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Entry version 67 (05 Jun 2019)
Sequence version 1 (01 May 2000)
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Protein

Thymidine kinase

Gene

TK

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Miscellaneous

Phosphorylates and thereby activates certain drugs used to treat herpes simplex infections like acyclovir (ACV), valaciclovir, and famciclovir to a toxic form, that leads to successful suppression of the infection, while the uninfected cell does not have this ability because it lacks TK. Mutations in thymidine kinase may induce HHV resistance to antiviral therapies in immunocompromised patients. The most frequently observed resistant strains are unable to express TK and are avirulent in animal models of disease. Resistance may be acquired less frequently by selecting variants which no longer recognize ACV or ACV triphosphate as substrates but which retain normal functions.
The sequence shown is that of strain TAS.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei83Proton acceptorUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei101SubstrateUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei222SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi56 – 63ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.21 2647

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9QNF7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TKUniRule annotation
Synonyms:UL23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10298 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Used in molecular biology as a selectable marker to identify transfected eukaryotic cells. Used in cancer suicide gene therapy to selectively kill transformed cells.

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795127

Drug and drug target database

More...
DrugBanki
DB00249 Idoxuridine
DB00577 Valaciclovir
DB00194 Vidarabine

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001750681 – 376Thymidine kinaseAdd BLAST376

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Early protein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9QNF7, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9QNF7

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9QNF7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QNF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04029 HSV_KITH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00693 Herpes_TK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QNF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASYPCHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV RLEQKMPTLL
60 70 80 90 100
RVYIDGPHGM GKTTTTQLLV ALGSRDDIVY VPEPMTYWQV LGASETIANI
110 120 130 140 150
YTTQHRLDQG EISAGDAAVV MTSAQITMGM PYAVTDAVLA PHIGGEAGSS
160 170 180 190 200
HAPPPALTLI FDRHPIAALL CYPAARYLMG SMTPQAVLAF VALIPPTLPG
210 220 230 240 250
TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG LLANTVRYLQ
260 270 280 290 300
GGGSWREDWG QLSGTAVPPQ GAEPQSNAGP RPHIGDTLFT LFRAPELLAP
310 320 330 340 350
NGDLYNVFAW ALDVLAKRLR PMHVFILDYD QSPAGCRDAL LQLTSGMVQT
360 370
HVTTPGSIPT ICDLARTFAR EMGEAN
Length:376
Mass (Da):40,897
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86A177947F9AB1C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti6C → G in strain: Isolate clinical h21, Isolate clinical h22, Isolate clinical h23, Isolate clinical h24, Isolate clinical h25, Isolate clinical LA/1, Isolate clinical LA/2 and Isolate clinical MA/1. 1
Natural varianti17A → V in strain: Isolate clinical CH/1. 1
Natural varianti23S → N in strain: Isolate clinical h3. 1
Natural varianti29L → V in strain: Isolate clinical h17. 1
Natural varianti41R → H in strain: Isolate clinical h4. 1
Natural varianti42L → P in strain: Isolate clinical h21, Isolate clinical h22, Isolate clinical h23, Isolate clinical h24, Isolate clinical h25, Isolate clinical CH/1. 1
Natural varianti51R → W in strain: Isolate clinical HE/2; acyclovir resistant. 1 Publication1
Natural varianti55D → N in strain: Isolate CL17; acyclovir resistant. 1 Publication1
Natural varianti65T → N in strain: Isolate CL18; acyclovir resistant. 1 Publication1
Natural varianti83E → K in strain: Isolate clinical LA/2; acyclovir resistant. 1 Publication1
Natural varianti84P → S in strain: Isolate CL19; acyclovir resistant. 1 Publication1
Natural varianti85M → I in strain: Isolate clinical VA/1. 1
Natural varianti89Q → R in strain: Isolate clinical CH/1, Isolate clinical h20, Isolate clinical h21, Isolate clinical h22, Isolate clinical h23, Isolate clinical h24, Isolate clinical h25, Isolate clinical LA/1, Isolate clinical LA/2, Isolate clinical MA/1, Isolate clinical PR/1 and Isolate clinical PR/2. 1
Natural varianti105H → P in strain: Isolate clinical CH/1; acyclovir resistant. 1 Publication1
Natural varianti158T → A in strain: Isolate clinical h20. 1
Natural varianti158T → I in strain: Isolate clinical h13. 1
Natural varianti173P → R in strain: Isolate CL20; acyclovir resistant. 1 Publication1
Natural varianti175A → V in strain: Isolate clinical BR/2; acyclovir resistant. 1 Publication1
Natural varianti191V → L in strain: Isolate clinical h3. 1
Natural varianti192A → V in strain: Isolate clinical LA/1 and Isolate clinical LA/2; acyclovir resistant. 1
Natural varianti200G → C in strain: Isolate CL21; acyclovir resistant. 1 Publication1
Natural varianti212R → K in strain: Isolate clinical h5. 1
Natural varianti240G → E in strain: Isolate clinical BR/1, Isolate clinical BR/2, Isolate clinical CH/1 and Isolate clinical VA/1. 1
Natural varianti243A → V in strain: Isolate clinical h5. 1
Natural varianti245T → M in strain: Isolate CL22; acyclovir resistant. 1 Publication1
Natural varianti251G → A in strain: Isolate clinical h25. 1
Natural varianti251G → C in strain: Isolate clinical LA/1, Isolate clinical LA/2, Isolate clinical MA/1, Isolate clinical PR/1 and Isolate clinical PR/2. 1
Natural varianti257E → Q in strain: Isolate clinical h25. 1
Natural varianti267V → L in strain: Isolate clinical CH/1, Isolate clinical LA/1, Isolate clinical LA/2 and Isolate clinical MA/1. 1
Natural varianti268P → T in strain: Isolate clinical CH/1, Isolate clinical LA/1, Isolate clinical LA/2, Isolate clinical MA/1, Isolate clinical PR/1 and Isolate clinical PR/2. 1
Natural varianti271G → V in strain: Isolate clinical h12. 1
Natural varianti279G → D in strain: Isolate clinical h11, Isolate clinical h12. 1
Natural varianti286D → E in strain: Isolate clinical CH/1, Isolate clinical LA/1, Isolate clinical LA/2, Isolate clinical MA/1, Isolate clinical PR/1 and Isolate clinical PR/2. 1
Natural varianti287T → M in strain: Isolate CL23; acyclovir resistant. 1 Publication1
Natural varianti316A → V in strain: Isolate clinical h15. 1
Natural varianti317K → R in strain: Isolate clinical h4. 1
Natural varianti332S → A in strain: Isolate clinical h17. 1
Natural varianti336C → Y in strain: Isolate CL24; acyclovir resistant. 1 Publication1
Natural varianti348V → I in strain: Isolate clinical h20. 1
Natural varianti355P → Q in strain: Isolate clinical h23 and Isolate clinical h24. 1
Natural varianti364L → P in strain: Isolate clinical BR/2. 1
Natural varianti374E → A in strain: Isolate clinical CH/1. 1
Natural varianti376N → H in strain: Isolate clinical MA/1, Isolate clinical PR/1 and Isolate clinical PR/2. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF243477 Genomic DNA Translation: AAF72491.1
AF243478 Genomic DNA Translation: AAF72492.1
AF243479 Genomic DNA Translation: AAF72493.1
AF243481 Genomic DNA Translation: AAF72495.1
AF243482 Genomic DNA Translation: AAF72496.1
AF243483 Genomic DNA Translation: AAF72497.1
AF243486 Genomic DNA Translation: AAF72500.1
AF243487 Genomic DNA Translation: AAF72501.1
AF243488 Genomic DNA Translation: AAF72502.1
AF243492 Genomic DNA Translation: AAF72506.1
AF243493 Genomic DNA Translation: AAF72507.1
AF243494 Genomic DNA Translation: AAF72508.1
AB009260 Genomic DNA Translation: BAA83999.1
AB032866 Genomic DNA Translation: BAA93054.1
AB032867 Genomic DNA Translation: BAA93055.1
AB032868 Genomic DNA Translation: BAA93056.1
AB032869 Genomic DNA Translation: BAA93057.1
AB032870 Genomic DNA Translation: BAA93058.1
AB032871 Genomic DNA Translation: BAA93059.1
AB032872 Genomic DNA Translation: BAA93060.1
AB032873 Genomic DNA Translation: BAA93061.1
AB032874 Genomic DNA Translation: BAA93062.1
AB032875 Genomic DNA Translation: BAA93063.1
AB032876 Genomic DNA Translation: BAA93064.1
AB032877 Genomic DNA Translation: BAA93065.1
AB032878 Genomic DNA Translation: BAA93066.1
AB032879 Genomic DNA Translation: BAA93067.1
AB032880 Genomic DNA Translation: BAA93068.1
AB032881 Genomic DNA Translation: BAA93069.1
AB032882 Genomic DNA Translation: BAA93070.1
AB032883 Genomic DNA Translation: BAA93071.1
AB032884 Genomic DNA Translation: BAA93072.1
AB032885 Genomic DNA Translation: BAA93073.1
AB032886 Genomic DNA Translation: BAA93074.1
AB032887 Genomic DNA Translation: BAA93075.1
AB032888 Genomic DNA Translation: BAA93076.1
AB032889 Genomic DNA Translation: BAA93077.1
AB032890 Genomic DNA Translation: BAA93078.1
AB047358 Genomic DNA Translation: BAB11915.1
AB047371 Genomic DNA Translation: BAB11948.1
AB047372 Genomic DNA Translation: BAB11949.1
AB047373 Genomic DNA Translation: BAB11950.1
AB047374 Genomic DNA Translation: BAB11951.1
AB047375 Genomic DNA Translation: BAB11952.1
AB047376 Genomic DNA Translation: BAB11953.1
AB047377 Genomic DNA Translation: BAB11954.1
AB047378 Genomic DNA Translation: BAB11955.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243477 Genomic DNA Translation: AAF72491.1
AF243478 Genomic DNA Translation: AAF72492.1
AF243479 Genomic DNA Translation: AAF72493.1
AF243481 Genomic DNA Translation: AAF72495.1
AF243482 Genomic DNA Translation: AAF72496.1
AF243483 Genomic DNA Translation: AAF72497.1
AF243486 Genomic DNA Translation: AAF72500.1
AF243487 Genomic DNA Translation: AAF72501.1
AF243488 Genomic DNA Translation: AAF72502.1
AF243492 Genomic DNA Translation: AAF72506.1
AF243493 Genomic DNA Translation: AAF72507.1
AF243494 Genomic DNA Translation: AAF72508.1
AB009260 Genomic DNA Translation: BAA83999.1
AB032866 Genomic DNA Translation: BAA93054.1
AB032867 Genomic DNA Translation: BAA93055.1
AB032868 Genomic DNA Translation: BAA93056.1
AB032869 Genomic DNA Translation: BAA93057.1
AB032870 Genomic DNA Translation: BAA93058.1
AB032871 Genomic DNA Translation: BAA93059.1
AB032872 Genomic DNA Translation: BAA93060.1
AB032873 Genomic DNA Translation: BAA93061.1
AB032874 Genomic DNA Translation: BAA93062.1
AB032875 Genomic DNA Translation: BAA93063.1
AB032876 Genomic DNA Translation: BAA93064.1
AB032877 Genomic DNA Translation: BAA93065.1
AB032878 Genomic DNA Translation: BAA93066.1
AB032879 Genomic DNA Translation: BAA93067.1
AB032880 Genomic DNA Translation: BAA93068.1
AB032881 Genomic DNA Translation: BAA93069.1
AB032882 Genomic DNA Translation: BAA93070.1
AB032883 Genomic DNA Translation: BAA93071.1
AB032884 Genomic DNA Translation: BAA93072.1
AB032885 Genomic DNA Translation: BAA93073.1
AB032886 Genomic DNA Translation: BAA93074.1
AB032887 Genomic DNA Translation: BAA93075.1
AB032888 Genomic DNA Translation: BAA93076.1
AB032889 Genomic DNA Translation: BAA93077.1
AB032890 Genomic DNA Translation: BAA93078.1
AB047358 Genomic DNA Translation: BAB11915.1
AB047371 Genomic DNA Translation: BAB11948.1
AB047372 Genomic DNA Translation: BAB11949.1
AB047373 Genomic DNA Translation: BAB11950.1
AB047374 Genomic DNA Translation: BAB11951.1
AB047375 Genomic DNA Translation: BAB11952.1
AB047376 Genomic DNA Translation: BAB11953.1
AB047377 Genomic DNA Translation: BAB11954.1
AB047378 Genomic DNA Translation: BAB11955.1

3D structure databases

SMRiQ9QNF7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9QNF7, 3 interactors
MINTiQ9QNF7

Chemistry databases

BindingDBiQ9QNF7
ChEMBLiCHEMBL1795127
DrugBankiDB00249 Idoxuridine
DB00577 Valaciclovir
DB00194 Vidarabine

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.1.21 2647
SABIO-RKiQ9QNF7

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKITH_HHV1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QNF7
Secondary accession number(s): Q9ENR2
, Q9ENR3, Q9ENR4, Q9ENR5, Q9ENR6, Q9ENR7, Q9ENR8, Q9ENR9, Q9ICF2, Q9ICF3, Q9ICH1, Q9IR31, Q9IR32, Q9IR33, Q9IR34, Q9IR35, Q9IR36, Q9IR37, Q9IR38, Q9IR39, Q9IR40, Q9IYZ6, Q9IZ00, Q9IZ01, Q9IZ04, Q9IZ05, Q9IZ06, Q9IZ08, Q9IZ09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: June 5, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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