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UniProtKB - Q9QUP5 (HPLN1_MOUSE)
Protein
Hyaluronan and proteoglycan link protein 1
Gene
Hapln1
Organism
Mus musculus (Mouse)
Status
Functioni
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
GO - Molecular functioni
- hyaluronic acid binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: InterPro
- central nervous system development Source: GO_Central
- skeletal system development Source: GO_Central
Keywordsi
Ligand | Hyaluronic acid |
Enzyme and pathway databases
Reactomei | R-MMU-3000178, ECM proteoglycans |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan and proteoglycan link protein 1Alternative name(s): Cartilage-linking protein 1 Short name: Cartilage-link protein Proteoglycan link protein |
Gene namesi | Name:Hapln1 Synonyms:Crtl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1337006, Hapln1 |
VEuPathDBi | HostDB:ENSMUSG00000021613 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: MGI
- synapse Source: SynGO
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000013179 | 1 – 9 | By similarity | 9 | |
ChainiPRO_0000013180 | 10 – 356 | Hyaluronan and proteoglycan link protein 1Add BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 63 ↔ 141 | By similarity | ||
Disulfide bondi | 183 ↔ 254 | By similarity | ||
Disulfide bondi | 207 ↔ 228 | By similarity | ||
Disulfide bondi | 281 ↔ 351 | By similarity | ||
Disulfide bondi | 306 ↔ 327 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q9QUP5 |
PaxDbi | Q9QUP5 |
PeptideAtlasi | Q9QUP5 |
PRIDEi | Q9QUP5 |
ProteomicsDBi | 273270 |
PTM databases
GlyConnecti | 2373, 9 N-Linked glycans (1 site) |
GlyGeni | Q9QUP5, 1 site, 9 N-linked glycans (1 site) |
iPTMneti | Q9QUP5 |
PhosphoSitePlusi | Q9QUP5 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000021613, Expressed in humerus cartilage element and 223 other tissues |
Genevisiblei | Q9QUP5, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 198904, 3 interactors |
IntActi | Q9QUP5, 1 interactor |
MINTi | Q9QUP5 |
STRINGi | 10090.ENSMUSP00000022108 |
Miscellaneous databases
RNActi | Q9QUP5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 154 | Ig-like V-typeAdd BLAST | 115 | |
Domaini | 161 – 256 | Link 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 261 – 353 | Link 2PROSITE-ProRule annotationAdd BLAST | 93 |
Sequence similaritiesi
Belongs to the HAPLN family.Curated
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
eggNOGi | ENOG502QRAR, Eukaryota |
GeneTreei | ENSGT00940000159267 |
HOGENOMi | CLU_052285_1_0_1 |
InParanoidi | Q9QUP5 |
OMAi | RVIHIQV |
OrthoDBi | 743812at2759 |
PhylomeDBi | Q9QUP5 |
TreeFami | TF332134 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9QUP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSLLLLVLI SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK
60 70 80 90 100
VFSHRGGNVT LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM
110 120 130 140 150
GYHKKTYGGY QGRVFLKGGS DNDASLVITD LTLEDYGRYK CEVIEGLEDD
160 170 180 190 200
TAVVALELQG VVFPYFPRLG RYNLNFHEAR QACLDQDAVI ASFDQLYDAW
210 220 230 240 250
RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY GFWDKDKSRY
260 270 280 290 300
DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL
310 320 330 340 350
LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY
CFRAYN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | Missing in AAD12253 (PubMed:12732630).Curated | 1 | |
Sequence conflicti | 35 | Q → H in AAH66853 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF137278 , AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1 AF139572 mRNA Translation: AAF24977.1 AF098460 mRNA Translation: AAD12253.1 AK032750 mRNA Translation: BAC28007.1 AK048107 mRNA Translation: BAC33244.1 BC066853 mRNA Translation: AAH66853.1 |
CCDSi | CCDS26671.1 |
RefSeqi | NP_038528.3, NM_013500.4 |
Genome annotation databases
Ensembli | ENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613 |
GeneIDi | 12950 |
KEGGi | mmu:12950 |
UCSCi | uc007rjf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF137278 , AF137275, AF137276, AF137277 Genomic DNA Translation: AAF24166.1 AF139572 mRNA Translation: AAF24977.1 AF098460 mRNA Translation: AAD12253.1 AK032750 mRNA Translation: BAC28007.1 AK048107 mRNA Translation: BAC33244.1 BC066853 mRNA Translation: AAH66853.1 |
CCDSi | CCDS26671.1 |
RefSeqi | NP_038528.3, NM_013500.4 |
3D structure databases
SMRi | Q9QUP5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198904, 3 interactors |
IntActi | Q9QUP5, 1 interactor |
MINTi | Q9QUP5 |
STRINGi | 10090.ENSMUSP00000022108 |
PTM databases
GlyConnecti | 2373, 9 N-Linked glycans (1 site) |
GlyGeni | Q9QUP5, 1 site, 9 N-linked glycans (1 site) |
iPTMneti | Q9QUP5 |
PhosphoSitePlusi | Q9QUP5 |
Proteomic databases
MaxQBi | Q9QUP5 |
PaxDbi | Q9QUP5 |
PeptideAtlasi | Q9QUP5 |
PRIDEi | Q9QUP5 |
ProteomicsDBi | 273270 |
Protocols and materials databases
Antibodypediai | 12888, 241 antibodies from 29 providers |
Genome annotation databases
Ensembli | ENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613 |
GeneIDi | 12950 |
KEGGi | mmu:12950 |
UCSCi | uc007rjf.2, mouse |
Organism-specific databases
CTDi | 1404 |
MGIi | MGI:1337006, Hapln1 |
VEuPathDBi | HostDB:ENSMUSG00000021613 |
Phylogenomic databases
eggNOGi | ENOG502QRAR, Eukaryota |
GeneTreei | ENSGT00940000159267 |
HOGENOMi | CLU_052285_1_0_1 |
InParanoidi | Q9QUP5 |
OMAi | RVIHIQV |
OrthoDBi | 743812at2759 |
PhylomeDBi | Q9QUP5 |
TreeFami | TF332134 |
Enzyme and pathway databases
Reactomei | R-MMU-3000178, ECM proteoglycans |
Miscellaneous databases
BioGRID-ORCSi | 12950, 0 hits in 65 CRISPR screens |
ChiTaRSi | Hapln1, mouse |
PROi | PR:Q9QUP5 |
RNActi | Q9QUP5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021613, Expressed in humerus cartilage element and 223 other tissues |
Genevisiblei | Q9QUP5, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | HPLN1_MOUSE | |
Accessioni | Q9QUP5Primary (citable) accession number: Q9QUP5 Secondary accession number(s): Q9D1G9, Q9Z1X7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families