UniProtKB - Q9QR71 (LANA1_HHV8P)

BLAST

>sp|Q9QR71|LANA1_HHV8P Protein LANA1 OS=Human herpesvirus 8 type P (isolate GK18) OX=868565 GN=LANA1 PE=1 SV=1
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPH
TLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV
SPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPP
EPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWAT
ESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKEC
SENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEED
DEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGD
GNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQRE
PQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQE
PQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQD
EQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEE
QQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQE
EQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQ
ELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQE
LEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETV
EEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPH
RPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQ
WKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSK
KVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT

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History
Entry version 68 (12 Sep 2018)
Sequence version 1 (01 May 2000)
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Protein

Protein LANA1

Gene

LANA1

Organism

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).8 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

suppression by virus of host NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21697472

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Host-virus interaction, Inhibition of host NF-kappa-B by virus

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein LANA1
Gene namesⁱ	Name:LANA1 ORF Names:ORF73
Organismⁱ	Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifierⁱ	868565 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Human herpesvirus 8
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000000942 Componentⁱ: Genome

Subcellular locationⁱ

Host nucleus
4 Publications
Manual assertion based on experiment inⁱ
- Ref.3
  "Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen."
  Ballestas M.E., Chatis P.A., Kaye K.M.
  Science 284:641-644(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION.
- Ref.4
  "Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies."
  Szekely L., Kiss C., Mattsson K., Kashuba E., Pokrovskaja K., Juhasz A., Holmvall P., Klein G.
  J. Gen. Virol. 80:2889-2900(1999) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
- Ref.7
  "Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65."
  Li X., Liang D., Lin X., Robertson E.S., Lan K.
  J. Virol. 85:8606-8615(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HOST RELA; CUL5; ELOB AND ELOC.
- Ref.9
  "Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression."
  Gjyshi O., Roy A., Dutta S., Veettil M.V., Dutta D., Chandran B.
  J. Virol. 89:7874-7892(2015) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HOST NFE2L2/NRF2.

Note:

Colocalizes with viral episomes on host chromosomes.2 Publications

GO - Cellular componentⁱ

host cell nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 21697472

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000423799	1 – 1129	Protein LANA1Add BLAST		1129

Proteomic databases

PRIDEⁱ	Q9QR71

PRIDEⁱ

Q9QR71

Interactionⁱ

Subunit structureⁱ

Homooligomer (PubMed:25947153). Interacts with host BRD2 (PubMed:16227282). Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472). Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248). Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929). Interacts with host BUB1 and PCNA (PubMed:26223641).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DNMT1	P26358	2	EBI-15602554,EBI-719459	From Homo sapiens.
DNMT3A	Q9Y6K1	3	EBI-15602554,EBI-923653	From Homo sapiens.
DNMT3B	Q9UBC3	2	EBI-15602554,EBI-80125	From Homo sapiens.

Protein-protein interaction databases

BioGridⁱ	1777030, 118 interactors
Database of interacting proteins More...DIPⁱ	DIP-61278N
IntActⁱ	Q9QR71, 4 interactors

Chemistry databases

BindingDBⁱ	Q9QR71

BindingDBⁱ

Q9QR71

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	991 – 993	Combined sources	3
Helixⁱ	996 – 998	Combined sources	3
Helixⁱ	999 – 1009	Combined sources	11
Helixⁱ	1010 – 1013	Combined sources	4
Beta strandⁱ	1023 – 1030	Combined sources	8
Helixⁱ	1032 – 1041	Combined sources	10
Beta strandⁱ	1043 – 1049	Combined sources	7
Beta strandⁱ	1058 – 1061	Combined sources	4
Beta strandⁱ	1067 – 1075	Combined sources	9
Helixⁱ	1076 – 1092	Combined sources	17
Beta strandⁱ	1100 – 1108	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9QR71
SMRⁱ	Q9QR71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1008 – 1129	DNA-binding domain1 PublicationAdd BLAST		122

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	59 – 263	Pro-richAdd BLAST	205
Compositional biasⁱ	370 – 393	Poly-GluAdd BLAST	24
Compositional biasⁱ	394 – 399	Poly-Asp	6
Compositional biasⁱ	431 – 434	Poly-Gln	4
Compositional biasⁱ	643 – 646	Poly-Gln	4
Compositional biasⁱ	692 – 695	Poly-Gln	4

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K21664
Database of Orthologous Groups More...OrthoDBⁱ	VOG090001NK

Family and domain databases

Gene3Dⁱ	3.30.70.390, 1 hit
InterProⁱ	View protein in InterPro IPR037007 EBNA1_DNA-bd_sf

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QR71-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPPGMRLRS GRSTGAPLTR GSCRKRNRSP ERCDLGDDLH LQPRRKHVAD 
        60         70         80         90        100
SVDGRECGPH TLPIPGSPTV FTSGLPAFVS SPTLPVAPIP SPAPATPLPP 
       110        120        130        140        150
PALLPPVTTS SSPIPPSHPV SPGTTDTHSP SPALPPTQSP ESSQRPPLSS 
       160        170        180        190        200
PTGRPDSSTP MRPPPSQQTT PPHSPTTPPP EPPSKSSPDS LAPSTLRSLR 
       210        220        230        240        250
KRRLSSPQGP STLNPICQSP PVSPPRCDFA NRSVYPPWAT ESPIYVGSSS 
       260        270        280        290        300
DGDTPPRQPP TSPISIGSSS PSEGSWGDDT AMLVLLAEIA EEASKNEKEC 
       310        320        330        340        350
SENNQAGEDN GDNEISKESQ VDKDDNDNKD DEEEQETDEE DEEDDEEDDE 
       360        370        380        390        400
EDDEEDDEED DEEDDEEDDE EEDEEEDEEE DEEEDEEEEE DEEDDDDEDN 
       410        420        430        440        450
EDEEDDEEED KKEDEEDGGD GNKTLSIQSS QQQQEPQQQE PQQQEPQQQE 
       460        470        480        490        500
PQQQEPQQQE PQQQEPQQQE PQQREPQQRE PQQREPQQRE PQQREPQQRE 
       510        520        530        540        550
PQQREPQQRE PQQREPQQRE PQQREPQQRE PQQQEPQQQE PQQQEPQQQE 
       560        570        580        590        600
PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQEPQQQE PQQQDEQQQD 
       610        620        630        640        650
EQQQDEQQQD EQQQDEQQQD EQQQDEQQQD EQEQQDEQQQ DEQQQQDEQE 
       660        670        680        690        700
QQEEQEQQEE QQQDEQQQDE QQQDEQQQDE QEQQDEQQQD EQQQQDEQEQ 
       710        720        730        740        750
QEEQEQQEEQ EQQEEQEQQE EQEQELEEQE QELEEQEQEL EEQEQELEEQ 
       760        770        780        790        800
EQELEEQEQE LEEQEQELEE QEQELEEQEQ ELEEQEQELE EQEQELEEQE 
       810        820        830        840        850
QELEEQEQEL EEQEQELEEQ EQEQELEEVE EQEQEQEEQE LEEVEEQEQE 
       860        870        880        890        900
QEEQEEQELE EVEEQEEQEL EEVEEQEEQE LEEVEEQEQQ GVEQQEQETV 
       910        920        930        940        950
EEPIILHGSS SEDEMEVDYP VVSTHEQIAS SPPGDNTPDD DPQPGPSREY 
       960        970        980        990       1000
RYVLRTSPPH RPGVRMRRVP VTHPKKPHPR YQQPPVPYRQ IDDCPAKARP 
      1010       1020       1030       1040       1050
QHIFYRRFLG KDGRRDPKCQ WKFAVIFWGN DPYGLKKLSQ AFQFGGVKAG 
      1060       1070       1080       1090       1100
PVSCLPHPGP DQSPITYCVY VYCQNKDTSK KVQMARLAWE ASHPLAGNLQ 
      1110       1120 
SSIVKFKKPL PLTQPGENQG PGDSPQEMT

Length:1,129

Mass (Da):131,346

Last modified:May 1, 2000 - v1

Checksum:ⁱ8F63855B45F79109

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF148805 Genomic DNA Translation: AAD46501.1
NCBI Reference Sequences More...RefSeqⁱ	YP_001129431.1, NC_009333.1

Genome annotation databases

GeneIDⁱ	4961527
KEGGⁱ	vg:4961527

Protein	Similar proteins		Species	Score	Length	Source
Q9QR71	ORF73		HHV8		1123	UniRef90_Q9QR71
LANA	)	HHV8		1117
LANA (Fragment)		HHV8		306
LANA (Fragment)		HHV8		337

Protein	Similar proteins		Species	Score	Length	Source
Q9QR71	ORF73		HHV8		1123	UniRef50_Q9QR71
ORF 73	)	Human herpesvirus 8 type M		1162
LANA	)	HHV8		1117
LANA (Fragment)		HHV8		306
LANA (Fragment)		HHV8		337
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF148805 Genomic DNA Translation: AAD46501.1
RefSeqⁱ	YP_001129431.1, NC_009333.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4UZB	X-ray	2.87	A/B	975-1113	[»]
	4UZC	X-ray	3.70	A/B/C/D	980-1116	[»]
	5GTC	X-ray	2.70	K	5-15	[»]
ProteinModelPortalⁱ	Q9QR71
SMRⁱ	Q9QR71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1777030, 118 interactors
DIPⁱ	DIP-61278N
IntActⁱ	Q9QR71, 4 interactors

Chemistry databases

BindingDBⁱ	Q9QR71

BindingDBⁱ

Q9QR71

Proteomic databases

PRIDEⁱ	Q9QR71

PRIDEⁱ

Q9QR71

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	4961527
KEGGⁱ	vg:4961527

Phylogenomic databases

KOⁱ	K21664
OrthoDBⁱ	VOG090001NK

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QR71

PROⁱ

PR:Q9QR71

Family and domain databases

Gene3Dⁱ	3.30.70.390, 1 hit
InterProⁱ	View protein in InterPro IPR037007 EBNA1_DNA-bd_sf
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LANA1_HHV8P
Accessionⁱ	Q9QR71Primary (citable) accession number: Q9QR71
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 16, 2013
	Last sequence update:	May 1, 2000
	Last modified:	September 12, 2018
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QR71 (LANA1_HHV8P)

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Protein LANA1

LANA1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ