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Protein

Glutaredoxin-1

Gene

Glrx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase-1
Short name:
TTase-1
Gene namesi
Name:Glrx
Synonyms:Glrx1, Grx, Grx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2135625 Glrx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23C → S: Loss of activity. 1 Publication1
Mutagenesisi26C → S: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001416012 – 107Glutaredoxin-1Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9N6-succinyllysineCombined sources1
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ9QUH0
MaxQBiQ9QUH0
PaxDbiQ9QUH0
PRIDEiQ9QUH0

PTM databases

iPTMnetiQ9QUH0
PhosphoSitePlusiQ9QUH0
SwissPalmiQ9QUH0

Expressioni

Gene expression databases

BgeeiENSMUSG00000021591 Expressed in 284 organ(s), highest expression level in oocyte
CleanExiMM_GLRX
ExpressionAtlasiQ9QUH0 baseline and differential
GenevisibleiQ9QUH0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022082

Structurei

3D structure databases

ProteinModelPortaliQ9QUH0
SMRiQ9QUH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiQ9QUH0
KOiK03676
OMAiKPGHLEC
OrthoDBiEOG091G0WLY
PhylomeDBiQ9QUH0
TreeFamiTF326994

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9QUH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKQ GLLEFVDITA
60 70 80 90 100
TNNTSAIQDY LQQLTGARTV PRVFIGKDCI GGCSDLISMQ QTGELMTRLK

QIGALQL
Length:107
Mass (Da):11,871
Last modified:January 23, 2007 - v3
Checksum:iDC0C7718DCD8805F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VM65A0A1Y7VM65_MOUSE
Glutaredoxin-1
Glrx
84Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013137 mRNA Translation: BAA86926.1
AF109314 mRNA Translation: AAF04780.1
AF276917 mRNA Translation: AAF86464.1
BC012642 mRNA Translation: AAH12642.1
CCDSiCCDS26651.1
RefSeqiNP_444338.2, NM_053108.4
XP_006517540.1, XM_006517477.1
UniGeneiMm.25844

Genome annotation databases

EnsembliENSMUST00000022082; ENSMUSP00000022082; ENSMUSG00000021591
ENSMUST00000223120; ENSMUSP00000152802; ENSMUSG00000021591
GeneIDi93692
KEGGimmu:93692
UCSCiuc007rfx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013137 mRNA Translation: BAA86926.1
AF109314 mRNA Translation: AAF04780.1
AF276917 mRNA Translation: AAF86464.1
BC012642 mRNA Translation: AAH12642.1
CCDSiCCDS26651.1
RefSeqiNP_444338.2, NM_053108.4
XP_006517540.1, XM_006517477.1
UniGeneiMm.25844

3D structure databases

ProteinModelPortaliQ9QUH0
SMRiQ9QUH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022082

PTM databases

iPTMnetiQ9QUH0
PhosphoSitePlusiQ9QUH0
SwissPalmiQ9QUH0

Proteomic databases

EPDiQ9QUH0
MaxQBiQ9QUH0
PaxDbiQ9QUH0
PRIDEiQ9QUH0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022082; ENSMUSP00000022082; ENSMUSG00000021591
ENSMUST00000223120; ENSMUSP00000152802; ENSMUSG00000021591
GeneIDi93692
KEGGimmu:93692
UCSCiuc007rfx.2 mouse

Organism-specific databases

CTDi2745
MGIiMGI:2135625 Glrx

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiQ9QUH0
KOiK03676
OMAiKPGHLEC
OrthoDBiEOG091G0WLY
PhylomeDBiQ9QUH0
TreeFamiTF326994

Enzyme and pathway databases

ReactomeiR-MMU-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRSiGlrx mouse
PROiPR:Q9QUH0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021591 Expressed in 284 organ(s), highest expression level in oocyte
CleanExiMM_GLRX
ExpressionAtlasiQ9QUH0 baseline and differential
GenevisibleiQ9QUH0 MM

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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