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Protein

Cyclin-dependent kinase-like 2

Gene

Cdkl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2Curated (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:Cdkl2Imported
Synonyms:Kkiamre, Kkm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858227 Cdkl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858161 – 568Cyclin-dependent kinase-like 2Add BLAST568

Proteomic databases

PaxDbiQ9QUK0
PRIDEiQ9QUK0

PTM databases

iPTMnetiQ9QUK0
PhosphoSitePlusiQ9QUK0

Expressioni

Tissue specificityi

Expressed in testis, kidney, lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000029403
ExpressionAtlasiQ9QUK0 baseline and differential
GenevisibleiQ9QUK0 MM

Structurei

3D structure databases

ProteinModelPortaliQ9QUK0
SMRiQ9QUK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG080204
InParanoidiQ9QUK0
KOiK08824
OMAiKVQKDAR
OrthoDBiEOG091G0BZP
PhylomeDBiQ9QUK0
TreeFamiTF101031

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to basket
Also known as: KKIAMRE-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP
210 220 230 240 250
LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP
260 270 280 290 300
LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ
310 320 330 340 350
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD
360 370 380 390 400
SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN
410 420 430 440 450
IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP
460 470 480 490 500
FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN
510 520 530 540 550
HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG
560
SPLSDDSEAD LPRMEHQH
Length:568
Mass (Da):64,056
Last modified:May 1, 2000 - v1
Checksum:iA43B75E2E9EB86C4
GO
Isoform 2 (identifier: Q9QUK0-2) [UniParc]FASTAAdd to basket
Also known as: KKIAMRE-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
     565-568: Missing.

Show »
Length:564
Mass (Da):63,641
Checksum:iDACDEF630CCE82D5
GO

Sequence cautioni

The sequence BAE43274 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56K → Q in BAE43274 (PubMed:16141072).Curated1
Sequence conflicti321 – 322NR → KK in BAA88428 (PubMed:14605869).Curated2
Sequence conflicti325 – 329EKDDA → KKKKK in BAA88428 (PubMed:14605869).Curated5
Sequence conflicti330 – 568Missing in BAA88428 (PubMed:14605869).CuratedAdd BLAST239

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016146548 – 564GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016147565 – 568Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029066 mRNA Translation: BAA88428.1
AB029067 mRNA Translation: BAA88429.1
AB029073 Genomic DNA Translation: BAA88439.1
AB029065 mRNA Translation: BAA88427.1
AK030598 mRNA Translation: BAE43274.1 Different initiation.
AK144574 mRNA Translation: BAE25943.1
AK145688 mRNA Translation: BAE26590.1
CCDSiCCDS19425.1 [Q9QUK0-2]
CCDS19426.1 [Q9QUK0-1]
RefSeqiNP_001263244.1, NM_001276315.1 [Q9QUK0-2]
NP_058608.1, NM_016912.2 [Q9QUK0-1]
NP_796244.2, NM_177270.4 [Q9QUK0-2]
XP_011247839.1, XM_011249537.2 [Q9QUK0-1]
XP_017176476.1, XM_017320987.1 [Q9QUK0-1]
XP_017176477.1, XM_017320988.1 [Q9QUK0-1]
UniGeneiMm.44963

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403 [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403 [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403 [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403 [Q9QUK0-2]
GeneIDi53886
KEGGimmu:53886
UCSCiuc008ycc.2 mouse [Q9QUK0-1]
uc008ycd.2 mouse [Q9QUK0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDKL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK0
Secondary accession number(s): Q3UL60
, Q3V3X7, Q9QYI1, Q9QYI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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