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Protein

Hyaluronan and proteoglycan link protein 1

Gene

Hapln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: InterPro
  • central nervous system development Source: GO_Central

Keywordsi

LigandHyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 1
Alternative name(s):
Cartilage-linking protein 1
Short name:
Cartilage-link protein
Proteoglycan link protein
Gene namesi
Name:Hapln1
Synonyms:Crtl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1337006 Hapln1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000131791 – 9By similarity9
ChainiPRO_000001318010 – 356Hyaluronan and proteoglycan link protein 1Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 141By similarity
Disulfide bondi183 ↔ 254By similarity
Disulfide bondi207 ↔ 228By similarity
Disulfide bondi281 ↔ 351By similarity
Disulfide bondi306 ↔ 327By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUP5
PaxDbiQ9QUP5
PeptideAtlasiQ9QUP5
PRIDEiQ9QUP5

PTM databases

iPTMnetiQ9QUP5
PhosphoSitePlusiQ9QUP5

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000021613 Expressed in 194 organ(s), highest expression level in humerus cartilage element
CleanExiMM_HAPLN1
GenevisibleiQ9QUP5 MM

Interactioni

Protein-protein interaction databases

BioGridi198904, 1 interactor
IntActiQ9QUP5, 2 interactors
MINTiQ9QUP5
STRINGi10090.ENSMUSP00000022108

Structurei

3D structure databases

ProteinModelPortaliQ9QUP5
SMRiQ9QUP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 154Ig-like V-typeAdd BLAST115
Domaini161 – 256Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini261 – 353Link 2PROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF28 Eukaryota
ENOG410XRS8 LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ9QUP5
KOiK06848
OMAiWRSGLDW
OrthoDBiEOG091G09EL
PhylomeDBiQ9QUP5
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSLLLLVLI SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK
60 70 80 90 100
VFSHRGGNVT LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM
110 120 130 140 150
GYHKKTYGGY QGRVFLKGGS DNDASLVITD LTLEDYGRYK CEVIEGLEDD
160 170 180 190 200
TAVVALELQG VVFPYFPRLG RYNLNFHEAR QACLDQDAVI ASFDQLYDAW
210 220 230 240 250
RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY GFWDKDKSRY
260 270 280 290 300
DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL
310 320 330 340 350
LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY

CFRAYN
Length:356
Mass (Da):40,478
Last modified:May 1, 2000 - v1
Checksum:i3FB4B8F30E28C9F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18Missing in AAD12253 (PubMed:12732630).Curated1
Sequence conflicti35Q → H in AAH66853 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137278
, AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1
AF139572 mRNA Translation: AAF24977.1
AF098460 mRNA Translation: AAD12253.1
AK032750 mRNA Translation: BAC28007.1
AK048107 mRNA Translation: BAC33244.1
BC066853 mRNA Translation: AAH66853.1
CCDSiCCDS26671.1
RefSeqiNP_038528.3, NM_013500.4
UniGeneiMm.266790

Genome annotation databases

EnsembliENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613
GeneIDi12950
KEGGimmu:12950
UCSCiuc007rjf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137278
, AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1
AF139572 mRNA Translation: AAF24977.1
AF098460 mRNA Translation: AAD12253.1
AK032750 mRNA Translation: BAC28007.1
AK048107 mRNA Translation: BAC33244.1
BC066853 mRNA Translation: AAH66853.1
CCDSiCCDS26671.1
RefSeqiNP_038528.3, NM_013500.4
UniGeneiMm.266790

3D structure databases

ProteinModelPortaliQ9QUP5
SMRiQ9QUP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198904, 1 interactor
IntActiQ9QUP5, 2 interactors
MINTiQ9QUP5
STRINGi10090.ENSMUSP00000022108

PTM databases

iPTMnetiQ9QUP5
PhosphoSitePlusiQ9QUP5

Proteomic databases

MaxQBiQ9QUP5
PaxDbiQ9QUP5
PeptideAtlasiQ9QUP5
PRIDEiQ9QUP5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613
GeneIDi12950
KEGGimmu:12950
UCSCiuc007rjf.2 mouse

Organism-specific databases

CTDi1404
MGIiMGI:1337006 Hapln1

Phylogenomic databases

eggNOGiENOG410IF28 Eukaryota
ENOG410XRS8 LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ9QUP5
KOiK06848
OMAiWRSGLDW
OrthoDBiEOG091G09EL
PhylomeDBiQ9QUP5
TreeFamiTF332134

Miscellaneous databases

PROiPR:Q9QUP5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021613 Expressed in 194 organ(s), highest expression level in humerus cartilage element
CleanExiMM_HAPLN1
GenevisibleiQ9QUP5 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHPLN1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUP5
Secondary accession number(s): Q9D1G9, Q9Z1X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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