UniProtKB - Q9QUK0 (CDKL2_MOUSE)
Protein
Cyclin-dependent kinase-like 2
Gene
Cdkl2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 126 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase-like 2Curated (EC:2.7.11.22)Alternative name(s): Serine/threonine-protein kinase KKIAMRE |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858227, Cdkl2 |
Subcellular locationi
Cytoskeleton
- centrosome Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085816 | 1 – 568 | Cyclin-dependent kinase-like 2Add BLAST | 568 |
Proteomic databases
PaxDbi | Q9QUK0 |
PRIDEi | Q9QUK0 |
PTM databases
iPTMneti | Q9QUK0 |
PhosphoSitePlusi | Q9QUK0 |
Expressioni
Tissue specificityi
Expressed in testis, kidney, lung and brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029403, Expressed in barrel cortex and 239 other tissues |
Genevisiblei | Q9QUK0, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000084199 |
Miscellaneous databases
RNActi | Q9QUK0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 289 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 286 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 45 – 51 | [NKR]KIAxRE | 7 |
Domaini
The [NKR]KIAxRE motif seems to be a cyclin-binding region.
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0593, Eukaryota |
GeneTreei | ENSGT00940000160368 |
HOGENOMi | CLU_000288_136_0_1 |
InParanoidi | Q9QUK0 |
OMAi | KHSPAGH |
PhylomeDBi | Q9QUK0 |
TreeFami | TF101031 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to basket
Also known as: KKIAMRE-beta
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP
210 220 230 240 250
LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP
260 270 280 290 300
LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ
310 320 330 340 350
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD
360 370 380 390 400
SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN
410 420 430 440 450
IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP
460 470 480 490 500
FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN
510 520 530 540 550
HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG
560
SPLSDDSEAD LPRMEHQH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YU22 | A0A0J9YU22_MOUSE | Cyclin-dependent kinase-like 2 | Cdkl2 | 75 | Annotation score: |
Sequence cautioni
The sequence BAE43274 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | K → Q in BAE43274 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 321 – 322 | NR → KK in BAA88428 (PubMed:14605869).Curated | 2 | |
Sequence conflicti | 325 – 329 | EKDDA → KKKKK in BAA88428 (PubMed:14605869).Curated | 5 | |
Sequence conflicti | 330 – 568 | Missing in BAA88428 (PubMed:14605869).CuratedAdd BLAST | 239 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016146 | 548 – 564 | GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_016147 | 565 – 568 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029066 mRNA Translation: BAA88428.1 AB029067 mRNA Translation: BAA88429.1 AB029073 Genomic DNA Translation: BAA88439.1 AB029065 mRNA Translation: BAA88427.1 AK030598 mRNA Translation: BAE43274.1 Different initiation. AK144574 mRNA Translation: BAE25943.1 AK145688 mRNA Translation: BAE26590.1 |
CCDSi | CCDS19425.1 [Q9QUK0-2] CCDS19426.1 [Q9QUK0-1] |
RefSeqi | NP_001263244.1, NM_001276315.1 [Q9QUK0-2] NP_058608.1, NM_016912.2 [Q9QUK0-1] NP_796244.2, NM_177270.4 [Q9QUK0-2] XP_011247839.1, XM_011249537.2 [Q9QUK0-1] XP_017176476.1, XM_017320987.1 [Q9QUK0-1] XP_017176477.1, XM_017320988.1 [Q9QUK0-1] |
Genome annotation databases
Ensembli | ENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403 [Q9QUK0-2] ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403 [Q9QUK0-1] ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403 [Q9QUK0-1] ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403 [Q9QUK0-2] |
GeneIDi | 53886 |
KEGGi | mmu:53886 |
UCSCi | uc008ycc.2, mouse [Q9QUK0-1] uc008ycd.2, mouse [Q9QUK0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029066 mRNA Translation: BAA88428.1 AB029067 mRNA Translation: BAA88429.1 AB029073 Genomic DNA Translation: BAA88439.1 AB029065 mRNA Translation: BAA88427.1 AK030598 mRNA Translation: BAE43274.1 Different initiation. AK144574 mRNA Translation: BAE25943.1 AK145688 mRNA Translation: BAE26590.1 |
CCDSi | CCDS19425.1 [Q9QUK0-2] CCDS19426.1 [Q9QUK0-1] |
RefSeqi | NP_001263244.1, NM_001276315.1 [Q9QUK0-2] NP_058608.1, NM_016912.2 [Q9QUK0-1] NP_796244.2, NM_177270.4 [Q9QUK0-2] XP_011247839.1, XM_011249537.2 [Q9QUK0-1] XP_017176476.1, XM_017320987.1 [Q9QUK0-1] XP_017176477.1, XM_017320988.1 [Q9QUK0-1] |
3D structure databases
SMRi | Q9QUK0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000084199 |
PTM databases
iPTMneti | Q9QUK0 |
PhosphoSitePlusi | Q9QUK0 |
Proteomic databases
PaxDbi | Q9QUK0 |
PRIDEi | Q9QUK0 |
Protocols and materials databases
Antibodypediai | 24675, 232 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403 [Q9QUK0-2] ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403 [Q9QUK0-1] ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403 [Q9QUK0-1] ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403 [Q9QUK0-2] |
GeneIDi | 53886 |
KEGGi | mmu:53886 |
UCSCi | uc008ycc.2, mouse [Q9QUK0-1] uc008ycd.2, mouse [Q9QUK0-2] |
Organism-specific databases
CTDi | 8999 |
MGIi | MGI:1858227, Cdkl2 |
Phylogenomic databases
eggNOGi | KOG0593, Eukaryota |
GeneTreei | ENSGT00940000160368 |
HOGENOMi | CLU_000288_136_0_1 |
InParanoidi | Q9QUK0 |
OMAi | KHSPAGH |
PhylomeDBi | Q9QUK0 |
TreeFami | TF101031 |
Miscellaneous databases
BioGRID-ORCSi | 53886, 0 hits in 18 CRISPR screens |
PROi | PR:Q9QUK0 |
RNActi | Q9QUK0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029403, Expressed in barrel cortex and 239 other tissues |
Genevisiblei | Q9QUK0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDKL2_MOUSE | |
Accessioni | Q9QUK0Primary (citable) accession number: Q9QUK0 Secondary accession number(s): Q3UL60 Q9QYI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index