UniProtKB - Q9QR71 (LANA1_HHV8P)
Protein LANA1
LANA1
Functioni
Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).
9 PublicationsGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- suppression by virus of host NF-kappaB cascade Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Host-virus interaction, Inhibition of host NF-kappa-B by virus |
Names & Taxonomyi
Protein namesi | Recommended name: Protein LANA1 |
Gene namesi | Name:LANA1 ORF Names:ORF73 |
Organismi | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) |
Taxonomic identifieri | 868565 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
Other locations
- Host nucleus 5 Publications
Note: Colocalizes with viral episomes on host chromosomes.2 Publications
Other locations
- host cell nucleus Source: UniProtKB
Keywords - Cellular componenti
Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423799 | 1 – 1129 | Protein LANA1Add BLAST | 1129 |
Proteomic databases
PRIDEi | Q9QR71 |
PTM databases
iPTMneti | Q9QR71 |
Interactioni
Subunit structurei
Homooligomer (PubMed:25947153).
Interacts with host BRD2 (PubMed:16227282).
Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472).
Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248).
Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929).
Interacts with host BUB1 and PCNA (PubMed:26223641).
Interacts with host NAP1L1; this interaction is required for LANA1-dependent DNA replication (PubMed:27599637).
8 PublicationsBinary interactionsi
Q9QR71
Protein-protein interaction databases
BioGRIDi | 1777030, 119 interactors |
DIPi | DIP-61278N |
IntActi | Q9QR71, 8 interactors |
Chemistry databases
BindingDBi | Q9QR71 |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9QR71 |
SASBDBi | Q9QR71 |
SMRi | Q9QR71 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 988 | DisorderedSequence analysisAdd BLAST | 988 | |
Regioni | 1008 – 1129 | DNA-binding domain1 PublicationAdd BLAST | 122 | |
Regioni | 1110 – 1129 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 54 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 83 – 120 | Pro residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 157 – 187 | Pro residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 188 – 216 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 291 – 324 | Basic and acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 325 – 415 | Acidic residuesSequence analysisAdd BLAST | 91 | |
Compositional biasi | 422 – 476 | Polar residuesSequence analysisAdd BLAST | 55 | |
Compositional biasi | 477 – 526 | Basic and acidic residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 527 – 598 | Polar residuesSequence analysisAdd BLAST | 72 | |
Compositional biasi | 599 – 892 | Acidic residuesSequence analysisAdd BLAST | 294 |
Family and domain databases
Gene3Di | 3.30.70.390, 1 hit |
InterProi | View protein in InterPro IPR037007, EBNA1_DNA-bd_sf |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAPPGMRLRS GRSTGAPLTR GSCRKRNRSP ERCDLGDDLH LQPRRKHVAD
60 70 80 90 100
SVDGRECGPH TLPIPGSPTV FTSGLPAFVS SPTLPVAPIP SPAPATPLPP
110 120 130 140 150
PALLPPVTTS SSPIPPSHPV SPGTTDTHSP SPALPPTQSP ESSQRPPLSS
160 170 180 190 200
PTGRPDSSTP MRPPPSQQTT PPHSPTTPPP EPPSKSSPDS LAPSTLRSLR
210 220 230 240 250
KRRLSSPQGP STLNPICQSP PVSPPRCDFA NRSVYPPWAT ESPIYVGSSS
260 270 280 290 300
DGDTPPRQPP TSPISIGSSS PSEGSWGDDT AMLVLLAEIA EEASKNEKEC
310 320 330 340 350
SENNQAGEDN GDNEISKESQ VDKDDNDNKD DEEEQETDEE DEEDDEEDDE
360 370 380 390 400
EDDEEDDEED DEEDDEEDDE EEDEEEDEEE DEEEDEEEEE DEEDDDDEDN
410 420 430 440 450
EDEEDDEEED KKEDEEDGGD GNKTLSIQSS QQQQEPQQQE PQQQEPQQQE
460 470 480 490 500
PQQQEPQQQE PQQQEPQQQE PQQREPQQRE PQQREPQQRE PQQREPQQRE
510 520 530 540 550
PQQREPQQRE PQQREPQQRE PQQREPQQRE PQQQEPQQQE PQQQEPQQQE
560 570 580 590 600
PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQDEQQQD
610 620 630 640 650
EQQQDEQQQD EQQQDEQQQD EQQQDEQQQD EQEQQDEQQQ DEQQQQDEQE
660 670 680 690 700
QQEEQEQQEE QQQDEQQQDE QQQDEQQQDE QEQQDEQQQD EQQQQDEQEQ
710 720 730 740 750
QEEQEQQEEQ EQQEEQEQQE EQEQELEEQE QELEEQEQEL EEQEQELEEQ
760 770 780 790 800
EQELEEQEQE LEEQEQELEE QEQELEEQEQ ELEEQEQELE EQEQELEEQE
810 820 830 840 850
QELEEQEQEL EEQEQELEEQ EQEQELEEVE EQEQEQEEQE LEEVEEQEQE
860 870 880 890 900
QEEQEEQELE EVEEQEEQEL EEVEEQEEQE LEEVEEQEQQ GVEQQEQETV
910 920 930 940 950
EEPIILHGSS SEDEMEVDYP VVSTHEQIAS SPPGDNTPDD DPQPGPSREY
960 970 980 990 1000
RYVLRTSPPH RPGVRMRRVP VTHPKKPHPR YQQPPVPYRQ IDDCPAKARP
1010 1020 1030 1040 1050
QHIFYRRFLG KDGRRDPKCQ WKFAVIFWGN DPYGLKKLSQ AFQFGGVKAG
1060 1070 1080 1090 1100
PVSCLPHPGP DQSPITYCVY VYCQNKDTSK KVQMARLAWE ASHPLAGNLQ
1110 1120
SSIVKFKKPL PLTQPGENQG PGDSPQEMT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148805 Genomic DNA Translation: AAD46501.1 |
RefSeqi | YP_001129431.1, NC_009333.1 |
Genome annotation databases
GeneIDi | 4961527 |
KEGGi | vg:4961527 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148805 Genomic DNA Translation: AAD46501.1 |
RefSeqi | YP_001129431.1, NC_009333.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ND0 | NMR | - | B | 1098-1116 | [»] | |
4UZB | X-ray | 2.87 | A/B | 975-1113 | [»] | |
4UZC | X-ray | 3.70 | A/B/C/D | 980-1116 | [»] | |
5GTC | X-ray | 2.70 | K | 5-15 | [»] | |
BMRBi | Q9QR71 | |||||
SASBDBi | Q9QR71 | |||||
SMRi | Q9QR71 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 1777030, 119 interactors |
DIPi | DIP-61278N |
IntActi | Q9QR71, 8 interactors |
Chemistry databases
BindingDBi | Q9QR71 |
PTM databases
iPTMneti | Q9QR71 |
Proteomic databases
PRIDEi | Q9QR71 |
Genome annotation databases
GeneIDi | 4961527 |
KEGGi | vg:4961527 |
Miscellaneous databases
PROi | PR:Q9QR71 |
Family and domain databases
Gene3Di | 3.30.70.390, 1 hit |
InterProi | View protein in InterPro IPR037007, EBNA1_DNA-bd_sf |
MobiDBi | Search... |
Entry informationi
Entry namei | LANA1_HHV8P | |
Accessioni | Q9QR71Primary (citable) accession number: Q9QR71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2013 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references