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Protein

Dickkopf-related protein 3

Gene

Dkk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).By similarity

GO - Molecular functioni

  • co-receptor binding Source: GO_Central
  • receptor antagonist activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-related protein 3
Short name:
Dickkopf-3
Short name:
Dkk-3
Short name:
mDkk-3
Gene namesi
Name:Dkk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1354952 Dkk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000722323 – 349Dickkopf-related protein 3Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 220By similarity
Disulfide bondi214 ↔ 231By similarity
Disulfide bondi219 ↔ 265By similarity
Disulfide bondi241 ↔ 273By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUN9
PaxDbiQ9QUN9
PeptideAtlasiQ9QUN9
PRIDEiQ9QUN9

PTM databases

iPTMnetiQ9QUN9
PhosphoSitePlusiQ9QUN9

Expressioni

Tissue specificityi

Highest expression in brain, eye and heart.

Developmental stagei

Expressed in the developing cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000030772 Expressed in 344 organ(s), highest expression level in epithelium of lens
CleanExiMM_DKK3
GenevisibleiQ9QUN9 MM

Interactioni

Subunit structurei

Interacts with LRP5 and LRP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QUN9, 1 interactor
STRINGi10090.ENSMUSP00000033036

Structurei

3D structure databases

ProteinModelPortaliQ9QUN9
SMRiQ9QUN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 195DKK-type Cys-1Add BLAST49
Regioni208 – 284DKK-type Cys-2Add BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 84Sequence analysisAdd BLAST46

Domaini

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.By similarity

Sequence similaritiesi

Belongs to the dickkopf family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000000221
HOGENOMiHOG000234342
HOVERGENiHBG004476
InParanoidiQ9QUN9
OMAiGNGTICD
OrthoDBiEOG091G0BUI
PhylomeDBiQ9QUN9
TreeFamiTF337340

Family and domain databases

InterProiView protein in InterPro
IPR006796 Dickkopf_N
IPR039863 DKK-like
PANTHERiPTHR12113 PTHR12113, 1 hit
PfamiView protein in Pfam
PF04706 Dickkopf_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRLGGILLC TLLAAAVPTA PAPSPTVTWT PAEPGPALNY PQEEATLNEM
60 70 80 90 100
FREVEELMED TQHKLRSAVE EMEAEEAAAK TSSEVNLASL PPNYHNETST
110 120 130 140 150
ETRVGNNTVH VHQEVHKITN NQSGQVVFSE TVITSVGDEE GKRSHECIID
160 170 180 190 200
EDCGPTRYCQ FSSFKYTCQP CRDQQMLCTR DSECCGDQLC AWGHCTQKAT
210 220 230 240 250
KGGNGTICDN QRDCQPGLCC AFQRGLLFPV CTPLPVEGEL CHDPTSQLLD
260 270 280 290 300
LITWELEPEG ALDRCPCASG LLCQPHSHSL VYMCKPAFVG SHDHSEESQL
310 320 330 340
PREAPDEYED VGFIGEVRQE LEDLERSLAQ EMAFEGPAPV ESLGGEEEI
Length:349
Mass (Da):38,388
Last modified:May 1, 2000 - v1
Checksum:i564CB3C4FB2EAB88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243964 mRNA Translation: CAB60111.1
AF177400 mRNA Translation: AAF02680.1
AK004853 mRNA Translation: BAB23617.1
BC046304 mRNA Translation: AAH46304.1
BC050934 mRNA Translation: AAH50934.1
CCDSiCCDS21752.1
RefSeqiNP_056629.1, NM_015814.2
XP_006508076.1, XM_006508013.1
UniGeneiMm.55143

Genome annotation databases

EnsembliENSMUST00000033036; ENSMUSP00000033036; ENSMUSG00000030772
GeneIDi50781
KEGGimmu:50781
UCSCiuc009jgi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243964 mRNA Translation: CAB60111.1
AF177400 mRNA Translation: AAF02680.1
AK004853 mRNA Translation: BAB23617.1
BC046304 mRNA Translation: AAH46304.1
BC050934 mRNA Translation: AAH50934.1
CCDSiCCDS21752.1
RefSeqiNP_056629.1, NM_015814.2
XP_006508076.1, XM_006508013.1
UniGeneiMm.55143

3D structure databases

ProteinModelPortaliQ9QUN9
SMRiQ9QUN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QUN9, 1 interactor
STRINGi10090.ENSMUSP00000033036

PTM databases

iPTMnetiQ9QUN9
PhosphoSitePlusiQ9QUN9

Proteomic databases

MaxQBiQ9QUN9
PaxDbiQ9QUN9
PeptideAtlasiQ9QUN9
PRIDEiQ9QUN9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033036; ENSMUSP00000033036; ENSMUSG00000030772
GeneIDi50781
KEGGimmu:50781
UCSCiuc009jgi.1 mouse

Organism-specific databases

CTDi27122
MGIiMGI:1354952 Dkk3

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
GeneTreeiENSGT00390000000221
HOGENOMiHOG000234342
HOVERGENiHBG004476
InParanoidiQ9QUN9
OMAiGNGTICD
OrthoDBiEOG091G0BUI
PhylomeDBiQ9QUN9
TreeFamiTF337340

Miscellaneous databases

PROiPR:Q9QUN9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030772 Expressed in 344 organ(s), highest expression level in epithelium of lens
CleanExiMM_DKK3
GenevisibleiQ9QUN9 MM

Family and domain databases

InterProiView protein in InterPro
IPR006796 Dickkopf_N
IPR039863 DKK-like
PANTHERiPTHR12113 PTHR12113, 1 hit
PfamiView protein in Pfam
PF04706 Dickkopf_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDKK3_MOUSE
AccessioniPrimary (citable) accession number: Q9QUN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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