UniProtKB - Q9QUH3 (APOA5_RAT)
Apolipoprotein A-V
Apoa5
Functioni
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL (By similarity).
May also be associated with chylomicrons (By similarity).
Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity).
Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity).
Binds heparin (By similarity).
By similarityGO - Molecular functioni
- cholesterol binding Source: GO_Central
- enzyme activator activity Source: RGD
- enzyme binding Source: RGD
- heparin binding Source: RGD
- lipase activator activity Source: RGD
- lipase binding Source: RGD
- lipid binding Source: RGD
- lipoprotein lipase activator activity Source: RGD
- lipoprotein particle receptor binding Source: RGD
- low-density lipoprotein particle receptor binding Source: RGD
- phosphatidylcholine binding Source: RGD
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: GO_Central
- phospholipid binding Source: RGD
GO - Biological processi
- acylglycerol homeostasis Source: RGD
- animal organ regeneration Source: RGD
- cholesterol biosynthetic process Source: GO_Central
- cholesterol efflux Source: GO_Central
- cholesterol homeostasis Source: RGD
- high-density lipoprotein particle assembly Source: GO_Central
- lipid transport Source: RGD
- lipoprotein metabolic process Source: GO_Central
- phosphatidylcholine metabolic process Source: GO_Central
- phospholipid efflux Source: GO_Central
- positive regulation of cholesterol esterification Source: GO_Central
- positive regulation of fatty acid biosynthetic process Source: RGD
- positive regulation of lipid biosynthetic process Source: GO_Central
- positive regulation of lipid catabolic process Source: RGD
- positive regulation of lipoprotein lipase activity Source: RGD
- positive regulation of triglyceride catabolic process Source: RGD
- positive regulation of very-low-density lipoprotein particle remodeling Source: RGD
- regulation of intestinal cholesterol absorption Source: GO_Central
- response to hormone Source: RGD
- tissue regeneration Source: RGD
- triglyceride catabolic process Source: RGD
- triglyceride homeostasis Source: RGD
- triglyceride metabolic process Source: RGD
- triglyceride-rich lipoprotein particle remodeling Source: RGD
- very-low-density lipoprotein particle remodeling Source: GO_Central
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation R-RNO-8963901, Chylomicron remodeling |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein A-VShort name: Apo-AV Short name: ApoA-V Alternative name(s): Apolipoprotein A5 Regeneration-associated protein 3 |
Gene namesi | Name:Apoa5 Synonyms:Rap3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70903, Apoa5 |
Subcellular locationi
Endosome
- Early endosome By similarity
- Late endosome By similarity
Golgi apparatus
- trans-Golgi network By similarity
Extracellular region or secreted
- Secreted By similarity
Note: In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network.By similarity
Endosome
- early endosome Source: UniProtKB-SubCell
- late endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- chylomicron Source: RGD
- extracellular region Source: RGD
- extracellular space Source: RGD
- high-density lipoprotein particle Source: RGD
- very-low-density lipoprotein particle Source: RGD
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chylomicron, Endosome, Golgi apparatus, HDL, Secreted, VLDLPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000001983 | 21 – 367 | Apolipoprotein A-VAdd BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9QUH3 |
PTM databases
iPTMneti | Q9QUH3 |
PhosphoSitePlusi | Q9QUH3 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Genevisiblei | Q9QUH3, RN |
Interactioni
Subunit structurei
Interacts with GPIHBP1 (By similarity).
Interacts with SORL1; this interaction leads to APOA5 internalization and sorting either to lysosomes and degradation, or to the trans-Golgi network (By similarity).
By similarityGO - Molecular functioni
- enzyme binding Source: RGD
- lipase binding Source: RGD
- lipoprotein particle receptor binding Source: RGD
- low-density lipoprotein particle receptor binding Source: RGD
Protein-protein interaction databases
IntActi | Q9QUH3, 1 interactor |
STRINGi | 10116.ENSRNOP00000024918 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 305 – 332 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 231 – 255 | Sequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | ENOG502S33P, Eukaryota |
HOGENOMi | CLU_747959_0_0_1 |
InParanoidi | Q9QUH3 |
PhylomeDBi | Q9QUH3 |
TreeFami | TF334458 |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAAVITWALA LLSVFATVQA RKSFWEYFGQ NSQGKGMMGQ QQKLAQESLK
60 70 80 90 100
GSLEQDLYNM NNFLEKLGPL REPGKEPPRL AQDPEGIRKQ LQQELEEVST
110 120 130 140 150
RLEPYMAAKH QQVGWNLEGL RQQLKPYTVE LMEQVGLSVQ DLQEQLRMVG
160 170 180 190 200
KGTKAQLLGG VDEAMSLLQD MQSRVLHHTD RVKELFHPYA ERLVTGIGHH
210 220 230 240 250
VQELHRSVAP HAVASPARLS RCVQTLSHKL TRKAKDLHTS IQRNLDQLRD
260 270 280 290 300
ELSTFIRVST DGADNRDSLD PQALSDEVRQ RLQAFRHDTY LQIAAFTQAI
310 320 330 340 350
DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY
360
GLHDQGHSQN NPEGHSG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHP7 | A0A0H2UHP7_RAT | Apolipoprotein A-V | Apoa5 rCG_58386 | 391 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202887 mRNA Translation: AAF25659.1 AF202888 mRNA Translation: AAF25660.1 BC089780 mRNA Translation: AAH89780.1 |
RefSeqi | NP_001264193.1, NM_001277264.1 NP_542143.1, NM_080576.2 |
Genome annotation databases
GeneIDi | 140638 |
KEGGi | rno:140638 |
UCSCi | RGD:70903, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202887 mRNA Translation: AAF25659.1 AF202888 mRNA Translation: AAF25660.1 BC089780 mRNA Translation: AAH89780.1 |
RefSeqi | NP_001264193.1, NM_001277264.1 NP_542143.1, NM_080576.2 |
3D structure databases
SMRi | Q9QUH3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9QUH3, 1 interactor |
STRINGi | 10116.ENSRNOP00000024918 |
PTM databases
iPTMneti | Q9QUH3 |
PhosphoSitePlusi | Q9QUH3 |
Proteomic databases
PaxDbi | Q9QUH3 |
Genome annotation databases
GeneIDi | 140638 |
KEGGi | rno:140638 |
UCSCi | RGD:70903, rat |
Organism-specific databases
CTDi | 116519 |
RGDi | 70903, Apoa5 |
Phylogenomic databases
eggNOGi | ENOG502S33P, Eukaryota |
HOGENOMi | CLU_747959_0_0_1 |
InParanoidi | Q9QUH3 |
PhylomeDBi | Q9QUH3 |
TreeFami | TF334458 |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation R-RNO-8963901, Chylomicron remodeling |
Miscellaneous databases
PROi | PR:Q9QUH3 |
Gene expression databases
Genevisiblei | Q9QUH3, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APOA5_RAT | |
Accessioni | Q9QUH3Primary (citable) accession number: Q9QUH3 Secondary accession number(s): Q5FVT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | June 2, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families