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Entry version 149 (11 Dec 2019)
Sequence version 1 (01 May 2000)
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Protein

Genome polyprotein

Gene
N/A
Organism
Hepatitis C virus subtype 2a
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei956For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei976For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei997For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteasePROSITE-ProRule annotation, Transferase
Biological processActivation of host autophagy by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virusSAAS annotation, Viral attachment to host cellSAAS annotation, Viral immunoevasion, Viral RNA replicationSAAS annotation, Virus entry into host cell
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHepatitis C virus subtype 2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31649 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaFlaviviridaeHepacivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000138744 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei722 – 745HelicalSequence analysisAdd BLAST24
Transmembranei757 – 782HelicalSequence analysisAdd BLAST26
Transmembranei788 – 807HelicalSequence analysisAdd BLAST20
Transmembranei819 – 840HelicalSequence analysisAdd BLAST22
Transmembranei877 – 897HelicalSequence analysisAdd BLAST21
Transmembranei1664 – 1687HelicalSequence analysisAdd BLAST24
Transmembranei1769 – 1785HelicalSequence analysisAdd BLAST17
Transmembranei1791 – 1816HelicalSequence analysisAdd BLAST26
Transmembranei1828 – 1849HelicalSequence analysisAdd BLAST22
Transmembranei1855 – 1874HelicalSequence analysisAdd BLAST20
Transmembranei1886 – 1906HelicalSequence analysisAdd BLAST21
Transmembranei3013 – 3032HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi488 ↔ 624Combined sources
Disulfide bondi496 ↔ 566Combined sources
Disulfide bondi510 ↔ 554Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi558N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi571 ↔ 601Combined sources
Disulfide bondi611 ↔ 648Combined sources
Glycosylationi649N-linked (GlcNAc...) asparagineCombined sources1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1030 – 1031Cleavage; by protease NS2-3PROSITE-ProRule annotation2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9QF35

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini907 – 1030Peptidase C18InterPro annotationAdd BLAST124
Domaini1031 – 1212Peptidase S29InterPro annotationAdd BLAST182
Domaini1221 – 1373Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini1365 – 1542Helicase C-terminalInterPro annotationAdd BLAST178
Domaini2656 – 2774RdRp catalyticInterPro annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni2193 – 2214DisorderedSequence analysisAdd BLAST22
Regioni2309 – 2333DisorderedSequence analysisAdd BLAST25
Regioni2350 – 2432DisorderedSequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 74PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2199 – 2214PolarSequence analysisAdd BLAST16
Compositional biasi2357 – 2391PolarSequence analysisAdd BLAST35

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K19358

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492 DEAD_Flavivir
IPR002521 HCV_core_C
IPR002522 HCV_core_N
IPR002519 HCV_env
IPR002531 HCV_NS1
IPR002518 HCV_NS2
IPR042205 HCV_NS2_C
IPR042209 HCV_NS2_N
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR038568 HCV_NS5A_1B_sf
IPR024350 HCV_NS5a_C
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF01543 HCV_capsid, 1 hit
PF01542 HCV_core, 1 hit
PF01539 HCV_env, 1 hit
PF01560 HCV_NS1, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF12941 HCV_NS5a_C, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9QF35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR
60 70 80 90 100
KTSERSQPRG RRQPIPKDRR STGKSWGKPG YPWPLYGNEG LGWAGWLLSP
110 120 130 140 150
RGSRPSWGPN DPRHRSRNVG KVIDTLTCGF ADLMGYIPVV GAPLGGVARA
160 170 180 190 200
LAHGVRVLED GVNFATGNLP GCSFSIFLLA LLSCITTPVS AAEVKNISTG
210 220 230 240 250
YMVTNDCTND SITWQLQAAV LHVPGCVPCE KVGNASQCWI PVSPNVAVQR
260 270 280 290 300
PGALTQGLRT HIDMVVMSAT LCSALYVGDL CGGVMLAAQM FIVSPQHHWF
310 320 330 340 350
VQDCNCSIYP GTITGHRMAW DMMMNWSPTA TMILAYAMRV PEVIIDIISG
360 370 380 390 400
AHWGVMFGLA YFSMQGAWAK VVVILLLAAG VDARTHTVGG SAAQTTGRLT
410 420 430 440 450
SLFDMGPRQK IQLVNTNGSW HINRTALNCN DSLHTGFIAS LFYTHSFNSS
460 470 480 490 500
GCPERMSACR SIEAFRVGWG ALQYEDNVTN PEDMRPYCWH YPPRQCGVVS
510 520 530 540 550
AKTVCGPVYC FTPSPVVVGT TDRLGAPTYT WGENETDVFL LNSTRPPLGS
560 570 580 590 600
WFGCTWMNSS GYTKTCGAPP CRTRADFNAS TDLLCPTDCF RKHPDTTYLK
610 620 630 640 650
CGSGPWLTPR CLIDYPYRLW HYPCTVNYTI FKIRMYVGGV EHRLTAACNF
660 670 680 690 700
TRGDRCNLED RDRSQLSPLL HSTTEWAILP CSYSDLPALS TGLLHLHQNI
710 720 730 740 750
VDVQFMYGLS PALTKYIVRW EWVILLFLLL ADARVCACLW MLILLGQAEA
760 770 780 790 800
ALEKLVILHA ASAASCNGFL YFVIFFVAAW YIKGRVVPLA TYSLTGLWSF
810 820 830 840 850
SLLLLALPQQ AYAYDASVHG QIGAALLVMI TLFTLTPGYK TLLSRFLWWL
860 870 880 890 900
CYLLTLGEAM VQEWAPPMQV RGGRDGIIWA VAIFYPGVVF DITKWLLAVL
910 920 930 940 950
GPAYLLKGAL TRVPYFVRAH ALLRMCTMAR HLAGGRYVQM ALLALGRWTG
960 970 980 990 1000
TYIYDHLTPM SDWAASGLRD LAVAVEPIIF SPMEKKVIVW GAETAACGDI
1010 1020 1030 1040 1050
LHGLPVSARL GREVLLGPAD GYTSKGWSLL APITAYAQQT RGLLGTIVVS
1060 1070 1080 1090 1100
MTGRDKTEQA GEIQVLSTVT QSFLGTSISG VLWTVYHGAG NKTLAGSRGP
1110 1120 1130 1140 1150
VTQMYSSAEG DLVGWPSPPG TKSLEPCTCG AVDLYLVTRN ADVIPARRRG
1160 1170 1180 1190 1200
DKRGALLSPR PLSTLKGSSG GPVLCPRGHA VGVFRAAVCS RGVAKSIDFI
1210 1220 1230 1240 1250
PVETLDIVTR SPTFSDNSTP PAVPQTYQVG YLHAPTGSGK STKVPVAYAA
1260 1270 1280 1290 1300
QGYKVLVLNP SVAATLGFGA YLSKAHGINP NIRTGVRTVT TGAPITYSTY
1310 1320 1330 1340 1350
GKFLADGGCA GGAYDIIICD ECHAVDSTTI LGIGTVLDQA ETAGVRLTVL
1360 1370 1380 1390 1400
ATATPPGSVT TPHPNIEEVA LGQEGEIPFY GRAIPLSYIK GGRHLIFCHS
1410 1420 1430 1440 1450
KKKCDELAAA LRGMGLNSVA YYRGLDVSVI PTQGDVVVVA TDALMTGYTG
1460 1470 1480 1490 1500
DFDSVIDCNV AVTQVVDFSL DPTFTITTQI VPQDAVSRSQ RRGRTGRGRL
1510 1520 1530 1540 1550
GIYRYVSTGE RASGMFDSVV LCECYDAGAA WYELTPSETT VRLRAYFNTP
1560 1570 1580 1590 1600
GLPVCQDHLE FWEAVFTGLT HIDAHFLSQT KQSGENFAYL TAYQATVCAR
1610 1620 1630 1640 1650
AKAPPPSWDV MWKCLTRLKP TLVGPTPLLY RLGSVTNEVT LTHPVTKYIA
1660 1670 1680 1690 1700
TCMQADLEVM TSTWVLAGGV LAAVAAYCLA TGCVCIIGRL HINQRAVVAP
1710 1720 1730 1740 1750
DKEVLYEAFD EMEECASRAA LIEEGQRIAE MLKSKIQGLL QQASKQAQDI
1760 1770 1780 1790 1800
QPTVQASWPK VEQFWAKHMW NFISGIQYLA GLSTLPGNPA VASMMAFSAA
1810 1820 1830 1840 1850
LTSPLSTSTT ILLNILGGWL ASQIAPPAGA TGFVVSGLVG AAVGSIGLGK
1860 1870 1880 1890 1900
VLVDILAGYG AGISGALVAF KIMSGEKPSM EDVVNLLPGI LSPGALVVGV
1910 1920 1930 1940 1950
ICAAILRRHV GPGEGAVQWM NRLIAFASRG NHVAPTHYVT ESDASQRVTQ
1960 1970 1980 1990 2000
LLGSLTITSL LRRLHNWITE DCPIPCGGSW LRDVWDWVCT ILTDFKNWLT
2010 2020 2030 2040 2050
SKLFPKMPGL PFVSCQKGYK GVWAGTGIMT TRCPCGANIS GNVRLGSMRI
2060 2070 2080 2090 2100
TGPKTCMNIW QGTFPINCYT EGQCVPKPAP NFKVAIWRVA ASEYAEVTQH
2110 2120 2130 2140 2150
GSYHYITGLT TDNLKVPCQL PSPEFFSWVD GVQIHRFAPT PKPFFRDEVS
2160 2170 2180 2190 2200
FCVGLNSFVV GSQLPCDPEP DTDVLMSMLT DPSHITAETA ARRLARGSPP
2210 2220 2230 2240 2250
SEASSSASQL SAPSLRATCT THGKAYDVDM VDANLFMGGD VTRIESGSKV
2260 2270 2280 2290 2300
VVLDSLDPMV EERSDLEPSI PSEYMLPKKR FPPALPAWAR PDYNPPLVES
2310 2320 2330 2340 2350
WKRPDYQPAT VAGCALPPPR KTPTPPPRRR RTVGLSEDSI GDALQQLAIK
2360 2370 2380 2390 2400
SFGQPPPSGD SGLSTGAGAA DSGSQTPPDE LALSETGSIS SMPPLEGELG
2410 2420 2430 2440 2450
DPDLEPEQVE PQPPPQGGVA APGSDSGSWS TCSEEDDSVV CCSMSYSWTG
2460 2470 2480 2490 2500
ALITPCSPEE EKLPINPLSN SLLRYHNKVY CTTTKSASLR AKKVTFDRMQ
2510 2520 2530 2540 2550
VLDSYYDSVL KDIKLAASKV TARLLTMEEA CQLTPPHSAR SKYGFGAKEV
2560 2570 2580 2590 2600
RSLSGRAVNH IKSVWKDLLE DSETPIPTTI MAKNEVFCVD PTKGGKKAAR
2610 2620 2630 2640 2650
LIVYPDLGVR VCEKMALYDI TQKLPQAVMG ASYGFQYSPA QRVEFLLKAW
2660 2670 2680 2690 2700
AEKKDPMGFS YDTRCFDSTV TERDIRTEES IYRACSLPEE AHTAIHSLTE
2710 2720 2730 2740 2750
RLYVGGPMFN SKGQTCGYRR CRASGVLTTS MGNTITCYVK ALAACKAAGI
2760 2770 2780 2790 2800
IAPTMLVCGD DLVVISESQG TEEDERNLRA FTEAMTRYSA PPGDPPRPEY
2810 2820 2830 2840 2850
DLELITSCSS NVSVALGPQG RRRYYLTRDP TTPIARAAWE TVRHSPVNSW
2860 2870 2880 2890 2900
LGNIIQYAPT IWARMVLMTH FFSILMAQDT LDQNLNFEMY GAVYSVSPLD
2910 2920 2930 2940 2950
LPAIIERLHG LDAFSLHTYT PHELTRVASA LRKLGAPPLR AWKSRARAVR
2960 2970 2980 2990 3000
ASLISRGGRA AVCGRYLFNW AVKTKLKLTP LPEARLLDLS SWFTVGAGGG
3010 3020 3030
DIYHSVSRAR PRLLLFGLLL LFVGVGLFLL PAR
Length:3,033
Mass (Da):329,267
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D894082FFF885C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177036 Genomic RNA Translation: AAF01178.1

NCBI Reference Sequences

More...
RefSeqi
YP_001469630.1, NC_009823.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11027172

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:11027172

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177036 Genomic RNA Translation: AAF01178.1
RefSeqiYP_001469630.1, NC_009823.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WEBX-ray2.40E456-655[»]
SMRiQ9QF35
ModBaseiSearch...
PDBe-KBiSearch...

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9QF35

Genome annotation databases

GeneIDi11027172
KEGGivg:11027172

Organism-specific databases

European Hepatitis C Virus Database

More...
euHCVdbi
AF177036

Phylogenomic databases

KOiK19358

Family and domain databases

Gene3Di1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit
InterProiView protein in InterPro
IPR011492 DEAD_Flavivir
IPR002521 HCV_core_C
IPR002522 HCV_core_N
IPR002519 HCV_env
IPR002531 HCV_NS1
IPR002518 HCV_NS2
IPR042205 HCV_NS2_C
IPR042209 HCV_NS2_N
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR038568 HCV_NS5A_1B_sf
IPR024350 HCV_NS5a_C
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
PfamiView protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF01543 HCV_capsid, 1 hit
PF01542 HCV_core, 1 hit
PF01539 HCV_env, 1 hit
PF01560 HCV_NS1, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF12941 HCV_NS5a_C, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9QF35_9HEPC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QF35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: December 11, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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