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UniProtKB - Q9QR71 (LANA1_HHV8P)

Entry version 83 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Protein LANA1

Gene

LANA1

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).

9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • suppression by virus of host NF-kappaB cascade Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Inhibition of host NF-kappa-B by virus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LANA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LANA1
ORF Names:ORF73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri868565 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000942 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004237991 – 1129Protein LANA1Add BLAST1129

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q9QR71

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QR71

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:25947153).

Interacts with host BRD2 (PubMed:16227282).

Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472).

Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248).

Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929).

Interacts with host BUB1 and PCNA (PubMed:26223641).

Interacts with host NAP1L1; this interaction is required for LANA1-dependent DNA replication (PubMed:27599637).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		1777030, 119 interactors

Database of interacting proteins

More...DIPi		DIP-61278N

Protein interaction database and analysis system

More...IntActi		Q9QR71, 8 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9QR71

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9QR71

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q9QR71

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QR71

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 988DisorderedSequence analysisAdd BLAST988
Regioni1008 – 1129DNA-binding domain1 PublicationAdd BLAST122
Regioni1110 – 1129DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 54Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi83 – 120Pro residuesSequence analysisAdd BLAST38
Compositional biasi157 – 187Pro residuesSequence analysisAdd BLAST31
Compositional biasi188 – 216Polar residuesSequence analysisAdd BLAST29
Compositional biasi291 – 324Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi325 – 415Acidic residuesSequence analysisAdd BLAST91
Compositional biasi422 – 476Polar residuesSequence analysisAdd BLAST55
Compositional biasi477 – 526Basic and acidic residuesSequence analysisAdd BLAST50
Compositional biasi527 – 598Polar residuesSequence analysisAdd BLAST72
Compositional biasi599 – 892Acidic residuesSequence analysisAdd BLAST294

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.390, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037007, EBNA1_DNA-bd_sf

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QR71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPGMRLRS GRSTGAPLTR GSCRKRNRSP ERCDLGDDLH LQPRRKHVAD 
        60         70         80         90        100
SVDGRECGPH TLPIPGSPTV FTSGLPAFVS SPTLPVAPIP SPAPATPLPP 
       110        120        130        140        150
PALLPPVTTS SSPIPPSHPV SPGTTDTHSP SPALPPTQSP ESSQRPPLSS 
       160        170        180        190        200
PTGRPDSSTP MRPPPSQQTT PPHSPTTPPP EPPSKSSPDS LAPSTLRSLR 
       210        220        230        240        250
KRRLSSPQGP STLNPICQSP PVSPPRCDFA NRSVYPPWAT ESPIYVGSSS 
       260        270        280        290        300
DGDTPPRQPP TSPISIGSSS PSEGSWGDDT AMLVLLAEIA EEASKNEKEC 
       310        320        330        340        350
SENNQAGEDN GDNEISKESQ VDKDDNDNKD DEEEQETDEE DEEDDEEDDE 
       360        370        380        390        400
EDDEEDDEED DEEDDEEDDE EEDEEEDEEE DEEEDEEEEE DEEDDDDEDN 
       410        420        430        440        450
EDEEDDEEED KKEDEEDGGD GNKTLSIQSS QQQQEPQQQE PQQQEPQQQE 
       460        470        480        490        500
PQQQEPQQQE PQQQEPQQQE PQQREPQQRE PQQREPQQRE PQQREPQQRE 
       510        520        530        540        550
PQQREPQQRE PQQREPQQRE PQQREPQQRE PQQQEPQQQE PQQQEPQQQE 
       560        570        580        590        600
PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQDEQQQD 
       610        620        630        640        650
EQQQDEQQQD EQQQDEQQQD EQQQDEQQQD EQEQQDEQQQ DEQQQQDEQE 
       660        670        680        690        700
QQEEQEQQEE QQQDEQQQDE QQQDEQQQDE QEQQDEQQQD EQQQQDEQEQ 
       710        720        730        740        750
QEEQEQQEEQ EQQEEQEQQE EQEQELEEQE QELEEQEQEL EEQEQELEEQ 
       760        770        780        790        800
EQELEEQEQE LEEQEQELEE QEQELEEQEQ ELEEQEQELE EQEQELEEQE 
       810        820        830        840        850
QELEEQEQEL EEQEQELEEQ EQEQELEEVE EQEQEQEEQE LEEVEEQEQE 
       860        870        880        890        900
QEEQEEQELE EVEEQEEQEL EEVEEQEEQE LEEVEEQEQQ GVEQQEQETV 
       910        920        930        940        950
EEPIILHGSS SEDEMEVDYP VVSTHEQIAS SPPGDNTPDD DPQPGPSREY 
       960        970        980        990       1000
RYVLRTSPPH RPGVRMRRVP VTHPKKPHPR YQQPPVPYRQ IDDCPAKARP 
      1010       1020       1030       1040       1050
QHIFYRRFLG KDGRRDPKCQ WKFAVIFWGN DPYGLKKLSQ AFQFGGVKAG 
      1060       1070       1080       1090       1100
PVSCLPHPGP DQSPITYCVY VYCQNKDTSK KVQMARLAWE ASHPLAGNLQ 
      1110       1120 
SSIVKFKKPL PLTQPGENQG PGDSPQEMT
Length:1,129
Mass (Da):131,346
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F63855B45F79109
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF148805 Genomic DNA Translation: AAD46501.1

NCBI Reference Sequences

More...RefSeqi		YP_001129431.1, NC_009333.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4961527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:4961527

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA Translation: AAD46501.1
RefSeqiYP_001129431.1, NC_009333.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ND0NMR-B1098-1116[»]
4UZBX-ray2.87A/B975-1113[»]
4UZCX-ray3.70A/B/C/D980-1116[»]
5GTCX-ray2.70K5-15[»]
BMRBiQ9QR71
SASBDBiQ9QR71
SMRiQ9QR71
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi1777030, 119 interactors
DIPiDIP-61278N
IntActiQ9QR71, 8 interactors

Chemistry databases

BindingDBiQ9QR71

PTM databases

iPTMnetiQ9QR71

Proteomic databases

PRIDEiQ9QR71

Genome annotation databases

GeneIDi4961527
KEGGivg:4961527

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9QR71

Family and domain databases

Gene3Di3.30.70.390, 1 hit
InterProiView protein in InterPro
IPR037007, EBNA1_DNA-bd_sf

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLANA1_HHV8P
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QR71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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