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Entry version 156 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Integrin alpha-IIb

Gene

Itga2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi273 – 281Sequence analysis9
Calcium bindingi327 – 335Sequence analysis9
Calcium bindingi395 – 403Sequence analysis9
Calcium bindingi456 – 464Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix binding Source: MGI
  • fibrinogen binding Source: MGI
  • identical protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-354192 Integrin alphaIIb beta3 signaling
R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-372708 p130Cas linkage to MAPK signaling for integrins
R-MMU-445144 Signal transduction by L1
R-MMU-5674135 MAP2K and MAPK activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-IIb
Alternative name(s):
GPalpha IIb
Short name:
GPIIb
Platelet membrane glycoprotein IIb
CD_antigen: CD41
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itga2b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96601 Itga2b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 988ExtracellularSequence analysisAdd BLAST957
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei989 – 1014HelicalSequence analysisAdd BLAST26
Topological domaini1015 – 1033CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430894

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000016280? – 1033Integrin alpha-IIb light chainBy similarity
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000001627832 – 1033Integrin alpha-IIbAdd BLAST1002
ChainiPRO_000001627932 – ?Integrin alpha-IIb heavy chainBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 96By similarity
Disulfide bondi138 ↔ 161By similarity
Disulfide bondi177 ↔ 197By similarity
Disulfide bondi503 ↔ 514By similarity
Disulfide bondi520 ↔ 575By similarity
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi632 ↔ 638By similarity
Disulfide bondi704 ↔ 717By similarity
Glycosylationi710N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi856 ↔ 905Interchain (between heavy and light chains)By similarity
Disulfide bondi911 ↔ 916By similarity
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9QUM0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9QUM0

PRoteomics IDEntifications database

More...
PRIDEi
Q9QUM0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9QUM0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9QUM0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9QUM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034664 Expressed in 97 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9QUM0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3116 Integrin alphaIIb-beta3 complex

Protein interaction database and analysis system

More...
IntActi
Q9QUM0, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9QUM0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099375

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9QUM0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QUM0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 96FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati109 – 173FG-GAP 2PROSITE-ProRule annotationAdd BLAST65
Repeati184 – 237FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati252 – 304FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati305 – 370FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati372 – 431FG-GAP 6PROSITE-ProRule annotationAdd BLAST60
Repeati434 – 495FG-GAP 7PROSITE-ProRule annotationAdd BLAST62

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1017 – 1021GFFKR motif5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3637 Eukaryota
ENOG410XPVZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231603

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006186

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9QUM0

KEGG Orthology (KO)

More...
KOi
K06476

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWLLEWV

Database of Orthologous Groups

More...
OrthoDBi
743479at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF
60 70 80 90 100
GFSVDFHKDK HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL
110 120 130 140 150
FDLRDETRNL GFQIFQTFKT GQGLGASVVS WNDVIVACAP WQHWNVLEKR
160 170 180 190 200
DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN TMSSVYAESF RGDKRYCEAG
210 220 230 240 250
FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG TLLWHVSNQR
260 270 280 290 300
FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL
310 320 330 340 350
DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR
360 370 380 390 400
KLAEVGRVYL FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG
410 420 430 440 450
YNDIAVAAPY GGPSGQGQVL IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS
460 470 480 490 500
LRGAVDIDDN GYPDLIVGAY GASKVAVYRA QPVVMATVQL MVQDSLNPTL
510 520 530 540 550
KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL DLQKPRQGRR
560 570 580 590 600
VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN
610 620 630 640 650
VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD
660 670 680 690 700
SPLLIGADNV LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE
710 720 730 740 750
RLVCTQKKEN ESRVALCELG NPMKKDTRIG ITMLVSVENL EEAGESVSFQ
760 770 780 790 800
LQVRSKNSQN PNSKVVMLPV AIQAEATVEL RGNSFPASLV VAAEEGDREQ
810 820 830 840 850
EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS DLLYILDVQP
860 870 880 890 900
QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP
910 920 930 940 950
VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL
960 970 980 990 1000
QSHAWFNVSS LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL
1010 1020 1030
GGLLLLTLLV LAMWKAGFFK RNRPPLEEDE EEE
Length:1,033
Mass (Da):112,678
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B4826E32B9130B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236S → T in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti236S → T in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti270A → S in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti270A → S in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti464D → G in AAF43997 (PubMed:10713093).Curated1
Sequence conflicti471G → W in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti471G → W in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti483V → G in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti483V → G in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti805R → S in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti805R → S in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti834P → H in AAD02339 (Ref. 6) Curated1
Sequence conflicti848 – 849VQ → LR in AAD02339 (Ref. 6) Curated2
Sequence conflicti865D → E in AAB23054 (PubMed:1512266).Curated1
Sequence conflicti933V → A in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti933V → A in AAD56216 (PubMed:10572112).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF169829 Genomic DNA Translation: AAF06996.1
AF170316 mRNA Translation: AAD56216.1
AK142289 mRNA Translation: BAE25013.1
AK154619 mRNA Translation: BAE32718.1
AL596258 Genomic DNA Translation: CAM18010.1
BC120493 mRNA Translation: AAI20494.1
S43388 mRNA Translation: AAB23054.2
AF045019 mRNA Translation: AAD02339.1
AF166384 mRNA Translation: AAF43997.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25500.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A43430

NCBI Reference Sequences

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RefSeqi
NP_034705.2, NM_010575.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.26646

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16399

UCSC genome browser

More...
UCSCi
uc007lrx.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169829 Genomic DNA Translation: AAF06996.1
AF170316 mRNA Translation: AAD56216.1
AK142289 mRNA Translation: BAE25013.1
AK154619 mRNA Translation: BAE32718.1
AL596258 Genomic DNA Translation: CAM18010.1
BC120493 mRNA Translation: AAI20494.1
S43388 mRNA Translation: AAB23054.2
AF045019 mRNA Translation: AAD02339.1
AF166384 mRNA Translation: AAF43997.1
CCDSiCCDS25500.1
PIRiA43430
RefSeqiNP_034705.2, NM_010575.2
UniGeneiMm.26646

3D structure databases

ProteinModelPortaliQ9QUM0
SMRiQ9QUM0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3116 Integrin alphaIIb-beta3 complex
IntActiQ9QUM0, 1 interactor
MINTiQ9QUM0
STRINGi10090.ENSMUSP00000099375

Chemistry databases

ChEMBLiCHEMBL3430894

PTM databases

iPTMnetiQ9QUM0
PhosphoSitePlusiQ9QUM0
SwissPalmiQ9QUM0

Proteomic databases

MaxQBiQ9QUM0
PaxDbiQ9QUM0
PRIDEiQ9QUM0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664
GeneIDi16399
KEGGimmu:16399
UCSCiuc007lrx.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3674
MGIiMGI:96601 Itga2b

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00940000160724
HOGENOMiHOG000231603
HOVERGENiHBG006186
InParanoidiQ9QUM0
KOiK06476
OMAiLWLLEWV
OrthoDBi743479at2759
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-354192 Integrin alphaIIb beta3 signaling
R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-372708 p130Cas linkage to MAPK signaling for integrins
R-MMU-445144 Signal transduction by L1
R-MMU-5674135 MAP2K and MAPK activation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9QUM0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034664 Expressed in 97 organ(s), highest expression level in blood
GenevisibleiQ9QUM0 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA2B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QUM0
Secondary accession number(s): Q3U3R7, Q64229, Q9Z2M0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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