Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Baculoviral IAP repeat-containing protein 1b

Gene

Naip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sensor component of the NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins such as S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi315ZincPROSITE-ProRule annotation1
Metal bindingi318ZincPROSITE-ProRule annotation1
Metal bindingi335ZincPROSITE-ProRule annotation1
Metal bindingi342ZincPROSITE-ProRule annotation1
Binding sitei520ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Immunity, Inflammatory response, Innate immunity
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 1b
Alternative name(s):
Neuronal apoptosis inhibitory protein 2
Gene namesi
Name:Naip2
Synonyms:Birc1b, Naip-rs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298226 Naip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223431 – 1447Baculoviral IAP repeat-containing protein 1bAdd BLAST1447

Proteomic databases

MaxQBiQ9QUK4
PaxDbiQ9QUK4
PRIDEiQ9QUK4

PTM databases

iPTMnetiQ9QUK4
PhosphoSitePlusiQ9QUK4

Expressioni

Gene expression databases

BgeeiENSMUSG00000078945 Expressed in 121 organ(s), highest expression level in large intestine
CleanExiMM_NAIP2
ExpressionAtlasiQ9QUK4 baseline and differential
GenevisibleiQ9QUK4 MM

Interactioni

Subunit structurei

Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein. Interacts with S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTH_II0824Q2T7282EBI-15944068,EBI-15944060From Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264).

Protein-protein interaction databases

DIPiDIP-59160N
IntActiQ9QUK4, 4 interactors
STRINGi10090.ENSMUSP00000070827

Structurei

3D structure databases

ProteinModelPortaliQ9QUK4
SMRiQ9QUK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 127BIR 1Add BLAST68
Repeati159 – 227BIR 2Add BLAST69
Repeati278 – 345BIR 3Add BLAST68
Domaini508 – 802NACHTPROSITE-ProRule annotationAdd BLAST295

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00500000044782
HOGENOMiHOG000236326
HOVERGENiHBG050689
InParanoidiQ9QUK4
KOiK12807
OMAiAQGEAQW
OrthoDBiEOG091G0115
TreeFamiTF105356

Family and domain databases

CDDicd00022 BIR, 3 hits
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR028789 Naip
IPR027417 P-loop_NTPase
PANTHERiPTHR10044:SF134 PTHR10044:SF134, 1 hit
PfamiView protein in Pfam
PF00653 BIR, 3 hits
PF05729 NACHT, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 3 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 2 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50837 NACHT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QUK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQGEAVEE IICEFDDDLV SELSTLLRVD ALSVLKRQQE EDHKTRMKMK
60 70 80 90 100
KGFNSQMRSE AKRLKTFETY DKFRSWTPQE MAAAGFYHTG VKLGVQCFCC
110 120 130 140 150
SLILFSTRLR KLPIENHKKL RPECEFLLGK DVGNIGKYDI RVKSPEKMLR
160 170 180 190 200
GDKARYHEEE ARLESFEDWP FYAHGTSPRV LSAAGFVFTG KRDTVQCFSC
210 220 230 240 250
GGCLGNWEEG DDPWKEHAKW FPKCEFLQSK KSPEEITQYV QSYEGFLHVT
260 270 280 290 300
GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPGAVEALV
310 320 330 340 350
KAGLFYTGKR DIVQCFSCGG CMEKWAEGDN PIEDHTKFFP NCVFLQTLKS
360 370 380 390 400
SAEVIPALQS HCALPEAMET TSESNHDDAA AVHSTVVDVS PSEAQELEPA
410 420 430 440 450
SSLVSVLCRD QDHSEAQGRG CASSGTYLPS TDLGQSEAQW LQEARSLSEQ
460 470 480 490 500
LRDTYTKATF RHMNLPEVYS SLGTDHLLSC DVSIISKHIS QPVQGSLTIP
510 520 530 540 550
EVFSNLNSVM CVEGEAGSGK TTFLKRIAFL WASGCCPLLY RFQLVFYLSL
560 570 580 590 600
SSITPGQELA KIICAQLLGA GGCISEVCLS SIIQQLQHQV LFLLDDYSGL
610 620 630 640 650
ASLPQALHTL ITKNYLSRTC LLIAVHTNKV RGIRPYLDTS LEIKEFPFYN
660 670 680 690 700
TVSVLRKLFS HDIMRVRKFI NYFGFHEELQ GIHKTPLFVA AVCTDWFKNP
710 720 730 740 750
SDQPFQDVAL FKAYMQYLSL KHKGAAKPLQ ATVSSCGQLA LTGLFSSCFE
760 770 780 790 800
FNSDNLAEAG VDEDEELTTC LMSKFTAQRL RPVYRFLGPL FQEFLAAVRL
810 820 830 840 850
TELLSSDRQE DQDLGLYYLR QINSPLKAMS IYHTFLKYVS SHPSSKAAPT
860 870 880 890 900
VVSHLLQLVD EKESLENMSE NEDYMKLHPE ALLWIECLRG LWQLSPESFS
910 920 930 940 950
LFISENLLRI CLNFAHESNT VAACSPVILQ FLRGRTLDLK VLSLQYFWDH
960 970 980 990 1000
PETLLLLKSI KISLNGNNWV QRIDFSLIEK SFEKVQPPTI DQDYAIAFQP
1010 1020 1030 1040 1050
INEVQKNLSE KKHIIKKYED MKHQIPLNIS TGYWKLSPKP YKIPKLEVQV
1060 1070 1080 1090 1100
TNTGPADQAL LQVLMEVFSA SQSIEFRLSD SSGFLESIRP ALELSKASVT
1110 1120 1130 1140 1150
KCSMSRLELS REDQKLLLTL PTLQSLEVSE TNQLPDQLFH NLHKFLGLKE
1160 1170 1180 1190 1200
LCVRLDSKPD VLSVLPGEFP NLHHMEKLSI RTSTESDLSK LVKLIQNSPN
1210 1220 1230 1240 1250
LHVFHLKCNF LSNCEPLMTV LASCKKLREI EFSGRCFEAM TFVNILPNFV
1260 1270 1280 1290 1300
FLKILNLRDQ QFPDKETSEK FAQALGSLRN LEKLFVPTGD GIHQVAKLIV
1310 1320 1330 1340 1350
RQCLQLPCLR VLVFAETLDD DSVLEIAKGA TRGGFQKLEN LDLTLNHKIT
1360 1370 1380 1390 1400
EEGYRNFFQV LDNLPNLKNL DISRHIPECI QIQAITVKAL GQCVSRLPSL
1410 1420 1430 1440
TRLGMLSWLL DEEDIKVIND VKERHPQSKR LTVHWRWVVP FSPVIQK
Length:1,447
Mass (Da):164,083
Last modified:July 27, 2011 - v2
Checksum:i9A9DFDA40B866393
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9C471A9C471_MOUSE
Baculoviral IAP repeat-containing p...
Naip2
1,391Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377D → G in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti403L → F in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti478L → I in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti540Y → N in AAD56761 (PubMed:10501978).Curated1
Sequence conflicti540Y → N in AAD56762 (PubMed:10501978).Curated1
Sequence conflicti540Y → N in AAC73002 (PubMed:10384056).Curated1
Sequence conflicti862K → N in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1079 – 1080SD → FN in AAD56759 (PubMed:10486205).Curated2
Sequence conflicti1089R → C in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1115K → E in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1122T → A in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1136D → E in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1157S → G in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1167G → R in AAD56759 (PubMed:10486205).Curated1
Sequence conflicti1271F → C in AAD56759 (PubMed:10486205).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135489 mRNA Translation: AAD56761.1
AF135490 mRNA Translation: AAD56762.1
AF102871 mRNA Translation: AAC73002.1
AF131205 Genomic DNA Translation: AAD56759.1
CT030167 Genomic DNA Translation: CAP19308.1
U66329 Genomic DNA Translation: AAC52977.1
CCDSiCCDS26726.1
PIRiT42628
RefSeqiNP_001119654.1, NM_001126182.2
NP_035002.2, NM_010872.3
UniGeneiMm.89961

Genome annotation databases

EnsembliENSMUST00000067975; ENSMUSP00000070827; ENSMUSG00000078945
ENSMUST00000117913; ENSMUSP00000113890; ENSMUSG00000078945
GeneIDi17948
KEGGimmu:17948
UCSCiuc007rqj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135489 mRNA Translation: AAD56761.1
AF135490 mRNA Translation: AAD56762.1
AF102871 mRNA Translation: AAC73002.1
AF131205 Genomic DNA Translation: AAD56759.1
CT030167 Genomic DNA Translation: CAP19308.1
U66329 Genomic DNA Translation: AAC52977.1
CCDSiCCDS26726.1
PIRiT42628
RefSeqiNP_001119654.1, NM_001126182.2
NP_035002.2, NM_010872.3
UniGeneiMm.89961

3D structure databases

ProteinModelPortaliQ9QUK4
SMRiQ9QUK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59160N
IntActiQ9QUK4, 4 interactors
STRINGi10090.ENSMUSP00000070827

PTM databases

iPTMnetiQ9QUK4
PhosphoSitePlusiQ9QUK4

Proteomic databases

MaxQBiQ9QUK4
PaxDbiQ9QUK4
PRIDEiQ9QUK4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067975; ENSMUSP00000070827; ENSMUSG00000078945
ENSMUST00000117913; ENSMUSP00000113890; ENSMUSG00000078945
GeneIDi17948
KEGGimmu:17948
UCSCiuc007rqj.2 mouse

Organism-specific databases

CTDi17948
MGIiMGI:1298226 Naip2

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00500000044782
HOGENOMiHOG000236326
HOVERGENiHBG050689
InParanoidiQ9QUK4
KOiK12807
OMAiAQGEAQW
OrthoDBiEOG091G0115
TreeFamiTF105356

Miscellaneous databases

PROiPR:Q9QUK4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078945 Expressed in 121 organ(s), highest expression level in large intestine
CleanExiMM_NAIP2
ExpressionAtlasiQ9QUK4 baseline and differential
GenevisibleiQ9QUK4 MM

Family and domain databases

CDDicd00022 BIR, 3 hits
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR028789 Naip
IPR027417 P-loop_NTPase
PANTHERiPTHR10044:SF134 PTHR10044:SF134, 1 hit
PfamiView protein in Pfam
PF00653 BIR, 3 hits
PF05729 NACHT, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 3 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 2 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50837 NACHT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBIR1B_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK4
Secondary accession number(s): A9C470, O09124, Q9R030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again