Hapln1

Functionⁱ

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functionⁱ

extracellular matrix structural constituent conferring compression resistance
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 22159717
hyaluronic acid binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: InterPro
central nervous system development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Hyaluronic acid

Ligand

Hyaluronic acid

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hyaluronan and proteoglycan link protein 1 Alternative name(s): Cartilage-linking protein 1 Short name: Cartilage-link protein Proteoglycan link protein
Gene namesⁱ	Name:Hapln1 Synonyms:Crtl1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:1337006 Hapln1

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PropeptideⁱPRO_0000013179	1 – 9	By similarity		9
ChainⁱPRO_0000013180	10 – 356	Hyaluronan and proteoglycan link protein 1Add BLAST		347

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	58	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	63 ↔ 141	By similarity
Disulfide bondⁱ	183 ↔ 254	By similarity
Disulfide bondⁱ	207 ↔ 228	By similarity
Disulfide bondⁱ	281 ↔ 351	By similarity
Disulfide bondⁱ	306 ↔ 327	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QUP5
PaxDbⁱ	Q9QUP5
PeptideAtlas More...PeptideAtlasⁱ	Q9QUP5
PRIDEⁱ	Q9QUP5

PTM databases

iPTMnetⁱ	Q9QUP5
PhosphoSitePlusⁱ	Q9QUP5

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000021613 Expressed in 194 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_HAPLN1
Genevisibleⁱ	Q9QUP5 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	198904, 1 interactor
IntActⁱ	Q9QUP5, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9QUP5
STRINGⁱ	10090.ENSMUSP00000022108

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QUP5
SMRⁱ	Q9QUP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	40 – 154	Ig-like V-typeAdd BLAST	115
Domainⁱ	161 – 256	Link 1PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	261 – 353	Link 2PROSITE-ProRule annotationAdd BLAST	93

Sequence similaritiesⁱ

Belongs to the HAPLN family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF28 Eukaryota ENOG410XRS8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000234353
HOVERGENⁱ	HBG051922
InParanoidⁱ	Q9QUP5
KEGG Orthology (KO) More...KOⁱ	K06848
OMAⁱ	WRSGLDW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	Q9QUP5
TreeFamⁱ	TF332134

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000538 Link_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit PF00193 Xlink, 2 hits
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00445 LINK, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56436 SSF56436, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS01241 LINK_1, 2 hits PS50963 LINK_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9QUP5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRSLLLLVLI SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK 
        60         70         80         90        100
VFSHRGGNVT LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM 
       110        120        130        140        150
GYHKKTYGGY QGRVFLKGGS DNDASLVITD LTLEDYGRYK CEVIEGLEDD 
       160        170        180        190        200
TAVVALELQG VVFPYFPRLG RYNLNFHEAR QACLDQDAVI ASFDQLYDAW 
       210        220        230        240        250
RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY GFWDKDKSRY 
       260        270        280        290        300
DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL 
       310        320        330        340        350
LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY 

CFRAYN

Length:356

Mass (Da):40,478

Last modified:May 1, 2000 - v1

Checksum:ⁱ3FB4B8F30E28C9F2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	18	Missing in AAD12253 (PubMed:12732630).Curated		1
Sequence conflictⁱ	35	Q → H in AAH66853 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF137278 , AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1 AF139572 mRNA Translation: AAF24977.1 AF098460 mRNA Translation: AAD12253.1 AK032750 mRNA Translation: BAC28007.1 AK048107 mRNA Translation: BAC33244.1 BC066853 mRNA Translation: AAH66853.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26671.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038528.3, NM_013500.4
UniGeneⁱ	Mm.266790

Genome annotation databases

Ensemblⁱ	ENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613
GeneIDⁱ	12950
KEGGⁱ	mmu:12950
UCSC genome browser More...UCSCⁱ	uc007rjf.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9QUP5	Hyaluronan and proteoglycan link protein 1		HUMAN		354	UniRef90_P10915
Hyaluronan and proteoglycan link protein 1		BOVIN		354
Hyaluronan and proteoglycan link protein 1		HORSE		354
Hyaluronan and proteoglycan link protein 1		PIG		354
Hyaluronan and proteoglycan link protein 1		RAT		354
+131

Protein	Similar proteins		Species	Score	Length	Source
Q9QUP5	Hyaluronan and proteoglycan link protein 1		HUMAN		354	UniRef50_P10915
Hyaluronan and proteoglycan link protein 1		BOVIN		354
Hyaluronan and proteoglycan link protein 1		HORSE		354
Hyaluronan and proteoglycan link protein 1		RAT		354
Hyaluronan and proteoglycan link protein 1		PIG		354
+254

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF137278 , AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1 AF139572 mRNA Translation: AAF24977.1 AF098460 mRNA Translation: AAD12253.1 AK032750 mRNA Translation: BAC28007.1 AK048107 mRNA Translation: BAC33244.1 BC066853 mRNA Translation: AAH66853.1
CCDSⁱ	CCDS26671.1
RefSeqⁱ	NP_038528.3, NM_013500.4
UniGeneⁱ	Mm.266790

3D structure databases

ProteinModelPortalⁱ	Q9QUP5
SMRⁱ	Q9QUP5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198904, 1 interactor
IntActⁱ	Q9QUP5, 2 interactors
MINTⁱ	Q9QUP5
STRINGⁱ	10090.ENSMUSP00000022108

PTM databases

iPTMnetⁱ	Q9QUP5
PhosphoSitePlusⁱ	Q9QUP5

Proteomic databases

MaxQBⁱ	Q9QUP5
PaxDbⁱ	Q9QUP5
PeptideAtlasⁱ	Q9QUP5
PRIDEⁱ	Q9QUP5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613
GeneIDⁱ	12950
KEGGⁱ	mmu:12950
UCSCⁱ	uc007rjf.2 mouse

Organism-specific databases

CTDⁱ	1404
MGIⁱ	MGI:1337006 Hapln1

Phylogenomic databases

eggNOGⁱ	ENOG410IF28 Eukaryota ENOG410XRS8 LUCA
GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000234353
HOVERGENⁱ	HBG051922
InParanoidⁱ	Q9QUP5
KOⁱ	K06848
OMAⁱ	WRSGLDW
OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	Q9QUP5
TreeFamⁱ	TF332134

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QUP5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021613 Expressed in 194 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_HAPLN1
Genevisibleⁱ	Q9QUP5 MM

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000538 Link_dom
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit PF00193 Xlink, 2 hits
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00445 LINK, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56436 SSF56436, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS01241 LINK_1, 2 hits PS50963 LINK_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HPLN1_MOUSE
Accessionⁱ	Q9QUP5Primary (citable) accession number: Q9QUP5 Secondary accession number(s): Q9D1G9, Q9Z1X7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QUP5 (HPLN1_MOUSE)

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Hyaluronan and proteoglycan link protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ