC84955.1
RefSeqiNP_075230.1, NM_022941.4
UniGeneiRn.163229

Genome annotation databases

GeneIDi65035
KEGGirno:65035
UCSCiRGD:621400 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133095 mRNA Translation: AAF22567.1
AF133094 mRNA Translation: AAF22566.1
AB104736 mRNA Translation: BAC82431.1
AB105071 Genomic DNA Translation: BAC84955.1
RefSeqiNP_075230.1, NM_022941.4
UniGeneiRn.163229

3D structure databases

ProteinModelPortaliQ9QUS1
SMRiQ9QUS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048836

Chemistry databases

ChEMBLiCHEMBL3509594

PTM databases

PhosphoSitePlusiQ9QUS1

Proteomic databases

PaxDbiQ9QUS1
PRIDEiQ9QUS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65035
KEGGirno:65035
UCSCiRGD:621400 rat

Organism-specific databases

CTDi9970
RGDi621400 Nr1i3

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiQ9QUS1
KOiK08541
OrthoDBiEOG091G0DMU
PhylomeDBiQ9QUS1
TreeFamiTF316304

Miscellaneous databases

PROiPR:Q9QUS1

Gene expression databases

GenevisibleiQ9QUS1 RN

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR1I3_RAT
AccessioniPrimary (citable) accession number: Q9QUS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again